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Acta pharmaceutica Sinica. B, ISSN 2211-3835, 2015, Volume 5, Issue 5, pp. 378 - 389
Hypoxia-inducible factor-1(HIF-1) has been recognized as an important cancer drug target.Many recent studies have provided convincing evidences of strong... 
Cancer drug discovery and development | HIF-1α inhibitors | HIF-1α | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | RCC, renal cell carcinoma | Ras, rat sarcoma | Raf, rapidly accelerated fibrosarcoma | EGF, epidermal growth factor | C-TAD, COOH-terminal TAD | HTS, high throughput screens | ARD-1, arrest-defective-1 | ELISA, enzyme-linked immunosorbent assay | pVHL, von Hippel-Lindau protein | LEP, leptin | ChIP, chromatin immunoprecipitation | IPAS, inhibitory PAS | IGF-BP3, IGF-factor-binding protein 3 | PAS, Per and Sim | mTOR, mammalian target of rapamycin | RT-PCR, reverse transcription polymerase chain reaction | CAC, circulating angiogenic cells | CoCl2, cobalt chloride | AKt, protein kinase B | TPT, topotecan | bHLH, basic-helix-loop-helix | LDHA, lactate dehydrogenase | GLUTs, glucose transporters | P, proline residue | ODDD, oxygen dependent degradation domain | TGF-α, transforming growth factor α | VEGF, vascular endothelial growth factor | CPTs, camptothecins | Mdm2, mouse double minute 2 homolog | PKM, pyruvate kinase M | AhR, aryl hydrocarbon receptor | K, lysine residue | IGF2, insulin-like growth factor 2 | GLUT3, glucose transporter 3 | CBP associated factor | eIF-4E, eukaryotic translation initiation factor 4E | MEK, MAPK | ADM, adrenomedullin | ARNT, aryl hydrocarbon nuclear translocator | HK2, hexokinase 2 | PHDs, prolyl-4-hydroxylases | PCAF, p300 | FIH-1, factor inhibiting HIF-1 | Review | SIRT 1, Sirtuin 1 | ERK kinase | C-MYC, myelocytomatosis virus oncogene cellular homolog | IGF-BP2, IGF-factor-binding protein 2 | N, asparagine residue | TAD, transactivation domains | HDAC, histone deacetylase | EMSA, electrophoretic mobility shift assay | LRP1, LDL-receptor-related protein 1 | Luc, luciferase | GAs, geldanamycins | HIF-1α, hypoxia-inducible factor-1α | HK1, hexokinase 1 | ID2, DNA-binding protein inhibitor | HPH, HIF-1 prolyl hydroxylases | NOS, nitric oxide synthase | N-TAD, NH2-terminal TAD | MNK, MAP kinase interacting kinase | MTs, microtubules | HRE, hypoxia response elements | ERK, extracellular signal-regulated kinase | EPO, erythropoietin | MAPK, mitogen-activated protein kinases | PI3K, phosphatidyl inositol-4,5-bisphosphate-3-kinase | DFO, deferoxamine | Top I, topoisomerase I | GLUT1, glucose transporter 1 | Hsp90, heat shock protein 90 | TGF-β3, transforming growth factor beta3 | 4E-BP1, eukaryotic translation initiation factor 4E (eIF-4E) binding protein p70 S6 kinase (S6K) | GA, geldanamycin
Journal Article
Molecular medicine (Cambridge, Mass.), ISSN 1528-3658, 10/2018, Volume 24, Issue 1, pp. 55 - 55
Intestinal barrier dysfunction is a significant clinical problem, commonly developing in a variety of acute or chronic pathological conditions. Herein, we... 
HMOX1 | NF-κB/HIF-1α pathway | Sepsis | Intestinal barrier dysfunction | microRNA-31 | Index Medicus
Journal Article
Journal of experimental & clinical cancer research, ISSN 1756-9966, 07/2018, Volume 37, Issue 1, pp. 170 - 170
Background: Chronic myelogenous leukemia (CML) is a myeloproliferative disorder caused by expression of the chimeric BCR-ABL tyrosine kinase oncogene,... 
miR-22/IPO7/HIF-1α axis | CML cells | SWATH-MS | Curcumin | Life Sciences & Biomedicine | Oncology | Science & Technology | Enzymes | Leukemia | Metabolism | Kinases | Cancer therapies | Proteins | Proteomics | Polyphenols | Hypoxia | Chromosomes | Drug dosages | Tumors | Apoptosis | Index Medicus
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 06/2018, Volume 38, Issue 11
Journal Article
Human pathology, ISSN 0046-8177, 2007, Volume 38, Issue 9, pp. 1310 - 1320
Summary The hypoxia-inducible factor (HIF) is a transcriptional factor with important roles in tumor biology. To clarify the possible involvement of the HIF- α... 
Pathology | HIF-1 α | HIF-2 α | Prognosis | VHL | Ovarian carcinoma | HIF-1α | HIF-2α | Life Sciences & Biomedicine | Science & Technology
Journal Article
Anticancer research, ISSN 0250-7005, 12/2011, Volume 31, Issue 12, pp. 4429 - 4437
Journal Article
Journal of molecular and cellular cardiology, ISSN 0022-2828, 2007, Volume 42, Issue 6, pp. 1036 - 1044
Abstract Hypoxia inducible factor-1α (HIF-1α) is a proangiogenic transcription factor stabilized and activated under hypoxia. It regulates the expression of... 
Cardiovascular | Bone marrow stem cells | Cardiomyocytes | Hypoxia | HIF-1α | HIF-1α neutralizing antibody | VEGF | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Cell Biology
Journal Article
Breast cancer research : BCR, ISSN 1465-5411, 12/2003, Volume 5, Issue 6, pp. R223 - 230
Background: Hypoxia-inducible factor-1alpha (HIF-1alpha) is part of a transcriptional factor that regulates genes involved in metabolic and vascular adaptation... 
HIF-1α splicing | Breast cancer | HIF-1α | HIF-1α natural antisense | Life Sciences & Biomedicine | Oncology | Science & Technology | breast cancer
Journal Article
Cardiovascular research, ISSN 0008-6363, 02/2011, Volume 89, Issue 2, pp. 426 - 435
Journal Article
Circulation research, ISSN 1524-4571, 04/2009, Volume 104, Issue 7, pp. 879 - 886
MicroRNAs are posttranscriptional gene regulators that are differentially expressed during various diseases and have been implicated in the underlying... 
Sirt1 | Preconditioning | Hif-1 | 199a | MiR | Cardiac & Cardiovascular Systems | Peripheral Vascular Disease | Life Sciences & Biomedicine | Hematology | Cardiovascular System & Cardiology | Science & Technology | miR-199a | Hif-1α Sirt1 | preconditioning
Journal Article
International journal of hyperthermia, ISSN 0265-6736, 08/2018, Volume 34, Issue 6, pp. 824 - 833
Transcriptional hypoxia-inducible factor-1α (HIF-1α) plays the fundamental role in adaptive processes in response to hypoxia. Specific HIF-1α target genes are... 
hyperthermia | HIF-1α | Anoxia | EPO | neuroprotection | VEGF | Index Medicus
Journal Article
Molecular Cancer Therapeutics, ISSN 1535-7163, 01/2008, Volume 7, Issue 1, pp. 90 - 100
We have reported previously that PX-478 ( S -2-amino-3-[4′- N,N ,-bis(chloroethyl)amino]phenyl propionic acid N -oxide dihydrochloride) has potent antitumor... 
PX-478 | hypoxia | HIF-1α | mechanism | Life Sciences & Biomedicine | Oncology | Science & Technology
Journal Article
by Shan, T and Ma, J and Ma, Q and Guo, K and Guo, J and Li, X and Li, W and Liu, J and Huang, C and Wang, F and Wu, E
Current molecular medicine, ISSN 1566-5240, 2013, Volume 13, Issue 6, pp. 1023 - 1034
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 0027-8424, 12/2015, Volume 112, Issue 49, pp. 15172 - 15177
Journal Article
Annals of physical and rehabilitation medicine, ISSN 1877-0657, 07/2018, Volume 61, pp. e412 - e412
Immobilization-induced muscle fibrosis is important regarding the pathogenesis of muscle contracture, and the therapeutic target for this fibrotic lesion is... 
HIf-1α inhibitor | Muscle contracture | Fibrosis
Journal Article
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