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BBA - Proteins and Proteomics, ISSN 1570-9639, 2008, Volume 1784, Issue 1, pp. 150 - 158
The phosphatidyl inositol 3-kinase (PI3K) can be activated by a variety of extracellular signals and involved in a number of cellular processes including cell... 
HDM2 | HIF-1 | Angiogenesis | PI3K | VEGF | PTEN | mTOR | Tumorigenesis | Akt | p70S6K1
Journal Article
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 05/2013, Volume 23, Issue 9, pp. 2480 - 2485
A growing number of the elements identified in intracellular signaling events that affect cell growth and transformation are proteins that physically interact... 
hdm2 | Anticancer agent | Protein-protein interaction | hdmx | p53
Journal Article
Annual Review of Pharmacology and Toxicology, ISSN 0362-1642, 2009, Volume 49, Issue 1, pp. 223 - 241
Journal Article
Genes and Cancer, ISSN 1947-6019, 2012, Volume 3, Issue 3-4, pp. 264 - 273
p53 is an important tumor suppressor, functioning as a transcriptional activator and repressor. Upon receiving signals from multiple stress related pathways,... 
translation | Mdm4 | Hdm2 | transcription | Monographs
Journal Article
BMB Reports, ISSN 1976-6696, 2017, Volume 50, Issue 7, pp. 373 - 378
The Jun activation-domain binding protein 1 (Jab1) induces p53 nuclear export and cytoplasmic degradation, but the underlying mechanism is poorly understood.... 
COP9 signalosome | Curcumin | Hdm2 | Jab1 | p53
Journal Article
ChemMedChem, ISSN 1860-7179, 07/2019, Volume 14, Issue 14, pp. 1304 - 1304
The Front Cover shows a crystal of HdmX in a drop of mother liquor and the X‐ray structures of the clinical trial compounds NVP‐CGM097 and NVP‐HDM201 bound to... 
protein–protein interactions | X-ray crystallography | Hdm2 | HdmX | anticancer agents | p53
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 01/2008, Volume 98, Issue 1, pp. 4 - 8
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 2005, Volume 15, Issue 3, pp. 765 - 770
Journal Article
Chembiochem : a European journal of chemical biology, ISSN 1439-4227, 4/2016, Volume 17, Issue 8, pp. 768 - 773
α-helix mediated protein-protein interactions (PPIs) represent important targets for small molecule inhibition, however generic approaches to inhibitor design... 
hDM2 | helix mimetics | chemical biology | protein-protein interactions | foldamers | p53
Journal Article
Current Opinion in Chemical Biology, ISSN 1367-5931, 2010, Volume 14, Issue 3, pp. 341 - 346
Journal Article
BMC CANCER, ISSN 1471-2407, 03/2013, Volume 13
Background: The p53 protein is expressed as multiple isoforms that differ in their N- and C-terminus due to alternative splicing, promoter or codon initiation... 
Hdm2 | Oligomerization | ONCOLOGY | Delta 40p53 | STABILITY | Isoforms | DEATH | TRANSLATION | DELTA-133P53 | TP53 | P53 | LIFE
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, ISSN 1570-9639, 01/2008, Volume 1784, Issue 1, pp. 150 - 158
The phosphatidyl inositol 3-kinase (P13K) can be activated by a variety of extracellular signals and involved in a number of cellular processes including cell... 
HDM2 | VEGF | angiogenesis | BIOCHEMISTRY & MOLECULAR BIOLOGY | PTEN | Akt | OVARIAN-CANCER | HUMAN BREAST-CANCER | p70S6K1 | AKT/PROTEIN KINASE-B | PHOSPHOINOSITIDE 3-KINASE | SMALL-MOLECULE INHIBITOR | HIF-1 | PHASE-II TRIAL | BIOPHYSICS | PROSTATE-CANCER | mTOR | SQUAMOUS-CELL CARCINOMA | tumorigenesis | P13K | ENDOTHELIAL GROWTH-FACTOR | HYPOXIA-INDUCIBLE FACTOR-1
Journal Article