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Journal of the National Cancer Institute, ISSN 0027-8874, 10/2018, Volume 110, Issue 10, pp. 1102 - 1114
Background: Mammalian cells express a single functional heparanase, an endoglycosidase that cleaves heparan sulfate and thereby promotes tumor metastasis,... 
METASTASIS | ANGIOGENESIS | ONCOLOGY | PG545 | MAMMALIAN HEPARANASE | CHEMORESISTANCE | TUMOR-GROWTH | TARGETING HEPARANASE | EXPRESSION | PROGRESSION | CHEMOTHERAPY
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 07/2019, Volume 23, Issue 7, pp. 4559 - 4568
Journal Article
Biomedical Research (India), ISSN 0970-938X, 2018, Volume 29, Issue 2, pp. 390 - 395
Journal Article
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 2014, Volume 14, Issue 3, pp. 286 - 293
Journal Article
Oncotarget, ISSN 1949-2553, 12/2018, Volume 9, Issue 96, pp. 36830 - 36832
Malignant mesothelioma is a highly aggressive form of cancer with poor prognosis due to lack of markers for early diagnosis and resistance to conventional... 
Therapies | Heparanase | Mesothelioma | Defbrotide | PG545
Journal Article
Oncotarget, 04/2018, Volume 9, Issue 27, pp. 19294 - 19306
Journal Article
Journal Article
Atherosclerosis, ISSN 0021-9150, 09/2018, Volume 276, pp. 155 - 162
Increased oxidative stress is associated with accelerated atherosclerosis. Emerging evidence highlights the role of heparanase in atherogenesis, where... 
Heparanase | Oxidative stress | PG545 | Atherosclerosis | E0 mice | E | mice
Journal Article
Cancer research, ISSN 0008-5472, 9/2015, Volume 75, Issue 18, pp. 3946 - 3957
Heparanase is the only enzyme in mammals capable of cleaving heparan sulfate, an activity implicated in tumor inflammation, angiogenesis and metastasis.... 
Heparanase | drug-resistance | autophagy | tumorigenicity | lysosome
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2015, Volume 25, Issue 4, pp. 412 - 428
Journal Article
Anticancer Research, ISSN 0250-7005, 08/2016, Volume 36, Issue 8, pp. 4019 - 4032
Background/Aim: Low-molecular-weight heparin (LMWH) has been suggested to reduce the risk of cancer progression in both preclinical and clinical studies but... 
Heparanase | LMWH | Metastasis | Colorectal cancer (CRC) | Chemokines
Journal Article
BMC CANCER, ISSN 1471-2407, 03/2017, Volume 17
Background: Expression and activity of heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is associated with... 
TARGET | ACTIVATION | ANGIOGENESIS | Anticancer activity | MAMMALIAN HEPARANASE | Metastasis | BREAST-CANCER CELLS | HEPATOCELLULAR-CARCINOMA | CARCINOMA IN-VITRO | ONCOLOGY | SULFATE | MICE | Heparanase inhibitors | EXPRESSION | triazolo-thiadiazoles
Journal Article
Atherosclerosis, ISSN 0021-9150, 04/2019, Volume 283, pp. 127 - 136
Calcification is a hallmark of advanced atherosclerosis and an active process akin to bone remodeling. Heparanase (HPSE) is an endo-β-glucuronidase, which... 
Calcification | Heparanase | Heparan sulfate proteoglycans | Bone remodeling | Atherosclerosis | CARDIAC & CARDIOVASCULAR SYSTEMS | MAMMALIAN HEPARANASE | OSTEOGENESIS | HEPARIN | POTENTIAL MECHANISM | BONE-FORMATION | SULFATE | CALCIUM | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | EXPRESSION | Genetic engineering | RNA | Sulfates | Analysis
Journal Article
by Jia, L and Ma, ST
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 10/2016, Volume 121, pp. 209 - 220
Heparanase, an only endo-beta-D-glucuronidase capable of cleaving heparan sulfate (HS) side chains at specific sites, contributes to remodeling of the... 
Heparan sulfate | CHEMISTRY, MEDICINAL |