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New Journal of Chemistry, ISSN 1144-0546, 2016, Volume 40, Issue 6, pp. 5121 - 5127
The cytotoxic effect of paracetamol in the presence of a diamine derivative was evaluated in liver cells. In this study,... 
ELECTRODE | ACETAMINOPHEN | CHEMISTRY, MULTIDISCIPLINARY | HEPATIC-NECROSIS
Journal Article
HEPATOLOGY, ISSN 0270-9139, 01/2010, Volume 51, Issue 1, pp. 246 - 254
Acetaminophen (APAP) overdose is a major cause of acute liver failure. The glutathione (GSH) precursor N-acetylcysteine (NAC) is used to treat patients with... 
REACTIVE NITROGEN | MITOCHONDRIAL PERMEABILITY TRANSITION | OXIDANT STRESS | INDUCED HEPATIC NECROSIS | PEROXYNITRITE | COVALENT BINDING | IN-VIVO | MOUSE HEPATOCYTES | GASTROENTEROLOGY & HEPATOLOGY | INDUCED LIVER-INJURY | CELL-DEATH
Journal Article
Journal of Antimicrobial Chemotherapy, ISSN 0305-7453, 03/2019, Volume 74, Issue 3, pp. 768 - 771
Abstract Background Fluconazole is a commonly prescribed first-generation triazole antifungal. Although the toxicity profile of fluconazole has been evaluated... 
INFECTIOUS DISEASES | COCCIDIOIDOMYCOSIS | INCREASE | CLINICAL-PRACTICE GUIDELINE | ACUTE HEPATIC-NECROSIS | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTIOUS-DISEASES SOCIETY
Journal Article
Journal Article
Pharmaceutical Research, ISSN 0724-8741, 9/2013, Volume 30, Issue 9, pp. 2174 - 2187
Acetaminophen (APAP) is one of the most widely used drugs. Though safe at therapeutic doses, overdose causes mitochondrial dysfunction and centrilobular... 
Biochemistry, general | Biomedical Engineering | drug transporters | nuclear receptors | acetaminophen | Biomedicine | Pharmacy | hepatotoxicity | drug metabolism | Medical Law | Pharmacology/Toxicology | ACUTE LIVER-FAILURE | PREGNANE-X RECEPTOR | APOPTOSIS-INDUCING FACTOR | COVALENT BINDING | MITOCHONDRIAL OXIDANT STRESS | CHEMISTRY, MULTIDISCIPLINARY | S-TRANSFERASE-PI | INDUCED HEPATIC-NECROSIS | CULTURED MOUSE HEPATOCYTES | BILIARY-EXCRETION | PHARMACOLOGY & PHARMACY | GLUTATHIONE DEPLETION | Acetaminophen - metabolism | Analgesics, Non-Narcotic - blood | Analgesics, Non-Narcotic - pharmacokinetics | Acetaminophen - toxicity | Humans | Liver - metabolism | Antipyretics - toxicity | Cytochrome P-450 Enzyme System - metabolism | Glutathione Transferase - metabolism | Analgesics, Non-Narcotic - metabolism | Chemical and Drug Induced Liver Injury - diagnosis | Acetaminophen - blood | Animals | Antipyretics - pharmacokinetics | Analgesics, Non-Narcotic - toxicity | Liver - drug effects | Chemical and Drug Induced Liver Injury - metabolism | Protein Binding | Acetaminophen - pharmacokinetics | Antipyretics - blood | Antipyretics - metabolism | Cellular proteins | Metabolites | Acetaminophen | Transferases | Cytochrome P-450 | Physiological aspects | Sulfates | Protein binding | Metabolism | Medical diagnosis | Hepatology | Index Medicus
Journal Article
Toxicology International, ISSN 0971-6580, 05/2016, Volume 23, Issue 2, pp. 199 - 201
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 10/2018, Volume 367, Issue 1, pp. 95 - 100
Acetaminophen is commonly used to reduce pain and fever. Unfortunately, overdose of acetaminophen is a leading cause of acute liver injury and failure in many... 
UNITED-STATES | DRUG-INDUCED HEPATOTOXICITY | PARACETAMOL-INDUCED HEPATOTOXICITY | COVALENT BINDING | BENZOQUINONE IMINE | HEPATIC-NECROSIS | IN-VIVO | PHARMACOLOGY & PHARMACY | INDUCED LIVER-INJURY | GENOME-WIDE ASSOCIATION | PROTEIN ADDUCTS
Journal Article
Journal Article
Toxicon, ISSN 0041-0101, 10/2019, Volume 168, pp. 122 - 125
An outbreak of acute poisoning of horses by pods is reported in the state of Goiás, Brazil. Three horses presented apathy, hyporexia, prostration, jaundice,... 
Poisonous plants | Enterolobium contortisiliquum pods | Hepatic necrosis | Equine | CATTLE | PATHOLOGY | RUMINANTS | AFLATOXIN | HEPATOGENOUS PHOTOSENSITIZATION | LIVER | PLANTS | PHARMACOLOGY & PHARMACY | TOXICOLOGY | Liver | Livestock | Poisoning
Journal Article
Journal of Veterinary Medical Science, ISSN 0916-7250, 2016
Two radiated tortoises (Astrochelys radiata) exhibited anorexia and hypokinesia. In both cases, hematological and serum biochemical examinations revealed high... 
massive hepatic necrosis | Astrochelys radiate | serum biochemical value | radiated tortoise
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 11/2012, Volume 264, Issue 3, pp. 387 - 394
Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the West. In mice, APAP hepatotoxicity can be rapidly induced with a single... 
Protein adducts | Mitochondria | Acetaminophen | Hepatotoxicity | Oxidant stress | c-Jun‐N-terminal kinase | C-Jun-N-terminal kinase | PEROXYNITRITE | COVALENT BINDING | HEPATIC-NECROSIS | MOUSE HEPATOCYTES | PERMEABILITY TRANSITION | CELL-DEATH | DNA FRAGMENTATION | GLUTATHIONE | PHARMACOLOGY & PHARMACY | TOXICOLOGY | c-Jun-N-terminal kinase | INDUCED HEPATOTOXICITY | Rats, Inbred F344 | Mitochondrial Proteins - genetics | MAP Kinase Kinase 4 - metabolism | Alanine Transaminase - genetics | Analgesics, Non-Narcotic - toxicity | Time Factors | Mitochondrial Proteins - metabolism | Glutamate Dehydrogenase - metabolism | Disease Models, Animal | Acetaminophen - toxicity | Mice, Inbred C57BL | Gene Expression Regulation | Antipyretics - toxicity | Rats | Mitochondria - metabolism | Mitochondria - drug effects | Glutamate Dehydrogenase - genetics | Rats, Sprague-Dawley | Animals | Chemical and Drug Induced Liver Injury - metabolism | MAP Kinase Kinase 4 - genetics | Protein Binding | Mice | Alanine Transaminase - metabolism | Oxidative Stress - drug effects | Oxidative stress | Liver diseases | Liver | Physiological aspects | Mitochondrial DNA | Comparative analysis | Index Medicus | Translocation | Oxidative metabolism | Toxicity | Data processing | Metabolism | Protein turnover | Necrosis | Proteins | c-Jun amino-terminal kinase | Models | Overdose | Intoxication | Injuries | OXIDATION | TRANSLOCATION | INJURIES | MITOCHONDRIA | RATS | TOXICITY | 60 APPLIED LIFE SCIENCES | NECROSIS | METABOLISM | OXIDIZERS | LIVER | MICE | PREFERRED SPECIES | protein adducts | oxidant stress | c-jun-N-terminal kinase | hepatotoxicity | mitochondria
Journal Article
by Kim, YH and Hwang, JH and Kim, KS and Noh, JR and Choi, DH and Kim, DK and Tadi, S and Yim, YH and Choi, HS and Lee, CH
JOURNAL OF HEPATOLOGY, ISSN 0168-8278, 07/2015, Volume 63, Issue 1, pp. 75 - 82
Background & Aims: Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure. Prolonged c-Jun N-terminal kinase (JNK) activation... 
CELLS | KAPPA-B ACTIVATION | ACTIVATED PROTEIN-KINASE | JNK | REGENERATION | Gadd45 beta | FAILURE | INDUCED LIVER-INJURY | RECEPTOR CAR | INDUCED HEPATIC-NECROSIS | Acetaminophen | Metformin | GASTROENTEROLOGY & HEPATOLOGY | Hepatotoxicity | EXPRESSION | DRUG-METABOLISM
Journal Article