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1. Full Text Chaperone-mediated Autophagy Targets Hypoxia-inducible Factor-1 alpha (HIF-1 alpha) for Lysosomal Degradation
by Hubbi, Maimon E and Hu, Hongxia and Kshitiz and Ahmed, Ishrat and Levchenko, Andre and Semenza, Gregg L
The Journal of biological chemistry, ISSN 0021-9258, 04/2013, Volume 288, Issue 15, pp. 10703 - 10714
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | HSC70 Heat-Shock Proteins - genetics | Cell Hypoxia - drug effects | Cell Hypoxia - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | HSC70 Heat-Shock Proteins - metabolism | Humans | Lysosomes - genetics | Autophagy - physiology | Autophagy - drug effects | Gene Knockdown Techniques | Chloroquine - pharmacology | Animals | Lysosomes - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Proteolysis | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Mice | Antirheumatic Agents - pharmacology | HeLa Cells | Index Medicus | Lysosomes | Protein Degradation | Autophagy | Transcriptional Regulation | Protein Synthesis and Degradation | Hypoxia-inducible Factor
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2. Full Text Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
by Isaacs, Jennifer S and Jung, Yun-Jin and Mimnaugh, Edward G and Martinez, Alfredo and Cuttitta, Frank and Neckers, Leonard M
The Journal of biological chemistry, ISSN 0021-9258, 2002, Volume 277, Issue 33, pp. 29936 - 29944
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Down-Regulation | HSP90 Heat-Shock Proteins - physiology | Ligases - metabolism | Multienzyme Complexes - metabolism | Proteasome Endopeptidase Complex | Hypoxia-Inducible Factor 1, alpha Subunit | Hydrolysis | Transcription Factors - metabolism | Ubiquitin-Protein Ligases | Cysteine Endopeptidases - metabolism | Transcription, Genetic | Von Hippel-Lindau Tumor Suppressor Protein | Tumor Cells, Cultured | Tumor Suppressor Proteins | Index Medicus
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3. Full Text Dimethyl fumarate inhibits the expression and function of hypoxia-inducible factor-1α (HIF-1α)
by Zhao, Guangzong and Liu, Yao and Fang, Jun and Chen, Yunzhen and Li, Huazhuang and Gao, Kehai
Biochemical and biophysical research communications, ISSN 0006-291X, 06/2014, Volume 448, Issue 3, pp. 303 - 307
Heat shock protein 90 (Hsp90) | The receptor of activated protein kinase C (RACK1) | Proteasomal degradation | Hypoxia | Hypoxia-inducible factor-1α (HIF-1α) | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Interleukin-8 - genetics | Cell Hypoxia - physiology | Gene Expression - drug effects | Proteasome Inhibitors - pharmacology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Osteoblasts - drug effects | RNA, Messenger - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Neuropeptides - metabolism | RNA, Messenger - metabolism | Vascular Endothelial Growth Factor A - genetics | Animals | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Fumarates - pharmacology | Receptors for Activated C Kinase | HSP90 Heat-Shock Proteins - metabolism | Mice | Cell Hypoxia - genetics | Dimethyl Fumarate | Osteoblasts - metabolism | 3T3 Cells | Index Medicus
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4. Full Text Regulation of transcription of hypoxia-inducible factor-1α (HIF-1α) by heat shock factors HSF2 and HSF4
by Chen, R and Liliental, J.E and Kowalski, P.E and Lu, Q and Cohen, S.N
Oncogene, ISSN 0950-9232, 06/2011, Volume 30, Issue 22, pp. 2570 - 2580
HIF-1α | heat shock element | HSE | heat shock factor | angiogenesis | VEGF | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Fundamental and applied biological sciences. Psychology | Transcription. Transcription factor. Splicing. Rna processing | Molecular genetics | Cell differentiation, maturation, development, hematopoiesis | Biological and medical sciences | Cell physiology | Molecular and cellular biology | Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Promoter Regions, Genetic | Signal Transduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Heat-Shock Proteins - metabolism | Humans | Vascular Endothelial Growth Factors - biosynthesis | Cell Line, Tumor | Transcription, Genetic | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Heat Shock Transcription Factors | Index Medicus
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5. Full Text Heat shock factor-1 knockout enhances cholesterol 7α-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis
by Krishnamurthy, Karthikeyan and Glaser, Shannon and Alpini, Gianfranco D and Cardounel, Arturo J and Liu, Zhenguo and Ilangovan, Govindasamy
Cardiovascular research, ISSN 0008-6363, 2016, Volume 111, Issue 1, pp. 74 - 83
Heat shock proteins | Obesity | Heat shock factor | Glycoproteins | Atherosclerosis | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Carotid Arteries - metabolism | Up-Regulation | Atherosclerosis - genetics | Male | Aorta - metabolism | PPAR gamma - metabolism | Time Factors | Carotid Artery Diseases - pathology | Aortic Diseases - prevention & control | Transcription, Genetic | ATP Binding Cassette Transporter, Subfamily B - genetics | Binding Sites | Diet, Western | Disease Models, Animal | Atherosclerosis - pathology | Genetic Predisposition to Disease | Signal Transduction | Plaque, Atherosclerotic | ATP Binding Cassette Transporter, Subfamily B - metabolism | Mice, Knockout | Aorta - pathology | Cholesterol 7-alpha-Hydroxylase - genetics | Aortic Diseases - genetics | Phenotype | Carotid Artery Diseases - enzymology | Carotid Artery Diseases - genetics | Mutation | Carotid Artery Diseases - prevention & control | AMP-Activated Protein Kinases - metabolism | Liver - enzymology | Transcription Factors - deficiency | DNA-Binding Proteins - deficiency | Heat Shock Transcription Factors | Atherosclerosis - enzymology | Transfection | Receptors, LDL - deficiency | Female | Aortic Diseases - enzymology | Aortic Diseases - pathology | Promoter Regions, Genetic | Receptors, LDL - genetics | Mice, Inbred C57BL | Cells, Cultured | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Animals | Cholesterol 7-alpha-Hydroxylase - metabolism | Adipose Tissue - enzymology | Carotid Arteries - pathology | Atherosclerosis - prevention & control | Index Medicus | ORIGINAL ARTICLES
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6. Full Text Minocycline accelerates hypoxia-inducible factor-1 alpha degradation and inhibits hypoxia-induced neovasculogenesis through prolyl hydroxylase, von Hippel–Lindau-dependent pathway
by Li, Ching-Hao and Li, Ching-Hao and Liao, Po-Lin and Liao, Po-Lin and Yang, Ya-Ting and Yang, Ya-Ting and Huang, Shih-Hsuan and Huang, Shih-Hsuan and Lin, Cheng-Hui and Lin, Cheng-Hui and Cheng, Yu-Wen and Cheng, Yu-Wen and Kang, Jaw-Jou and Kang, Jaw-Jou
Archives of toxicology, ISSN 0340-5761, 3/2014, Volume 88, Issue 3, pp. 659 - 671
Biomedicine | Environmental Health | Occupational Medicine/Industrial Medicine | Hypoxia-inducible factor-1 alpha | Minocycline | Neovasculogenesis | Prolyl hydroxylase | Pharmacology/Toxicology | von Hippel–Lindau | Biomedicine general | Von Hippel-Lindau | Life Sciences & Biomedicine | Toxicology | Science & Technology | Cell Hypoxia - drug effects | Human Umbilical Vein Endothelial Cells - drug effects | Minocycline - pharmacology | Prolyl Hydroxylases - metabolism | Humans | Phosphatidylinositol 3-Kinases - metabolism | Vascular Endothelial Growth Factor C - genetics | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Cell Line - drug effects | Glucose Transporter Type 1 - genetics | Signal Transduction - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Neovascularization, Pathologic - drug therapy | Vascular Endothelial Growth Factor C - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Medical colleges | Endothelial growth factors | College graduates | Heat shock proteins | Drugstores | Development and progression | Glucose | Gene expression | Dextrose | Glucose metabolism | Resveratrol | Physiological aspects | Tumors | Oxidative stress | Hypoxia | Kinases | Vascular endothelial growth factor | Index Medicus
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7. Full Text Heat Shock Factor-1 Knockout Enhances Cholesterol Metabolism and Attenuates Atherosclerosis
by Krishnamurthy, Karthikeyan and Liu, Zhenguo and Ilangovan, Govindasamy
Free radical biology & medicine, ISSN 0891-5849, 11/2016, Volume 100, pp. S184 - S185
Physiological aspects | Heat shock proteins | Coronary heart disease | Cholesterol | Atherosclerosis | RNA | Liver | Cytochrome P-450 | Blood lipids | Gene expression | Heart diseases | Deoxycholic acid
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8. Full Text Dexamethasone impairs hypoxia-inducible factor-1 function
by Wagner, A.E and Huck, G and Stiehl, D.P and Jelkmann, W and Hellwig-Bürgel, T
Biochemical and biophysical research communications, ISSN 0006-291X, 2008, Volume 372, Issue 2, pp. 336 - 340
HIF-1 repression | Heat-shock protein 90 | Transcriptional cross-talk | Wound healing | Nuclear import | Glucocorticoid receptor | Transrepression | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Anaerobiosis | Cell Hypoxia | Dexamethasone - pharmacology | Gene Expression - drug effects | Humans | Cell Line, Tumor | Glucocorticoids - pharmacology | Receptors, Glucocorticoid - metabolism | Hypoxia-Inducible Factor 1 - metabolism | Hypoxia-Inducible Factor 1 - antagonists & inhibitors | Receptors, Glucocorticoid - agonists | Physiological aspects | Dexamethasone | Endothelial growth factors | Gene expression | Central nervous system depressants | Index Medicus | TRANSCRIPTION FACTORS | DEXAMETHASONE | HEPATOMAS | HEALING | 60 APPLIED LIFE SCIENCES | LUCIFERASE | GROWTH FACTORS | HEAT-SHOCK PROTEINS | ANOXIA | DNA | INFLAMMATION | WOUNDS | RECEPTORS
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9. Full Text Targeting Heat Shock Protein 90 in Pancreatic Cancer Impairs Insulin-like Growth Factor-I Receptor Signaling, Disrupts an Interleukin-6/Signal-Transducer and Activator of Transcription 3/Hypoxia-Inducible Factor-1α Autocrine Loop, and Reduces Orthotopic Tumor Growth
by Sven A. Lang and Christian Moser and Andreas Gaumann and Dagmar Klein and Gabriel Glockzin and Felix C. Popp and Marc H. Dahlke and Pompiliu Piso and Hans J. Schlitt and Edward K. Geissler and Oliver Stoeltzing
Clinical cancer research, ISSN 1078-0432, 11/2007, Volume 13, Issue 21, pp. 6459 - 6468
pancreatic cancer | heat-shock protein 90 | hypoxia-inducible factor-1α | insulin-like growth factor-I receptor | interleukin-6 | STAT3 | Life Sciences & Biomedicine | Oncology | Science & Technology
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10. Full Text Targeting chaperones, heat shock factor-1, and unfolded protein response: Promising therapeutic approaches for neurodegenerative disorders
by Bose, Shambhunath and Cho, Jungsook
Ageing research reviews, ISSN 1568-1637, 2016, Volume 35, pp. 155 - 175
Neurology | Internal Medicine | Protein quality control system | Heat shock factor-1 | Protein misfolding | Molecular chaperones | Neurodegenerative disorders | Unfolded protein response | Life Sciences & Biomedicine | Geriatrics & Gerontology | Science & Technology | Cell Biology | Brain - metabolism | Animals | Molecular Chaperones - metabolism | Humans | Autophagy - physiology | Neurodegenerative Diseases - metabolism | Proteasome Endopeptidase Complex - metabolism | Neurodegenerative Diseases - drug therapy | Drug Discovery | Unfolded Protein Response - physiology | Protein Folding | Heat shock proteins | Control systems | Nervous system | Degeneration | Health aspects | Nervous system diseases | Multiple sclerosis | Phosphatases | Amyloid beta-protein | Superoxide | Genetic translation | Cell death | Prions | Protein kinases | Alzheimer's disease | Protein binding | Index Medicus
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