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halichondrioides (40) 40
metabolites (31) 31
animals (30) 30
chemistry, organic (28) 28
chemistry, medicinal (26) 26
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plant sciences (21) 21
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plakortis - chemistry (11) 11
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plakortis-halichondrioides (7) 7
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article (5) 5
caribbean sponge (5) 5
esters (5) 5
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okinawan marine sponge (5) 5
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polyketides - chemistry (5) 5
simplex (5) 5
asymmetric-synthesis (4) 4
bioactive cyclic peroxides (4) 4
biochemistry & molecular biology (4) 4
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genus plakortis (4) 4
lactones - chemistry (4) 4
mice (4) 4
polyketide peroxides (4) 4
spectrophotometry, ultraviolet (4) 4
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acid (3) 3
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4-butyrolactone - analogs & derivatives (2) 2
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Journal of the American Chemical Society, ISSN 0002-7863, 02/2018, Volume 140, Issue 5, pp. 1937 - 1944
The Plakortin polyketides represent a structurally and biologically fascinating class of marine natural products. Herein, we report a unified strategy that... 
NATURAL-PRODUCT SYNTHESIS | ELECTRON-TRANSFER | PLAKORTIS-HALICHONDRIOIDES | (+/-)-GRACILIOETHERS E | MUKAIYAMA-MICHAEL REACTIONS | INTRAMOLECULAR 2+2 PHOTOCYCLOADDITION | C-H OXIDATION | OXYGENATED POLYKETIDES | MARINE SPONGES | PLAKINASTRELLA-MAMILLARIS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 06/2016, Volume 81, Issue 12, pp. 5135 - 5143
Fifteen polyketides, including the first hydroxylated plakortone (12) and plakdiepoxide (15), the first polyketide to embed a vicinal diepoxide, have been... 
REARRANGEMENT | METABOLITES | CHEMICAL DIVERSITY | NATURAL-PRODUCTS | HALICHONDRIOIDES | ANGULOSPICULATUS | STEREOCHEMISTRY | CHEMISTRY, ORGANIC | CYCLIC PEROXIDES | ENDOPEROXIDES | MARINE SPONGE | Peroxides | Chemistry, Organic | Ketenes (Class of compounds) | Chemical properties | Research
Journal Article
Natural Product Reports, ISSN 0265-0568, 6/2016, Volume 33, Issue 7, pp. 861 - 88
Covering: up to early 2016 Marine sponges are widely known as a rich source of natural products, especially of polyketide origin, with a wealth of chemical... 
CHEMISTRY, MEDICINAL | ASYMMETRIC-SYNTHESIS | PLAKORTIS HALICHONDRIOIDES ACTIVATORS | NATURAL-PRODUCTS | PLAKEVULIN-A | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | CATALYTIC ENANTIOSELECTIVE PEROXIDATION | PLAKINASTRELLA-MAMILLARIS | BIOACTIVE CYCLIC PEROXIDES | CARIBBEAN SPONGE | C-H OXIDATION | FATTY-ACID DERIVATIVES
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 08/2016, Volume 81, Issue 15, pp. 6848 - 6854
A chemoselective oxidative cleavage of synthetic gracilioether B, 11-epi-gracilioether C benzoate, and des-hydroxy­gracilioether C with pyridinium... 
METABOLITES | PLAKORTIS-HALICHONDRIOIDES | ONE-POT | DIELS-ALDER REACTION | H OXIDATION | CHEMISTRY, ORGANIC | SILVER-NITRATE | OXYGENATED POLYKETIDES | PLAKINASTRELLA-MAMILLARIS | 2-PI+2-PI CYCLOADDITION | MARINE SPONGE | Usage | Chemical properties | Ring formation (Chemistry) | Chemical synthesis | Acetone
Journal Article
Arkivoc, ISSN 1551-7004, 04/2015, Volume 2015, Issue 5, pp. 164 - 175
Bioassay-guided fractionation of the extract of Jamaican marine sponge Plakortis sp. followed by preparative TLC and HPLC yielded several known methyl ester... 
Plakortis sponge | Cytotoxicity | Polyketides | Cyclic peroxides | cyclic peroxides | ATPASE | CHEMISTRY, ORGANIC | HALICHONDRIOIDES ACTIVATORS | polyketides | cytotoxicity
Journal Article
Organic Letters, ISSN 1523-7060, 03/2016, Volume 18, Issue 5, pp. 1032 - 1035
Journal Article
Tetrahedron, ISSN 0040-4020, 01/2013, Volume 69, Issue 1, pp. 334 - 340
The first total synthesis of andavadoic acid, a naturally occurring five-membered ring peroxide, and its absolute configuration assignment are reported.... 
Andavadoic acid | Hydroperoxysilylation | Cyclization | Endoperoxides | Plakortolides | PLAKORTIS-HALICHONDRIOIDES | PEROXYLACTONE | CHEMISTRY, ORGANIC | PLAKINASTRELLA-ONKODES | CARBONYL-COMPOUNDS | MARINE SPONGE | SECONDARY ALCOHOLS | CYCLIC PEROXIDES | EFFICIENT DEOXYGENATION | GENERAL PROCEDURE | MOLECULAR-OXYGEN
Journal Article
ORGANIC LETTERS, ISSN 1523-7060, 01/2004, Volume 6, Issue 1, pp. 75 - 78
Two novel polyketides, spiculoic acids A (1) and B (2), have been isolated from extracts of the Caribbean marine sponge Plakortis angulospiculatus. The... 
HALICHONDRIOIDES | CHEMISTRY, ORGANIC | PLAKOTENIN | PAPUA-NEW-GUINEA
Journal Article
Organic and Biomolecular Chemistry, ISSN 1477-0520, 06/2014, Volume 12, Issue 22, pp. 3686 - 3700
The first enantioselective total synthesis of epiplakinic acid F (1) was achieved through a pivotal step involving a radical-mediated asymmetric peroxidation... 
DIELS-ALDER APPROACH | SPONGE PLAKORTIS-HALICHONDRIOIDES | ENANTIOSELECTIVE SYNTHESIS | RADICAL CYCLIZATION | ATOM-TRANSFER | BIOLOGICAL EVALUATION | CHEMISTRY, ORGANIC | SUBSTITUTED VINYLCYCLOPROPANES | 3-MEMBERED RINGS | CHEMICAL SYNTHESIS | 3+2 CYCLOADDITION
Journal Article
Natural product reports, ISSN 0265-0568, 07/2016, Volume 33, Issue 7, pp. 861 - 880
Covering: up to early 2016Marine sponges are widely known as a rich source of natural products, especially of polyketide origin, with a wealth of chemical... 
Marine Biology | Biological Products - chemical synthesis | Biological Products - chemistry | Polyketide Synthases - metabolism | Animals | Peroxides - chemical synthesis | Peroxides - chemistry | Polyketides - chemical synthesis | Polyketides - chemistry | Molecular Structure | Porifera - chemistry | Anti-Infective Agents
Journal Article
Tetrahedron, ISSN 0040-4020, 11/2013, Volume 69, Issue 46, pp. 9813 - 9818
The polyketide secondary metabolites spongosoritin A and gracilioethers A–C contain a unique methyl [2(5H)-furanylidene]ethanoate core. A synthetic model of a... 
Cyclisation/dehydration cascade | Methyl [2(5H)-furanylidene]ethanoate | Sodio-lithio dianion enolate | Gracilioether | METABOLITES | PLAKORTIS-HALICHONDRIOIDES | CHEMISTRY, ORGANIC | GENUS PLAKORTIS | MARINE SPONGE | Construction | Biomimetics | Metabolites | Natural products | Cascades | Tetrahedrons | Formations | Isomers
Journal Article
Tetrahedron, ISSN 0040-4020, 1998, Volume 54, Issue 13, pp. 3057 - 3068
As part of a program to discover new drugs for the treatment of tropical diseases, we have isolated and identified six new metabolites from the Palauan sponge... 
CHEMISTRY, ORGANIC | METABOLITES | HALICHONDRIOIDES | LEISHMANIA
Journal Article
Tetrahedron, ISSN 0040-4020, 05/2012, Volume 68, Issue 19, pp. 3717 - 3724
Journal Article
Tetrahedron, ISSN 0040-4020, 06/2012, Volume 68, Issue 24, pp. 4635 - 4640
Six new polyketides, simplexolides A–E (1–5) and a furan ester, plakorfuran A (6), together with four known furanylidenic methyl esters (7–10) were isolated... 
Mosher’s method | Antimalarial | Simplexolide | Antifungal | Absolute configuration | Plakortis simplex | Cytotoxicity | Mosher's method | METABOLITES | ACID | ANGULOSPICULATUS | CHEMISTRY, ORGANIC | ABSOLUTE STEREOCHEMISTRY | GENUS PLAKORTIS | HALICHONDRIOIDES | CYCLIC PEROXIDES | Heterocyclic compounds | Esters | Analysis
Journal Article
Journal Article
Asian Pacific Journal of Tropical Biomedicine, ISSN 2221-1691, 2012, Volume 2, Issue 3, pp. S1784 - S1789
Sponges (phylum Porifera) are sessile marine invertebrates and are known to be the richest source of pharmacologically-active compounds. This work was taken to... 
Spongosorites halichondrioides | Antimicrobials | Disc-diffusion assay | Artemia salina toxicity assay
Journal Article
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