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Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 764 - 17
Checkpoint kinases sense replicative stress to prevent DNA damage. Here we show that the histone deacetylases HDAC1/HDAC2 sustain the phosphorylation of the... 
CANCER-CELLS | RIBONUCLEOTIDE REDUCTASE | CHK1 | TUMOR SUPPRESSION | DNA-DAMAGE RESPONSE | MULTIDISCIPLINARY SCIENCES | GENOME INTEGRITY | DOUBLE-STRAND BREAKS | HISTONE DEACETYLASE INHIBITORS | REPLICATION FORK COLLAPSE | ATR | Phosphorylation | Ataxia Telangiectasia Mutated Proteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Tumor Suppressor Protein p53 - genetics | CDC2 Protein Kinase - metabolism | Checkpoint Kinase 2 - metabolism | Checkpoint Kinase 2 - genetics | Protein-Tyrosine Kinases - genetics | Cell Cycle Proteins - genetics | Nuclear Proteins - genetics | Histone Deacetylase 1 - genetics | Histone Deacetylase 2 - genetics | CDC2 Protein Kinase - genetics | Cell Cycle Proteins - metabolism | Gene Expression Regulation | Protein Phosphatase 2 - genetics | Tumor Suppressor Protein p53 - metabolism | Nuclear Proteins - metabolism | Checkpoint Kinase 1 - metabolism | Cell Cycle | Protein Phosphatase 2 - metabolism | Histone Deacetylase 2 - metabolism | Ataxia Telangiectasia Mutated Proteins - genetics | Checkpoint Kinase 1 - genetics | Histone Deacetylase 1 - metabolism | Histone deacetylase | p53 Protein | DNA damage | Serine | Homologous recombination | Homology | Dephosphorylation | Kinases | Phosphatase | Damage prevention | Cell fate | Cell cycle | Inhibition | HDAC2 protein | Null cells | Deoxyribonucleic acid--DNA | Stresses | CHK2 protein | Threonine | Phase transformations | CHK1 protein | Protein-serine/threonine phosphatase | Replication protein A | Protein A | Ablation | Stress | DNA biosynthesis | S phase | Replication | Threonine phosphatase | Phase transition | Tumors | Apoptosis
Journal Article
Cancer Letters, ISSN 0304-3835, 2012, Volume 320, Issue 1, pp. 14 - 22
Abstract The chromosomal translocation t(11;22)(q24;q12) yields the EWS-Fli1 fusion gene, which contributes to the development of Ewing Family Tumors (EFTs).... 
Hematology, Oncology and Palliative Medicine | Histone deacetylase 1 | EWS-Fli1 | P53 | CELLS | DNA-BINDING | HISTONE-DEACETYLASE INHIBITORS | DEPENDENT KINASE INHIBITOR | LYSINE RESIDUES | GENE | ONCOLOGY | SARCOMA | TRANSCRIPTIONAL REGULATION | POSTTRANSLATIONAL MODIFICATION | FUSION PROTEINS | NIH 3T3 Cells | Oncogene Proteins, Fusion - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Apoptosis - drug effects | Humans | Transcriptional Activation - drug effects | E1A-Associated p300 Protein - metabolism | Tumor Suppressor Protein p53 - genetics | Bone Neoplasms - metabolism | Proto-Oncogene Protein c-fli-1 - metabolism | Bone Neoplasms - genetics | Acetylation | Hydroxamic Acids - pharmacology | Proto-Oncogene Proteins c-mdm2 - metabolism | Sarcoma, Ewing - metabolism | Proto-Oncogene Protein c-fli-1 - genetics | RNA-Binding Protein EWS - genetics | Tumor Suppressor Protein p53 - metabolism | RNA-Binding Protein EWS - metabolism | Animals | Oncogene Proteins, Fusion - genetics | Cell Line, Tumor | Mice | Sarcoma, Ewing - genetics | Histone Deacetylase 1 - metabolism | Electronic funds transfer systems | Development and progression | Genetic transcription | Tumor proteins | Genes | Tumors | Proteins | Chromatin | Rodents | Medical prognosis | Tumorigenesis | Fluorides | Deoxyribonucleic acid--DNA | Apoptosis | Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 728 - 13
Bilateral symmetry is a striking feature of the vertebrate body plan organization. Vertebral precursors, called somites, provide one of the best illustrations... 
FGF8 | PROTEIN IDENTIFICATION TECHNOLOGY | MOUSE EMBRYOGENESIS | SHOTGUN PROTEOMICS | BILATERAL SYMMETRY | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | SOMITE SEGMENTATION | DYNAMIC EXPRESSION | HISTONE DEACETYLASE | G9A | Histones - chemistry | Epigenesis, Genetic | E1A-Associated p300 Protein - genetics | E1A-Associated p300 Protein - physiology | Histone Deacetylase 2 - physiology | Somites - growth & development | E1A-Associated p300 Protein - metabolism | Histone Deacetylase 1 - physiology | Embryo, Mammalian - metabolism | Somites - ultrastructure | Repressor Proteins - physiology | Tretinoin - metabolism | Histone Deacetylase 1 - genetics | Repressor Proteins - metabolism | Tretinoin - physiology | Somites - metabolism | Histone Deacetylase 2 - genetics | Proteins - physiology | Histone-Lysine N-Methyltransferase - genetics | Nerve Tissue Proteins - physiology | Signal Transduction | Repressor Proteins - genetics | Mice, Transgenic | Embryonic Development | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Proteins - genetics | Animals | Proteins - metabolism | Histone-Lysine N-Methyltransferase - metabolism | Embryo, Mammalian - cytology | Proteomics | Mice | Histone Deacetylase 2 - metabolism | Histones - metabolism | Histone-Lysine N-Methyltransferase - physiology | Histone Deacetylase 1 - metabolism | Histone deacetylase | Regulators | Vertebrae | Somites | Somitogenesis | Embryos | DNA-directed RNA polymerase | Mutants | Recruitment | Polymerase | Proteins | Acids | Ribonucleic acids | Rodents | Histone methyltransferase | HDAC2 protein | Retinoic acid | RNA polymerase II | Symmetry
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2013, Volume 8, Issue 11, p. e79201
Wogonin is a plant monoflavonoid which has been reported to inhibit cell growth and/or induce apoptosis in various tumors. The present study examined the... 
CANCER-CELLS | CARCINOMA-CELLS | BREAST-CANCER | PROTEIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | C-MYC | DOWN-REGULATION | DEGRADATION | TRANSCRIPTION FACTOR | EXPRESSION | F-Box-WD Repeat-Containing Protein 7 | Adenocarcinoma of Lung | Apoptosis - drug effects | Humans | Lung Neoplasms - metabolism | Glycogen Synthase Kinase 3 beta | RNA, Messenger - metabolism | Adenocarcinoma - metabolism | Membrane Potential, Mitochondrial | Adenocarcinoma - genetics | Gene Expression Regulation, Neoplastic - drug effects | Histone Deacetylase 1 - genetics | Lung Neoplasms - genetics | Cell Survival - drug effects | Histone Deacetylase 2 - genetics | F-Box Proteins - metabolism | Flavanones - pharmacology | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Ubiquitin-Protein Ligases - metabolism | Glycogen Synthase Kinase 3 - metabolism | S-Phase Kinase-Associated Proteins - metabolism | Proto-Oncogene Proteins c-myc - metabolism | Signal Transduction - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Proto-Oncogene Proteins c-myc - genetics | Histone Deacetylase 2 - metabolism | Cell Cycle - drug effects | Histone Deacetylase 1 - metabolism | Adenocarcinoma | Ubiquitin | Histone deacetylase | Phosphorylation | Change detection | Leukemia | Lung cancer | c-Myc protein | Multiple myeloma | XIAP protein | Biology | mRNA | Myc protein | Drug resistance | Kinases | Cell adhesion & migration | Anticancer properties | Degradation | Proteins | Liver cancer | Angiogenesis | Pathways | Tumor necrosis factor-TNF | HDAC2 protein | Medical research | Enzymes | Immunoglobulins | Cyclin-dependent kinases | Apoptosis-inducing factor | Poly(ADP-ribose) polymerase | Exposure | Breast cancer | Gene expression | Mcl-1 protein | Skp2 protein | Ligands | Viability | Tumors | Apoptosis | Cancer
Journal Article
by Hu, XT and Zhu, BL and Zhao, LG and Wang, JW and Liu, L and Lai, YJ and He, L and Deng, XJ and Chen, GJ
FASEB JOURNAL, ISSN 0892-6638, 04/2017, Volume 31, Issue 4, pp. 1482 - 1493
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2014, Volume 9, Issue 6, pp. e99467 - e99467
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2016, Volume 11, Issue 7, p. e0160228
Journal Article
Journal Article
International Journal of Hematology, ISSN 0925-5710, 07/2017, Volume 106, Issue 1, pp. 99 - 107
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2011, Volume 6, Issue 11, p. e28103
Histone deacetylase 2 (HDAC2) is crucial for embryonic development, affects cytokine signaling relevant for immune responses and is often significantly... 
WAF1/CIP1 GENE PROMOTER | APOPTOSIS | TRANSCRIPTION | GROWTH | BIOLOGY | HEPATOMA-CELLS | VALPROATE | HISTONE DEACETYLASE INHIBITORS | CANCER | SP1 SITES | Transcription, Genetic - drug effects | Mitogens - pharmacology | Humans | Sp1 Transcription Factor - metabolism | G1 Phase - drug effects | Promoter Regions, Genetic - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Carcinoma, Hepatocellular - genetics | Protein Binding - drug effects | Cell Cycle Proteins - genetics | Liver Neoplasms - pathology | G1 Phase - genetics | Gene Expression Regulation, Neoplastic - drug effects | Liver Neoplasms - enzymology | Binding Sites | Gene Targeting | Liver Neoplasms - genetics | Cell Cycle Proteins - metabolism | Carcinoma, Hepatocellular - enzymology | Enzyme Activation - drug effects | Proto-Oncogene Proteins c-myc - metabolism | S Phase - genetics | Animals | Wnt Signaling Pathway - drug effects | Carcinoma, Hepatocellular - pathology | Histone Deacetylase Inhibitors - pharmacology | Cell Proliferation - drug effects | Mice | S Phase - drug effects | Histone Deacetylase 2 - metabolism | Cell Transformation, Neoplastic - pathology | Embryonic development | DNA synthesis | Hepatoma | Genes | Liver | Cell cycle | Cell proliferation | Regulations | Histone deacetylase | Phosphorylation | Chromatin | Deregulation | Transcription | INK4a protein | Hepatocellular carcinoma | Cyclin D1 | Cyclin-dependent kinase 4 | Proteins | Liver cancer | E2F protein | Reduction | Embryogenesis | Cell growth | Xenografts | HDAC2 protein | Deoxyribonucleic acid--DNA | Immune response | p16 Protein | Sp1 protein | Gene expression | Embryonic growth stage | DNA biosynthesis | Cyclin-dependent kinase 2 | Pathology | Signaling | Cyclin-dependent kinase inhibitor p21 | Disruption | Solid tumors | Aberration | Prostate cancer | Binding sites | Tumors | Cancer | Apoptosis | Deoxyribonucleic acid | DNA
Journal Article
Scientific Reports, ISSN 2045-2322, 08/2015, Volume 5, Issue 1, p. 13396
Journal Article
Scientific Reports, ISSN 2045-2322, 12/2018, Volume 8, Issue 1, pp. 6669 - 9
Identifying effective drug targets, with little or no side effects, remains an ever challenging task. A potential pitfall of failing to uncover the correct... 
NETWORK ANALYSIS | PROTEINS | PATHWAY | MULTIDISCIPLINARY SCIENCES | SYSTEMS BIOLOGY | Histone deacetylase | Retinoid X receptor α | Drug development | Grb2 protein | Proteins | ESR1 protein | Side effects | Janus kinase 2 | Lck protein | Janus kinase | Syk protein | Lyn protein | HDAC2 protein | Cancer | Fyn protein
Journal Article