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1. Full Text Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1 alpha (HIF-1 alpha) for Lysosomal Degradation
by Hubbi, ME and Hu, HX and Kshitiz and Ahmed, I and Levchenko, A and Semenza, GL
JOURNAL OF BIOLOGICAL CHEMISTRY, ISSN 0021-9258, 04/2013, Volume 288, Issue 15, pp. 10703 - 10714
Hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that mediates adaptive responses to hypoxia. We demonstrate that lysosomal... 
FACTOR 1-ALPHA | TRANSCRIPTIONAL ACTIVITY | PROTEIN | PYRUVATE-KINASE | GENE | TRANSACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GROWTH | INHIBITOR | HIF-ALPHA | EXPRESSION | HSC70 Heat-Shock Proteins - genetics | Cell Hypoxia - drug effects | Cell Hypoxia - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | HSC70 Heat-Shock Proteins - metabolism | Humans | Lysosomes - genetics | Autophagy - physiology | Autophagy - drug effects | Gene Knockdown Techniques | Chloroquine - pharmacology | Animals | Lysosomes - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Proteolysis | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Antirheumatic Agents - pharmacology | HeLa Cells | Lysosomes | Protein Degradation | Autophagy | Transcriptional Regulation | Protein Synthesis and Degradation | Hypoxia-inducible Factor
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2. Full Text Hsp10 and Hsp60 suppress ubiquitination of insulin-like growth factor-1 receptor and augment insulin-like growth factor-1 receptor signaling in cardiac muscle: Implications on decreased myocardial protection in diabetic cardiomyopathy
by Shan, Yue-Xin and Yang, Tung-Lin and Mestril, Ruben and Wang, Ping H
Journal of Biological Chemistry, ISSN 0021-9258, 11/2003, Volume 278, Issue 46, pp. 45492 - 45498
We have investigated the effects of two heat shock proteins, Hsp10 and Hsp60, on insulin-like growth factor-1 receptor (IGF-1R) signaling in cardiac muscle... 
APOPTOSIS | OVEREXPRESSION | CELLS | ACTIVATION | RAT | PHOSPHATIDYLINOSITOL 3-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISCHEMIA | STRESS | EXPRESSION | CYTOSOLIC HEAT-SHOCK-PROTEIN-60 | Animals, Newborn | Chaperonin 10 - physiology | Receptor, IGF Type 1 - metabolism | Phosphorylation | Oligonucleotides, Antisense - pharmacology | Chaperonin 60 - physiology | Signal Transduction | Cell Survival | Cells, Cultured | Ubiquitin - metabolism | Rats | RNA, Messenger - metabolism | Rats, Sprague-Dawley | Cycloheximide - pharmacology | Animals | Time Factors | Diabetes Mellitus, Experimental | Myocardium - metabolism | Adenoviridae - genetics | Protein Processing, Post-Translational | Protein Synthesis Inhibitors - pharmacology | Genetic Vectors | Hsp60 protein | p90Rsk protein | MEK protein | Hsp10 protein
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3. Full Text Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
by Isaacs, Jennifer S and Jung, Yun-Jin and Mimnaugh, Edward G and Martinez, Alfredo and Cuttitta, Frank and Neckers, Leonard M
The Journal of biological chemistry, ISSN 0021-9258, 2002, Volume 277, Issue 33, pp. 29936 - 29944
HIF-1alpha is a normally labile proangiogenic transcription factor that is stabilized and activated in hypoxia. Although the von Hippel Lindau (VHL) gene... 
SIGNAL-TRANSDUCTION | FACTOR 1-ALPHA | HUMAN ERYTHROPOIETIN GENE | PROLYL HYDROXYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | DIOXIN RECEPTOR | CELL GLUCOCORTICOID RECEPTOR | HELIX-LOOP-HELIX | HEAT-SHOCK PROTEIN | ENDOTHELIAL GROWTH-FACTOR | Down-Regulation | HSP90 Heat-Shock Proteins - physiology | Ligases - metabolism | Multienzyme Complexes - metabolism | Proteasome Endopeptidase Complex | Hypoxia-Inducible Factor 1, alpha Subunit | Hydrolysis | Transcription Factors - metabolism | Ubiquitin-Protein Ligases | Cysteine Endopeptidases - metabolism | Transcription, Genetic | Von Hippel-Lindau Tumor Suppressor Protein | Tumor Cells, Cultured | Tumor Suppressor Proteins
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4. Full Text A potentially common peptide target in secreted heat shock protein-90α for hypoxia-inducible factor-1α-positive tumors
by Sahu, Divya and Zhao, Zhengwei and Tsen, Fred and Cheng, Chieh-Fang and Park, Ryan and Situ, Alan J and Dai, Jinyao and Eginli, Ariana and Shams, Sharmineh and Chen, Mei and Ulmer, Tobias S and Conti, Peter and Woodley, David T and Li, Wei
Molecular Biology of the Cell, ISSN 1059-1524, 02/2012, Volume 23, Issue 4, pp. 602 - 613
Deregulated accumulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a hallmark of many solid tumors. Directly targeting HIF-1 alpha for therapeutics... 
BREAST-CANCER | MIGRATION | HSP90 | PROTEIN SECONDARY STRUCTURE | MOLECULAR CHAPERONE | CANCER-CELL INVASION | RECEPTOR | HSP90-ALPHA | EXPRESSION | MOTILITY | CELL BIOLOGY | Neoplasms - metabolism | RNA, Small Interfering - genetics | Aryl Hydrocarbon Receptor Nuclear Translocator - antagonists & inhibitors | Neoplasm Invasiveness | Humans | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Peptides - pharmacology | Animals | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Mice | Neoplasms - pathology | Cell Movement
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5. Full Text Hypoxia Inducible Factor-1: Its Potential Role In Cerebral Ischemia
by Singh, Neetu and Sharma, Gaurav and Mishra, Vikas and Raghubir, Ram
Cellular and Molecular Neurobiology, ISSN 0272-4340, 5/2012, Volume 32, Issue 4, pp. 491 - 507
A divergence in the supply and consumption of oxygen in brain tissue initiates complex cycle of biochemical and molecular events resulting in neuronal death.... 
HIF-1 | Neuroprotection | HSP90 | Neurosciences | Biomedicine | Neurobiology | ROS | I/R injury | Cell Biology | NITRIC-OXIDE SYNTHASE | PROLYL HYDROXYLASES PHD1 | TRANSLOCATOR PROTEIN ARNT | NEUROSCIENCES | CELL-DEATH | CELL BIOLOGY | PRIMARY CORTICAL-NEURONS | FACTOR 1-ALPHA | GENE-EXPRESSION | TUMOR-SUPPRESSOR PROTEIN | MITOCHONDRIAL COMPLEX-III | PAS DOMAIN PROTEIN | Brain - metabolism | Humans | Brain Ischemia - pathology | Brain - pathology | Brain Ischemia - metabolism | Signal Transduction - physiology | Brain Ischemia - physiopathology | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Oxygen Consumption - physiology | Glucose metabolism | Ischemia | Neurons | Cell death | Genes | Physiological aspects | Heat shock proteins | DNA binding proteins | Glucose | Dextrose | Cells
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6. Full Text Ring-truncated deguelin derivatives as potent Hypoxia Inducible Factor-1α (HIF-1α) inhibitors
by Kim, Jeong Hun and Kim, Young-Myeong and Kim, Kyu-Won and Kim, Joohwan and Kim, Ho Shin and Kim, Jun Yong and Hong, Mannkyu and Lee, Jeewoo and Lee, Su-Chan and Lee, Ho-Young and Suh, Young-Ger and Oh, Dong-Chan and Seo, Ji Hae and Choi, Hoon and Park, So-Jung and Park, Hyun-Ju
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2015, Volume 104, pp. 157 - 164
A series of fluorophenyl and pyridine analogues of and were synthesized as ring-truncated deguelin surrogates and evaluated for their HIF-1α inhibition. Their... 
HIF-1 | HSP90 | Deguelin | Hypoxia Inducible Factor-1 | Antitumor | Heat shock protein 90 | CHEMISTRY, MEDICINAL | ATP BINDING | CANCER | HSP90 INHIBITORS | FACTOR 1-ALPHA | THERAPY | SHOCK-PROTEIN 90 | BINDING-SITE | C-TERMINAL DOMAIN | EXPRESSION | Antineoplastic Agents - chemical synthesis | Humans | Rotenone - analogs & derivatives | Angiogenesis Inhibitors - pharmacology | Rotenone - chemistry | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Retinal Vessels - drug effects | Structure-Activity Relationship | Antineoplastic Agents - chemistry | Dose-Response Relationship, Drug | Cell Movement - drug effects | Rotenone - chemical synthesis | Retinal Vessels - cytology | Rotenone - pharmacology | Cell Line, Tumor | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Angiogenesis Inhibitors - chemical synthesis | Angiogenesis Inhibitors - chemistry | Drug Screening Assays, Antitumor | Endothelial Cells - drug effects | Index Medicus
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7. Full Text Dimethyl fumarate inhibits the expression and function of hypoxia-inducible factor-1α (HIF-1α)
by Zhao, Guangzong and Liu, Yao and Fang, Jun and Chen, Yunzhen and Li, Huazhuang and Gao, Kehai
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2014, Volume 448, Issue 3, pp. 303 - 307
Osteocyte hypoxia has been induced by skeletal unloading and fracture. Hypoxia-dependent regulation of gene expression is mediated by hypoxia-sensitive... 
Heat shock protein 90 (Hsp90) | The receptor of activated protein kinase C (RACK1) | Proteasomal degradation | Hypoxia | Hypoxia-inducible factor-1α (HIF-1α) | HSP90 | ACTIVATION | BIOPHYSICS | Hypoxia-inducible factor-1 alpha (HIF-1 alpha) | STABILIZATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEGRADATION | CHEMOKINE | Interleukin-8 - genetics | Cell Hypoxia - physiology | Gene Expression - drug effects | Proteasome Inhibitors - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Osteoblasts - drug effects | RNA, Messenger - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Neuropeptides - metabolism | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Animals | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Fumarates - pharmacology | Receptors for Activated C Kinase | HSP90 Heat-Shock Proteins - metabolism | Mice | Cell Hypoxia - genetics | Dimethyl Fumarate | Osteoblasts - metabolism | 3T3 Cells
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8. Full Text Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel–Lindau-dependent pathway
by Li, Ching-Hao and Li, Ching-Hao and Liao, Po-Lin and Liao, Po-Lin and Yang, Ya-Ting and Yang, Ya-Ting and Huang, Shih-Hsuan and Huang, Shih-Hsuan and Lin, Cheng-Hui and Lin, Cheng-Hui and Cheng, Yu-Wen and Cheng, Yu-Wen and Kang, Jaw-Jou and Kang, Jaw-Jou
Archives of Toxicology, ISSN 0340-5761, 3/2014, Volume 88, Issue 3, pp. 659 - 671
Hypoxia-mediated stress responses are important in tumor progression, especially when tumor growth causes the tumor to become deprived of its blood supply. The... 
Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Hypoxia-inducible factor-1 alpha | Minocycline | Neovasculogenesis | Prolyl hydroxylase | Pharmacology/Toxicology | von Hippel–Lindau | Biomedicine general | Von Hippel-Lindau | PROTEIN | METASTASIS | ANGIOGENESIS | MECHANISMS | CELL-DEATH | P53 | von Hippel-Lindau | TETRACYCLINES | TOXICOLOGY | HIF-1-ALPHA | VHL | EXPRESSION | Cell Hypoxia - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Minocycline - pharmacology | Prolyl Hydroxylases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor C - genetics | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Cell Line - drug effects | Glucose Transporter Type 1 - genetics | Signal Transduction - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Neovascularization, Pathologic - drug therapy | Vascular Endothelial Growth Factor C - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Medical colleges | Endothelial growth factors | College graduates | Heat shock proteins | Drugstores | Development and progression | Glucose | Gene expression | Dextrose | Glucose metabolism | Resveratrol | Physiological aspects | Tumors | Oxidative stress | Hypoxia | Kinases | Vascular endothelial growth factor | Index Medicus
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9. Full Text Heat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis
by Krishnamurthy, Karthikeyan and Glaser, Shannon and Alpini, Gianfranco D and Cardounel, Arturo J and Liu, Zhenguo and Ilangovan, Govindasamy
Cardiovascular Research, ISSN 0008-6363, 2016, Volume 111, Issue 1, pp. 74 - 83
Stress response, in terms of activation of stress factors, is known to cause obesity and coronary heart disease such as atherosclerosis in human. However, the... 
Heat shock proteins | Obesity | Heat shock factor | Glycoproteins | Atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | DIETARY-FAT | TRANSCRIPTION FACTOR-1 | MACROPHAGE | ALPHA | DEFICIENT MICE | RESISTANCE GENE | INFLAMMATION | PPAR-GAMMA | NF-KAPPA-B | HEAT-SHOCK-PROTEIN-27 | Carotid Arteries - metabolism | Up-Regulation | Atherosclerosis - genetics | Male | Aorta - metabolism | PPAR gamma - metabolism | Time Factors | Carotid Artery Diseases - pathology | Aortic Diseases - prevention & control | Transcription, Genetic | ATP Binding Cassette Transporter, Subfamily B - genetics | Binding Sites | Diet, Western | Disease Models, Animal | Atherosclerosis - pathology | Genetic Predisposition to Disease | Signal Transduction | Plaque, Atherosclerotic | ATP Binding Cassette Transporter, Subfamily B - metabolism | Mice, Knockout | Aorta - pathology | Cholesterol 7-alpha-Hydroxylase - genetics | Aortic Diseases - genetics | Phenotype | Carotid Artery Diseases - enzymology | Carotid Artery Diseases - genetics | Mutation | Carotid Artery Diseases - prevention & control | AMP-Activated Protein Kinases - metabolism | Liver - enzymology | Transcription Factors - deficiency | DNA-Binding Proteins - deficiency | Heat Shock Transcription Factors | Atherosclerosis - enzymology | Transfection | Receptors, LDL - deficiency | Female | Aortic Diseases - enzymology | Aortic Diseases - pathology | Promoter Regions, Genetic | Receptors, LDL - genetics | Mice, Inbred C57BL | Cells, Cultured | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Animals | Cholesterol 7-alpha-Hydroxylase - metabolism | Adipose Tissue - enzymology | Carotid Arteries - pathology | Atherosclerosis - prevention & control | ORIGINAL ARTICLES
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10. Full Text Heat shock protein‐70 and hypoxia inducible factor‐1α in type 2 diabetes mellitus patients complicated with retinopathy
by Sayed, Khulood M and Mahmoud, Aida A
Acta Ophthalmologica, ISSN 1755-375X, 08/2016, Volume 94, Issue 5, pp. e361 - e366
Purpose To elucidate the role of heat shock protein‐70 (HSP70) and hypoxia inducible factor‐1α (HIF‐1α) in diabetic retinopathy (DR) patients. Design and... 
hypoxia inducible factor 1‐α | heat shock protein | diabetic retinopathy | Type 2 DM | Hypoxia inducible factor 1-α | Diabetic retinopathy | Heat shock protein | hypoxia inducible factor 1-α | Glucose Tolerance Test | Enzyme-Linked Immunosorbent Assay | Glycated Hemoglobin A - metabolism | Humans | Middle Aged | Male | Biomarkers - blood | Diabetic Retinopathy - blood | Diabetes Mellitus, Type 2 - blood | HSP70 Heat-Shock Proteins - blood | Hypoxia-Inducible Factor 1, alpha Subunit - blood | Female | ROC Curve | Diabetic Retinopathy - etiology | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - complications
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11. Full Text Heat Shock Factor-1 Knockout Enhances Cholesterol Metabolism and Attenuates Atherosclerosis
by Krishnamurthy, Karthikeyan and Liu, Zhenguo and Ilangovan, Govindasamy
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2016, Volume 100, pp. S184 - S185
Coronary heart disease and diabetes are highly prevalent among obese populations due to aberrant dietary cholesterol metabolism. Here we investigated the... 
Physiological aspects | Heat shock proteins | Coronary heart disease | Cholesterol | Atherosclerosis | RNA | Liver | Cytochrome P-450 | Blood lipids | Gene expression | Heart diseases | Deoxycholic acid
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12. Full Text Regulation of transcription of hypoxia-inducible factor-1α (HIF-1α) by heat shock factors HSF2 and HSF4
by Chen, R and Liliental, J.E and Kowalski, P.E and Lu, Q and Cohen, S.N
Oncogene, ISSN 0950-9232, 06/2011, Volume 30, Issue 22, pp. 2570 - 2580
Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is a principal regulator of angiogenesis and other cellular responses to hypoxic stress in both normal and tumor... 
HIF-1α | heat shock element | HSE | heat shock factor | angiogenesis | VEGF | FACTOR FAMILY | CELLS | HIF-1 alpha | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | CELL BIOLOGY | RESPONSE ELEMENT | GENE | ONCOLOGY | GENETICS & HEREDITY | PROTEOTOXIC STRESS | LENS DEVELOPMENT | PROMOTER | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Promoter Regions, Genetic | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Heat-Shock Proteins - metabolism | Humans | Vascular Endothelial Growth Factors - biosynthesis | Cell Line, Tumor | Transcription, Genetic | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Heat Shock Transcription Factors
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13. Full Text Activation of heat shock response augments fibroblast growth factor-1 expression in wounded lung epithelium
by Scheraga, Rachel G and Thompson, Christopher and Tulapurkar, Mohan E and Nagarsekar, Ashish C and Cowan, Mark and Potla, Ratnakar and Sun, Junfeng and Cai, Rongman and Logun, Carolea and Shelhamer, James and Todd, Nevins W and Singh, Ishwar S and Luzina, Irina G and Atamas, Sergei P and Hasday, Jeffrey D
American Journal of Physiology - Lung Cellular and Molecular Physiology, ISSN 1040-0605, 2016, Volume 311, Issue 5, pp. L941 - L955
We previously showed that coincident exposure to heat shock (HS; 42 degrees C for 2 h) and TNF-alpha synergistically induces apoptosis in mouse lung... 
Heat shock factor-1 | Epithelial wound healing | Idiopathic pulmonary fibrosis | Fibroblast growth factor-1 | Heat shock | HYPERTHERMIA | APOPTOSIS | PHYSIOLOGY | fibroblast growth factor-1 | FACTOR MESSENGER-RNA | heat shock | KAPPA-B-ALPHA | MECHANISMS | idiopathic pulmonary fibrosis | epithelial wound healing | PROTEIN INDUCTION | RESPIRATORY SYSTEM | heat shock factor-1 | CELL-MIGRATION | A549 CELLS | IDIOPATHIC PULMONARY-FIBROSIS | ACUTE EXACERBATION | Idiopathic Pulmonary Fibrosis - genetics | Lung Injury - pathology | Epithelial Cells - metabolism | Humans | Apoptosis - genetics | Fibroblast Growth Factor 1 - genetics | Promoter Regions, Genetic - genetics | Heat Shock Transcription Factors | DNA-Binding Proteins - metabolism | Polymerase Chain Reaction | Lung - metabolism | Wound Healing - genetics | Binding Sites | Cell Line | Epithelium - pathology | Lung - pathology | Epithelium - metabolism | Fibroblast Growth Factor 1 - metabolism | Gene Expression Regulation | Epithelial Cells - pathology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | HSP70 Heat-Shock Proteins - metabolism | Heat-Shock Response - genetics | Transcription Factors - metabolism | Lung Injury - genetics | Animals | Mice | Heat shock proteins | Fibroblast growth factors | Lungs | Epithelial cells | Health aspects | Call for Papers
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14. Full Text Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/Signal-Transducer and Activator of Transcription 3/Hypoxia-Inducible Factor-1α Autocrine Loop, and Reduces Orthotopic Tumor Growth
by Sven A. Lang and Christian Moser and Andreas Gaumann and Dagmar Klein and Gabriel Glockzin and Felix C. Popp and Marc H. Dahlke and Pompiliu Piso and Hans J. Schlitt and Edward K. Geissler and Oliver Stoeltzing
Clinical Cancer Research, ISSN 1078-0432, 11/2007, Volume 13, Issue 21, pp. 6459 - 6468
Purpose: Inhibitors of heat-shock protein 90 (Hsp90) may interfere with oncogenic signaling pathways, including Erk, Akt, and hypoxia-inducible factor-1α... 
pancreatic cancer | heat-shock protein 90 | hypoxia-inducible factor-1α | insulin-like growth factor-I receptor | interleukin-6 | STAT3 | PROMOTER ACTIVITY | COLON-CANCER | NUDE-MICE | CARCINOMA CELLS | ANGIOGENESIS | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | GASTRIC-CANCER | HSP90 INHIBITOR 17-ALLYLAMINO-17-DEMETHOXYGELDANAMYCIN | EXPRESSION | CELL-LINE
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