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Methods in Molecular Biology, ISSN 1064-3745, 2019, Volume 2009, pp. 243 - 255
Hedgehog and Wnt proteins are modified by covalent attachment of the fatty acids palmitate and palmitoleate, respectively. These lipid modifications are... 
Hedgehog | Wnt proteins | Hedgehog acyltransferase | Porcupine | Fatty acylation
Journal Article
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 09/2019, Volume 78, Issue 9, pp. 1269 - 1273
ObjectivesSystemic sclerosis (SSc) is characterised by aberrant hedgehog signalling in fibrotic tissues. The hedgehog acyltransferase (HHAT) skinny hedgehog... 
INHIBITION | PALMITOYLATION | THERAPY | RHEUMATOLOGY | SONIC HEDGEHOG | GLI2
Journal Article
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 33, pp. 13507 - 13513
Journal Article
Analytical Biochemistry, ISSN 0003-2697, 12/2015, Volume 490, pp. 66 - 72
Hedgehog signaling is critical for correct embryogenesis and tissue development. However, on maturation, signaling is also found to be aberrantly activated in... 
MBOAT | Click chemistry | Hedgehog acyltransferase | Protein palmitoylation | CHEMISTRY, ANALYTICAL | HUMAN-CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | PROBES | PROTEIN LIPIDATION | PATHWAY | INHIBITORS | CANCER PROGRESSION | SONIC-HEDGEHOG | Acyltransferases - antagonists & inhibitors | Hedgehog Proteins - chemistry | Detergents - chemistry | Humans | Hedgehog Proteins - metabolism | Substrate Specificity | Acyltransferases - metabolism | Acyltransferases - genetics | Recombinant Fusion Proteins - metabolism | Maltose - chemistry | Protein Processing, Post-Translational - drug effects | HEK293 Cells | Palmitoyl Coenzyme A - analogs & derivatives | Oligopeptides - chemistry | Streptavidin - chemistry | Peptide Fragments - metabolism | Biotinylation | Immobilized Proteins - chemistry | Enzyme-Linked Immunosorbent Assay | Click Chemistry | Enzyme Inhibitors - pharmacology | Lipoylation - drug effects | Solubility | Palmitoyl Coenzyme A - metabolism | Fatty Acids, Unsaturated - pharmacology | Oligopeptides - metabolism | Recombinant Fusion Proteins - chemistry | Peptide Fragments - chemistry | Maltose - analogs & derivatives | Streptavidin - metabolism | Immobilized Proteins - metabolism | Acyltransferases - chemistry | Measurement | Post-translational modification | Embryonic development | Detergents, Synthetic | Thiols | Peptides | Analysis | Fatty acids | Enzyme-linked immunosorbent assay | Acylation | OTG, n-octyl β-d-glucopyranoside | PTM, posttranslational modification | SDS, sodium dodecyl sulfate | GOAT, ghrelin-O-acyltransferase | YnC15, heptadec-16-ynoic acid | click–ELISA, click chemistry armed enzyme-linked immunosorbent assay | TBTA, tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine | MBOAT, membrane bound O-acyltransferase | HRP, horseradish peroxidase | PBS, phosphate-buffered saline | Hh, hedgehog | PAGE, polyacrylamide gel electrophoresis | HEK293a, human embryonic kidney 293a | RT, room temperature | BSA, bovine serum albumin | TCEP, tris(2-carboxyethyl)phosphine | CoA, coenzyme A | Shh, sonic hedgehog | CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate | HTS, high-throughput screen | cat–ELCCA, catalytic assay using an enzyme-linked click chemistry assay | DDM, n-dodecyl β-d-maltopyranoside | Hhat, hedgehog acyltransferase | PCR, polymerase chain reaction
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, p. e89899
Overexpression of Hedgehog family proteins contributes to the aetiology of many cancers. To be highly active, Hedgehog proteins must be palmitoylated at their... 
LIPID MODIFICATIONS | ACTIVATION | INHIBITION | PATHWAY | MULTIDISCIPLINARY SCIENCES | GROWTH | DESERT | DIFFERENTIATION |