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Biochemical Journal, ISSN 0264-6021, 03/2014, Volume 458, Issue 3, pp. 421 - 437
The RBR (RING-BetweenRING-RING) or TRIAD [two RING fingers and a DRIL (double RING finger linked)] E3 ubiquitin ligases comprise a group of 12 complex... 
Ubiquitination | Catalysis | Ubiquitin ligase | Structure | ubiquitin ligase | INDUCED CELL-DEATH | ANDROGEN RECEPTOR TRANSACTIVATION | KAPPA-B ACTIVATION | LINEAR POLYUBIQUITIN CHAINS | BIOCHEMISTRY & MOLECULAR BIOLOGY | catalysis | CHAIN ASSEMBLY COMPLEX | AMYOTROPHIC-LATERAL-SCLEROSIS | ALPHA-SYNUCLEIN | structure | ubiquitination | RING-FINGER PROTEINS | CONJUGATING ENZYME | FAMILIAL PARKINSONS-DISEASE | Animals | DNA Repair | Humans | Ubiquitin-Protein Ligases - metabolism | Protein Conformation | Membrane Proteins - metabolism | Enzyme Activation | Ubiquitin-Protein Ligases - chemistry | Protein Interaction Maps | RNA - metabolism | HECT, homologous with E6-associated protein C-terminus | Ubl, ubiquitin-like | IBR, InBetweenRING | ANKIB1, ankyrin repeat- and IBR domain-containing 1 | SH3, Src homology 3 | Eps15, epidermal growth factor receptor pathway substrate 15 | UBA, ubiquitin-associated | RWD, RING finger and WD repeat-containing | CCCP, carbonyl cyanide m-chlorophenylhydrazone | CRL, Cul-RING-ligase | TOMM70A, translocase of outer mitochondrial membrane 70 homologue A | NF-κB, nuclear factor κB | NZF, Npl4 ZNF | cIAP2, cellular inhibitor of apoptosis 2 | MIRO, mitochondrial Rho GTPase | TRAF6, tumour-necrosis-factor-receptor-associated factor 6 | NEMO, NF-κB essential modulator | MDM2, murine double minute 2 | TRIAD, two RING fingers and a DRIL (double RING finger linked) | HOIP, HOIL-1-interacting protein | BRcat, benign-catalytic | SHARPIN, SHANK-associated RH domain interactor | Review | RING1-BRcat-Rcat | Parc, parkin-like cytoplasmic p53-binding protein | SUMO, small ubiquitin-related modifier | LUBAC, linear ubiquitin chain assembly complex | HOIL-1, haem-oxidized IRP2 ubiquitin ligase 1 | RNF, RING finger protein | CPH, Cul7, Parc and HERC2 proteins | HDAC, histone deacetylase | RBR, RING-BetweenRING-RING | Cdk5, cyclin-dependent kinase 5 | SILAC, stable isotope labelling by amino acids in cell culture | RanBP2, RAN-binding protein 2 | FANCL, Fanconi anaemia, complementation group L | PINK1, PTEN-induced putative kinase 1 | PKC, protein kinase C | CK1, casein kinase 1 | NEDD, neural-precursor-cell-expressed developmentally down-regulated | ZNF, zinc finger | UBE2L, ubiquitin-conjugating enzyme E2L | UIM, ubiquitin-interacting motif | Cul, cullin | Rcat, required-for-catalysis
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 399 - 406
Beclin 1, a subunit of the class III phosphatidylinositol 3-kinase complex, is a tumour suppressor with a central role in endocytic trafficking, cytokinesis... 
Phosphoinositide | Ubiquitination | VPS34 | Neural-precursor-cell-expressed developmentally down-regulated 4 (Nedd4) | Homologous with E6-associated protein C-terminus (HECT) | Cancer | WW DOMAINS | N4WBP5A | COMPLEX | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | neural-precursor-cell-expressed developmentally down-regulated 4 (Nedd4) | E3 UBIQUITIN LIGASES | AUTOPHAGY | INDUCTION | homologous with E6-associated protein C-terminus (HECT) | phosphoinositide | ubiquitination | cancer | PHYSIOLOGICAL FUNCTIONS | REVEALS | Beclin-1 | Membrane Proteins - genetics | Humans | Endosomal Sorting Complexes Required for Transport - metabolism | Ubiquitin - chemistry | Ubiquitin - metabolism | Ubiquitin-Protein Ligases - metabolism | Class III Phosphatidylinositol 3-Kinases - metabolism | Endosomal Sorting Complexes Required for Transport - genetics | Gene Expression Regulation - physiology | Phosphatidylinositol 3-Kinases - metabolism | Apoptosis Regulatory Proteins - metabolism | Phosphatidylinositol 3-Kinases - genetics | Class III Phosphatidylinositol 3-Kinases - genetics | Proteolysis | Apoptosis Regulatory Proteins - genetics | Nedd4 Ubiquitin Protein Ligases | Membrane Proteins - metabolism | HeLa Cells | Protein Stability | Ubiquitin-Protein Ligases - genetics | HECT, homologous with E6-associated protein C-terminus | CCD, coiled-coil domain | ECD, evolutionarily conserved domain | CHX, cycloheximide | HA, haemagglutinin | DTT, dithiothreitol | siRNA, small interfering RNA | AIP4, atrophin-interacting protein 4 | HRP, horseradish peroxidase | Ub, ubiquitin | DMEM, Dulbecco's modified Eagle's medium | Nedd4, neural-precursor-cell-expressed developmentally down-regulated 4 | BH3, Bcl-2 homology 3 | PI3K-III, class III PI 3-kinase | GST, glutathione transferase | TRAF6, tumour-necrosis-factor-receptor-associated factor 6
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Biochemical Society Transactions, ISSN 0300-5127, 02/2014, Volume 42, Issue 1, pp. 103 - 107
E3 ubiquitin ligases that direct substrate proteins to the ubiquitin-proteasome system are promising, though largely unexplored drug targets both because of... 
Cell signalling | Degradation | Drug design | Antioxidant response | Ubiquitylation | Cancer | Protein Structure, Tertiary | Cullin Proteins - antagonists & inhibitors | Protein Structure, Secondary | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Cullin Proteins - physiology | Molecular Targeted Therapy | Multiprotein Complexes - antagonists & inhibitors | Multiprotein Complexes - physiology | Cullin Proteins - chemistry | Multiprotein Complexes - chemistry | Ubiquitination | Intracellular Signaling Peptides and Proteins - chemistry | Drug Design | Protein Structure, Quaternary | Intracellular Signaling Peptides and Proteins - physiology | Kelch-Like ECH-Associated Protein 1 | Rbx, RING box protein | CRL, Cullin–RING ligase | HECT, homologous with E6-associated protein C-terminus | BTB, broad complex | drug design | Nrf2, nuclear factor erythroid 2-related factor 2 | bric-à-brac | RING, really interesting new gene | KEAP1, Kelch-like ECH-associated protein 1 | Biochemical Society Focused Meeting | degradation | BACK, BTB and C-terminal Kelch | antioxidant response | POZ, pox virus and zinc finger | KLHL, Kelch-like | cell signalling | ARE, antioxidant-response element | MATH, meprin and TRAF (tumour-necrosis-factor-receptor-associated factor) homology | cancer | SPOP, speckle-type POZ protein | ubiquitylation | tramtrack
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2009, Volume 419, Issue 1, pp. 57 - 63
The inositol phosphatase, MTMR4 (myotubularin-related protein 4), was identified as a novel interactor of the ubiquitin ligase Nedd4... 
Myotubularin-related protein 4 (MTMR4) | Muscle atrophy | Neural-precursor-cell-expressed developmentally down-regulated 4 (Nedd4) | Ubiquitin ligase | Inositol phosphatase | Myotubularin | ubiquitin ligase | LOCALIZATION | myotubularin | SPECIFICITY | EPITHELIAL NA+ CHANNEL | BIOCHEMISTRY & MOLECULAR BIOLOGY | C2 DOMAIN | neural-precursor-cell-expressed developmentally down-regulated 4 (Nedd4) | myotubularin-related protein 4 (MTMR4) | PHOSPHOINOSITIDES | SKELETAL-MUSCLE | MYOTUBULARINS | MULTIVESICULAR-BODY | muscle atrophy | MEMBRANE-TRANSPORT | ASSOCIATION | inositol phosphatase | Protein Structure, Tertiary | Cell Line | Immunoprecipitation | Endosomal Sorting Complexes Required for Transport | Humans | Ubiquitin-Protein Ligases - metabolism | Rats | Male | Blotting, Western | Ubiquitination | Animals | Protein Tyrosine Phosphatases, Non-Receptor - metabolism | Nedd4 Ubiquitin Protein Ligases | HeLa Cells | Muscles - metabolism | Protein Binding - physiology | HECT, homologous with E6-associated protein C-terminus | h, human | HEK, human embryonic kidney | ENaC, epithelial sodium channel | MTMR4, myotubularin-related protein 4 | DMEM, Dulbecco's modified Eagle's medium | DSP, dual-specificity phosphatase | GST, glutathione transferase | GFP, green fluorescent protein | LAMP, lysosome-associated membrane protein | BCA, bicinchoninic acid | PX, phox homology domain | XLMTM, X-linked myotubular myopathy | Accelerated Publication | HA, haemagglutinin | CCD, charge-coupled device | Nedd4, neural-precursor-cell-expressed developmentally down-regulated 4 | PTP, protein tyrosine phosphatase | HPRT, hypoxanthine–guanine phosphoribosyltransferase
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2007, Volume 405, Issue 3, pp. 569 - 581
The ubiquitin-conjugating enzyme Cdc34 (cell division cycle 34) plays an essential role in promoting the G(1)-S-phase transition of the eukaryotic cell cycle... 
Phosphorylation | E2 ubiquitin-conjugating enzyme | Cell division cycle 34 (Cdc34) | Yeast | S-phase kinase-associated protein 1 (Skp1)/cullin/F-box (SCF) ubiquitin ligase | Cell cycle | cell cycle | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | cell division cycle 34 (Cdc34) | SACCHAROMYCES-CEREVISIAE | yeast | SELF-ASSOCIATION | STRUCTURAL BASIS | CONJUGATING ENZYME | DEGRADATION | CASEIN KINASE-II | UBC3 | LIGASE COMPLEX | phosphorylation | Gene Expression Regulation, Fungal | Amino Acid Sequence | Anaphase-Promoting Complex-Cyclosome | Cell Line | Cell Proliferation | SKP Cullin F-Box Protein Ligases - genetics | Humans | Ubiquitin - metabolism | Molecular Sequence Data | Ubiquitin-Protein Ligase Complexes - genetics | SKP Cullin F-Box Protein Ligases - metabolism | Acyltransferases - metabolism | Saccharomyces cerevisiae - cytology | Saccharomyces cerevisiae - metabolism | Ubiquitin-Protein Ligase Complexes - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Cell Cycle - physiology | Mutation | Ubiquitin-Conjugating Enzymes | Dyneins | F-box (SCF) ubiquitin ligase | S-phase kinase-associated protein 1 (Skp1) | cullin | CHX, cycloheximide | RING, really interesting new gene | 5-FOA, 5-fluoro-orotic acid | DTT, dithiothreitol | Na PPi, sodium pyrophosphate | Skp1, S-phase kinase-associated protein 1 | CDK, cyclin-dependent kinase | CK2, protein kinase CK2 | hCdc34, human Cdc34 | UPS, ubiquitin–proteasome system | GST, glutathione S-transferase | HEK-293 cells, human embryonic kidney 293 cells | ORF, open reading frame | Cdc34, cell division cycle 34 | SCF, Skp1 | F-box | HECT, homologous to E6-associated protein C-terminus
Journal Article