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Forensic Science International: Genetics Supplement Series, ISSN 1875-1768, 10/2019
Journal Article
Biochemical Journal, ISSN 0264-6021, 05/2015, Volume 467, Issue 3, pp. 365 - 386
In the last decade, the ubiquitin-proteasome system has emerged as a valid target for the development of novel therapeutics. E3 ubiquitin ligases are... 
Ubiquitin | Ubiquitination | Small molecule | Structure | Structure-based design | Assembly | small molecule | ANAPHASE-PROMOTING COMPLEX | SOCS-BOX | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-BOX PROTEINS | KAPPA-B-ALPHA | structure | structure-based design | ubiquitin | CANCER-THERAPY | ubiquitination | COP9 SIGNALOSOME | assembly | TUMOR-SUPPRESSOR PROTEIN | SUBSTRATE-ASSISTED INHIBITION | CELL-CYCLE | PROTEASOME SYSTEM | Protein Structure, Tertiary | Protein Subunits | Cullin Proteins - antagonists & inhibitors | Proteasome Inhibitors - pharmacology | Humans | Models, Molecular | Proteasome Inhibitors - chemistry | Drug Discovery - methods | Cullin Proteins - chemistry | Cullin Proteins - genetics | Drug Design | Protein Structure, Quaternary | Molecular Structure | MEL26, maternal effect lethal 26 | HECT, homologous with E6-associated protein C-terminus | DCAF, DDB1–Cul4A-associated factor | CPH, conserved within Cul7, PARC and HERC2 | CSA, Cockayne syndrome A | NAE, NEDD8-activating enzyme | Rbx1, RING-box protein 1 | PPI, protein–protein interaction | C, anaphase-promoting complex | SV5, simian virus 5 | Fbxw, F-box | Skp2, S-phase kinase-associated protein 2 | IAA, indole-3-acetic acid | Cpd, compound | Fbw | SMER3, small-molecule enhancer of rapamycin 3 | mTOR, mammalian target of rapamycin | HERC2, HECT domain- and RLD (regulator of chromosome condensation 1 protein-like domain) domain-containing E3 ubiquitin protein ligase 2 | IκB, inhibitor of NF-κB | UPS, ubiquitin–proteasome system | Nrf2, nuclear factor-erythroid 2-related factor 2 | Protac, proteolysis-targeting chimaeric molecule | WD repeat-containing protein | ZIM (zinc finger expressed in inflorescence) domain protein 1 | NF-κB, nuclear factor κB | leucine-rich motif-containing protein | CTD, C-terminal domain | Ub, ubiquitin | Vif, virion infectivity factor | NTD, N-terminal domain | GHR, growth hormone receptor | CRBN, cereblon | HIF-1α, hypoxia-inducible factor 1α | SH2, Src homology 2 | BP, β-propeller | UBL, ubiquitin-like protein | FP, fluorescence polarization | Cks1, cyclin-dependent protein kinase regulatory subunit 1 | CSN, COP9 (constitutive photomorphogenesis 9) signalosome complex | ITC, isothermal titration calorimetry | RING, really interesting new gene | Ubc12, ubiquitin-conjugating enzyme 12 | KLHL, Kelch-like protein | Review | VPRBP, Vpr-binding protein | SCF, Skp1–Cdc53–F-box Cdc4 | POZ, pox virus and zinc finger | JAZ1, jasmonate | Keap1, Kelch-like enoyl-CoA hydratase-associated protein 1 | PARC, p53-associated parkin-like cytoplasmic protein | DDB, damage-specific DNA-binding protein | JA-Ile, jasmonoyl-isoleucine | Fbxl, F-box | MATH, meprin and TRAF (tumour necrosis factor receptor-associated factor) homology | CRL, Cullin–RING E3 ubiquitin ligase | other domain-containing protein | COI1, coronatine-insensitive protein 1 | EloBC, ElonginB–ElonginC complex | broad complex | VHL, von Hippel–Lindau | Vpr, viral protein R | Aux, auxin | STAT, signal transducer and activator of transcription | CAND1, Cullin-associated NEDD8-dissociated protein 1 | Fbxo, F-box | TIR1, transport inhibitor response 1 | CBFβ, core binding factor β | BCR, BTB–Cul3–Rbx1 | cyclosome | SOCS, suppressor of cytokine signalling | NEDD, neural-precursor-cell-expressed developmentally down-regulated | BTB, bric-a-brac | APC | Cdc, cell division cycle | Cul, Cullin | SPOP, speckle-type POZ protein | β-TrCP, β-transducin repeat-containing protein | tramtrack | ASB, ankyrin repeat and SOCS-box
Journal Article
Journal Article
Journal Article
Developmental Biology, ISSN 0012-1606, 09/2018, Volume 441, Issue 2, pp. 313 - 318
Understanding the genetic basis of trait evolution is critical to identifying the mechanisms that generated the immense amount of diversity observable in the... 
Astyanax mexicanus | Genome editing | Cavefish | CRISPR/Cas9 | oca2 | PELVIC REDUCTION | CAVE FISH | DEVELOPMENTAL BIOLOGY | EYE COLOR | STICKLEBACKS | ZEBRAFISH GENOME | HERC2 | EFFICIENT TARGETED MUTAGENESIS | GENE | CONVERGENCE | ADAPTIVE EVOLUTION | Index Medicus
Journal Article
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 04/2019, Volume 512, Issue 2, pp. 421 - 427
HERC2 is a giant protein with E3 ubiquitin ligase activity and other known and suspected functions. Mutations of are implicated in the pathogenesis of various... 
Neurodevelopment | Autism | HERC2 | Bioinformatics | Proteomics | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIA | DEVELOPMENTAL DELAY | BIOPHYSICS | DEFICIENT | MUTATION | BIOLOGY | PROTEIN PROFILES | Ubiquitin | Medical colleges | Ligases | Analysis | Physiological aspects | Mass spectrometry | Investigations
Journal Article
Current Biology, ISSN 0960-9822, 03/2009, Volume 19, Issue 5, pp. R192 - R193
Predicting complex human phenotypes from genotypes has recently gained tremendous interest in the emerging field of consumer genomics, particularly in light of... 
HERC2 | GENETIC-DETERMINANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | POLYMORPHISM | HAPLOTYPE | HEALTH | HUMAN PIGMENTATION | EUROPEANS | Eye Color | Regression Analysis | European Continental Ancestry Group - genetics | Phenotype | Area Under Curve | Humans | Sensitivity and Specificity | Genotype | Models, Genetic | Polymorphism, Single Nucleotide | Pharmacogenetics | Genetic aspects
Journal Article
Journal of Investigative Dermatology, ISSN 0022-202X, 02/2010, Volume 130, Issue 2, pp. 520 - 528
Journal Article
Forensic Science International: Genetics, ISSN 1872-4973, 2010, Volume 5, Issue 3, pp. 170 - 180
Abstract A new era of ‘DNA intelligence’ is arriving in forensic biology, due to the impending ability to predict externally visible characteristics (EVCs)... 
Pathology | IrisPlex | Forensic | Eye colour | HGDP-CEPH | Genotyping | Prediction | OCA2 | MEDICINE, LEGAL | HUMAN PIGMENTATION | MITOCHONDRIAL-DNA | IDENTIFICATION | HERC2 | GENETIC-DETERMINANTS | GENETICS & HEREDITY | MULTIPLEX ASSAY | POPULATION-STRUCTURE | DIVERSITY | SINGLE NUCLEOTIDE POLYMORPHISMS | DNA - genetics | Reproducibility of Results | Eye Color - genetics | DNA Primers | Base Sequence | Humans
Journal Article