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Original Article - Spectrum of epilepsy in tuberous sclerosis, 04/2004
Tuberous sclerosis (TS) is an autosomal dominant disease that affects the brain, skin, eye, heart and kidney. The diagnostic criteria for tuberous sclerosis... 
Neurology | Epilepsy, facial angiofibroma, hypsarrhythmia, hamartin, sub-ependymal nodules, tuberin, tuberous sclerosis, vigabatrin ni04064
Journal
Biochemical Society Transactions, ISSN 0300-5127, 06/2008, Volume 31, Issue 3, p. 573
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 06/2008, Volume 31, Issue 3, p. 592
Journal Article
by Wang, YQ and Zhang, XY and Tang, W and Lin, ZH and Xu, LM and Dong, RF and Li, YN and Li, JY and Zhang, ZX and Li, XZ and Zhao, L and Wei, JJ and Shao, CS and Kong, BH and Liu, ZJ
CELL DEATH AND DIFFERENTIATION, ISSN 1350-9047, 12/2017, Volume 24, Issue 12, pp. 2089 - 2100
Activation of mammalian target of rapamycin (mTOR) signaling pathway is associated with poor prognosis of epithelial ovarian cancer. The TSC1-TSC2 complex is a... 
RAPAMYCIN | ACTIVATION | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUBERIN | MIRNA-130A | STARVATION | AUTOPHAGY | CANCER | EXPRESSION | HAMARTIN | CELL BIOLOGY | Index Medicus | Original Paper
Journal Article
Journal Article
PloS one, ISSN 1932-6203, 2019, Volume 14, Issue 6, pp. e0218354 - e0218354
[This corrects the article DOI: 10.1371/journal.pone.0091952.]. 
Tuberous sclerosis | T cells | Muscle proteins | TOR protein | Downloading | Images | Homeostasis | Hamartin | Lymphocytes T | TSC1 protein | Sclerosis | Format | Lymphocytes | Mutation | Cell size | Paths
Journal Article
Molecular Therapy, ISSN 1525-0016, 09/2019, Volume 27, Issue 9, pp. 1527 - 1528
The SVZ contains neural stem cells and transits amplifying cells, microglia, ependyma, neuroblasts, and astrocytes. [...]identifying the cells that are... 
Hydrocephalus | Astrocytes | Mortality | Clinical trials | Hamartin | TSC1 protein | Kinases | Microglia | Proteins | Tuberin | Neuroblasts | Stem cells | Neural stem cells | Mutation | Gene therapy
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 2019, Volume 26, Issue 10, pp. 2015 - 2028
Loss of either TSC1 or TSC2 causes tuberous sclerosis complex (TSC) via activation of mTOR signaling pathway. The two prominent features of TSC are skin... 
Tuberous sclerosis 2 protein | TOR protein | Cell proliferation | Kidneys | Transcription | Therapeutic applications | Tuberous sclerosis | Hamartin | TSC1 protein | Sclerosis | TSC2 protein | Signal transduction | Cell activation | Pheomelanin | Skin diseases | Tumorigenesis | Null cells | PTEN protein | Melanin
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2017, Volume 24, Issue 12, pp. 2089 - 2100
Activation of mammalian target of rapamycin (mTOR) signaling pathway is associated with poor prognosis of epithelial ovarian cancer. The TSC1-TSC2 complex is a... 
Tuberous sclerosis 2 protein | TOR protein | Cell proliferation | NF-κB protein | Starvation | Leukocyte migration | Ovarian carcinoma | Crosstalk | Hamartin | Rapamycin | Inflammation | TSC1 protein | Kinases | Autophagy | Ovarian cancer | Metastases | TSC2 protein | Signal transduction | Signaling | 3' Untranslated regions | Phagocytosis | Cell migration | Cancer
Journal Article
Neuroscience Letters, ISSN 0304-3940, 07/2019, Volume 706, pp. 223 - 230
Hamartin, a component of the tuberous sclerosis complex (TSC) that actively inhibits the mammalian target of rapamycin (mTOR), may mediate the endogenous... 
Hamartin | AZD2014 | Rapamycin | mTORC2 | mTORC1 | TUBEROUS SCLEROSIS GENE | FOCAL CEREBRAL-ISCHEMIA | TSC1 | ENDOPLASMIC-RETICULUM STRESS | CELL-GROWTH | IDENTIFICATION | NEUROSCIENCES | DUAL MTORC1 | BRAIN | Stroke (Disease) | Proteins | Neurosciences | Ischemia | Neurons | Cell death | Tuberous sclerosis | Investigations
Journal Article
American Journal of Medical Genetics Part A, ISSN 1552-4825, 08/2019, Volume 179, Issue 8, pp. 1423 - 1425
Tuberous sclerosis complex (TSC) is an autosomal dominant syndrome characterized by mostly benign tumors of the brain, skin, heart, kidney, and eye.... 
Nigeria | tuberous sclerosis | diverse populations | COMPLEX | RECOMMENDATIONS | GENETICS & HEREDITY | Arrhythmia | Tuberous sclerosis | Skin | Tuberous sclerosis 2 protein | TSC2 protein | Tuberin | Brain tumors | Skin diseases | Hamartin | TSC1 protein | Sclerosis
Journal Article
Modern Pathology, ISSN 0893-3952, 2019, Volume 32, Issue 7, pp. 957 - 966
Primary malignant melanoma of esophagus is very rare, and its clinicopathologic and genetic features have not been extensively investigated. In this study, 20... 
KIT OCCUR | RECURRENT MUTATIONS | SURGICAL OUTCOMES | BRAF | MUCOSAL | SPECTRUM | PATHOLOGY | SEQUENCING REVEALS | SF3B1 | EXPRESSION | MELANOCYTES | Melanoma | Hamartin | Insulin-like growth factors | TSC1 protein | Pigmentation | Cdc4 protein | Esophagus | Skin cancer | Next-generation sequencing | Molecular modelling | Pain | Dysphagia | Mutation | Tumors
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2013, Volume 19, Issue 3, pp. 351 - 357
Previous attempts to identify neuroprotective targets by studying the ischemic cascade and devising ways to suppress it have failed to translate to efficacious... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | BRAIN-INJURY | BIOCHEMISTRY & MOLECULAR BIOLOGY | FOCAL CEREBRAL-ISCHEMIA | HEAT-SHOCK PROTEIN | RAT MODEL | DELAYED NEURONAL DEATH | CELL BIOLOGY | HIPPOCAMPUS | RAPAMYCIN PROTECTS | CA1 | TRANSIENT FOREBRAIN ISCHEMIA | Rats, Wistar | Multiprotein Complexes | Male | Hypoxia-Ischemia, Brain - prevention & control | Autophagy - drug effects | Neuroprotective Agents - metabolism | Mechanistic Target of Rapamycin Complex 1 | RNA Interference | Tumor Suppressor Proteins - genetics | Prosencephalon - blood supply | CA3 Region, Hippocampal - metabolism | CA1 Region, Hippocampal - metabolism | Hypoxia-Ischemia, Brain - metabolism | Tumor Suppressor Proteins - metabolism | Adenine - analogs & derivatives | CA1 Region, Hippocampal - physiology | CA3 Region, Hippocampal - physiology | Cells, Cultured | Ischemic Preconditioning | Prosencephalon - injuries | Rats | Adenine - pharmacology | Sirolimus - pharmacology | Animals | Proteins - metabolism | Hypoxia | RNA, Small Interfering | TOR Serine-Threonine Kinases | Proteins - antagonists & inhibitors | Stroke (Disease) | Complications and side effects | Autophagy (Cytology) | Care and treatment | Physiological aspects | Genetic aspects | Research | Pharmacology | Ischemia | Gene expression | Neurons | Autophagy | Index Medicus | global cerebral ischemia | endogenous neuroprotection | autophagy | CA3 | proteomics | hippocampus | hamartin | preconditioning
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 11/2017, Volume 23, Issue 21, pp. 6487 - 6497
Journal Article