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Journal Article
Biochemical journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | kinase inhibitor | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | cancer | serum and glucocorticoid protein kinase (SGK) | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 07/2004, Volume 381, Issue 1, pp. 113 - 123
.... A 1.8 kb full-length cDNA containing an open reading frame of 1197 bp, which encodes a 43.6 kDa protein, was isolated from adult mouse kidney... 
Cystathioninaemia | Cystathionine γ-lyase | Cystathionase | Cysteine | Trans-sulphuration | Methionine | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Liver - enzymology | Cystathionine gamma-Lyase - immunology | Kidney - embryology | Humans | Kidney - enzymology | DNA, Complementary - genetics | Cercopithecus aethiops | Gene Expression Regulation, Developmental - genetics | Molecular Sequence Data | Male | Liver - embryology | Promoter Regions, Genetic - genetics | Intestine, Small - enzymology | COS Cells - enzymology | Transfection - methods | Base Sequence | Cloning, Molecular - methods | Cystathionine gamma-Lyase - genetics | Cell Line | Mice, Inbred C57BL | Rats | Mice, Inbred Strains | Organ Specificity | Cystathionine gamma-Lyase - biosynthesis | Rats, Sprague-Dawley | Immunohistochemistry - methods | Animals | Stomach - enzymology | Mice | Sequence Analysis, DNA - methods | Index Medicus | cystathionine γ-lyase | cystathioninaemia | trans-sulphuration | CBS, cystathionine β-synthase | cysteine | ORF, open reading frame | cystathionase | USF-1, upstream stimulatory factor-1 | UTR, untranslated region | CSE, cystathionine γ-lyase | E15.5, embryonic day 15.5 | PLP, pyridoxal 5′-phosphate | methionine | MZF1, myeloid zinc finger protein 1 | RACE, rapid amplification of cDNA ends | HEK-293 cells, human embryonic kidney 293 cells | PFA, paraformaldehyde | poly(A)+, polyadenylated | Sp1, specificity protein 1
Journal Article
Biochemical journal, ISSN 0264-6021, 09/2005, Volume 390, Issue 2, pp. 407 - 418
...)]. These peptides, originating from human heparin binding proteins and/or anti-DNA antibodies, once conjugated to a therapeutic molecule, can deliver the molecule to either the cytoplasm or the nucleus of mammalian cells. Vectocell (R... 
Proteoglycan | Tat peptide | Therapeutic drug delivery | Membrane translocation | Delivery vector | Cell-penetrating peptide | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Temperature | Humans | Molecular Sequence Data | Drug Carriers - toxicity | Viral Proteins - metabolism | Drug Carriers - chemistry | Cell Nucleus - metabolism | Peptides - metabolism | Peptides - toxicity | Recombination, Genetic - genetics | Integrases - metabolism | Cell Membrane - metabolism | Recombinant Proteins - metabolism | Amino Acid Sequence | Cell Line | Drug Carriers - metabolism | Peptides - chemistry | Recombinant Proteins - chemistry | Drug Carriers - pharmacology | Cytosol - chemistry | Peptides - pharmacology | Protein Transport | Animals | Cytosol - metabolism | Cell Nucleus - chemistry | Kinetics | Attachment Sites, Microbiological - genetics | Index Medicus | TMR, tetramethylrhodamine | therapeutic drug delivery | DMEM, Dulbecco's modified Eagle's medium | SLO, streptolysin O | DPV, Diatos peptide vector | DMF, dimethylformamide | CtxB, cholera toxin B subunit | GFP, green fluorescent protein | MTD, maximum tolerated dose | membrane translocation | GST, glutathione S-transferase | HEK-293 cells, human embryonic kidney 293 cells | LDH, lactate dehydrogenase | GAG, glycosaminoglycan | delivery vector | EGFP, enhanced green fluorescence protein | cell-penetrating peptide | proteoglycan | CHO-K1, Chinese-hamster ovary K1 | PO, peroxidase | TRITC, tetramethylrhodamine β-isothiocyanate | MBCD, methyl-β-cyclodextrin | PFA, paraformaldehyde | FCS, fetal calf serum
Journal Article
Biochemical journal, ISSN 1470-8728, 01/2007, Volume 401, Issue 1, pp. 29 - 38
Hormones and growth factors induce the activation of a number of protein kinases that belong to the AGC subfamily, including isoforms of PKA, protein kinase B... 
Kinase-specific inhibitor | Phosphorylation | p90 ribosomal S6 kinase (RSK) | BI-D1870 | Mitogen-activated protein kinase (MAPK) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Pteridines - pharmacology | Humans | Enzyme Inhibitors - pharmacology | Morpholines - pharmacology | Rats | Ribosomal Protein S6 Kinases, 90-kDa - metabolism | Animals | Ribosomal Protein S6 Kinases, 90-kDa - genetics | Ribosomal Protein S6 Kinases, 90-kDa - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Kinetics | Chromones - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | MES, mouse embryonic stem | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | PKA, cAMP-dependent protein kinase A | FKHR, forkhead in rhabdosarcoma transcription factor | RSK, p90 ribosomal S6 kinase | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | SGK1, serum- and glucocorticoid-induced kinase-1 | PDK1, phosphoinositide-dependent kinase 1 | PKB, protein kinase B | Lck, lymphocyte kinase | ROCK, Rho-dependent protein kinase | MKK1, MAPK kinase-1 | protein kinase G | AGC, cAMP-dependent protein kinase | phosphorylation | protein kinase C | kinase-specific inhibitor | HEK-293, human embryonic kidney 293 | ERK1, extracellular-signal-regulated kinase 1 | GST, glutathione S-transferase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | mitogen-activated protein kinase (MAPK) | PH, pleckstrin homology | PLK1, polo-like kinase 1 | CK1, casein kinase-1 | FBS, foetal bovine serum | MSK, mitogen- and stress-activated protein kinase | CDK2–A, cyclin-dependent kinase 2 complexed with cyclin A | DYRK1a, dual-specificity tyrosine-phosphorylated and -regulated kinase 1a | GSK3α, glycogen synthase kinase 3α | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical journal, ISSN 1470-8728, 11/2005, Volume 392, Issue 1, pp. 29 - 38
.... Sucrose gradient analyses and immunoprecipitation studies of primary human kidney epithelial cells showed the polycystins and their associated proteins E-cadherin and β... 
CRAC domain (cholesterol recognition/interaction amino acid domain) | Lipid raft | Kidney epithelial cell | Reggie-1 | Cholesterol | Polycystin | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Protein Structure, Tertiary | Cell Line | Epithelial Cells - metabolism | Cadherins - metabolism | Signal Transduction | Membrane Microdomains - metabolism | Humans | Cells, Cultured | Kidney - cytology | Cholesterol - metabolism | beta Catenin - metabolism | Amino Acid Motifs | Caveolin 1 - metabolism | Multiprotein Complexes - metabolism | Multiprotein Complexes - chemistry | Animals | Proteins - metabolism | Membrane Proteins - chemistry | TRPP Cation Channels | Membrane Proteins - metabolism | Proteins - chemistry | Index Medicus | GFP, green fluorescent protein | HEK-293 cells, human embryonic kidney 293 cells | polycystin | PKC, protein kinase C | mAb, monoclonal antibody | reggie-1 | MDCK cells, Madin–Darby canine kidney cells | CC, chelerythrine chloride | kidney epithelial cell | CRAC, cholesterol recognition | EGFP, enhanced GFP | HRP, horseradish peroxidase | lipid raft | MBP, myelin basic protein | interaction amino acid domain | ADPKD, autosomal dominant polycystic kidney disease | CRAC domain (cholesterol recognition | FBS, foetal bovine serum | cholesterol | MβCD, methyl-β-cyclodextrin | interaction amino acid | PP2, 4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazolo[3,4-d]pyrimidine | PFO, perfringolysin O
Journal Article
Biochemical journal, ISSN 0264-6021, 06/2006, Volume 396, Issue 3, pp. 537 - 545
P-glycoprotein (P-gp; ABCB1) actively transports a broad range of structurally unrelated compounds out of the cell... 
Cysteine-scanning mutagenesis | P-glycoprotein | Drug transport | Drug-binding pocket | Transmembrane segment 1 (TM1) | Protein modification | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Fluoresceins - pharmacology | Colchicine - pharmacology | Cyclosporine - pharmacology | Humans | Verapamil - analogs & derivatives | Binding Sites - physiology | Disulfides - analysis | Flupenthixol - pharmacology | Binding Sites - drug effects | Dithiothreitol - pharmacology | Amino Acid Sequence | Cell Line | Cricetinae | Demecolcine - pharmacology | Adenosine Triphosphatases - metabolism | ATP-Binding Cassette, Sub-Family B, Member 1 - physiology | Verapamil - pharmacology | Point Mutation | Animals | ATP-Binding Cassette, Sub-Family B, Member 1 - genetics | Mesylates - pharmacology | Vinblastine - pharmacology | Verapamil - metabolism | Amino Acid Substitution | Protein Structure, Tertiary - physiology | Index Medicus | P-gp, P-glycoprotein | cysteine-scanning mutagenesis | drug transport | protein modification | TMD, TM domain | TBS, Tris-buffered saline | DTT, dithiothreitol | NBD, nucleotide-binding domain | drug-binding pocket | M11M, 3,6,9-trioxaundecane-1,11-diyl bismethanethiosulphonate | calcein-AM, calcein acetoxymethyl ester | TMD2, C-terminal TMD containing TM7–TM12 | PXR, pregnane X receptor | M4M, 1,4-butanediyl bismethanethiosulphonate | ABC transporter, ATP-binding-cassette transporter | M8M, 3,6-dioxaoctane-1,8-diyl bismethanethiosulphonate | BHK cell, baby hamster kidney cell | TM, transmembrane | TMD1, N-terminal TMD containing TM1–TM6 | HEK-293 cell, human embryonic kidney 293 cell | TM1 (etc.), TM segment 1 (etc.) | transmembrane segment 1 (TM1) | M17M, 3,6,9,12,15-pentaoxaheptadecane-1,17-diyl bismethanethiosulphonate | MTS, methanethiosulphonate
Journal Article
Biochemical journal, ISSN 0264-6021, 06/2007, Volume 404, Issue 2, pp. 179 - 190
MDP (muramyl dipeptide), a component of peptidoglycan, interacts with NOD2 (nucleotide-binding oligomerization domain 2) stimulating the NOD2-RIP2... 
Pro-inflammatory cytokines | Nucleotide-binding oligomerization domain 2 (NOD2) | Muramyl dipeptide (MDP) | Receptor-interacting protein 2 (RIP2) | Transforming-growth-factor-β-activated kinase-1 (TAK1) | Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Cell Line | Signal Transduction | Humans | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | MAP Kinase Kinase Kinases - metabolism | Acetylmuramyl-Alanyl-Isoglutamine - metabolism | DNA Primers | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Acetylmuramyl-Alanyl-Isoglutamine - pharmacology | Nod2 Signaling Adaptor Protein - metabolism | Base Sequence | Interleukin-1beta - biosynthesis | Pyridines - pharmacology | Catalysis | Enzyme Activation | Tumor Necrosis Factor-alpha - biosynthesis | Cytokines - biosynthesis | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Interleukin-1beta - antagonists & inhibitors | Index Medicus | KI, kinase inactive | CK1, ‘casein kinase 1’ | TLR, Toll-like receptor | WT, wild-type | TNF, tumour necrosis factor | muramyl dipeptide (MDP) | HEK-293, human embryonic kidney 293 cells | JNK, c-Jun N-terminal kinase | MDP, muramyl dipeptide | TAK1, transforming-growth-factor-β-activated kinase-1 | transforming-growth-factor-β-activated kinase-1 (TAK1) | ERK, extracellular-signal-regulated kinase | K63-pUb, Lys63-linked polyubiquitin | RIP2, receptor-interacting protein 2 | MKK1, MAPK kinase-1 | receptor-interacting protein 2 (RIP2) | IκB, inhibitor of NF-κB | TAB, TAK1-binding protein | GAK, cyclin G-associated kinase | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | IKKβ, inhibitor of nuclear factor κB kinase β | GST, glutathione S-transferase | NF-κB, nuclear factor κB | NEMO, nuclear factor κB essential modifier | HA, haemagglutinin | NOD, nucleotide-binding oligomerization domain | TRAF6, TNF-receptor-associated factor 6 | nucleotide-binding oligomerization domain 2 (NOD2) | M-TriDAP, muramyl-N-acetyl-L-Ala-D-Glu-m-diaminopimelic acid | pro-inflammatory cytokines | IL, interleukin | LPS, lipopolysaccharide | shRNA, short hairpin RNA | VSV-G, vesicular-stomatitis-virus envelope glycoprotein | PBMCs, peripheral-blood mononuclear cells | Tpl2, tumour progression locus 2 | FCS, foetal-calf serum | MAPK, mitogen-activated protein kinase
Journal Article