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Journal of Neuroscience, ISSN 0270-6474, 10/2012, Volume 32, Issue 40, pp. 13819 - 13840
Genetically encoded calcium indicators (GECIs) are powerful tools for systems neuroscience. Recent efforts in protein engineering have significantly increased... 
MOTOR-NEURONS | PRIMARY VISUAL-CORTEX | OPTICAL SENSOR | PROTEIN | CELLULAR RESOLUTION | IN-VIVO | NETWORK ACTIVITY | GENE-EXPRESSION | BARREL CORTEX | NEUROSCIENCES | CA2+ INDICATORS | Olfactory Receptor Neurons - physiology | Hippocampus - chemistry | Humans | Peptides - genetics | Recombinant Fusion Proteins - analysis | Crystallography, X-Ray | Green Fluorescent Proteins - genetics | Neuromuscular Junction - chemistry | Neuropil - ultrastructure | Neurons - ultrastructure | Lasers | Astrocytes - chemistry | Green Fluorescent Proteins - isolation & purification | Neuroimaging - methods | Neuropil - physiology | Neurons - chemistry | Genes, Synthetic | Models, Molecular | Rats | Recombinant Fusion Proteins - chemistry | Astrocytes - ultrastructure | Olfactory Receptor Neurons - chemistry | Caenorhabditis elegans | Larva | Retinal Bipolar Cells - ultrastructure | Recombinant Fusion Proteins - genetics | Drosophila melanogaster - growth & development | Protein Conformation | Mice | Peptides - analysis | Fluorescent Dyes - analysis | Fluorometry - methods | Olfactory Receptor Neurons - ultrastructure | Synaptic Transmission | Retinal Bipolar Cells - physiology | Neurons - physiology | Female | Green Fluorescent Proteins - chemistry | Calcium Signaling | Fluorescent Dyes - chemistry | Green Fluorescent Proteins - analysis | Mutagenesis, Site-Directed | Peptides - chemistry | Neuropil - chemistry | Retinal Bipolar Cells - chemistry | HEK293 Cells - chemistry | Hippocampus - cytology | HEK293 Cells - ultrastructure | Neuromuscular Junction - ultrastructure | Zebrafish - growth & development | Animals | Genetic Vectors | Photic Stimulation | Index Medicus | GCaMP5 | functional imaging | genetically encoded calcium indicator | GECI | GCaMP3
Journal Article
Cell Reports, ISSN 2211-1247, 02/2017, Volume 18, Issue 9, pp. 2113 - 2123
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 08/2011, Volume 108, Issue 32, pp. E440 - E449
Astrocytes regulate synaptic connectivity in the CNS through secreted signals. Here we identified two astrocyte-secreted proteins, hevin and SPARC, as... 
Extracellular matrix | Synaptic cleft 1 | Matricellular protein | Osteonectin | SPARC-Like | osteonectin | SC1 | synaptic cleft 1 | RAT | EXTRACELLULAR-MATRIX GLYCOPROTEIN | INTEGRIN | MULTIDISCIPLINARY SCIENCES | RECEPTOR | matricellular protein | CELL-SURVIVAL | SUPERIOR COLLICULUS | SPARC-Like 1 | EXPRESSION | extracellular matrix | SUPERFICIAL LAYERS | BRAIN | Central Nervous System - ultrastructure | Central Nervous System - metabolism | Extracellular Matrix Proteins - deficiency | Humans | Superior Colliculi - ultrastructure | Calcium-Binding Proteins - antagonists & inhibitors | Culture Media, Conditioned - pharmacology | Retinal Ganglion Cells - metabolism | Retinal Ganglion Cells - cytology | Osteonectin - deficiency | Synapses - metabolism | HEK293 Cells | Neurogenesis - drug effects | Extracellular Matrix Proteins - metabolism | Astrocytes - cytology | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Protein Structure, Tertiary | Astrocytes - drug effects | Retinal Ganglion Cells - ultrastructure | Synapses - drug effects | Extracellular Matrix Proteins - chemistry | Superior Colliculi - metabolism | Extracellular Matrix Proteins - antagonists & inhibitors | Superior Colliculi - drug effects | Osteonectin - metabolism | Rats | Calcium-Binding Proteins - deficiency | Synapses - ultrastructure | Osteonectin - chemistry | Rats, Sprague-Dawley | Astrocytes - ultrastructure | Animals | Central Nervous System - cytology | Superior Colliculi - cytology | Mice | Retinal Ganglion Cells - drug effects | Astrocytes - secretion | Proteins | Brain | Rodents | Cells | Retinal ganglion cells | Synaptogenesis | Astrocytes | Neural networks | Central nervous system | Superior colliculus | Synapses | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2023 - 11
Journal Article
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 07/2015, Volume 16, Issue 8, pp. 829 - 837
The transcription factor XBP1 has been linked to the development of highly secretory tissues such as plasma cells and Paneth cells, yet its function in... 
ALTERNATIVELY ACTIVATED MACROPHAGES | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | ER-STRESS | BONE-MARROW | DISEASE | GENE-EXPRESSION | MICE | IMMUNOLOGY | PLASMA-CELL DIFFERENTIATION | MAJOR BASIC-PROTEIN | Endoribonucleases - genetics | Eosinophils - metabolism | Humans | Gene Expression Profiling | Endoplasmic Reticulum Stress - genetics | Eosinophils - immunology | Granulocyte Precursor Cells - ultrastructure | Endoplasmic Reticulum Stress - immunology | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Cell Differentiation - genetics | Signal Transduction - immunology | Flow Cytometry | Gene Expression - immunology | HEK293 Cells | Transcription Factors - immunology | Protein-Serine-Threonine Kinases - metabolism | Granulocyte Precursor Cells - immunology | Eosinophils - ultrastructure | Microscopy, Electron, Transmission | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Granulocyte Precursor Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mice, Transgenic | Signal Transduction - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Regulatory Factor X Transcription Factors | Mice, Knockout | Transcription Factors - metabolism | Cell Differentiation - immunology | Microscopy, Confocal | Animals | Protein-Serine-Threonine Kinases - immunology | Mice, Inbred BALB C | Endoribonucleases - immunology | Transcription factors | Genetic aspects | Properties | Cell differentiation | Eosinophils | Immune system | Index Medicus
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2017, Volume 216, Issue 12, pp. 4217 - 4233
The mechanistic target of rapamycin complex 1 (mTORC1) is a protein kinase complex that localizes to lysosomes to up-regulate anabolic processes and... 
ACTIVATION | BINDS | BECLIN 1 | AMINO-ACIDS | PHOSPHATIDYLINOSITOL 3-KINASE COMPLEXES | GROWTH | KINASE | AUTOPHAGY | VPS34 | STRESS | CELL BIOLOGY | Retinal Pigment Epithelium - metabolism | Epithelial Cells - metabolism | Phosphatidylinositol Phosphates - metabolism | Vesicular Transport Proteins - metabolism | Humans | Endoplasmic Reticulum - metabolism | Endoplasmic Reticulum - ultrastructure | DNA-Binding Proteins - metabolism | Mechanistic Target of Rapamycin Complex 1 - genetics | Cell Nucleus - metabolism | Lysosomes - metabolism | Biological Transport | HEK293 Cells | Autophagy - genetics | Signal Transduction | Vesicular Transport Proteins - genetics | Gene Expression Regulation | Class III Phosphatidylinositol 3-Kinases - metabolism | Epithelial Cells - ultrastructure | Transcription Factors - genetics | Cell Nucleus - ultrastructure | DNA-Binding Proteins - genetics | Mechanistic Target of Rapamycin Complex 1 - metabolism | Lysosomes - ultrastructure | Transcription Factors - metabolism | Class III Phosphatidylinositol 3-Kinases - genetics | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Cell Line, Tumor | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | HeLa Cells | Retinal Pigment Epithelium - cytology | TOR protein | Phosphates | Translocation | Protein kinase C | Lysosomes | Amino acids | Activation | Rapamycin | Phosphatidylinositol 3-phosphate | Autophagy | Cells | Recruitment | Proteins | Positioning devices (machinery) | Signaling | Cell activation | Protein kinase | Lipid kinase | Endoplasmic reticulum | Phagocytosis | Index Medicus | 19 | s | 29
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 2015, Volume 17, Issue 8, pp. 1074 - 1087
Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics... 
JOUBERT-SYNDROME | RPGRIP1 | TRANSPORT | CENTRIOLE BIOGENESIS | PROTEIN | C-ELEGANS | MUTATIONS | PHOTORECEPTOR CELLS | MASTER REGULATOR | PRIMARY CILIA | CELL BIOLOGY | Humans | Pregnancy Proteins - genetics | Databases, Genetic | Suppressor Factors, Immunologic - genetics | Photoreceptor Cells - ultrastructure | Pregnancy Proteins - metabolism | Ellis-Van Creveld Syndrome - genetics | Cerebellum - abnormalities | Genetic Testing - methods | Suppressor Factors, Immunologic - metabolism | Membrane Proteins - deficiency | Transfection | RNA Interference | HEK293 Cells | Kidney Diseases, Cystic - genetics | Genomics - methods | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Caenorhabditis elegans - metabolism | Cilia - pathology | Caenorhabditis elegans - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Abnormalities, Multiple | Genetic Markers | Eye Abnormalities - genetics | Cilia - metabolism | Zebrafish - genetics | Cilia - genetics | Mice, Knockout | Proteins - genetics | Caenorhabditis elegans - ultrastructure | Phenotype | Animals | Cerebellar Diseases - genetics | Ciliary Motility Disorders - pathology | Proteins - metabolism | Photoreceptor Cells - metabolism | Zebrafish - metabolism | Retina - abnormalities | High-Throughput Nucleotide Sequencing | Ciliary Motility Disorders - metabolism | Mutation | Ciliary Motility Disorders - genetics | RNA | Cilia and ciliary motion | Genetic research | Biosynthesis | Genetic aspects | Research | Gene expression | Properties | Index Medicus | reverse genetics | cilia | ciliopathies | Joubert syndrome | whole-genome siRNA screen | Jeune syndrome
Journal Article