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JOURNAL OF CLINICAL INVESTIGATION, ISSN 0021-9738, 06/2007, Volume 117, Issue 6, pp. 1616 - 1626
Skeletal development and turnover occur in close spatial and temporal association with angiogenesis. Osteoblasts are ideally situated in bone to sense oxygen... 
INACTIVATION | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | GENE | TRANSCRIPTION | TUMOR-SUPPRESSOR PROTEIN | FACTOR-I | HIF-1-ALPHA | O-2 HOMEOSTASIS | CARTILAGE | DELETION | Bones | Neovascularization | Research | Growth
Journal Article
International Journal of Oncology, ISSN 1019-6439, 01/2016, Volume 48, Issue 1, pp. 281 - 292
Theaflavin-3, 3'-digallate (TF3) is a black tea polyphenol produced from polymerization and oxidization of the green tea ployphenols epicatechin gallate and... 
C-Myc | Tumor angiogenesis | Notch-1 pathway | 3'-digallate | A ktpathway | Theaflavin-3 | CANCER-CELLS | MAJOR COMPONENT | c-Myc | Akt pathway | FOXO TRANSCRIPTION FACTORS | INHIBITS TUMOR-GROWTH | GREEN TEA | theaflavin-3, 3 '-digallate | IN-VITRO | BLACK TEA POLYPHENOL | ONCOLOGY | SIGNALING PATHWAY | tumor angiogenesis | HIF-1-ALPHA | Oncogene Protein v-akt - biosynthesis | Vascular Endothelial Growth Factor A - biosynthesis | Mitogen-Activated Protein Kinase Kinases - genetics | Humans | Ovarian Neoplasms - pathology | Catechin - administration & dosage | Vascular Endothelial Growth Factor A - genetics | Neovascularization, Pathologic - pathology | Ovarian Neoplasms - genetics | Proto-Oncogene Proteins c-myc - biosynthesis | Oncogene Protein v-akt - genetics | Female | Hypoxia-Inducible Factor 1, alpha Subunit - biosynthesis | Carcinoma - pathology | Ovarian Neoplasms - drug therapy | Carcinoma - drug therapy | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mitogen-Activated Protein Kinase Kinases - biosynthesis | Receptor, Notch1 - biosynthesis | Biflavonoids - administration & dosage | Signal Transduction - drug effects | Neovascularization, Pathologic - drug therapy | Cell Line, Tumor | Carcinoma - genetics | Neovascularization, Pathologic - genetics | Catechin - analogs & derivatives | Proto-Oncogene Proteins c-myc - genetics | Receptor, Notch1 - genetics | Index Medicus
Journal Article
Current Cancer Drug Targets, ISSN 1568-0096, 2013, Volume 13, Issue 3, pp. 245 - 251
Studies on erythropoietin regulation led to discovery of hypoxia-inducible factor 1 (HIF-1), a transcription factor which is central component of oxygen... 
HIF-1 | PI3K | Hypoxia | AKT | MAPK | Growth factors | Tumor suppressors | Oncogenes | hypoxia | HYPOXIA-INDUCIBLE FACTOR | TRANSCRIPTIONAL ACTIVITY | SIGNALING PATHWAYS | growth factors | PHOSPHATIDYLINOSITOL 3-KINASE | oncogenes | FACTOR-I | FACTOR 1-ALPHA | MITOCHONDRIAL RESPIRATORY-CHAIN | NORMOXIC CONDITIONS | ONCOLOGY | tumor suppressors | HIF-1-ALPHA EXPRESSION | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2013, Volume 110, Issue 46, pp. 18490 - 18495
Journal Article
Cellular Signalling, ISSN 0898-6568, 05/2014, Volume 26, Issue 5, pp. 1030 - 1039
Sorafenib, the first-line systemic drug for advanced hepatocellular carcinoma (HCC), has demonstrated limited benefits with very low response rates. Thus it is... 
Hepatocellular carcinoma | Hypoxia | Hypoxia-inducible factor-2 α | Epidermal growth factor receptor-α | Sorafenib | Transforming growth factor-α | Hypoxia-inducible factor-2 alpha | DOXORUBICIN | Transforming growth factor-alpha | CANCER | EGFR | HYPOXIA-INDUCIBLE FACTORS | CELL BIOLOGY | GROWTH-FACTOR RECEPTOR | OVEREXPRESSION | Epidermal growth factor receptor-alpha | HIF-1-ALPHA | EXPRESSION | PROMOTES | Niacinamide - analogs & derivatives | Receptor, Epidermal Growth Factor - genetics | Humans | Gene Expression Regulation, Neoplastic | Male | Extracellular Signal-Regulated MAP Kinases - metabolism | Receptor, Epidermal Growth Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Liver Neoplasms - pathology | Antineoplastic Agents - pharmacology | Transforming Growth Factor alpha - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Transforming Growth Factor alpha - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Transforming Growth Factor alpha - genetics | Up-Regulation - drug effects | Drug Resistance, Neoplasm - genetics | Animals | Signal Transduction - drug effects | Mice, Nude | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Mice, Inbred BALB C | Phenylurea Compounds - pharmacology | Niacinamide - pharmacology | Quinazolines - pharmacology | Carcinoma, Hepatocellular - metabolism | Cellular | Inhibitors | Effectiveness | Pathways | Activation | Growth factors | Apoptosis | Tumors
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 12/2017, Volume 118, Issue 12, pp. 4862 - 4871
Journal Article
Diabetes/Metabolism Research and Reviews, ISSN 1520-7552, 09/2016, Volume 32, Issue 6, pp. 534 - 543
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2009, Volume 106, Issue 34, pp. 14391 - 14396
Approximately 50% of cancer patients receive radiation treatment either alone or in combination with other therapies. Tumor hypoxia has long been associated... 
Phosphorylation | Cell death | DNA damage | Cell lines | Cell cycle | Small interfering RNA | Hypoxia | Kidney cells | Tumors | Cancer | ROS | ACTIVATION | STABILIZATION | MULTIDISCIPLINARY SCIENCES | HIF-2-ALPHA PROMOTES | CANCER-THERAPY | HIF-1 | PEROXIDASE | cancer | DNA Damage | HIF-1-ALPHA | EXPRESSION | RENAL-CARCINOMA | HYPOXIA-INDUCIBLE FACTOR-1 | Biological Sciences
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