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Science, ISSN 0036-8075, 6/2010, Volume 328, Issue 5985, pp. 1570 - 1573
Cholesterol metabolism is tightly regulated at the cellular level. Here we show that miR-33, an intronic microRNA (miRNA) located within the gene encoding... 
MicroRNA | Hepatocytes | HDL lipoproteins | Liver | Genes | REPORTS | Homeostasis | Gene expression regulation | Macrophages | Cholesterols | Endothelial cells | TANGIER-DISEASE | HDL | LIPID-METABOLISM | CASSETTE TRANSPORTER 1 | CELLULAR CHOLESTEROL | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MUTATIONS | ATP Binding Cassette Transporter, Sub-Family G, Member 1 | Membrane Glycoproteins - metabolism | Cholesterol, Dietary - administration & dosage | Lipoproteins - genetics | Lipoproteins, HDL - blood | Humans | Lipoproteins, HDL - metabolism | MicroRNAs - metabolism | Transfection | ATP-Binding Cassette Transporters - genetics | Dietary Fats - administration & dosage | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Sterol Regulatory Element Binding Protein 2 - genetics | Sterol Regulatory Element Binding Protein 2 - metabolism | ATP Binding Cassette Transporter 1 | Cell Line | Introns | Liver - metabolism | Mice, Inbred C57BL | Gene Expression Regulation | Apolipoprotein A-I - metabolism | Cholesterol - metabolism | Membrane Glycoproteins - genetics | Proteins - genetics | Carrier Proteins - genetics | Macrophages - metabolism | Animals | Carrier Proteins - metabolism | Proteins - metabolism | Mice | MicroRNAs - genetics | Hypercholesterolemia - genetics | Macrophages, Peritoneal - metabolism | Hypercholesterolemia - metabolism | Physiological aspects | Control | Research | High density lipoproteins | Cholesterol metabolism | Lipoproteins | Cellular biology | Ribonucleic acid--RNA | Gene expression | Cholesterol | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2015, Volume 309, Issue 8, pp. E736 - E746
Metabolomic profiling of obese individuals revealed altered concentrations of many metabolites, especially branched-chain amino acids (BCAA), possibly linked... 
Branched-chain amino acids | Cardiometabolic risk factors | Visceral obesity | HOMEOSTASIS | PHYSIOLOGY | TRYPTOPHAN-METABOLISM | WEIGHT-LOSS | visceral obesity | PATTERNS | branched-chain amino acids | cardiometabolic risk factors | AMINO-ACID-METABOLISM | METABOLOMICS | INSULIN-RESISTANCE | ENDOCRINOLOGY & METABOLISM | FAT | HUMAN OBESITY | EXPRESSION | Metabolomics | Amino Acids, Branched-Chain - metabolism | Humans | Middle Aged | Gene Expression Profiling | RNA, Messenger - metabolism | Thinness - metabolism | Tryptophan - metabolism | Adipose Tissue - metabolism | Amino Acids - metabolism | Overweight - metabolism | Subcutaneous Fat - metabolism | Adult | Female | Body Fat Distribution | Kynurenine - metabolism | Cardiovascular Diseases - metabolism | Cholesterol, HDL - metabolism | Risk Factors | Insulin Resistance | Cell Size | Adipokines - metabolism | Intra-Abdominal Fat - metabolism | Adipocytes - pathology | Blotting, Western | Obesity - metabolism | Triglycerides - metabolism | Cholesterol, LDL - metabolism | Dyslipidemias - metabolism | 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - genetics | Blood Glucose - metabolism | 3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - metabolism | Adipose tissues | Metabolic diseases | Amino acids | Metabolites | Health aspects | Risk factors | Enzymes | Tissue | Obesity | Gene expression | Index Medicus
Journal Article
2012, 1. Aufl., ISBN 0470408219, xxxvi, 605
A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapiesWith high-density lipoproteins (HDL) playing an increasing role in... 
Cardiovascular system | Treatment | High density lipoproteins | Metabolism | Diseases
Book
Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, 05/2017, Volume 102, Issue 5, pp. 1642 - 1651
Context: Low-grade inflammation is associated with obesity and the metabolic syndrome (MetS). Preclinical evidence suggests that resveratrol (RSV) has... 
SUPPLEMENTATION | OBESE MEN | ALKALINE-PHOSPHATASE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | SECRETION | HEALTH | CORONARY-ARTERY-DISEASE | CHALLENGES | Blood Pressure | Body Composition | Stilbenes - therapeutic use | Humans | Leptin - metabolism | Middle Aged | Male | Metabolic Syndrome - metabolism | Muscle, Skeletal - metabolism | Adipose Tissue - immunology | Metabolic Syndrome - drug therapy | Fructosamine - metabolism | Adipose Tissue - metabolism | Muscle, Skeletal - immunology | Liver - diagnostic imaging | Quadriceps Muscle - immunology | Metabolic Syndrome - immunology | Real-Time Polymerase Chain Reaction | Double-Blind Method | Magnetic Resonance Spectroscopy | Cholesterol, HDL - metabolism | Liver - metabolism | Insulin Resistance | Cholesterol - metabolism | Intra-Abdominal Fat - metabolism | Absorptiometry, Photon | Blotting, Western | Triglycerides - metabolism | Receptors, Urokinase Plasminogen Activator - metabolism | Intra-Abdominal Fat - diagnostic imaging | Magnetic Resonance Imaging | Antioxidants - therapeutic use | Insulin - metabolism | Muscle, Skeletal - diagnostic imaging | Interleukin-6 - immunology | Cholesterol, LDL - metabolism | Blood Glucose - metabolism | Quadriceps Muscle - metabolism | C-Reactive Protein - immunology | C-reactive protein | Pressure effects | Liver | Interleukin | Medical services | Homeostasis | Clinical trials | Lipids | Standard error | Glucose | Metabolic syndrome | Composition effects | Blood | Body composition | Interleukin 6 | Body mass index | Urokinase | Glucose metabolism | Randomization | Body composition (biology) | Resveratrol | Blood pressure | Bioindicators | Lipid metabolism | Supplementation | Deposition | Middle age | Dietary supplements | Muscles | Inflammation | Gene expression | Metabolism | Low density lipoprotein | Cholesterol | Skeletal muscle | U-Plasminogen activator | Body mass | Biopsy | Body size | Men | Plasma levels | Metabolic disorders | Index Medicus | Abridged Index Medicus
Journal Article
The Journal of Clinical Endocrinology & Metabolism, ISSN 0021-972X, 03/2017, Volume 102, Issue 3, pp. 810 - 821
Context: Polycystic ovary syndrome ( PCOS) is a complex syndrome showing clinical features of an endocrine/metabolic disorder, including hyperinsulinemia and... 
POLYCYSTIC-OVARY-SYNDROME | IONIZATION-MASS-SPECTROMETRY | RISK-FACTORS | TESTOSTERONE | BIOLOGICAL SAMPLES | ENDOCRINOLOGY & METABOLISM | IMPAIRED GLUCOSE-TOLERANCE | NONALCOHOLIC STEATOHEPATITIS | FAT-CELL LIPOLYSIS | OLDER CHINESE | OBESE WOMEN | Arachidonic Acid - metabolism | Gas Chromatography-Mass Spectrometry | Linoleic Acid - metabolism | Humans | Dehydroepiandrosterone Sulfate - metabolism | Case-Control Studies | Young Adult | Testosterone - metabolism | Polycystic Ovary Syndrome - complications | Diet, High-Fat | Mass Spectrometry | Chromatography, Liquid | Adult | Female | Hyperandrogenism - metabolism | Fatty Acids - metabolism | Phosphatidylglycerols - metabolism | Disease Models, Animal | Hyperinsulinism - metabolism | Ceramides - metabolism | Hyperinsulinism - complications | Polycystic Ovary Syndrome - metabolism | Cholesterol, HDL - metabolism | Obesity - complications | Eicosapentaenoic Acid - metabolism | Rats | Sex Hormone-Binding Globulin - metabolism | Lipid Metabolism | Fatty Acids, Unsaturated - metabolism | Rats, Sprague-Dawley | Obesity - metabolism | Triglycerides - metabolism | Hyperandrogenism - complications | Insulin - metabolism | Animals | Cholesterol, LDL - metabolism | Phosphatidic Acids - metabolism | Androgens - metabolism | Blood Glucose - metabolism | Docosahexaenoic Acids - metabolism | Polycystic ovary syndrome | Obesity | Hyperinsulinemia | Lecithin | Polyunsaturated fatty acids | Lipids | Mass spectroscopy | Liquid chromatography | Phospholipids | Metabolism | Arachidonic acid | Insulin | Fatty acids | Patients | Chromatography | Biological activity | Subgroups | Gas chromatography | Androgens | Molecular modelling | Metabolites | Lipid metabolism | Mass spectrometry | Metabolic disorders | Index Medicus | Abridged Index Medicus
Journal Article
Nature Communications, ISSN 2041-1723, 04/2015, Volume 6, Issue 1, pp. 6498 - 6498
Journal Article
Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7341, pp. 57 - 65
Metabolomics studies hold promise for the discovery of pathways linked to disease processes. Cardiovascular disease (CVD) represents the leading cause of death... 
CHLAMYDIA-PNEUMONIAE | TRIMETHYLAMINE-N-OXIDE | DNA METHYLATION | MULTIDISCIPLINARY SCIENCES | MURINE MACROPHAGES | MOUSE | GENE-EXPRESSION | ATHEROSCLEROSIS | MICE | CORONARY-HEART-DISEASE | MASS-SPECTROMETRY | Choline - metabolism | Dietary Fats - metabolism | Metabolomics | Liver - enzymology | Diet - adverse effects | Atherosclerosis - genetics | Betaine - metabolism | Humans | Phosphatidylcholines - administration & dosage | Phosphatidylcholines - metabolism | Choline - blood | Dietary Fats - pharmacology | Oxygenases - metabolism | Cardiovascular Diseases - blood | Female | Atherosclerosis - microbiology | Betaine - blood | Methylamines - pharmacology | Cardiovascular Diseases - diagnosis | Methylamines - metabolism | Receptors, Scavenger - metabolism | Biomarkers - metabolism | Phosphatidylcholines - blood | Cardiovascular Diseases - metabolism | Risk Assessment | Atherosclerosis - chemically induced | Mice, Inbred C57BL | Phosphatidylcholines - pharmacology | Gene Expression Regulation | Methylamines - blood | Gastrointestinal Tract - microbiology | Biomarkers - blood | Dietary Fats - blood | Atherosclerosis - metabolism | Gastrointestinal Tract - metabolism | Cardiovascular Diseases - microbiology | Macrophages - metabolism | Phenotype | Animals | Choline - administration & dosage | Choline - pharmacology | Germ-Free Life | Cholesterol, HDL - blood | Mice | Oxygenases - genetics | Lecithin | Microbiota (Symbiotic organisms) | Physiological aspects | Research | Cardiovascular diseases | Metabolism | Health aspects | Risk factors | Plasma | Nuclear magnetic resonance--NMR | Heart attacks | Pathogenesis | Lipids | Cardiovascular disease | Probiotics | Metabolites | Diet | Atherosclerosis | Bacteria | Insulin resistance | Mass spectrometry | Index Medicus | atherosclerosis | intestinal microbiota | choline | diet | phospholipid | metabolomics
Journal Article
Diabetes, ISSN 0012-1797, 06/2006, Volume 55, Issue 6, pp. 1554 - 1561
Journal Article
Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 12/2013, Volume 33, Issue 12, pp. 2715 - 2723
OBJECTIVE—High-density lipoprotein (HDL) displays multiple atheroprotective activities and is highly heterogeneous in structure, composition, and function; the... 
Functionality | Lipidome | Lipidomics | Phospholipids | Sphingolipids | HDL, small, dense | Phosphatidylserine | small | HUMAN-SERUM | HUMAN PLASMA | sphingolipids | functionality | phospholipids | TANDEM MASS-SPECTROMETRY | dense | HDL | phosphatidylserine | SCAVENGER RECEPTOR | ENDOTHELIAL-CELLS | DISEASE | PERIPHERAL VASCULAR DISEASE | lipidome | HDL PARTICLES | LIPID-COMPOSITION | HEMATOLOGY | BINDING | lipidomics | APOLIPOPROTEIN-A-I | Inflammation - pathology | Oxidative Stress | Cholesterol - blood | Humans | Middle Aged | Male | Inflammation - blood | Tandem Mass Spectrometry | Inflammation - metabolism | Inflammation Mediators - metabolism | Chromatography, Liquid | Adult | Phospholipids - blood | Lipoproteins, LDL - metabolism | Lipoproteins, HDL3 - blood | Lipoproteins, HDL3 - metabolism | Phospholipids - metabolism | Thrombosis - blood | Thrombosis - prevention & control | Atherosclerosis - pathology | Ceramides - metabolism | Oxidation-Reduction | Endothelial Cells - metabolism | Sphingolipids - metabolism | Cholesterol - metabolism | Atherosclerosis - metabolism | Atherosclerosis - blood | Particle Size | Thrombosis - pathology | Macrophages - metabolism | Thrombosis - metabolism | Blood Platelets - metabolism | Cell Line, Tumor | Aged | Inflammation - prevention & control | Endothelial Cells - pathology | Atherosclerosis - prevention & control | Apoptosis | Index Medicus | Endothelial Cells | Macrophages | Atherosclerosis | Ceramides | Inflammation Mediators | Blood Platelets | Lipoproteins, HDL3 | Inflammation | Thrombosis | Cholesterol | Lipoproteins, LDL
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 12/2016, Volume 311, Issue 6, pp. H1360 - H1366
Anesthesia can affect respiratory, circulatory, and endocrine systems but is necessary for certain experimental procedures such as echocardiography and blood... 
Ketamine-xylazine | Pentobarbital sodium | Isoflurane | pentobarbital sodium | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | ketamine-xylazine | MECHANISMS | BODY-TEMPERATURE | COMBINATION | BLOOD-PRESSURE | INSULIN | IMPACT | PERIPHERAL VASCULAR DISEASE | MICE | isoflurane | STRESS | HYPERTENSIVE-RATS | Renin - metabolism | Anesthetics, Dissociative - pharmacology | Isoflurane - pharmacology | Pentobarbital - pharmacology | Male | Fatty Acids, Nonesterified - metabolism | Heart Rate - drug effects | Aldosterone - metabolism | Xylazine - pharmacology | Renin - drug effects | Blood Pressure - drug effects | Dopamine - metabolism | Anesthetics, Inhalation - pharmacology | Angiotensin II - drug effects | Echocardiography | Angiotensin II - metabolism | Cholesterol, HDL - drug effects | Cholesterol, HDL - metabolism | Aorta - drug effects | Insulin Resistance | Rats | Cholesterol, LDL - drug effects | Cholesterol - metabolism | Rats, Sprague-Dawley | Triglycerides - metabolism | Blood Glucose - drug effects | Insulin - metabolism | Animals | Norepinephrine - metabolism | Lipid Metabolism - drug effects | Cholesterol, LDL - metabolism | Glucose - metabolism | Renin-Angiotensin System - drug effects | Hemodynamics - drug effects | Hypnotics and Sedatives - pharmacology | Blood Glucose - metabolism | Ketamine - pharmacology | Epinephrine - metabolism | Lipids | Anesthesia | Ultrasonic imaging | Glucose | Metabolism | Rodents | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 20, pp. 17536 - 17542
Apolipoprotein E (apoE) is a major apolipoprotein in the brain. The epsilon 4 allele of apoE is a major risk factor for Alzheimer disease, and apoE deficiency... 
CHOLESTEROL-METABOLISM | PROTEIN-KINASE-C | RECEPTOR-RELATED PROTEIN | LIPOPROTEIN RECEPTORS | LDL-RECEPTOR | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | MOUSE MODEL | ENDOTHELIAL-CELLS | A-BETA | PLAQUE-FORMATION | Protein Kinase C - genetics | Apolipoprotein E4 - genetics | Humans | Astrocytes - pathology | Low Density Lipoprotein Receptor-Related Protein-1 - genetics | Antigens, CD - genetics | Alzheimer Disease - pathology | Antigens, CD - metabolism | Occludin | Phosphorylation - genetics | Protein Isoforms - metabolism | Pericytes - pathology | Protein Kinase C - metabolism | Tumor Suppressor Proteins - genetics | Membrane Proteins - metabolism | Tight Junctions - metabolism | Receptors, LDL - genetics | Tumor Suppressor Proteins - metabolism | Apolipoprotein E4 - metabolism | Endothelial Cells - metabolism | Membrane Proteins - genetics | Pericytes - metabolism | Cells, Cultured | Low Density Lipoprotein Receptor-Related Protein-1 - metabolism | Receptors, LDL - metabolism | Permeability | Apolipoprotein E3 - metabolism | Blood-Brain Barrier - metabolism | Gene Knock-In Techniques | Mice, Knockout | Blood-Brain Barrier - pathology | Apolipoprotein E3 - genetics | Animals | Models, Biological | Alzheimer Disease - metabolism | Mice | Alzheimer Disease - genetics | Endothelial Cells - pathology | Enzyme Activation - genetics | Tight Junctions - pathology | Astrocytes - metabolism | Protein Isoforms - genetics | Index Medicus | HDL | Neurobiology | PKC | Alzheimer Disease | Apolipoproteins | Endothelium | Tight Junction | Blood-Brain Barrier
Journal Article