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gene expression regulation (6) 6
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apoptosis (5) 5
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life (5) 5
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original paper (5) 5
rt, reverse transcriptase (5) 5
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Research in Pharmaceutical Sciences, ISSN 1735-5362, 08/2018, Volume 13, Issue 4, pp. 353 - 359
Blockade of α4 integrin by antibodies could be an appropriate treatment strategy in multiple sclerosis and Crohn's disease. Considering disadvantages of... 
HEK-293T | Multiple sclerosis | ITGA4 | Integrin α4 | Original
Journal Article
Biochemical Journal, ISSN 0264-6021, 2007, Volume 407, Issue 1, pp. 49 - 59
High-affinity cellular copper uptake is mediated by the CTR (copper transporter) 1 family of proteins. The highly homologous hCTR (human CTR) 2 protein has... 
Copper transporter 2 (Ctr2) | Copper biosensor | Copper uptake | Metallothionein | Zinc | Copper transporter 1 (Ctr1) | MOLECULAR CHARACTERIZATION | copper transporter 2 (Ctr2) | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL-CHARACTERIZATION | metallothionein | MENKES DISEASE | SACCHAROMYCES-CEREVISIAE | PLASMA-MEMBRANE | STIMULATED ENDOCYTOSIS | TRANSFERRIN RECEPTOR | P-TYPE ATPASE | copper transporter 1 (Ctr1) | zinc | SUPEROXIDE-DISMUTASE | TRANSCRIPTION FACTOR | copper biosensor | copper uptake | Amino Acid Sequence | Lysosomes - chemistry | Humans | Cells, Cultured | Cation Transport Proteins - physiology | Molecular Sequence Data | Endosomes - metabolism | Cation Transport Proteins - analysis | Sequence Alignment | Lysosomes - metabolism | Transfection | Biological Transport | Cation Transport Proteins - metabolism | Copper - metabolism | Endosomes - chemistry | Cation Transport Proteins - genetics | Cytosol - metabolism | Cell Membrane - metabolism | HeLa Cells | Index Medicus | eGFP, enhanced green fluorescent protein | BCS, bathocuproinedisulfonic acid | ATP7A, copper-transporting P1B-type ATPase | TfR, transferrin receptor | CTR, copper transporter | EGS, ethylene glycolbis(succinimidylsuccinate) | FCS, foetal calf serum | hCTR, human CTR | vsvG, vesicular-stomatitis-virus glycoprotein | DMEM, Dulbecco's modified Eagle's medium | DFO, desferrioxamine | HEK-293T cell, human embryonic kidney cell expressing the large T-antigen of SV40 (simian virus 40) | LAMP, lysosome-associated membrane protein | TGN, trans-Golgi network | MTF, metal responsive transcription factor | MEF, mouse embryonic fibroblast | MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide | MRE, metal-responsive element | RLU, relative light units
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2010, Volume 430, Issue 3, pp. 551 - 558
The bacterial Ras-like protein Era has been reported previously to bind 16S rRNA within the 30S ribosomal subunit and to play a crucial role in ribosome... 
Ribosome assembly | Translation | Era G-protein-like 1 (ERAL1) | rRNA | Mitoribosome | APOPTOSIS | COMPLEX | PROTEIN | ribosome assembly | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | mitoribosome | CELL-CYCLE ARREST | HOMOLOG | DEATH | MESSENGER-RNAS | MAMMALIAN MITOCHONDRIA | translation | Cell Line | RNA-Binding Proteins - genetics | Molecular Chaperones - metabolism | Humans | Molecular Chaperones - genetics | RNA, Ribosomal - metabolism | RNA, Ribosomal, 28S - metabolism | Mitochondrial Proteins - biosynthesis | RNA Stability | GTP-Binding Proteins - genetics | RNA, Ribosomal - genetics | RNA - genetics | Blotting, Northern | RNA Interference | HeLa Cells | RNA, Ribosomal, 28S - genetics | RNA-Binding Proteins - metabolism | GTP-Binding Proteins - metabolism | RNA - metabolism | Index Medicus | DAP3, death-associated protein 3 | KH, K homology | NT, non-targeting | UTR, untranslated region | ERAL1, Era G-protein-like 1 | RNP, ribonucleoprotein | ROS, reactive oxygen species | MEM, minimal essential medium | ICT1, immature colon carcinoma transcript 1 | CLIP, cytoplasmic linker protein | COX, cyclo-oxygenase | NDUFA9, NADH dehydrogenase (ubiquinone) 1 α subcomplex 9 | FBS, fetal bovine serum | MTND, mitochondrially encoded NADH dehydrogenase | NEAA, non-essential amino acids | IP, immunoprecipitation | NDUFB8, NADH dehydrogenase (ubiquinone) 1 β subcomplex 8 | siRNA, small interfering RNA | GDH, glutamate dehydrogenase | LSU, large subunit | MGC, mammalian gene collection | HEK-293T, HEK (human embryonic kidney)-293 cells expressing the large T-antigen of SV40 (simian virus 40) | MRP, mammalian ribosomal protein | SSU, small subunit | SD, Shine–Dalgarno | mt, mitochondrial | TFB1M, transcription factor B1, mitochondrial | HSP70, heat-shock protein 70
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2009, Volume 417, Issue 1, pp. 391 - 400
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 2, pp. 557 - 564
The DNMT3A (DNA methyltransferase 3A) and DNMT3B genes encode putative de novo methyltransferases and show complex transcriptional regulation in the presence... 
Mithramycin A | DNA methyltransferase (DNMT) | Gene regulation | Sp3 | Specificity protein 1 (Sp1) | CELLS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | FAMILY | mithramycin A | specificity protein 1 (Sp1) | gene regulation | CYTOSINE-5 METHYLTRANSFERASES | CLONING | DNMT3B | DIFFERENTIATION | PROMOTER | EXPRESSION | Gene Expression Regulation, Enzymologic - drug effects | Transcription, Genetic - drug effects | Adenoviridae | Kidney - embryology | Humans | Transcription Factors - deficiency | Sp1 Transcription Factor - metabolism | DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors | Gene Expression Regulation, Enzymologic - physiology | Promoter Regions, Genetic - drug effects | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - deficiency | DNA-Binding Proteins - metabolism | RNA, Messenger - biosynthesis | Kidney - metabolism | Mutagenesis, Site-Directed - genetics | RNA, Messenger - antagonists & inhibitors | Sp3 Transcription Factor | Sp1 Transcription Factor - physiology | Cell Line | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Oligonucleotides, Antisense - pharmacology | Binding Sites - genetics | DNA - metabolism | Plicamycin - pharmacology | Plicamycin - analogs & derivatives | Transcription Factors - metabolism | DNA (Cytosine-5-)-Methyltransferases - genetics | Oligonucleotides, Antisense - genetics | Kidney - chemistry | Zinc Fingers - genetics | Transcription, Genetic - genetics | Kidney - virology | Cell Line, Transformed | Index Medicus | EMSA, electrophoretic mobility-shift assay | Sp, specificity protein | DNMT, DNA methyltransferase | HEK-293T cells, human embryonic kidney 293T cells | RT, reverse transcriptase | TSP, transcription start site | GAPDH, glyceraldehyde-3-phosphate dehydrogenase
Journal Article
Biochemical Journal, ISSN 0264-6021, 03/2007, Volume 402, Issue 3, pp. 419 - 427
To this day, a significant proportion of the human genome remains devoid of functional characterization. In this study, we present evidence that the previously... 
Steroid metabolism | DHRS10 | 17β-hydroxysteroid dehydrogenase | Pre-receptor control | Crystal structure | Short-chain dehydrogenase/reductase | BRAIN-INJURY | 17-BETA-HYDROXYSTEROID DEHYDROGENASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | short-chain dehydrogenase/reductase | WEIGHT-LOSS | SHORT-CHAIN DEHYDROGENASES/REDUCTASES | HUMAN ADIPOSE-TISSUE | steroid metabolism | crystal structure | pre-receptor control | ESTROGEN | REDUCTASE | MOLECULAR-CLONING | TYPE-1 | 17 beta-hydroxysteroid dehydrogenase | EXPRESSION | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Gene Expression | Oxidation-Reduction | Protein Structure, Secondary | Humans | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | Organ Specificity | Cytosol - enzymology | Sequence Alignment | 17-Hydroxysteroid Dehydrogenases - isolation & purification | 17-Hydroxysteroid Dehydrogenases - genetics | Ligands | Structural Homology, Protein | Kinetics | 17-Hydroxysteroid Dehydrogenases - chemistry | 17-Hydroxysteroid Dehydrogenases - metabolism | Binding Sites | NAD - metabolism | Index Medicus | GFP, green fluorescent protein | RMSD, root mean square deviation | HEK-293T cells, HEK-293 cells (human embryonic kidney cells) expressing the large T-antigen of SV40 (simian virus 40) | NCS, non-crystallographic symmetry | TCEP, tris-(2-carboxyethyl)phosphine | reductase | HSD, hydroxysteroid dehydrogenase | SDR, short-chain dehydrogenase | ER, oestrogen receptor | MDR, medium-chain dehydrogenase | DHEA, dehydroepiandrosterone | short-chain dehydrogenase
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2004, Volume 381, Issue 1, pp. 213 - 219
Proteins of the NACHT [NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from... 
CLAN | Caspase 1 | Nod2 | Nod1 | Nuclear factor κB (NF-κB) | Interleukin-1β | nuclear factor kappa B (NF-kappa B) | APOPTOSIS | ACTIVATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | caspase 1 | BACTERIAL PEPTIDOGLYCAN | SELF-ASSOCIATION | PROCASPASE-9 | interleukin-1 beta | CARD PROTEIN | SYNDROME | OLIGOMERIZATION | NF-KAPPA-B | Neuronal Apoptosis-Inhibitory Protein | Peptidoglycan - metabolism | Protein Kinases - metabolism | Kidney - embryology | Humans | DNA, Complementary - genetics | Molecular Sequence Data | Monocytes - metabolism | NF-kappa B - metabolism | Nerve Tissue Proteins - chemistry | Peptides - metabolism | Protein Isoforms - metabolism | Cloning, Molecular | Receptor-Interacting Protein Serine-Threonine Kinase 2 | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Cell Line | NF-kappa B - antagonists & inhibitors | Carrier Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins | Nod2 Signaling Adaptor Protein | Immunity, Innate | Macromolecular Substances | Nerve Tissue Proteins - metabolism | Adaptor Proteins, Signal Transducing | Apoptosis Regulatory Proteins | Carrier Proteins - metabolism | CARD Signaling Adaptor Proteins | Nod1 Signaling Adaptor Protein | Interleukin-1 - secretion | Nucleoside-Phosphate Kinase - metabolism | Index Medicus | NB-ARC domain, nucleotide-binding domain shared by Apaf-1, certain R gene products and CED-4 | NACHT, NAIP (neuronal apoptosis inhibitory protein), CIITA (MHC class II transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein) | TLR, Toll-like receptor | CARDIAK, CARD-containing interleukin-1β-converting-enzyme-associated kinase | Apaf-1, apoptotic protease-activating factor 1 | RICK, RIP-like interacting CLARP kinase | CLAN, CARD, LRR and NACHT domain-containing protein | interleukin-1β | ECL®, enhanced chemiluminescence | NAC, nucleotide-binding domain and CARD-containing protein | CARD, caspase-recruitment domain | NALP, NACHT, LRR and PYRIN protein 1 | PAN, PAAD- and NACHT-containing protein | NF-κB, nuclear factor κB | ORF, open reading frame | RIP2, receptor-interacting protein | LRR, leucine-rich repeat | IKK, inhibitory κB kinase | PAAD, pyrin, AIM (absent-in-melanoma), ASC (apoptosis-associated speck-like protein containing a CARD) and death-domain-like | PGN, peptidoglycan | LPS, lipopolysaccharide | RACE, rapid amplification of cDNA ends | nuclear factor κB (NF-κB) | PAMP, pathogen-associated molecular pattern | HEK-293T, human embryonic kidney
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 10/2005, Volume 391, Issue Pt 2, pp. 221 - 230
Interaction of leptin with its receptors resembles that of interleukin-6 and granulocyte colony-stimulating factor, which interact with their receptors through... 
antagonists | site-directed mutagenesis | energy traitsfer (FRET) | DOMAIN | ACTIVATION | COMPLEX | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | CLUSTER-ANALYSIS | FAMILY | fluorescence resonance | A-B loop of leptin | CLONING | CHICKEN | EXPRESSION | hydrophobic strand | immunoglobulin-like domain (IGD) | Leptin - antagonists & inhibitors | Receptors, Leptin | Amino Acid Sequence | Leptin - chemistry | Gene Expression Regulation - genetics | Humans | Leptin - metabolism | Molecular Sequence Data | Receptors, Cell Surface - metabolism | Leptin - genetics | Recombinant Proteins | Receptors, Cell Surface - antagonists & inhibitors | Animals | Cell Line, Tumor | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Receptors, Cell Surface - chemistry | Sheep | Mice | Mutation | Binding Sites | Receptors, Cell Surface - genetics | Index Medicus | APB, acceptor photobleaching | WT, wild-type | YFP, yellow fluorescent protein | fluorescence resonance energy transfer (FRET) | h, human | v, viral | HCA, hydrophobic cluster analysis | A–B loop of leptin | ERK, extracellular-signal-regulated kinase | G-CSF, granulocyte colony-stimulating factor | IL-6, interleukin-6 | ch, chicken | IGD, immunoglobulin-like domain | CFP, cyan fluorescent protein | CRH, cytokine receptor homology domain | LEPR, leptin receptor | m, mouse | IBs, inclusion bodies | SPR, surface plasmon resonance, STAT3, signal transducer and activator of transcription 3 | CHO, Chinese-hamster ovary | LBD, leptin-binding domain | MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide | HEK-293T cells, human embryonic kidney 293T cells | MAPK, mitogen-activated protein kinase | TFA, trifluoroacetic acid
Journal Article
Biochemical Journal, ISSN 0264-6021, 07/2007, Volume 405, Issue 2, pp. 369 - 378
The 'de novo methyltransferase' Dnmt3a (DNA methyltransferase 3a) has been shown to mediate transcriptional repression. Posttranslational modification of... 
DNA methyltransferase 3a (Dnmt3a) | Chromobox 4 (Cbx4) | E3 ligase | SUMOylation | Pro-Trp-Trp-Pro domain (PWWP domain) | Small ubiquitin-related modifier (SUMO) | MAJOR SATELLITE REPEATS | chromobox 4 (Cbx4) | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTIONAL REPRESSION | DEACETYLASES | PERICENTRIC HETEROCHROMATIN | HISTONE H3 | METHYLATION PATTERNS | E3 LIGASE ACTIVITY | small ubiquitin-related modifier (SUMO) | PC2 | PWWP DOMAIN | Protein Structure, Tertiary | Amino Acid Sequence | Humans | Cells, Cultured | Ubiquitin-Protein Ligases - metabolism | Molecular Sequence Data | Polycomb-Group Proteins | DNA (Cytosine-5-)-Methyltransferases - metabolism | Repressor Proteins - physiology | DNA Methylation | Sequence Alignment | Animals | Transfection | Heterochromatin - enzymology | Ligases | Mice | SUMO-1 Protein - metabolism | Index Medicus | Ni-NTA, Ni2+-nitrilotroacetate | HIPK2, homeodomain-interacting protein kinase 2 | EZH2, Enhancer of Zeste homologue 2 | GAL4AD, GAL4 activation domain | PHD, plant homeodomain | TDG, thymine DNA glycosylase | Cbx, chromobox | SUMO, small ubiquitin-related modifier | HEK-293T, human embryonic kidney 293T | HDAC, histone deacetylase | HP1, heterochromatin protein 1 | CtBP, C-terminal-binding protein | PIAS, protein inhibitor of activated STAT (signal transducer and activator of transcription) | GAL4, galactosidase 4 protein | GFP, green fluorescent protein | GST, glutathione S-transferase | IPTG, isopropyl β-D-thiogalactopyranoside | H3K9, histone H3 Lys9 | NLS, nuclear localization signal | PcG, Polycomb group | PWWP, Pro-Trp-Trp-Pro | HA, haemagglutinin | SD, synthetic defined | SIP1, Smad-interacting protein 1 | Dnmt, DNA methyltransferase | GAL4BD, GAL4 DNA-binding domain
Journal Article
Biochemical Journal, ISSN 0264-6021, 11/2011, Volume 439, Issue 3, pp. 381 - 390
JNK (c-Jun N-terminal kinase) is part of a MAPK (mitogen-activated protein kinase) signalling cascade. Scaffold proteins simultaneously associate with various... 
c-Jun N-terminal kinase (JNK) | D domain | Scaffold | WD repeat domain 62 (WDR62) | Mitogen-activated protein kinase 7 (MKK7) | Mitogen-activated protein kinase (MAPK) | BIOCHEMISTRY & MOLECULAR BIOLOGY | N-TERMINAL KINASE | mitogen-activated protein kinase (MAPK) | TRANSDUCTION | CASCADE | MAP KINASES | mitogen-activated protein kinase 7 (MKK7) | IDENTIFICATION | MKK7 | scaffold | PATHWAY | SITES | MUTATIONS | SIGNALING SPECIFICITY | MAP Kinase Kinase 7 - genetics | Mitogen-Activated Protein Kinase 9 - chemistry | Amino Acid Sequence | JNK Mitogen-Activated Protein Kinases - chemistry | Humans | MAP Kinase Kinase 7 - chemistry | Molecular Sequence Data | Repetitive Sequences, Amino Acid - genetics | Protein Structure, Tertiary - genetics | Mitogen-Activated Protein Kinase 9 - genetics | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - chemistry | Nuclear Matrix-Associated Proteins - genetics | HEK293 Cells | Protein Binding | HeLa Cells | JNK Mitogen-Activated Protein Kinases - genetics | Nuclear Matrix-Associated Proteins - chemistry | Binding Sites | Sequence Deletion - genetics | Index Medicus | WCE, whole-cell extraction | JNK, c-Jun N-terminal kinase | DTT, dithiothreitol | Tat, transactivator of transcription | HRP, horseradish peroxidase | SAPK, stress-activated protein kinase | HEK-293T cells, human embryonic kidney 293 cells expressing the large T-antigen of SV40 (simian virus 40) | GST, glutathione transferase | EGFP, enhanced green fluorescent protein | GFP, green fluorescent protein | MAP2K, MAPK kinase | FBS, fetal bovine serum | MAP3K, MAPK kinase kinase | CIP, calf intestinal phosphatase | DAPI, 4′,6-diamidino-2-phenylindole | MKK, MAPK kinase | JIP, JNK-interacting protein | HA, haemagglutinin | JDP2, Jun dimerization protein 2 | aa, amino acids | MBP, maltose-binding protein | MAPK, mitogen-activated protein kinase | WDR62, WD repeat domain 62
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2007, Volume 401, Issue 1, pp. 217 - 226
PHD1-3 (prolyl hydroxylases 1-3) catalyse the hydroxylation of HIF (hypoxia-inducible factor)-alpha subunit that triggers the substrate ubiquitination and... 
Hypoxia | Protein degradation | Ubiquitination | Complex formation | Siah2 | Prolyl hydroxylase domain containing 3 (PHD3) | hypoxia | INDUCIBLE FACTOR | prolyl hydroxylase domain containing 3 (PHD3) | STABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | P53 | RESPONSES | ubiquitination | PATHWAY | UBIQUITYLATION | HIF-1-ALPHA | complex formation | HIF-ALPHA | protein degradation | TRANSCRIPTIONAL REPRESSOR | Recombinant Proteins - metabolism | Cell Line | Sequence Deletion | Cell Hypoxia - physiology | Dioxygenases - metabolism | Hydroxylation | Humans | Ubiquitin-Protein Ligases - metabolism | Nuclear Proteins - metabolism | Hypoxia-Inducible Factor-Proline Dioxygenases | Polycomb-Group Proteins | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Kidney | Procollagen-Proline Dioxygenase - metabolism | DNA-Binding Proteins - metabolism | Transcription Factors - metabolism | Dioxygenases - genetics | Transfection | Procollagen-Proline Dioxygenase - genetics | Plasmids | Kinetics | Nuclear Proteins - genetics | Ubiquitin-Protein Ligases - genetics | Index Medicus | HEK-293, human embryonic kidney 293 | GST, glutathione S-transferase | Ab, antibody | PHD, prolyl hydroxylase domain containing | RING, really interesting new gene | pVHL, von-Hippel–Lindau protein | DTT, dithiothreitol | HIF, hypoxia-inducible factor | DMEM, Dulbecco's modified Eagle's medium | ODD, oxygen-dependent degradation | HEK-293T cells, HEK-293 cells expressing the large T-antigen of (simian virus 40) | Mdm2, murine double minute 2
Journal Article
Journal Article
BIOCHEMICAL JOURNAL, ISSN 0264-6021, 07/2006, Volume 397, Issue 1, pp. 179 - 186
The heterodimeric transcription factor HIF (hypoxia-inducible factor) is central to the regulation of gene expression by oxygen. Three oxygen-dependent prolyl... 
HYPOXIA-INDUCIBLE FACTOR | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | hypoxia inducible factor (HIF) | IDENTIFICATION | TRANSLATION | protein stability | RESPONSIVE ELEMENT | FAMILY | alternative initiation | proteasomal inhibition | GENE | prolyl hydroxylase domain 1 (PHD1) | Siah | oxygen | EXPRESSION | Cell Hypoxia - physiology | Protein Biosynthesis | Endothelial Cells | Isoenzymes | Estrogens | Humans | Gene Expression Regulation | Kidney - cytology | Breast Neoplasms | Oxygen - metabolism | Procollagen-Proline Dioxygenase - metabolism | Animals | Procollagen-Proline Dioxygenase - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Fibroblasts | Mice | Tumor Cells, Cultured | Procollagen-Proline Dioxygenase - chemistry | Proteasome Inhibitors | Index Medicus | VHL, von Hippel-Lindau | mAb, monoclonal antibody | RING, really interesting new gene | HEK-293T cell, human embryonic kidney 293T cell | Siah, seven in absentia homologue | DTT, dithiothreitol | HIF, hypoxia-inducible factor | NODD, N-terminal oxygen-dependent degradation domain | siRNA, small interfering RNA | CODD, C-terminal oxygen-dependent degradation domain | IVTT, in vitro transcription | EGLN2, Egl Nine like 2 | MEF, mouse embryonic fibroblast | translation | HUVEC, human umbilical-vein endothelial cells | PHD1, prolyl hydroxylase domain 1 | pVHL, VHL protein
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2007, Volume 403, Issue 2, pp. 305 - 312
Sulfatases are enzymes that hydrolyse a diverse range of sulfate esters. Deficiency of lysosomal sulfatases leads to human diseases characterized by the... 
Adeno-associated virus (AAV) | Sulfatase | Lentivirus | Sulfatase-modifying factor 1 (SUMF1) | Formylglycine-generating enzyme (FGE) | Lysosomal storage disorder | adeno-associated virus (AAV) | FORMYLGLYCINE-GENERATING ENZYME | GENE DELIVERY | BIOCHEMISTRY & MOLECULAR BIOLOGY | sulfatase | METACHROMATIC LEUKODYSTROPHY | ARYLSULFATASE-A | lysosomal storage disorder | LENTIVIRAL VECTORS | THERAPY | MOUSE MODEL | DISEASE | formylglycine-generating enzyme (FGE) | MICE | sulfatase-modifying factor 1 (SUMF1) | MPS-IIIA | lentivirus | Sulfatases - genetics | Isoenzymes - genetics | Humans | Cells, Cultured | Male | Sulfatases - deficiency | Mutation - genetics | Cysteine - genetics | Protein Transport | Lentivirus - metabolism | Animals | Muscles - enzymology | Isoenzymes - metabolism | Sulfatases - metabolism | Adenoviridae - genetics | Lentivirus - genetics | Cysteine - metabolism | Mice | Index Medicus | HSPC, haemopoietic stem | MPS, mucopolysaccharidosis | progenitor cells | AAV, adeno-associated virus | SUMF1, sulfatase-modifying factor 1 | BM, bone marrow | DMEM, Dulbecco's modified Eagle's medium | CDPX, X-linked dominant chondrodysplasia punctata | LV, lentivirus | MSD, multiple sulfatase deficiency | PBMC, peripheral blood mononuclear cell | GFP, green fluorescent protein | MLD, metachromatic leukodystrophy | IDS, iduronate sulfatase | GAG, glycosaminoglycan | p-NC, p-nitrocatechol sulfate | DAPI, 4′,6-diamidino-2-phenylindole | ARS, arylsulfatase | HA, haemagglutinin | PGK, phosphoglycerate kinase | SGSH, sulfamidase | CMV, cytomegalovirus | HEK-293T, human embryonic kidney
Journal Article