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Nature Cell Biology, ISSN 1465-7392, 10/2010, Volume 12, Issue 10, pp. 1007 - 1013
Stem cells reside in specialized microenvironments or 'niches' that regulate their function. In vitro studies using hypoxic culture conditions (< 5% O2) have... 
OXYGEN | HIF-2-ALPHA | TRANSCRIPTION | GROWTH | VASCULAR NICHE | HIF-1-ALPHA | DIFFERENTIATION | BETA-CATENIN | HYPOXIA | HEMATOPOIETIC STEM | CELL BIOLOGY
Journal Article
Blood, ISSN 0006-4971, 07/2011, Volume 118, Issue 3, pp. 485 - 487
Journal Article
Plastic and Reconstructive Surgery, ISSN 0032-1052, 04/2019, Volume 143, Issue 4, pp. 780e - 781e
Journal Article
JOURNAL OF HEPATOLOGY, ISSN 0168-8278, 10/2018, Volume 69, Issue 4, pp. 772 - 773
Journal Article
Cancer Research, ISSN 0008-5472, 04/2010, Volume 70, Issue 7, pp. 2675 - 2685
Hypoxia-inducible factor-1 alpha (HIF-1 alpha) is widely considered to be one of the key regulators of tumor angiogenesis. The upstream regulation is complex... 
TARGET | POSTTRANSCRIPTIONAL REGULATION | FACTOR 1-ALPHA | HIF-1 | CELLS | HIF-2-ALPHA | ONCOLOGY | GROWTH-FACTOR | HIF-1-ALPHA | MATURATION | CANCER
Journal Article
FRONTIERS IN IMMUNOLOGY, ISSN 1664-3224, 09/2014, Volume 5
Studying the metabolism of immune cells in recent years has emphasized the tight link existing between the metabolic state and the phenotype of these cells.... 
CELLS | PGC-1 beta | HUMAN MONONUCLEAR PHAGOCYTES | HIF | NITRIC-OXIDE SYNTHASE | glycolysis | MURINE MACROPHAGES | macrophage | PERITONEAL-MACROPHAGES | IMMUNOLOGY | MACROPHAGE ACTIVATION | OVARIAN-CARCINOMA | metabolism | HIF-1-ALPHA | EXPRESSION | ALTERNATIVE ACTIVATION
Journal Article
Molecular Cell, ISSN 1097-2765, 2010, Volume 38, Issue 6, pp. 864 - 878
To survive in hypoxic environments, organisms must be able to cope with redox imbalance and oxygen deficiency. The SIRT1 deacetylase and the HIF-1... 
PROTEINS | HUMDISEASE | SIGNALING | CELLS | TRANSCRIPTIONAL ACTIVITY | REGULATES SIRT1 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | HIF-1-ALPHA | VHL | HIF-ALPHA | CANCER | CALORIE RESTRICTION | CELL BIOLOGY
Journal Article
Cancer Research, ISSN 0008-5472, 01/2007, Volume 67, Issue 2, pp. 563 - 572
Adaptation to hypoxia is a critical step in tumor progression and is, in part, regulated by the transcription factor hypoxia-inducible factor-1 alpha (HIF-1... 
BREAST-CANCER | FACTOR 1-ALPHA | HIF-1 | OVEREXPRESSION | ONCOLOGY | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | ANGIOGENIC SWITCH | HIF-1-ALPHA | EXPRESSION | CARCINOMA | TUMORS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2009, Volume 284, Issue 10, pp. 6038 - 6042
Vascular endothelial growth factor (VEGF) is a potent mitogen and permeability factor for endothelial cells that plays a central role in angiogenesis, vascular... 
PATHWAYS | CANCER CELLS | ANGIOGENESIS | PERMEABILITY | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | SECRETION | HIF-1-ALPHA | HYPOXIA | INTERLEUKIN-8 | Accelerated Publications
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2009, Volume 284, Issue 25, pp. 16767 - 16775
Hypoxia-inducible factor (HIF) controls an extensive range of adaptive responses to hypoxia. To better understand this transcriptional cascade we performed... 
STEM-CELLS | CELLULAR ADAPTATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | C-MYC | PROMOTER REGION | FACTOR-I | HIF-1-ALPHA | TARGET GENE | UP-REGULATION | CANCER | Transcription, Chromatin, and Epigenetics
Journal Article
Journal of Immunology, ISSN 0022-1767, 06/2007, Volume 178, Issue 12, pp. 7516 - 7519
Sepsis, the leading cause of death in intensive care units, reflects a detrimental host response to infection in which bacteria or LPS act as potent activators... 
HYPOXIA-INDUCIBLE FACTOR | ACTIVATION | GENE | MACROPHAGES | FACTOR-I | HIF-1-ALPHA | IMMUNOLOGY | NF-KAPPA-B | CELL | EPIDEMIOLOGY | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 10/2011, Volume 31, Issue 19, pp. 4087 - 4096
Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley... 
MIR-210 | MIR-155 | STEM-CELLS | PROGNOSTIC-FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | GENE-EXPRESSION | TARGETS | HIF-1-ALPHA | IDENTIFICATION | CANCER | CELL BIOLOGY
Journal Article
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 2017, Volume 37, Issue 12, pp. E199 - E200
Journal Article
JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 06/2007, Volume 117, Issue 6, pp. 1616 - 1626
Skeletal development and turnover occur in close spatial and temporal association with angiogenesis. Osteoblasts are ideally situated in bone to sense oxygen... 
INACTIVATION | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | GENE | TRANSCRIPTION | TUMOR-SUPPRESSOR PROTEIN | FACTOR-I | HIF-1-ALPHA | O-2 HOMEOSTASIS | CARTILAGE | DELETION | Bones | Neovascularization | Research | Growth
Journal Article
by Liu, R and Liao, XY and Pan, MX and Tang, JC and Chen, SF and Zhang, Y and Lu, PX and Lu, L and Zou, YY and Qin, XP and Bu, LH and Wan, Q
JOURNAL OF IMMUNOLOGY, ISSN 0022-1767, 03/2019, Volume 202, Issue 6, pp. 1704 - 1714
Glycine is a simple nonessential amino acid known to have neuroprotective properties. Treatment with glycine results in reduced infarct volume of the brain,... 
BRAIN-INJURY | NEUROINFLAMMATION | INFLAMMATION | PTEN | RECEPTOR | NEURODEGENERATION | DYSFUNCTION | HIF-1-ALPHA | INDUCTION | IMMUNOLOGY | PROTECTS
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 02/2010, Volume 16, Issue 3, pp. 784 - 789
Tumor-associated macrophages (TAM) have been linked with the progression of cancer by favoring tumor angiogenesis, growth, and metastasis. The precise... 
BREAST-CANCER | ACTIVATION | ONCOLOGY | INFLAMMATION | MOUSE MODEL | IKK-BETA | HIF-1-ALPHA | HYPOXIA | HUMAN MONOCYTES | PROGRESSION | INNATE IMMUNITY
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 05/2019, Volume 79, Issue 10, pp. 2564 - 2579
We hypothesized that candidate dependencies for which there are small molecules that are either approved or in advanced development for a nononcology... 
HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | HIF PROLYL HYDROXYLASES | GENE | ONCOLOGY | ANEMIA | HIF-1-ALPHA | HYPOXIA | SUPPRESSION | ROXADUSTAT FG-4592 | EXPRESSION | HIF1-ALPHA
Journal Article
BLOOD, ISSN 0006-4971, 02/2019, Volume 133, Issue 8, pp. 830 - 839
NOTCH1 is mutated in 10% of chronic lymphocytic leukemia (CLL) patients and is associated with poor outcome. However, NOTCH1 activation is identified in... 
SURVIVAL | CELLS | COMPLEX | CYCLIN-E | PATHWAY | RESISTANCE | CHRONIC LYMPHOCYTIC-LEUKEMIA | DEGRADATION | HIF-1-ALPHA | FBW7 | HEMATOLOGY
Journal Article
Journal of Immunology, ISSN 0022-1767, 01/2019, Volume 202, Issue 2, pp. 514 - 526
Chronic inflammation in tissues often causes the development of hypoxia. Herpes stromal keratitis (HSK) is a corneal chronic inflammatory condition that... 
PATHOGENESIS | INDUCIBLE FACTORS | HIF-2-ALPHA | EPITHELIAL-CELLS | LACTATE | NEUTROPHILS | REGULATORS | GLUCOSE TRANSPORTERS | HIF-1-ALPHA | IMMUNOLOGY | EXPRESSION
Journal Article
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