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Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 01/2019, Volume 62, Issue 2, pp. 857 - 874
We designed and synthesized quinazolin-2,4-dione-based hydroxamic acids to serve as selective competitive inhibitors of histone deacetylase-6 (HDAC6). The most... 
CHEMISTRY, MEDICINAL | ARYL | COMBINATION | HDAC6 | PACLITAXEL
Journal Article
11/2012
The AC133 epitope of the pentaspan transmembrane glycoprotein CD133 has been used as a cell-surface marker for normal and cancer stem cells from a broad range... 
0369 | β-catenin | 0379 | 0307 | N-glycosylation | HDAC6 | CD133 | AF4
Dissertation
Journal of Medicinal Chemistry, ISSN 0022-2623, 02/2018, Volume 61, Issue 3, pp. 905 - 917
A series of bicyclic arylamino/heteroarylamino hydroxamic acids (7-31) have been examined as novel histone deacetylase 6 (HDAC6) inhibitors. One compound (13)... 
CHEMISTRY, MEDICINAL | CELL-GROWTH | PANOBINOSTAT | CANCER | HDAC6 INHIBITOR | Index Medicus
Journal Article
Journal of medicinal chemistry, ISSN 0022-2623, 04/2019, Volume 62, Issue 9, pp. 4426 - 4443
The discovery of isozyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biological functions of individual HDACs and for... 
POTENT | DESIGN | CHEMISTRY, MEDICINAL | ANALOGS | AUTOPHAGY | CANCER | HDAC6
Journal Article
Genes and Cancer, ISSN 1947-6019, 2010, Volume 1, Issue 7, pp. 779 - 786
The efficient management of misfolded protein aggregates is essential for cell viability and requires three interconnected pathways: the molecular chaperone... 
Ubiquitin | Actin | Autophagy | p62 | HDAC6 | actin | autophagy | ubiquitin | Monographs
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 10, pp. 3369 - 3384
Staphylococcus aureus is a major etiological agent of sepsis and induces endothelial cell (EC) barrier dysfunction and inflammation, two major hallmarks of... 
endothelium | BARRIER DYSFUNCTION | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | aureus | ACUTE LUNG INJURY | reactive oxygen species (ROS) | barrier disruption | HDAC6 | microtubule | lung injury | Staphylococcus aureus (S | inflammation | histone deacetylase 6 (HDAC6) | PATHWAY | GEF-H1 | EXPRESSION | EPIDEMIOLOGY | CLASP2
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2019, Volume 294, Issue 15, pp. 5813 - 5826
MutL homolog 1 (MLH1) is a key DNA mismatch repair protein, which plays an important role in maintenance of genomic stability and the DNA damage response.... 
CELLS | HYPERMETHYLATION | DNA damage response | BIOCHEMISTRY & MOLECULAR BIOLOGY | MISMATCH-REPAIR | MLH1 | DNA repair | HDAC6 | acetylation | HISTONE DEACETYLASES | histone deacetylase 6 (HDAC6) | drug resistance | MUTATIONS | EXPRESSION | DNA mismatch repair
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 05/2017, Volume 8, Issue 5, pp. 510 - 515
A series of nonhydroxamate HDAC6 inhibitors were prepared in our effort to develop potent and selective compounds for possible use in central nervous system... 
HDAC6 inhibitors | mercaptoacetamides | CNS disorders | brain permeable | TARGET | CHEMISTRY, MEDICINAL | DISEASES | CANCER | HDAC6
Journal Article
Autophagy, ISSN 1554-8627, 2014, Volume 10, Issue 3, pp. 532 - 534
Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory responses to cigarette smoke (CS) associated with respiratory epithelial... 
Autophagy | Lung | HDAC6 | Cilia | COPD | lung | Autophagic Punctum | cilia | autophagy
Journal Article
Phytomedicine : international journal of phytotherapy and phytopharmacology, ISSN 0944-7113, 08/2019, p. 153062
The isothiocyanate sulforaphane (SFN) has multiple protein targets in mammalian cells, affecting processes of fundamental importance for the maintenance of... 
Journal Article
BMB Reports, ISSN 1976-6696, 2018, Volume 51, Issue 8, pp. 394 - 399
Human immunodeficiency virus-1 (HIV-1) transactivator of transcription (Tat) is an important viral factor in neuroinflammation. Hindsiipropane B, present in... 
HIV-1 Tat | Inflammation | NADPH oxidase | Chemokines | HDAC6
Journal Article
Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 08/2019, Volume 27, Issue 15, pp. 3408 - 3420
Several human diseases are associated with aberrant epigenetic pathways mediated by histone deacetylases (HDACs), especially HDAC6, a class IIb HDACs, which... 
Computer-aided drug design | Selective HDAC6 inhibitors | SAR of thiazolyl-hydroxamates | DESIGN | CHEMISTRY, MEDICINAL | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | GLIDE | HDAC6 | Epigenetic inheritance | Medical research | Analysis | Pharmacy | Therapeutics | Medicine, Experimental | Homeopathy | Materia medica and therapeutics
Journal Article
Cell Cycle, ISSN 1538-4101, 12/2017, Volume 16, Issue 24, pp. 2313 - 2314
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 07/2019, Volume 74-75, pp. 1 - 11
HDAC6, a structural and functional distinct member of the HDAC-family, shows great promise as a target to treat several cancers and neurodegenerative diseases.... 
KB631 | B16.F10 melanoma | Carbon-11 | HDAC6
Journal Article