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Biochemical and Biophysical Research Communications, ISSN 0006-291X, 06/2015, Volume 461, Issue 3, pp. 560 - 567
Journal Article
Journal Article
Journal Article
British Journal of Cancer, ISSN 0007-0920, 05/2009, Volume 100, Issue 10, pp. 1666 - 1673
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 2017, Volume 37, Issue 5
Journal Article
Molecular Cancer Research, ISSN 1541-7786, 06/2011, Volume 9, Issue 6, pp. 757 - 765
The hypoxia-inducible transcription factors (HIF) 1 alpha and HIF-2 alpha play a critical role in cellular response to hypoxia. Elevated HIF-alpha expression... 
STEM-CELLS | TUMOR HYPOXIA | ONCOLOGY | GENE-EXPRESSION | HISTONE DEMETHYLASES | HIF-1-ALPHA | FACTOR (HIF)-1-ALPHA | UP-REGULATION | HIF-ALPHA | HIF-2-ALPHA PROMOTES | CANCER-THERAPY | CELL BIOLOGY | hypoxia | hypoxia-inducible factor | HIF-1α and HIF-2α | promoter | transcription
Journal Article
Drug Resistance Updates, ISSN 1368-7646, 2011, Volume 14, Issue 3, pp. 191 - 201
Abstract Resistance towards chemotherapy, either primary or acquired, represents a major obstacle in clinical oncology. Three basic categories underlie most... 
Infectious Disease | Hematology, Oncology and Palliative Medicine | HIF-2α | Hypoxia | HIF-1α | Microenvironment | Drug resistance | Autophagy | Cancer | p53 | TRANSCRIPTIONAL ACTIVITY | HIF-1 alpha | HIF-2 alpha | INDUCIBLE FACTOR 1-ALPHA | ENDOTHELIAL-GROWTH-FACTOR | DNA-DAMAGE RESPONSE | HIPPEL-LINDAU PROTEIN | BREAST-CANCER | PROSTATE-CANCER CELLS | FACTOR-I-ALPHA | PHARMACOLOGY & PHARMACY | MULTIDRUG-RESISTANCE | TUMOR-GROWTH | Neoplasms - metabolism | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Autophagy - drug effects | Tumor Suppressor Protein p53 - genetics | Hypoxia - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Antineoplastic Agents - pharmacology | Tumor Microenvironment - drug effects | Cell Hypoxia - drug effects | Basic Helix-Loop-Helix Transcription Factors - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Tumor Suppressor Protein p53 - metabolism | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Mitochondria - metabolism | Mitochondria - drug effects | Neoplasms - drug therapy | Cell Cycle | Signal Transduction - drug effects | Cell Line, Tumor | Cell Proliferation - drug effects | Cell Hypoxia - genetics | Neoplasms - pathology | Drug Resistance, Neoplasm - drug effects | Chemotherapy | Cell death | Drug interactions | Biochemistry | DNA binding proteins | Tumor proteins | Tumors
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2011, Volume 51, Issue 10, pp. 1882 - 1892
Recently we have shown that hypoxia as well as overexpression of the stable form of hypoxia-inducible factor-1α (HIF-1α) diminished the expression of... 
Angiogenesis | Free radicals | Transcription factor | c-Myc | SP-1 | HYPOXIA-INDUCIBLE FACTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | HIF-1 | INHIBITION | IN-VIVO | GROWTH | ENDOCRINOLOGY & METABOLISM | TARGET GENE | TRANSCRIPTIONAL REGULATION | PROMOTES | Interleukin-8 - genetics | RNA, Small Interfering - genetics | Humans | Transcriptional Activation - drug effects | Sp1 Transcription Factor - metabolism | Hypoxia - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Protein Binding - drug effects | Tumor Suppressor Proteins - genetics | Interleukin-8 - metabolism | Cell Line | Promoter Regions, Genetic | Tumor Suppressor Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Gene Expression Regulation - immunology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Transgenes - genetics | Hypoxia - immunology | Proto-Oncogene Proteins c-myc - metabolism | Gene Expression Regulation - drug effects | Hypoxia - genetics | Endothelium, Vascular - metabolism | NF-E2-Related Factor 2 - metabolism | Endothelium, Vascular - pathology | Proto-Oncogene Proteins c-myc - genetics | Interleukin-8 - immunology | GFP, green fluorescent protein | ARNT, aryl hydrocarbon receptor nuclear translocator | VEGF, vascular endothelial growth factor | Original Contribution | IL-8, interleukin-8 | SEAP, secreted alkaline phosphatase | HIF, hypoxia-inducible factor | siRNA, small interfering RNA | AdHIF-1α | ARE, antioxidant-response element | AdHIF-2α, adenoviral vectors containing HIF-1α or HIF-2α cDNA, respectively | TP, thymidine phosphorylase | NQO1, NAD(P)H:quinone oxidoreductase | HO-1, heme oxygenase-1
Journal Article
Genes and Development, ISSN 0890-9369, 03/2006, Volume 20, Issue 5, pp. 557 - 570
The division, differentiation, and function of stem cells and multipotent progenitors are influenced by complex signals in the microenvironment, including... 
Oct-4 | HIF | HIF-2α | TGF-α | VEGF | Stem cells | Hypoxia | Cancer | hypoxia | stem cells | HIF-2 alpha | INDUCIBLE FACTOR 1-ALPHA | DEVELOPMENTAL BIOLOGY | TGF-alpha | PAS DOMAIN PROTEIN-1 | CELL BIOLOGY | OXYGEN | FACTOR-1-ALPHA | GENETICS & HEREDITY | GENE-EXPRESSION | cancer | MICE | DIFFERENTIATION | TRANSCRIPTION FACTOR | ES CELLS | CARCINOMA
Journal Article