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Toxicology, ISSN 0300-483X, 02/2018, Volume 395, pp. 45 - 53
Nickel ions (Ni ) eluted from biomedical devices cause inflammation and Ni allergy. Although Ni and Co elicit common effects, Ni induces a generally stronger... 
HSP90 | THP-1 | Nickel | HIF-1α | HIF-1β | Interleukin 8 | ACTIVATION | HIF-1 alpha | HIF-1 beta | DENDRITIC CELLS | DERMATITIS | CONTACT ALLERGY | ELUTION | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | INFLAMMATION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | SECRETION | PROTEINS | COBALT | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2015, Volume 112, Issue 49, pp. 15172 - 15177
Journal Article
Breast cancer research : BCR, ISSN 1465-5411, 12/2003, Volume 5, Issue 6, pp. R223 - 230
Background: Hypoxia-inducible factor-1alpha (HIF-1alpha) is part of a transcriptional factor that regulates genes involved in metabolic and vascular adaptation... 
HIF-1α splicing | Breast cancer | HIF-1α | HIF-1α natural antisense | HYPOXIA-INDUCIBLE FACTOR | HIF-1 alpha natural antisense | HIF-1 alpha | VARIANTS | TUMOR | breast cancer | INDUCTION | FACTOR 1-ALPHA | CARCINOGENESIS | FACTOR-1-ALPHA | ONCOLOGY | HIF-1 alpha splicing | EXPRESSION | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 03/2019, Volume 29, Issue 6, pp. 853 - 858
Three novel series of ursolic acid derivatives containing an aminoguanidine moietiy were designed, synthesized, and evaluated for anti-tumor activity as HIF-1α... 
Cytotoxicity | Aminoguanidine | Ursolic acid | HIF-1α inhibitor | Anticancer activity | CHEMISTRY, MEDICINAL | PROTEIN | INDUCIBLE FACTOR-I | DRUG-DELIVERY | ANTIBACTERIAL | CHEMISTRY, ORGANIC | HYPOXIA | HIF-1 | BIOLOGICAL EVALUATION | INHIBITORS | HIF-1 alpha inhibitor
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2007, Volume 26, Issue 1, pp. 63 - 74
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2007, Volume 42, Issue 6, pp. 1036 - 1044
Journal Article
by Masoud, GN and Li, W
ACTA PHARMACEUTICA SINICA B, ISSN 2211-3835, 09/2015, Volume 5, Issue 5, pp. 378 - 389
Hypoxia-inducible factor-1 (HIF-1) has been recognized as an important cancer drug target. Many recent studies have provided convincing evidences of strong... 
Cancer drug discovery and development | TRANSCRIPTIONAL ACTIVITY | DNA-BINDING | HIF-1 alpha | PROTEASOMAL DEGRADATION | FACTOR-I | ANTITUMOR-ACTIVITY | SIGNAL-TRANSDUCTION | SMALL-MOLECULE INHIBITORS | TUMOR-SUPPRESSOR PROTEIN | PHARMACOLOGY & PHARMACY | HIF-1 alpha inhibitors | HYPOXIA-INDUCIBLE FACTOR-1 | ENDOTHELIAL GROWTH-FACTOR
Journal Article
ACS Nano, ISSN 1936-0851, 01/2019, Volume 13, Issue 1, pp. 236 - 247
Despite its central role in tumor progression and treatment resistance, poor vascularization that necessitates penetration of therapeutics through tumor... 
hypoxia | HIF-1α | PEGylation | drug resistance | tumor penetration | ferritin nanocage | CANCER-CELLS | ACRIFLAVINE | HIF-1 alpha | MATERIALS SCIENCE, MULTIDISCIPLINARY | BARRIER | TRANSCRIPTION | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | CHEMISTRY, MULTIDISCIPLINARY | NANOPARTICLES | HIF-1 | TRANSFERRIN RECEPTOR | H-FERRITIN | RESISTANCE | BINDING
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 2009, Volume 1793, Issue 2, pp. 368 - 377
HIPK2 has been implicated in restraining tumor progression by more than one mechanism, involving both its catalytic and transcriptional co-repressor functions.... 
HIF-1α mRNA | HIF-1α promoter | RNA interference | Luciferase activity | ChIP | HIPK2 | CANCER CELLS | ANGIOGENESIS | HIF-1 alpha promoter | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIF-1 alpha mRNA | DNA-DAMAGE | FACTOR EXPRESSION | INTERACTING PROTEIN KINASE-2 | MEDIATED APOPTOSIS | P53 | CELL BIOLOGY | HIF-1 | PROTEIN-KINASE-2 | GENE-TRANSCRIPTION
Journal Article
11/2011
Increased glucose metabolism may occur in malignant tumours due to altered gene expression or a response to hypoxia. It has been shown that tumours with high... 
HIF-1 | hypoxia | radiation | 0760 | metabolism | cancer | lactate
Dissertation
Gene, ISSN 0378-1119, 03/2019, Volume 687, pp. 99 - 108
The aim of this study was to explore the hemodynamic and morphological changes of the choke vessels, and to investigate the role of HIF-1α in the flap... 
iNOS | HIF-1α | Choke vessels | Perforator flap | VEGF | HIF-1 alpha | GENETICS & HEREDITY | Index Medicus
Journal Article
Cell Cycle, ISSN 1538-4101, 01/2010, Volume 9, Issue 1, pp. 75 - 79
Diabetic wounds are a significant public health burden, with slow or non-healing diabetic foot ulcers representing the leading cause of non-traumatic lower... 
Proteins | Binding | Landes | Calcium | Biology | Bioscience | Cell | Cycle | Organogenesis | Cancer | p300 | HIF-1 | Methylglyoxal | Hypoxia | HIF-1α | Diabetes | Neovascularization | Vasculogenesis | DFO | hypoxia | vasculogenesis | HIF-1 alpha | ANGIOGENESIS | VEGF | neovascularization | ISCHEMIA | CELL BIOLOGY | methylglyoxal | THERAPY | TRANSACTIVATION | VESSEL DEVELOPMENT | diabetes | EXPRESSION | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Journal of Experimental and Clinical Cancer Research, ISSN 1756-9966, 07/2018, Volume 37, Issue 1, pp. 170 - 170
Background: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene,... 
miR-22/IPO7/HIF-1α axis | CML cells | SWATH-MS | Curcumin | CHRONIC MYELOGENOUS LEUKEMIA | miR-22/IPO7/HIF-1 alpha axis | STEM-CELLS | HUMAN PANCREATIC-CANCER | CHRONIC MYELOID-LEUKEMIA | IN-VITRO | INHIBITION | ONCOLOGY | PATHWAY | GROWTH | EXPRESSION | IMATINIB RESISTANCE | Enzymes | Leukemia | Metabolism | Kinases | Cancer therapies | Proteins | Proteomics | Polyphenols | Hypoxia | Chromosomes | Drug dosages | Tumors | Apoptosis | Index Medicus
Journal Article
Journal of Cancer, ISSN 1837-9664, 2015, Volume 6, Issue 1, pp. 19 - 28
Recently microRNAs (miRNAs) have been attractive targets with their key roles in biological regulation through post-transcription to control mRNA stability and... 
miRNA3195 | miRNA374b | Melatonin | HIF-1 alpha | PC-3 cells | VEGF | HIF-1 | ONCOLOGY | MICRORNAS | melatonin | INHIBITOR | EXPRESSION
Journal Article
Journal Article