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PLoS ONE, ISSN 1932-6203, 10/2017, Volume 12, Issue 10, p. e0186615
Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive and fatal disease. Histone deacetylase 6 (HDAC6) alters function and fate of various... 
EPITHELIAL-MESENCHYMAL TRANSITION | LUNG FIBROSIS | IN-VITRO | TGF-BETA | HISTONE DEACETYLASE INHIBITION | MULTIDISCIPLINARY SCIENCES | TUBULIN ACETYLATION | DISEASE | AUTOPHAGY | MYOFIBROBLAST DIFFERENTIATION | EXPRESSION | Idiopathic Pulmonary Fibrosis - genetics | Ribosomal Protein S6 Kinases - metabolism | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Phosphoprotein Phosphatases - metabolism | Male | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor A - metabolism | RNA, Messenger - metabolism | Autophagy - drug effects | Idiopathic Pulmonary Fibrosis - metabolism | Mechanistic Target of Rapamycin Complex 1 | Autophagosomes - drug effects | Multiprotein Complexes - metabolism | Tubulin - metabolism | Bleomycin | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Aged, 80 and over | Female | Indoles - pharmacology | Lung - metabolism | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Hydroxamic Acids - pharmacology | Fibroblasts - metabolism | Lung - pathology | Collagen Type I - metabolism | Histone Deacetylases - genetics | Histone Deacetylase 6 | RNA, Messenger - genetics | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | Autophagosomes - metabolism | Mice, Knockout | Transforming Growth Factor beta - pharmacology | Animals | Signal Transduction - drug effects | Fibroblasts - drug effects | Idiopathic Pulmonary Fibrosis - pathology | Hydroxamic Acids - therapeutic use | Indoles - therapeutic use | Aged | Transforming Growth Factor beta - metabolism | Idiopathic Pulmonary Fibrosis - drug therapy | Histone deacetylase | Deregulation | Collagen (type I) | Phosphorylation | Disease | Mesenchyme | Pathogenesis | Critical care | AKT protein | Leucine | Kinases | Autophagy | Proteins | Fibroblasts | Vascular endothelial growth factor | Internal medicine | Lung diseases | Environmental health | 1-Phosphatidylinositol 3-kinase | Medicine | Pulmonary fibrosis | Inhibitors | Lungs | Lysine | Deacetylation | Collagen | Fibrosis | Mice | Protein phosphatase | Phagocytosis
Journal Article
Clinical Epigenetics, ISSN 1868-7075, 2012, Volume 4, Issue 1, pp. 5 - 5
The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes, which have specific and critical functions in development and tissue... 
Histone deacetylase | Noncoding RNAs | Epigenetics | HDAC inhibitors | Gene expression | HDAC | HDAC complexes | ONCOLOGY | noncoding RNAs | histone deacetylase | gene expression | epigenetics | Physiological aspects | Enzymes | Epigenetic inheritance | Research | Genetic transcription
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2019, Volume 514, Issue 3, pp. 1009 - 1016
CCAAT enhancer binding protein (C/EBP ), as an important transcription factor involved in cell proliferation, differentiation and metabolism, was up-regulated... 
C/EBPα | HCC | HDACs | miR-124-3p | miR-25
Journal Article
Journal of Cancer Research and Clinical Oncology, ISSN 0171-5216, 2/2019, Volume 145, Issue 2, pp. 393 - 409
Journal Article
Oncotarget, ISSN 1949-2553, 04/2019, Volume 10, Issue 28, p. 2755
Myocyte enhancer factor (MEF)-2 plays a critical role in proliferation, differentiation, and development of various cell types in a tissue specific manner.... 
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 10/2019, Volume 518, Issue 2, pp. 396 - 401
Nuclear Dbf2-related kinase 2 (NDR2) is a highly conserved kinase that belongs to the NDR/LATS serine-threonine kinase family. NDR2 is involved in many... 
p300/CBP | NDR2 | HDACs | Acetylation | SIRT1 | Acetates | Serine
Journal Article
Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, 2017, Volume 95, Issue 3, pp. 260 - 267
The regulatory paradigm in cardiac hypertrophy involves alterations in gene expression that is mediated by chromatin remodeling. Various data suggest that... 
magnesium valproate | HDAC de classe II | HDAC de classe I | partial abdominal aortic constriction (PAAC) | constriction partielle de l’aorte abdominale | class II HDAC | class I HDAC | valproate de magnésium
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 10/2016, Volume 121, pp. 451 - 483
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2012, Volume 18, Issue 2, pp. 408 - 416
Purpose: Metastasis is responsible for the death of most cancer patients, yet few therapeutic agents are available which specifically target the molecular... 
HDAC INHIBITORS | CELLS | ONCOLOGY | H2A | GENES | PREDICTING METASTASIS | MUTATIONS | PREDISPOSE | BAP1 | INSIGHTS | eye | differentiation | metastasis | uveal melanoma | HDAC inhibitor | valproic acid
Journal Article
Biochimica et Biophysica Acta - Molecular Cell Research, ISSN 0167-4889, 2019
Perpetuation of atrial fibrillation (AF) is caused by electropathology, which is defined as impairment of electrical activation caused by structural and... 
Cytoskeleton | HDACs | Electropathology | Microtubule | Atrial fibrillation | Structural remodeling
Journal Article
Journal of autoimmunity, ISSN 0896-8411, 12/2019, p. 102379
Rheumatoid Arthritis (RA) represents a chronic T cell-mediated inflammatory autoimmune disease. Studies have shown that epigenetic mechanisms contribute to the... 
Journal Article
Organic Preparations and Procedures International, ISSN 0030-4948, 09/2018, Volume 50, Issue 5, pp. 517 - 521
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1422-0067, 03/2019, Volume 20, Issue 5, p. 1110
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) counteract with each other to regulate gene expression by altering chromatin structure.... 
HDACs | ACTIVATED PROTEIN-KINASE | SUBEROYLANILIDE HYDROXAMIC ACID | BIOCHEMISTRY & MOLECULAR BIOLOGY | HDAC INHIBITION | HDAC inhibitors | VORINOSTAT SAHA | human diseases | TNF-ALPHA EXPRESSION | chemokines | CHEMISTRY, MULTIDISCIPLINARY | IN-VITRO | CARDIAC-HYPERTROPHY | GENE-EXPRESSION | cytokines | INFLAMMATORY CYTOKINES | NF-KAPPA-B
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 08/2000, Volume 97, Issue 18, pp. 10014 - 10019
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2014, Volume 15, Issue 3, pp. 1403 - 1410
Epigenetic regulators like histone deacetylases (1 and 2), and viral onco-proteins (E6/E7) are known to be overexpressed in cervical cancer cells. The present... 
MDR | HDACs | E6/E7 | Cervical cancer | Cisplatin | HDAC INHIBITORS | RISK | cervical cancer | P53 | CARCINOGENESIS | ONCOLOGY | TARGETS | cisplatin | MULTIDRUG-RESISTANCE | PROTEINS | EXPRESSION | CYCLE
Journal Article