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Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e63152
Gain of function (GOF) mutations in protein tyrosine phosphatase Ptpn11 have been identified in childhood leukemias, and these mutations are sufficient to... 
OF-FUNCTION MUTATION | GROWTH-FACTOR RECEPTOR | STEM-CELLS | COLONY-STIMULATING FACTOR | HEMATOPOIETIC-CELL DEVELOPMENT | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | LEUKEMOGENESIS | ACUTE MYELOID-LEUKEMIA | BINDING | NOONAN-SYNDROME | Hematopoietic Stem Cells - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Reactive Oxygen Species - metabolism | Cytokines - metabolism | Signal Transduction | Bone Marrow Cells - cytology | Hematopoietic Stem Cells - metabolism | Mitochondria - metabolism | Myeloproliferative Disorders - genetics | Mice, Knockout | Animals | Cell Differentiation - drug effects | Hematopoietic Stem Cells - cytology | Myeloproliferative Disorders - metabolism | Acetylcysteine - pharmacology | Myeloid Cells - metabolism | Bone Marrow Cells - drug effects | Mice | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Bone Marrow Cells - metabolism | Disease Models, Animal | Tyrosine | Phosphatases | Cytokines | Physiological aspects | Phenols | Genetic aspects | Hematopoietic stem cells | Leukemia | Stem cell transplantation | Oncology | Mitochondrial DNA | Kinases | Phosphatase | Proteins | Antioxidants | Mitochondria | Allografts | Granulocytes | Rodents | Bone marrow | Children | Growth factors | Deoxyribonucleic acid--DNA | Oxygen | Hematology | Hypersensitivity | Metabolism | Myeloproliferative diseases | Substrates | Medicine | Signaling | Molecular modelling | Stem cells | Laboratory animals | Protein-tyrosine-phosphatase | Cancer | Deoxyribonucleic acid | DNA
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 09/2013, Volume 12, Issue 9, pp. 1738 - 1748
Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that plays an overall positive role in growth factor and cytokine... 
SIGNAL-TRANSDUCTION | HEMATOPOIETIC-CELLS | SOMATIC PTPN11 MUTATIONS | OF-FUNCTION MUTATION | MOLECULAR-DYNAMICS | COLONY-STIMULATING FACTOR | ONCOLOGY | JUVENILE MYELOMONOCYTIC LEUKEMIA | GENERAL FORCE-FIELD | ACUTE MYELOID-LEUKEMIA | NOONAN-SYNDROME | Catalytic Domain - drug effects | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism | Humans | Leukemia, Myeloid - pathology | Noonan Syndrome - pathology | Indoles - metabolism | Enzyme Inhibitors - chemistry | Drug Design | Indoles - pharmacology | Triazines - chemistry | Molecular Structure | Tumor Cells, Cultured | Drug Evaluation, Preclinical | Child | Cell Line | Triazines - metabolism | Triazines - pharmacology | Catalytic Domain - genetics | Enzyme Inhibitors - pharmacology | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - antagonists & inhibitors | Enzyme Inhibitors - analysis | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - chemistry | Signal Transduction - genetics | Gene Knockout Techniques | Noonan Syndrome - drug therapy | Leukemia, Myeloid - drug therapy | Animals | Signal Transduction - drug effects | Cell Proliferation - drug effects | Mice | Mutation | Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics | Indoles - chemistry | Drug Screening Assays, Antitumor | Inhibitor | PTPN11 (SHP2) | Phosphatase | Drug development | Leukemia
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 01/2013, Volume 110, Issue 1, pp. E79 - E88
Journal Article
Current Opinion in Cell Biology, ISSN 0955-0674, 1997, Volume 9, Issue 2, pp. 193 - 204
Journal Article