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index medicus (267) 267
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cell line (147) 147
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animals (130) 130
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research article (117) 117
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hek293 cells (61) 61
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phosphorylation (41) 41
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activation (37) 37
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kidney - cytology (36) 36
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gst, glutathione s-transferase (33) 33
calcium - metabolism (32) 32
cells, cultured (32) 32
hek-293 cells, human embryonic kidney 293 cells (32) 32
biotechnology & applied microbiology (30) 30
ha, haemagglutinin (29) 29
neurosciences (29) 29
er, endoplasmic reticulum (27) 27
gfp, green fluorescent protein (27) 27
kidney - metabolism (27) 27
protein binding (27) 27
patch-clamp techniques (26) 26
analysis (25) 25
apoptosis (25) 25
mapk, mitogen-activated protein kinase (25) 25
recombinant proteins - metabolism (25) 25
hek-293 cells, human embryonic kidney cells (23) 23
hek-293, human embryonic kidney (23) 23
calcium (21) 21
erk, extracellular-signal-regulated kinase (21) 21
hek-293 cell (21) 21
in-vivo (21) 21
mutation (21) 21
dtt, dithiothreitol (20) 20
gene-expression (20) 20
kinetics (19) 19
gene expression (18) 18
in-vitro (18) 18
protein (18) 18
signal transduction (18) 18
binding sites (17) 17
cricetinae (17) 17
electrophysiology (17) 17
hek-293 cell, human embryonic kidney cell (17) 17
identification (17) 17
kidney - embryology (17) 17
pkc, protein kinase c (17) 17
cancer (16) 16
dose-response relationship, drug (16) 16
egf, epidermal growth factor (16) 16
gene expression regulation (16) 16
protein transport (16) 16
rt, reverse transcriptase (16) 16
binding (15) 15
biophysics (15) 15
gapdh, glyceraldehyde-3-phosphate dehydrogenase (15) 15
hrp, horseradish peroxidase (15) 15
inhibition (15) 15
male (15) 15
mutagenesis, site-directed (15) 15
protein structure, tertiary (15) 15
receptor (15) 15
sirna, small interfering rna (15) 15
biotechnology (14) 14
cell membrane - metabolism (14) 14
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fbs, fetal bovine serum (14) 14
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pi3k, phosphoinositide 3-kinase (14) 14
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cho cells (13) 13
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hela cells (13) 13
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wt, wild-type (13) 13
biochemical research methods (12) 12
cloning (12) 12
down-regulation (12) 12
localization (12) 12
molecular-cloning (12) 12
toxicology (12) 12
transcription factors - metabolism (12) 12
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Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 01/2019, Volume 109, pp. 2309 - 2317
Cisplatin, as an effective chemotherapeutic agent, is widely used to treat verious types of cancers. Nephrotoxicity induced by cisplatin seriously limits its... 
Icariin | Cytotoxicity | Cisplatin | HEK-293 cells | PI3K/Akt | MEDICINE, RESEARCH & EXPERIMENTAL | APOPTOSIS | OXIDATIVE STRESS | INJURY | MAPK | BCL-2 | INHIBITION | BAX | PHARMACOLOGY & PHARMACY | INDUCED NEPHROTOXICITY | NF-KAPPA-B | EXPRESSION | Antimitotic agents | Chemotherapy | Flavonoids | Flavones | Interleukins | Bioflavonoids | Nitric oxide | Inflammation | Antineoplastic agents | Cancer | Index Medicus
Journal Article
RSC Advances, ISSN 2046-2069, 2016, Volume 6, Issue 84, pp. 81092 - 81100
Ginsenosides and anthocyanins have already been reported to exhibit protective effects on intracellular defense against oxidative stress. Nuclear factor... 
HEK-293 CELLS | APOPTOSIS | OXIDATIVE STRESS | IN-VITRO | ACTIVATION | SIGNALING PATHWAY | GROWTH | INDUCED ENDOTHELIAL DYSFUNCTION | TNF-ALPHA | CHEMISTRY, MULTIDISCIPLINARY | RG3 | Antioxidants | Proteins | Stresses | Enzymes | Kidneys | Pathways | Gene expression | Assaying
Journal Article
NEUROSCIENCE LETTERS, ISSN 0304-3940, 01/2010, Volume 469, Issue 2, pp. 268 - 272
Human embryonic kidney (HEK293) cells are widely used for the heterologous expression of voltage- and ligand-gated ion channels. Patch clamp analysis of HEK293... 
Tetrodotoxin | HEK-293 CELLS | Sodium channels | HEK293 cells | Tefluthrin | NEUROSCIENCES | Na(v)1.7
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | Index Medicus | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
by Jiang, B and Sun, XF and Cao, K and Wang, R
MOLECULAR AND CELLULAR BIOCHEMISTRY, ISSN 0300-8177, 09/2002, Volume 238, Issue 1-2, pp. 69 - 79
The human embryonic kidney cells (HEK-293) have been widely used as one mammalian expression system in the study of voltage-gated K+ (K-V) channels.... 
HEK293 CELLS | GATED POTASSIUM CHANNELS | CALCIUM CHANNELS | BLOCK | HEK-293 cell | RAT TAIL ARTERY | VENTRICULAR MYOCYTES | K-V channel genes | tetraethylammonium chloride | CELL BIOLOGY | 4-aminopyridine | NEURONS | OUTWARD CURRENTS | delayed rectifier | transient outward K+ current | EXPRESSION | SMOOTH-MUSCLE CELLS
Journal Article
Journal Article
Plastic and Reconstructive Surgery, ISSN 0032-1052, 02/2005, Volume 115, Issue 2, pp. 506 - 514
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2014, Volume 588, Issue 18, pp. 3469 - 3474
The degradation and biological role of the cyclic pyrimidine nucleotide cCMP is largely elusive. We investigated nucleoside 3′,5′-cyclic monophosphate (cNMP)... 
HPLC–MS | Cyclic CMP | Cyclic nucleotides | Enzyme kinetics | Second messenger | Phosphodiesterase | cNMP | human lung carcinoma cell line | A549 | high performance liquid chromatography tandem mass spectrometry | adenosine 3′,5′-cyclic monophosphate | glutathione-S-transferase protein tag | inosine 5′-monophosphate | nucleoside 3′,5′-cyclic monophosphate | uridine 3′,5′-cyclic monophosphate | rat neuroblastoma cells | cXMP | insect cell line | cTMP | guanosine 5′-monophosphate | hyperpolarization-activated cyclic nucleotide-gated cation channel | uridine 5′-monophosphate | human embryonic kidney cell line | AMP | guanosine 3′,5′-cyclic monophosphate | U-937 | CMP | PKA | Sf9 | adenylyl cyclase toxin | Bordetella pertussis | GMP | IMP | PKG | HuT 78 | HCN | HPLC–MS/MS | CyaA | thymidine 3′,5′-cyclic monophosphate | UMP | hexahistidine tag | cIMP | cGMP | cAMP | cCMP | inosine 3′,5′-cyclic monophosphate | cytidine 5′-monophosphate | PDE | human promonocytic cell line | xanthosine 3′,5′-cyclic monophosphate | xanthosine 5′-monophosphate | human lymphoblast cell line | HEK-293 | protein kinase G | cUMP | protein kinase A | P. aeruginosa | multidrug resistance-associated protein 5 | exotoxin Y | Spodoptera frugiperda | GST | thymidine 5′-monophosphate | B103 | MRP5 | HIS | adenosine 5′-monophosphate | TMP | cytidine 3′,5′-cyclic monophosphate | XMP | phosphodiesterase | ExoY | HPLCMS | MAMMALIAN-TISSUES | CELLS | SPECIFICITY | PURINE | HPLC-MS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CYCLASE ACTIVITY | CELL BIOLOGY | BIOPHYSICS | CYCLIC CMP PHOSPHODIESTERASE | SUBSTRATE | PYRIMIDINE | LIVER | NUCLEOTIDE PHOSPHODIESTERASES | Cyclic CMP - chemistry | Sulfonamides - chemistry | Humans | Nitro Compounds - chemistry | Substrate Specificity | Cyclic Nucleotide Phosphodiesterases, Type 7 - chemistry | Spodoptera | Hydrolysis | Sf9 Cells | Animals | Cyclic AMP - chemistry | Cell Line, Tumor | Cyclic Nucleotide Phosphodiesterases, Type 7 - antagonists & inhibitors | Kinetics | Phosphodiesterase Inhibitors - chemistry | Second Messenger Systems | Index Medicus
Journal Article
Biochemical Journal, ISSN 0264-6021, 08/2006, Volume 397, Issue 3, pp. 461 - 471
Sphingosine 1-phosphate (S1P), produced by Sphk (sphingosine kinases), is a multifunctional lipid mediator that regulates immune cell trafficking and vascular... 
Extracellular export | Platelet-poor plasma | Sphingosine kinase | Platelet-rich plasma | Sphingosine 1-phosphate (S1P) gradient | Sphingosine 1-phosphate | NEUTRAL CERAMIDASE | sphingosine 1-phosphate (S1P) gradient | PHOSPHORYLATION | sphingosine kinase | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGICAL SAMPLES | FUNCTIONAL-CHARACTERIZATION | CELL-GROWTH | platelet-rich plasma | QUANTITATIVE-ANALYSIS | extracellular export | FTY720 | MOLECULAR-CLONING | platelet-poor plasma | sphingosine 1-phosphate | ACID SPHINGOMYELINASE | 1-PHOSPHATE | Endothelium, Vascular - cytology | Isoenzymes - blood | Humans | Mice, Inbred C57BL | Cells, Cultured | Lysophospholipids - blood | Isoenzymes - secretion | Mice, Knockout | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Protein Transport | Culture Media, Conditioned | Extracellular Space - metabolism | Sphingosine - analogs & derivatives | Animals | Phosphotransferases (Alcohol Group Acceptor) - secretion | Sphingosine - biosynthesis | Isoenzymes - metabolism | Intracellular Space - metabolism | Lysophospholipids - biosynthesis | Phosphotransferases (Alcohol Group Acceptor) - blood | Sphingosine - blood | Mice | Receptors, Lysosphingolipid - metabolism | Index Medicus | CM, conditioned medium | PRP, platelet-rich plasma | HEK-293 cell, human embryonic kidney cell | DMS, N,N′-dimethylsphingosine | PPP, platelet-poor plasma | S1P, sphingosine 1-phosphate | hSphk, human Sphk | DMEM, Dulbecco's modified Eagle's medium | NRS, non-immune rabbit serum | RT, reverse transcriptase | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | GFP, green fluorescent protein | GST, glutathione S-transferase | Acc. No., accession number | S1PR, S1P receptor | Q-RT–PCR, quantitative RT–PCR | FBS, fetal bovine serum | plateletrich plasma | siRNA, small interfering RNA | HUVEC, human umbilical-vein endothelial cells | ER, endoplasmic reticulum | Sphk, sphingosine kinase
Journal Article