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Journal Article
Nature (London), ISSN 1476-4687, 2011, Volume 475, Issue 7356, pp. 386 - 389
The generation of functional hepatocytes independent of donor liver organs is of great therapeutic interest with regard to regenerative medicine and possible... 
MURINE MODEL | HEPATIC-DYSFUNCTION | PANCREAS PROGENITORS | TYROSINEMIA TYPE-I | LIVER-FUNCTION | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | FACTOR NETWORK | DIRECT CONVERSION | GENE-EXPRESSION | ENRICHED TRANSCRIPTION FACTORS | Hydrolases - genetics | Liver - enzymology | Hepatocyte Nuclear Factor 1-alpha - genetics | Tail - cytology | Liver Diseases - pathology | Gene Expression Profiling | Hepatocyte Nuclear Factor 3-gamma - genetics | Hepatocytes - metabolism | Hepatocyte Nuclear Factor 1-alpha - metabolism | Liver - physiopathology | Regenerative Medicine - methods | DNA-Binding Proteins - deficiency | Cell Differentiation - genetics | Hepatocytes - cytology | Hepatocyte Nuclear Factor 3-gamma - metabolism | Liver Diseases - enzymology | Hepatocytes - transplantation | Hepatocytes - physiology | Fibroblasts - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - deficiency | GATA4 Transcription Factor - metabolism | Tissue Engineering - methods | Transduction, Genetic | Cells, Cultured | Cyclin-Dependent Kinase Inhibitor p16 - genetics | Liver Diseases - therapy | GATA4 Transcription Factor - genetics | Survival Rate | Hydrolases - deficiency | Mice, SCID | Cell Lineage | Animals | Liver - physiology | Mice, Inbred NOD | Fibroblasts - cytology | Liver - cytology | Mice | Liver Diseases - physiopathology | Physiological aspects | Fibroblasts | Transcription factors | Research | Embryonic stem cells | Liver cells | Proteins | Gene expression | Tissue engineering | Cell adhesion & migration
Journal Article
PLoS neglected tropical diseases, ISSN 1935-2735, 2013, Volume 7, Issue 10, p. e2471
Chikungunya virus (CHIKV) is a mosquito-borne arthrogenic alphavirus that causes acute febrile illness in humans accompanied by joint pains and in many cases,... 
IN-VITRO | ASSAY | PROTEIN | REPLICATION | VIABILITY | DISEASE | INFECTION | RIBAVIRIN | ALAMAR BLUE | CHLOROQUINE | PARASITOLOGY | TROPICAL MEDICINE | Staining and Labeling - methods | Cell Line | Cell Survival - drug effects | Oxidation-Reduction | Humans | Protein Kinase Inhibitors - isolation & purification | Oxazines - metabolism | Alphavirus Infections - virology | Alphavirus Infections - drug therapy | Xanthenes - metabolism | Cell Death | Hepatocytes - virology | Inhibitory Concentration 50 | Chikungunya virus - physiology | Protein Kinase Inhibitors - pharmacology | Antiviral Agents - isolation & purification | Hepatocytes - drug effects | Hepatocytes - physiology | Optical Imaging - methods | High-Throughput Screening Assays - methods | Drugs | Antiviral agents | Control | Chikungunya virus | Structure-activity relationship (Pharmacology) | Structure-activity relationships | Identification and classification | Apoptosis | Testing | Hepatocytes/virology | Antiviral Agents/isolation & purification | Alphavirus Infections/virology | Hepatocytes/drug effects | Cell Survival/drug effects | Hepatocytes/physiology | Optical Imaging/methods | Protein Kinase Inhibitors/isolation & purification | Xanthenes/metabolism | Chikungunya virus/physiology | Cell Survival/drug effectsm | Life Sciences | Microbiology and Parasitology | Oxazines/metabolism | Alphavirus Infections/drug therapy | High-Throughput Screening Assays/methods | Protein Kinase Inhibitors/pharmacology | Staining and Labeling/methods | Medical research | Genomes | Infections | Viral infections
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2014, Volume 513, Issue 7516, pp. 110 - 114
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are among the most common genetic alterations in intrahepatic cholangiocarcinoma (IHCC), a deadly liver... 
PROGENITORS | INTRAHEPATIC CHOLANGIOCARCINOMA | HOMEOSTASIS | LIVER-REGENERATION | MULTIDISCIPLINARY SCIENCES | MUTATION | GROWTH | MICE | PROLIFERATION | EXPRESSION | ras Proteins - genetics | Proto-Oncogene Proteins p21(ras) | Hepatocyte Nuclear Factor 4 - antagonists & inhibitors | Humans | ras Proteins - metabolism | Hepatocytes - pathology | Male | Hepatocytes - metabolism | Bile Duct Neoplasms - enzymology | Cell Differentiation - genetics | Neoplasm Metastasis | Hepatocyte Nuclear Factor 4 - biosynthesis | Female | Bile Duct Neoplasms - genetics | Cell Lineage - genetics | Cholangiocarcinoma - enzymology | Disease Models, Animal | Cell Division - genetics | Proto-Oncogene Proteins - metabolism | Hepatocyte Nuclear Factor 4 - metabolism | Bile Ducts, Intrahepatic - pathology | Mutant Proteins - genetics | Isocitrate Dehydrogenase - genetics | Mice, Transgenic | Mutant Proteins - metabolism | Proto-Oncogene Proteins - genetics | Hepatocyte Nuclear Factor 4 - genetics | Mutation - genetics | Bile Ducts, Intrahepatic - enzymology | Cholangiocarcinoma - pathology | Animals | Cholangiocarcinoma - genetics | Stem Cells - pathology | Isocitrate Dehydrogenase - metabolism | Glutarates - metabolism | Mice | Bile Duct Neoplasms - pathology | Hepatocytes - enzymology | Index Medicus | Càncer | Diferenciació cel·lular | Gallbladder diseases | Metabolisme | Cell diferentiation | Metabolism | Malalties de la vesícula biliar | Cancer
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2012, Volume 57, Issue 3, pp. 628 - 636
Journal Article
eLife, ISSN 2050-084X, 2012, Volume 1, Issue 1, p. e00049
Human hepatitis B virus (HBV) infection and HBV-related diseases remain a major public health problem. Individuals coinfected with its satellite hepatitis D... 
viruses | receptor | Sodium taurocholate cotransporting polypeptide | hepatitis D virus | infectious disease | liver | hepatitis B virus | biochemistry | microbiology | virus infection | CLOSED CIRCULAR DNA | IN-VITRO | HEPATOCELLULAR-CARCINOMA | DELTA-VIRUS | TUPAIA HEPATOCYTES | RAT HEPATOCYTES | ADULT HUMAN HEPATOCYTES | BIOLOGY | PRE-S SEQUENCE | LARGE SURFACE PROTEIN | ENVELOPE PROTEINS | Liver - virology | Liver - pathology | Receptors, Virus - metabolism | Taurocholic Acid - metabolism | Humans | Hepatitis Delta Virus - metabolism | Molecular Sequence Data | Hepatocytes - pathology | Hepatocytes - metabolism | Receptors, Virus - genetics | Virus Internalization | Organic Anion Transporters, Sodium-Dependent - genetics | Photochemical Processes | Organic Anion Transporters, Sodium-Dependent - chemistry | Biological Transport | Hepatitis B virus - chemistry | Tupaia | Viral Envelope Proteins - metabolism | Hepatitis Delta Virus - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Gene Expression | Viral Envelope Proteins - genetics | Peptides - chemistry | Liver - metabolism | Symporters - chemistry | Symporters - metabolism | Animals | Hepatitis Delta Virus - chemistry | Receptors, Virus - chemistry | Symporters - genetics | Viral Envelope Proteins - chemistry | Hepatitis B virus - genetics | Hepatocytes - virology | Protein Binding | Hepatitis B virus - metabolism | Primary Cell Culture | Organic Anion Transporters, Sodium-Dependent - metabolism | Antigens | Polypeptides | Liver | Envelope protein | Amino acids | Viruses | Infections | Genomes | Proteins | Hepatitis | Sodium | Rodents | Public health | Viral infections | Hepatitis B
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 2006, Volume 34, Issue 1, pp. 75 - 83
Most human hepatocyte cell lines lack a substantial set of liver-specific functions, especially major cytochrome P450 (P450)-related enzyme activities, making... 
MAINTENANCE | RAT HEPATOCYTES | ADULT HUMAN HEPATOCYTES | LIVER | LINE | CULTURED HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | AFLATOXIN B-1 | DIMETHYL-SULFOXIDE | INDUCTION | DRUG-METABOLIZING-ENZYMES | Aflatoxin B1 - pharmacology | Cell Survival - drug effects | Gene Expression - drug effects | Isoenzymes - genetics | Humans | RNA, Messenger - genetics | RNA, Messenger - analysis | Chlorpromazine - pharmacology | Dimethyl Sulfoxide - pharmacology | Gene Expression Profiling | Receptors, Cytoplasmic and Nuclear - genetics | Hepatocytes - metabolism | Xenobiotics - pharmacology | Glucuronosyltransferase - genetics | Hepatocytes - cytology | Acetaminophen - pharmacology | Carcinoma, Hepatocellular - genetics | Reverse Transcriptase Polymerase Chain Reaction - methods | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | Cytochrome P-450 Enzyme System - genetics | Inhibitory Concentration 50 | Hepatocytes - drug effects | Amiodarone - pharmacology | Gene Expression | Isoenzymes | Cell Survival | Amiodarone | Reverse Transcriptase Polymerase Chain Reaction | Receptors, Cytoplasmic and Nuclear | Chlorpromazine | Cytochrome P-450 Enzyme System | Life Sciences | Microbiology and Parasitology | Hepatocytes | Acetaminophen | Aflatoxin B1 | Dimethyl Sulfoxide | Carcinoma, Hepatocellular | Xenobiotics | RNA, Messenger | Glucuronosyltransferase
Journal Article
Journal Article
Journal Article