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Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
.... On the basis of this information, the effects of compounds that we have studied in cells and other data in the literature, we recommend the use of the following small-molecule inhibitors... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
Biochemical journal, ISSN 0264-6021, 06/2009, Volume 420, Issue 3, pp. 391 - 402
L1-CAM (L1 cell-adhesion molecule), or more simply L1, plays an important role ill the progression of human carcinoma... 
Presenilin (PS)/γ-secretase activity | Raft | Nuclear translocation | Signalling | L1 cell-adhesion molecule (L1-CAM) | A disintegrin and metalloprotease 10 (ADAM10) | MIGRATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | raft | AMYLOID PRECURSOR PROTEIN | CLEAVAGE | presenilin (PS)/gamma-secretase activity | nuclear translocation | a disintegrin and metalloprotease 10 (ADAM10) | COLORECTAL-CANCER | LIPID RAFTS | GENE-EXPRESSION | L1 ADHESION MOLECULE | GAMMA-SECRETASE | BINDING | signalling | INTRACELLULAR DOMAIN | Amyloid Precursor Protein Secretases - genetics | RNA, Small Interfering - genetics | Cricetulus | Membrane Microdomains - metabolism | Humans | Neural Cell Adhesion Molecule L1 - genetics | Ovarian Neoplasms - pathology | Receptors, Retinoic Acid - genetics | Ovarian Neoplasms - genetics | Cell Nucleus - metabolism | Flow Cytometry | Transfection | Presenilins - metabolism | Presenilins - genetics | Female | Transcription, Genetic | Membrane Proteins - metabolism | Ovarian Neoplasms - metabolism | Active Transport, Cell Nucleus | Neural Cell Adhesion Molecule L1 - metabolism | CHO Cells | Cell Line | Cricetinae | Lysosome-Associated Membrane Glycoproteins - metabolism | Signal Transduction | Membrane Proteins - genetics | ADAM10 Protein | Binding Sites - genetics | Reverse Transcriptase Polymerase Chain Reaction | ADAM Proteins - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Cell Line, Tumor | ADAM Proteins - genetics | Microscopy, Fluorescence | mAb, monoclonal antibody | CRABPII, cellular retinoic acid-binding protein II | LAMP-1, lysosomal-associated membrane protein 1 | pAb, polyclonal antibody | MT1-MMP, membrane type-1 matrix metalloproteinase | hL1, human L1 | TAPI-0, N-(R)-[2-(hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-naphthylalanyl-L-alanine amide | DRM, detergent-resistant membrane | ECL®, enhanced chemiluminescence | ERK, extracellular-signal-regulated kinase | HRP, horseradish peroxidase | L1cyt, the cytoplasmic part of L1 | L1, L1 cell-adhesion molecule | qRT-PCR, quantitative real-time PCR | FNIII, fibronectin III | MDK, midkine or neurite growth-promoting factor 2 | ADAM, a disintegrin and metalloprotease | TACE, tumour-necrosis factor-α converting enzyme | FCS, fetal-calf serum | DAPT, N-[N-(3,5-difluorophenacetyl)-L-alanyl]-(S)-phenylglycine t-butyl ester (also known as presenilin inhibitor IX) | presenilin (PS) | ICD, intracellular domain | γ-secretase activity | siRNA, small interfering RNA | CTF, C-terminal fragment | CHO, Chinese-hamster ovary | HEK-293, human embryonic kidney-293 | PS, presenilin(-1) | APP, amyloid precursor protein | RIP, regulated intramembrane proteolysis
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 402, Issue 3, pp. 515 - 523
.... The palmitoylation was not essential for the secretion of Wnt-5a, but was necessary for its ability to suppress Wnt-3a-dependent T-cell factor transcriptional activity and to stimulate cell migration... 
Posttranslational modification | Frizzled 5 (Fz5) | Glycosylation | Palmitoylation | Wnt-5a | TRANSFORMATION | PHOSPHORYLATION | frizzled 5 (Fz5) | BIOCHEMISTRY & MOLECULAR BIOLOGY | glycosylation | post-translational modification | BETA-CATENIN | PATHWAY | CELL-MIGRATION | GROWTH | FOCAL ADHESION KINASE | PROTEINS | DEPENDENT ACTIVATION | EXPRESSION | palmitoylation | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Cell Line | Signal Transduction | Humans | Molecular Sequence Data | Proto-Oncogene Proteins - genetics | Proto-Oncogene Proteins - chemistry | Wnt-5a Protein | Wnt Proteins - metabolism | Transcription Factor 7-Like 2 Protein | Wnt Proteins - chemistry | Wnt Proteins - isolation & purification | TCF Transcription Factors - metabolism | Sequence Alignment | Animals | Wnt Proteins - genetics | Fatty Acids, Monounsaturated - metabolism | Protein Binding | Mice | Protein Processing, Post-Translational | Proto-Oncogene Proteins - isolation & purification | Cell Movement | HEK-293T cells, HEK-293 cells expressing the large T-antigen of SV40 (simian virus 40) | CM, conditioned medium | WT, wild-type | ECM, extracellular matrix | NLK, Nemo-like kinase | LRP5 | JNK, c-Jun N-terminal kinase | GFP, green fluorescent protein | Fz, Frizzled | PKC, protein kinase C | FAK, focal adhesion kinase | CRD, cysteine-rich domain | Lef, lymphoid enhancer factor | MALDI–TOF-MS, matrix-assisted laser-desorption ionization–time-of-flight MS | 6, lipoprotein receptor-related protein 5 | siRNA, small interfering RNA | Tcf, T-cell factor | PNGase F, peptide N-glycosidase F | HEK-293, human embryonic kidney-293 | TFA, trifluoroacetic acid
Journal Article
Biochemical journal, ISSN 1470-8728, 2005, Volume 392, Issue 2, pp. 313 - 324
.... Surprisingly, the G0S2 mRNA level was highest in brown and white adipose tissue and was greatly up-regulated during mouse 3T3-L1 and human SGBS (Simpson–Golabi–Behmel syndrome) adipogenesis... 
expression | adipogenesis | ppar-gamma-2 | adipocyte differentiation | transcription factors | alpha | protein | acute-phase response | fenofibrate | gamma activators | Growth arrest | Peroxisome-proliferator-activated receptor (PPAR) | switch gene 2 (G0S2) | Adipogenesis | Up-Regulation | Oligonucleotide Array Sequence Analysis | Humans | Endoplasmic Reticulum - metabolism | Molecular Sequence Data | Substrate Specificity | Adipocytes - cytology | Male | Hepatocytes - metabolism | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Hepatocytes - cytology | Base Sequence | Gene Deletion | Cell Cycle Proteins - genetics | Response Elements - genetics | Cell Line | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Rats | PPAR alpha - genetics | Sequence Homology, Nucleic Acid | Protein Transport | Animals | Adipocytes - metabolism | Liver - cytology | Mice | PPAR alpha - metabolism | Liver | Genomics | PPAR alpha | Adipocytes | Endoplasmic Reticulum | Life Sciences | Promoter Regions, Genetic | Response Elements | Biochemistry, Molecular Biology | Hepatocytes | RNA, Messenger | Cell Cycle Proteins | h, human | RXR, retinoid X receptor | SEAP, secreted alkaline phosphatase | G0S2, G0 | ChIP, chromatin immunoprecipitation | G1 switch gene 2 | DMEM, Dulbecco's modified Eagle's medium | PPRE, PPAR-responsive element | growth arrest | Q-PCR, real-time quantitative PCR | RT, reverse transcriptase | CYP4A10, cytochrome P450, family 4, subfamily a, polypeptide 10 | GFP, green fluorescent protein | DsRed, Discosoma sp. red fluorescent protein | m, mouse | BAT, brown adipose tissue | HEK-293 cells, human embryonic kidney-293 cells | G1 switch gene 2 (G0S2) | BODIPY®, 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene | Avg Diff, average difference | PPAR, peroxisome-proliferator-activated receptor | peroxisome-proliferator-activated receptor (PPAR) | WAT, white adipose tissue | GPDH, glycerol 3-phosphate dehydrogenase | aP2, adipocyte fatty-acid-binding protein | BMP-2, bone morphogenetic protein-2 | SGBS, Simpson–Golabi–Behmel syndrome | ER, endoplasmic reticulum
Journal Article
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 407, Issue 2, pp. 231 - 241
... (human embryonic kidney)-293 cells was induced by IGF-1 (insulin-like growth factor-1), EGF (epidermal growth factor... 
14-3-3 | Akt/protein kinase B (PKB) | GTPase-activating protein (GAP) | p90 ribosomal S6 kinase (RSK) | Akt substrate of 160 kDa (AS160) | Serum- and glucocorticoid-induced protein kinase (SGK) | MAMMALIAN TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | Akt substrate of 160kDa (AS160) | AKT SUBSTRATE | CELL-GROWTH | GTPASE-ACTIVATING PROTEIN | SKELETAL-MUSCLE | INSULIN-STIMULATED PHOSPHORYLATION | GLUT4 TRANSLOCATION | S6 KINASE | PROTEOMIC ANALYSIS | RAB-GAP | serum- and glucocorticoid-induced protein kinase (SGK) | Cell Line | Insulin-Like Growth Factor I - pharmacology | Phosphorylation | Humans | GTPase-Activating Proteins - metabolism | Insulin | Amino Acids | Aminoimidazole Carboxamide - pharmacology | Hypoglycemic Agents - pharmacology | 14-3-3 Proteins - metabolism | Ribonucleotides - pharmacology | Aminoimidazole Carboxamide - analogs & derivatives | Protein Binding | Epidermal Growth Factor - pharmacology | Binding Sites | ACC, acetyl-CoA carboxylase | AGC kinase, protein kinase A | AICAR, 5-amino-4-imidazolecarboxamide1-β-D-ribofuranoside | PI3K, phosphoinositide 3-kinase | EGF, epidermal growth factor | TOS motif, mTOR signalling motif | PAS, phospho-Akt substrate | pSer, phosphorylated serine | TSC, tuberous sclerosis complex | AS160, Akt substrate of 160 kDa | PKB, protein kinase B (also known as Akt) | AMPK, AMP-activated protein kinase | RSK, p90 ribosomal S6 kinase | DSP, dithiobis(succinimidyl propionate) | protein kinase C-family | ERK, extracellular-signal-regulated kinase | PDK1, phosphoinositide-dependent kinase 1 | protein kinase B (PKB) | IGF-1, insulin-like growth factor-1 | Akt substrate of 160 kDa (AS160) | GLUT4, glucose transporter 4 | protein kinase G | mTOR, mammalian target of rapamycin | TORC1, mTOR–raptor (regulatory associated protien of mTOR) complex | 4E-BP1, eukaryotic initiation factor 4E-binding protein 1 | GST, glutathione S-transferase | PKC, protein kinase C | PP2A, protein phosphatase 2A | Akt | SGK, serum- and glucocorticoid-induced protein kinase | HA, haemagglutinin | GSV, GLUT4 storage vesicle | p70S6K, p70 S6 kinase | PTB, phosphotyrosine binding domain | pThr, phosphorylated threonine | GAP, GTPase-activating protein | HEK-293, human embryonic kidney-293 | IRAP, insulin-responsive aminopeptidase | Rheb, Ras enriched in brain | MAPK, mitogen-activated protein kinase
Journal Article
Bioorganic & medicinal chemistry, ISSN 0968-0896, 2011, Volume 19, Issue 23, pp. 7168 - 7180
The farnesoid X receptor (FXR) is involved in glucose and lipid metabolism regulation, which makes it an attractive target for the metabolic syndrome,... 
Farnesoid X receptor | Virtual screening | FXR agonist | Molecular modeling | Lead identification | ACTIVATION | CHEMISTRY, MEDICINAL | ANTAGONIST | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DRUG DISCOVERY | CHEMISTRY, ORGANIC | BILE-ACID RECEPTOR | IDENTIFICATION | NUCLEAR RECEPTOR | POTENT | DATABASE | FARNESOID-X-RECEPTOR | Humans | Receptors, Cytoplasmic and Nuclear - chemistry | Drug Design | HEK293 Cells | Models, Molecular | Receptors, Cytoplasmic and Nuclear - agonists | Structure-Activity Relationship | Binding Sites | Receptors, Cytoplasmic and Nuclear - metabolism | Models | Universities and colleges | Hydrogen | Hydrogen bonding | Analysis | Deoxycholic acid | DMEM, Dulbecco’s Modified Eagle’s Medium | DCA, deoxycholic acid | LRH-1, liver receptor homolog 1 | NCI, National Cancer Institute | SD file, structure-data file | BSEP, bile salt export pump | AF, activation function | CA, cholic acid | LCA, lithocholic acid | PDB, Protein Data Bank | WDI, World Drug Index | RXR, 9-cis-retionic acid receptor | FXR, farnesoid X receptor | CDCA, chenodeoxycholic acid | FBS, fetal bovine serum | 6-ECDCA, 6-ethylchenodeoxycholic acid | SHP-1, small heterodimer partner 1 | EF, enrichment factor | H-bond, hydrogen bond | LXR, liver X receptor | IBABP, intestinal bile acid-binding protein | HEK-293, human embryonic kidney-293
Journal Article
Biochemical journal, ISSN 0264-6021, 12/2007, Volume 408, Issue 2, pp. 277 - 286
.... The promoter activity was up-regulated by TNF alpha stimulation in cells transfected with a luciferase reporter vector encoding the region from -282 to -123 of the human PHGPx gene compared... 
CCAAT/enhancer-binding protein (C/EBP) | Promoter activity | HL60 cell | Tumour necrosis factor α (TNFα) | Phospholipid hydroperoxide glutathione peroxidase (PHGPx) | APOPTOSIS | KAPPA-B ACTIVATION | NEUTROPHIL | C/EBP-BETA | BIOCHEMISTRY & MOLECULAR BIOLOGY | promoter activity tumour necrosis factor alpha (TNF alpha) | INDUCTION | HYDROPEROXIDE GLUTATHIONE-PEROXIDASE | SUPPRESSION | phospholipid hydroperoxide glutathione peroxidase (PHGPx) | OVEREXPRESSION | EPITHELIAL-CELLS | GENE-EXPRESSION | Cell Line | Transcription Factors - physiology | Humans | Up-Regulation - genetics | Transcription Factors - genetics | Glutathione Peroxidase - biosynthesis | Glutathione Peroxidase - genetics | Promoter Regions, Genetic - physiology | CCAAT-Enhancer-Binding Proteins - physiology | Up-Regulation - physiology | Tumor Necrosis Factor-alpha - physiology | HL-60 Cells | CCAAT-Enhancer-Binding Proteins - genetics | MEK, MAPK | PHGPx, phospholipid hydroperoxide GPx | NF-Y, nuclear factor-Y | HEK-293 cell, human embryonic kidney-293 cell | NAC, N-acetylcysteine | JNK, c-Jun N-terminal kinase | CREB, cAMP-response-element-binding protein | tumour necrosis factor α (TNFα) | ChIP, chromatin immunoprecipitation | EBP | promoter activity | DMEM, Dulbecco's modified Eagle's medium | PDTC, pyrrolidinecarbodithioate | GPx, glutathione peroxidase | RT, reverse transcriptase | CCAAT | ICAM-1, intercellular adhesion molecule 1 | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | enhancer-binding protein | PMN, polymorphonuclear cell | COX, cyclo-oxygenase | NF-κB, nuclear factor κB | EBP, CCAAT | RBL2H3, rat basophilic leukaemia 2H3 | enhancer-binding protein (C | EMSA, electrophoretic mobility-shift assay | IL, interleukin | FBS, foetal bovine serum | LPS, lipopolysaccharide | ERK (extracellular-signal-regulated kinase) kinase | MAPK, mitogen-activated protein kinase
Journal Article
Biochemical and biophysical research communications, ISSN 0006-291X, 2004, Volume 324, Issue 3, pp. 1069 - 1080
.... In the present study, we were interested to determine if the expression of giardial CWPs as heterologous proteins in a higher eukaryotic cell would result in their trafficking across the secretory... 
Secretory vesicles | Transfection | Encystation | HEK-293 | Signal peptide | Giardia duodenalis | Cyst wall proteins | Secretory pathway | Endoplasmic reticulum | Golgi apparatus | BIOCHEMISTRY & MOLECULAR BIOLOGY | transfection | EXCYSTATION | secretory pathway | MECHANISMS | ANTIGENS | GOLGI | encystation | signal peptide |