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JOURNAL OF INVESTIGATIVE DERMATOLOGY, ISSN 0022-202X, 11/2019, Volume 139, Issue 11, pp. 2385 - 2385
Journal Article
by Atwood, SX and Li, MC and Lee, A and Tang, JY and Oro, AE
NATURE, ISSN 0028-0836, 02/2013, Volume 494, Issue 7438, pp. 484 - 488
Growth of basal cell carcinomas (BCCs) requires high levels of hedgehog (HH) signalling through the transcription factor GLI(1). Although inhibitors of... 
HEDGEHOG PATHWAY | GENE | MULTIDISCIPLINARY SCIENCES | RESISTANCE | CANCER
Journal Article
Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 16, pp. 13899 - 13913
Journal Article
03/2012
The Sonic hedgehog (Shh) signaling pathway plays a critical role in murine gastric development. When Shh is knocked out in the mouse embryonic stomach,... 
0369 | mouse | hedgehog pathway | 0307 | 0758 | gastric development | Gli3
Dissertation
Autophagy, ISSN 1554-8627, 2015, Volume 11, Issue 2, pp. 355 - 372
Journal Article
The Journal of urology, ISSN 0022-5347, 8/2016, Volume 196, Issue 2, pp. 343 - 348
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 12/2013, Volume 73, Issue 23, pp. 7068 - 7078
Medulloblastoma, originating in the cerebellum, is the most common malignant brain tumor in children. Medulloblastoma consists of four major groups where... 
COLLABORATE | ONCOLOGY | IN-VIVO | POLYCISTRON | TARGETING MICRORNA | MICE | BLOOD-BRAIN-BARRIER | TUMOR SUPPRESSORS | PRECURSORS | CHEMOTHERAPY | SONIC HEDGEHOG PATHWAY
Journal Article
Annales de Dermatologie et de Venereologie, ISSN 0151-9638, 11/2018, Volume 145, pp. VS36 - VS41
Until recently, advanced BCC were only accessible to a highly morbid surgery not necessarily proving to be carcinologic, and leaving terrible dysmorphic... 
Sonidegib | Immunotherapy | Advanced BCC | Vismodegib | Hedgehog pathway
Journal Article
Molecular Oncology, ISSN 1574-7891, 02/2015, Volume 9, Issue 2, pp. 389 - 397
Basal cell carcinomas (BCCs) and a subset of medulloblastomas are characterized by loss-of-function mutations in the tumor suppressor gene, PTCH1. PTCH1... 
Basal cell carcinoma | SMO | Primary resistance | PTCH1 | Secondary resistance | Vismodegib | Hedgehog pathway
Journal Article
International Journal of Food Sciences and Nutrition, ISSN 0963-7486, 07/2019, Volume 70, Issue 5, pp. 570 - 578
Sulforaphane (SFN) is the major component extracted from broccoli/broccoli sprouts. It has been shown to possess anti-cancer activity. Gastric cancer is common... 
suppression | gastric cancer stem cells | Sulforaphane | Sonic hedgehog pathway
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 12/2019, Volume 520, Issue 2, pp. 277 - 283
LncRNA LINC01510 (LINC01510) was a newly identified tumor-related lncRNA whose dysregulation and potential function have been reported in several tumors.... 
miR-335 | SHH | LncRNA LINC01510 | Metastasis | Papillary thyroid carcinoma | Hedgehog pathway
Journal Article
Dermatology Online Journal, ISSN 1087-2108, 2018, Volume 24, Issue 2
Vismodegib is a small molecule inhibitor of the Hedgehog signaling pathway that has shown efficacy in the control of locally advanced or metastatic basal cell... 
Basal cell carcinoma | Vismodegib | Hedgehog pathway
Journal Article
ACS Medicinal Chemistry Letters, ISSN 1948-5875, 06/2010, Volume 1, Issue 3, pp. 130 - 134
The blockade of aberrant hedgehog (Hh) signaling has shown promise for therapeutic intervention in cancer. A cell-based phenotypic high-throughput screen was... 
medulloblastoma | Hedgehog signaling pathway | Smoothened | HEDGEHOG PATHWAY | CHEMISTRY, MEDICINAL | INHIBITION | BASAL-CELL CARCINOMA | MICE | CANCER
Journal Article
11/2012
Clinical management of esophageal adenocarcinoma (EAC) relies on radiation therapy, yet radioresistance is a pervasive challenge in this disease. The... 
Xenograft models | Radiosensitivity | Limiting dilution assay | Radiation | qRT-PCR | Cancer stem cell | Radioresistance | Esophageal adenocarcinoma | Hedgehog pathway | Tumour-initiating cell
Dissertation
JAMA DERMATOLOGY, ISSN 2168-6068, 09/2019, Volume 155, Issue 9, pp. 1078 - 1080
This phase 2, open-label, placebo-controlled examines topical itraconazole as a treatment for basal cell carcinoma. 
HEDGEHOG PATHWAY | DERMATOLOGY
Journal Article
British Journal of Ophthalmology, ISSN 0007-1161, 07/2018, Volume 103, Issue 6, pp. 775 - 780
Background/Aims Locally advanced (T4 per American Joint Committee on Cancer (AJCC) 8th edition) periocular basal cell carcinoma (BCC) can lead to loss of the... 
treatment surgery | neoplasia | treatment medical | RESISTANCE | OPHTHALMOLOGY | RISK | HEDGEHOG PATHWAY | INHIBITION
Journal Article
Seminars in Cancer Biology, ISSN 1044-579X, 11/2019
Journal Article
Anti-Cancer Drugs, ISSN 0959-4973, 01/2018, Volume 29, Issue 3, pp. 208 - 215
Cancer stem cells (CSCs) play an essential role in the progression of many tumors. Sonic hedgehog (Shh) and Wnt/β-catenin pathways are crucial in maintaining... 
Curcumin | Inhibition | Wnt/β-catenin pathway | Breast cancer stem cells | Sonic hedgehog pathway
Journal Article
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