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Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2019, Volume 519, Issue 1, pp. 166 - 171
Rheumatoid arthritis (RA) is a common immune-related disease worldwide, which is characterized by impaired fibroblast-like synoviocytes (FLS) proliferation and... 
HDAC4 | NF-κB | miR-138 | Inflammatory cytokines | Rheumatoid arthritis | PGRN
Journal Article
Bone, ISSN 8756-3282, 11/2019, Volume 128, p. 115052
End plate chondrocyte degeneration is a major cause of intervertebral disc degeneration. Mechanical biophysical forces, including intermittent cyclic... 
HDAC4 | Degeneration | End plate chondrocyte | Wnt/β-catenin | MiR-365 | Mechanical tension
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 11/2018, Volume 19, Issue 11, p. 3558
Journal Article
Differentiation, ISSN 0301-4681, 2009, Volume 78, Issue 5, pp. 260 - 268
The transforming growth factor-beta (TGF-β) superfamily members play diverse roles in cartilage development and maintenance. TGF-β up-regulates chondrogenic... 
Mesenchymal stem cell | HDAC4 | TGF-β1 | Chondrogenesis | Synovium
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 2016, Volume 25, Issue 18, pp. 3887 - 3907
Journal Article
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 06/2017, Volume 312, Issue 6, pp. L936 - L944
Myofibroblasts are important mediators of fibrogenesis; thus blocking fibroblast-to-myofibroblast differentiation (FMD) may be an effective strategy to treat... 
HDAC4 | NOX4 | Reactive oxygen species | α-smooth muscle actin | Myofibroblasts | IPF | myofibroblasts | reactive oxygen species
Journal Article
Oncotarget, ISSN 1949-2553, 2016, Volume 7, Issue 48, pp. 78220 - 78221
Journal Article
NEUROBIOLOGY OF DISEASE, ISSN 0969-9961, 07/2016, Volume 91, pp. 182 - 193
Mounting evidence suggests that epigenetic modifications play critical roles in the survival/death of stressed neurons. Chief among these modifications is the... 
HDAC4 | SURVIVAL | Stroke | CaMKIV | NEUROSCIENCES | KINASE IV | IMPORT | INHIBITION | GENE-EXPRESSION | MICE | DIFFERENTIATION | CEREBRAL-ISCHEMIA | INTRACELLULAR TRAFFICKING
Journal Article
BioMed Research International, ISSN 2314-6133, 2019, Volume 2019, p. 1315257
Prenatal environmental exposures are considered to contribute to the development of allergic sensitization by epigenetic mechanisms. The role of histone... 
IMMUNE | HDAC4 | MEDICINE, RESEARCH & EXPERIMENTAL | METHYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ASTHMA | MECHANISMS | EPIGENOME | LOCI
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 01/2019, Volume 29, Issue 1, pp. 83 - 88
We have identified a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor , with >500-fold selectivity over class I HDACs... 
Hydroxamic acid | CNS-penetrant | CHDI-390576 | Class IIa HDAC inhibitor | HDAC4 inhibition | Breccia | Lubrication and lubricants | Analysis
Journal Article
BBA - Gene Regulatory Mechanisms, ISSN 1874-9399, 04/2019, Volume 1862, Issue 4, pp. 493 - 508
Leukocyte integrin-dependent downregulation of the transcription factor is required for monocyte differentiation and macrophage functions, but the precise gene... 
Promoter | HDAC4 | Integrin | lncRNA | IRAK1 | FOXP1 | TRANSCRIPTION FACTORS | MYELOID DEVELOPMENT | MACROPHAGES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MECHANISMS | BIOPHYSICS | MONOCYTE DIFFERENTIATION
Journal Article
Cell Reports, ISSN 2211-1247, 10/2019, Volume 29, Issue 3, pp. 749 - 763.e12
HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When is deleted postnatally, mice are... 
dexamethasone | acetylation | HDAC4 | myosin heavy chain | denervation | deacetylation | atrophy | PGC-1α | skeletal muscle | Hsc70 | class IIa HDAC
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2016, Volume 11, Issue 11, p. e0166182
Irisin is a recently identified myokine which brings increases in energy expenditure and contributes to the beneficial effects of exercise through the browning... 
HDAC4 | CELLS | MITOCHONDRIAL PERMEABILITY TRANSITION | DIABETIC MICE | INHIBITION | STIMULATION | MULTIDISCIPLINARY SCIENCES | CARDIAC-HYPERTROPHY | DISEASE | PRESERVES MYOCARDIAL PERFORMANCE | CARDIOPROTECTION | Cell Line | Histone Deacetylases - genetics | Small Ubiquitin-Related Modifier Proteins - metabolism | Caspase 3 - metabolism | Annexin A5 - genetics | Histone Deacetylases - metabolism | Fibronectins - metabolism | Cell Hypoxia | Gene Expression Regulation, Enzymologic | Small Ubiquitin-Related Modifier Proteins - genetics | Myocardial Reperfusion Injury - metabolism | Myocytes, Cardiac - pathology | Annexin A5 - metabolism | Myocardial Reperfusion Injury - pathology | Animals | Proteolysis | Caspase 3 - genetics | Myocytes, Cardiac - metabolism | Fibronectins - genetics | Mice | Myocardial Reperfusion Injury - genetics | Adipose tissues | Analysis | Apoptosis | Ubiquitin | Heart | Histone deacetylase | Adipose tissue | Transcription | Disease | Mitochondrial permeability transition pore | Toxicity | Membrane permeability | Cytotoxicity | Tissues | HDAC4 protein | Caspase-3 | Medical schools | Western blotting | Degradation | Mitochondria | Rodents | Surgery | Cell cycle | Energy expenditure | Caspase | Cardiomyocytes | Lactate dehydrogenase | Permeability | Metabolism | L-Lactate dehydrogenase | Browning | Plasmids | Cell death | Stem cells | Hypoxia | MPTP | Annexin V | Diabetes | Lactic acid | Electron transport
Journal Article
Journal Article
by Cao, K and Wang, H and Fang, YY and Wang, Y and Wei, L and Chen, X and Jiang, Z and Wei, XC and Hu, Y
FRONTIERS IN ONCOLOGY, ISSN 2234-943X, 09/2019, Volume 9
Background/Aims: Osteosarcoma (OS) is commonly characterized by lower survival rates and high incidences of local recurrence due to its highly aggressive... 
HDAC4 | ACTIVATION | PCNA | MECHANISM | UBIQUITIN | progression | CANCER | ONCOLOGY | ubiquitination | DEGRADATION | INHIBITORS | osteosarcoma | EZH2 | Osteochondroma | Antigens | Osteosarcoma
Journal Article
Journal Article