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The New England journal of medicine, ISSN 1533-4406, 2012, Volume 366, Issue 1, pp. 34 - 43
Journal Article
Vaccine, ISSN 0264-410X, 2016, Volume 34, Issue 44, pp. 5314 - 5320
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 47, pp. 8520 - 8529
Highlights ► T-cell immunity is required to contain HSV infection. ► HSV vaccines tested thus far elicited predominantly antibody response. ► A candidate... 
Allergy and Immunology | Genital herpes | Therapeutic vaccine | CD8+ T cell | Heat shock protein | CD8 | T cell | MEDICINE, RESEARCH & EXPERIMENTAL | CONTROLLED-TRIAL | CONFERS PROTECTION | CD8(+) T cell | ANTIGEN PRESENTATION | PERIPHERAL-BLOOD | IMMUNOLOGY | CYTOTOXIC T-LYMPHOCYTE | HEAT-SHOCK PROTEINS | HERPES-SIMPLEX-VIRUS | SENSORY GANGLIA | RECURRENT GENITAL HERPES | GLYCOPROTEIN-D | HSC70 Heat-Shock Proteins - genetics | Adjuvants, Immunologic - administration & dosage | Humans | Middle Aged | Vaccines, Synthetic - genetics | Viral Proteins - immunology | Viral Proteins - genetics | Male | HSC70 Heat-Shock Proteins - immunology | Vaccines, Synthetic - immunology | Herpes Simplex Virus Vaccines - immunology | CD4-Positive T-Lymphocytes - immunology | Herpesvirus 2, Human - genetics | Herpes Genitalis - prevention & control | Herpes Simplex Virus Vaccines - administration & dosage | Herpesvirus 2, Human - immunology | Vaccines, Synthetic - adverse effects | Herpes Simplex Virus Vaccines - adverse effects | Adult | Female | Vaccines, Synthetic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Herpes Genitalis - immunology | Herpes Simplex Virus Vaccines - genetics | Viral antibodies | Peptides | Oncology, Experimental | Heat shock proteins | Antibodies | Research | Universities and colleges | T cells | Cancer | Pain | Lymphocytes | Clinical trials | Cytotoxicity | Infections | Vaccines
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 10, p. e109890
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 04/2015, Volume 10, Issue 4, p. e0121518
HSV-2 vaccine is needed to prevent genital disease, latent infection, and virus transmission. A replication-deficient mutant virus (dl5-29) has demonstrated... 
DELETION MUTANT | METAANALYSIS | MULTIDISCIPLINARY SCIENCES | SIMPLEX-VIRUS 2 | GENITAL HERPES | INFECTION | GLYCOPROTEIN | Virus Shedding - drug effects | Vagina - drug effects | Humans | Vagina - immunology | Interleukin-5 - biosynthesis | Herpes Simplex Virus Vaccines - immunology | Virus Latency - drug effects | Herpesvirus 2, Human - genetics | Herpes Genitalis - prevention & control | Herpes Simplex Virus Vaccines - administration & dosage | Immunity, Cellular - drug effects | Female | Herpes Genitalis - mortality | Herpes Genitalis - immunology | Th1-Th2 Balance - drug effects | Antibodies, Viral - biosynthesis | Virus Replication - drug effects | Immunization | Viral Envelope Proteins - genetics | Guinea Pigs | Interferon-gamma - secretion | Mice, SCID | Interleukin-5 - secretion | Animals | Herpesvirus 2, Human - immunology | Antibodies, Neutralizing - biosynthesis | Herpes Genitalis - virology | Viral Envelope Proteins - chemistry | Survival Analysis | Vagina - virology | Immunity, Humoral - drug effects | Viral Envelope Proteins - immunology | Mice | Herpes Simplex Virus Vaccines - genetics | Interferon-gamma - biosynthesis | Virulence (Microbiology) | Vaccines | Observations | Health aspects | Herpes simplex virus | Testing | Shedding | Animal models | Severe combined immunodeficiency | Antibodies | Viruses | Lymphocytes T | Infections | Suckling behavior | Interleukin 5 | Splenocytes | Immune system | Pathogens | Immune response | Effectiveness | Recurrent infection | Mortality | Immunodeficiency | Vagina | Latent infection | Muscles | Secretions | Immune response (humoral) | Latency | Pathogenicity | Immunogenicity | Guinea pigs | γ-Interferon | Replication | Deficient mutant
Journal Article
Journal of Virology, ISSN 0022-538X, 09/2013, Volume 87, Issue 17, pp. 9788 - 9801
Journal Article
Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 47, pp. 8530 - 8541
Abstract Efforts to develop a subunit vaccine against genital herpes have been hampered by lack of knowledge of the protective antigens of HSV-2, the causative... 
Allergy and Immunology | Cellular immunity | Genital herpes | Therapeutic vaccine | Heat shock protein | MEDICINE, RESEARCH & EXPERIMENTAL | GP96 | IMMUNOLOGY | CYTOTOXIC T-LYMPHOCYTES | IMMUNIZATION | RESPONSES | HERPES-SIMPLEX-VIRUS | PEPTIDE COMPLEXES | INFECTION | GLYCOPROTEIN VACCINE | TYPE-2 | RECURRENT GENITAL HERPES | HLA-A2 Antigen - genetics | Adjuvants, Immunologic - administration & dosage | Saponins - administration & dosage | Vaccines, Subunit - genetics | Humans | Viral Proteins - immunology | Herpes Genitalis - therapy | HSC70 Heat-Shock Proteins - immunology | Vaccines, Synthetic - immunology | Herpes Simplex Virus Vaccines - immunology | CD4-Positive T-Lymphocytes - immunology | Herpesvirus 2, Human - genetics | Herpes Genitalis - prevention & control | Herpes Simplex Virus Vaccines - administration & dosage | Vaccines, Synthetic - adverse effects | Leukocytes, Mononuclear - immunology | Herpes Simplex Virus Vaccines - adverse effects | Herpes Genitalis - immunology | Disease Models, Animal | HSC70 Heat-Shock Proteins - genetics | Guinea Pigs | HLA-A2 Antigen - immunology | Mice, Inbred C57BL | Vaccines, Synthetic - genetics | Viral Proteins - genetics | Mice, Transgenic | Vaccines, Subunit - immunology | Animals | Herpesvirus 2, Human - immunology | Vaccines, Subunit - administration & dosage | Mice | Mice, Inbred BALB C | Vaccines, Synthetic - administration & dosage | CD8-Positive T-Lymphocytes - immunology | Herpes Simplex Virus Vaccines - genetics | Peptides | Lymphocytes | Herpes viruses | Heat shock proteins | Packaging | Vaccines | Kinases
Journal Article