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Journal of immunology (Baltimore, Md. : 1950), ISSN 0022-1767, 11/2016, Volume 197, Issue 9, pp. 3639 - 3649
H ypoxia I nducible F actor α (HIF-α) isoforms regulate key macrophage (Mϕ) functions during ischemic inflammation. HIF-2α drives pro-inflammatory cytokine... 
phagocytosis | MARCO | HIF-2α | normoxic
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 07/2013, Volume 49, Issue 1, pp. 78 - 85
Journal Article
Circulation, ISSN 0009-7322, 01/2019, Volume 139, Issue 4, pp. 502 - 517
BACKGROUND:Hypoxia-inducible factors (HIFs), especially HIF-1α and HIF-2α, are key mediators of the adaptive response to hypoxic stress and play essential... 
lung | endothelial cells | hypoxia inducible factors | angiopoietin, TIE2 | HIF-2α | Notch
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 27, pp. 19123 - 19135
Hypoxia-inducible factors (HIFs) facilitate cellular adaptation to environmental stress such as low oxygen conditions (hypoxia) and consequently promote tumor... 
Epigenetics | Hypoxia | DNMT1 | CD70 | HIF-2α
Journal Article
National Medical Journal of China, ISSN 0376-2491, 01/2018, Volume 98, Issue 4, pp. 269 - 273
Journal Article
Hepatology (Baltimore, Md.), ISSN 0270-9139, 3/2013, Volume 57, Issue 3, pp. 1088 - 1097
Hypoxia inducible factors (HIFs) are activated in many tumors and show either promoter or suppressor activity depending on the tumor cell biology and... 
E2F1 | apoptosis | HIF-2α | TFDP3
Journal Article
Chinese Journal of Cancer Prevention and Treatment, ISSN 1673-5269, 09/2018, Volume 25, Issue 17, pp. 1222 - 1226
Journal Article
Frontiers in Oncology, ISSN 2234-943X, 09/2017, Volume 7, p. 211
The development of breast cancer cells is linked to hypoxia. The hypoxia-induced factor HIF-1α influences metastasis through neovascularization. Hypoxia seems... 
Hypoxia | Breast cancer | HIF-1α | Adipocytes | HIF-2α | hypoxia | breast cancer | adipocytes
Journal Article
Genes and Development, ISSN 0890-9369, 03/2006, Volume 20, Issue 5, pp. 557 - 570
The division, differentiation, and function of stem cells and multipotent progenitors are influenced by complex signals in the microenvironment, including... 
Oct-4 | HIF | HIF-2α | TGF-α | VEGF | Stem cells | Hypoxia | Cancer | hypoxia | stem cells | HIF-2 alpha | INDUCIBLE FACTOR 1-ALPHA | DEVELOPMENTAL BIOLOGY | TGF-alpha | PAS DOMAIN PROTEIN-1 | CELL BIOLOGY | OXYGEN | FACTOR-1-ALPHA | GENETICS & HEREDITY | GENE-EXPRESSION | cancer | MICE | DIFFERENTIATION | TRANSCRIPTION FACTOR | ES CELLS | CARCINOMA
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2019, Volume 509, Issue 3, pp. 797 - 802
Both Von Hippel-Lindau tumor suppressor (VHL) and Never-in-mitosis A (NIMA)-related kinase 1 (NEK1) are involved in primary cilium formation, but whether VHL... 
Ubiquitin | NEK1 | VHL | Renal cancer | HIF-2α | HIF-2 alpha | BIOPHYSICS | HIF | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | TUMOR-SUPPRESSOR
Journal Article
BBA - General Subjects, ISSN 0304-4165, 01/2014, Volume 1840, Issue 1, pp. 106 - 112
Duodenal cytochrome b (Dcytb) is a mammalian plasma ferric reductase enzyme that catalyses the reduction of ferric to ferrous ion in the process of iron... 
Gene silencing | Hif-2α | DHA | Dcytb | Cells
Journal Article
Nature, ISSN 0028-0836, 2016, Volume 539, Issue 7627, pp. 112 - 117
Clear cell renal cell carcinoma (ccRCC) is characterized by inactivation of the von Hippel-Lindau tumour suppressor gene (VHL)(1,2). Because no other gene is... 
HIF-2-ALPHA | INHIBITION | RNA | PAS-B DOMAIN | MULTIDISCIPLINARY SCIENCES | IN-VIVO | TUMOR-SUPPRESSOR GENE | HIF2-ALPHA | HYPOXIA-INDUCIBLE FACTOR-2 | TRANSCRIPTION FACTOR | EXPRESSION | Sulfones - therapeutic use | Kidney Neoplasms - genetics | Humans | Gene Expression Regulation, Neoplastic | Carcinoma, Renal Cell - genetics | Male | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Molecular Targeted Therapy | Sulfones - pharmacology | Indans - therapeutic use | Erythropoietin - blood | Sunitinib | Basic Helix-Loop-Helix Transcription Factors - metabolism | Female | Indoles - pharmacology | Indans - administration & dosage | Carcinoma, Renal Cell - drug therapy | Pyrroles - therapeutic use | Binding Sites | Reproducibility of Results | Basic Helix-Loop-Helix Transcription Factors - genetics | Carcinoma, Renal Cell - pathology | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Mice, SCID | Xenograft Model Antitumor Assays | Carcinoma, Renal Cell - metabolism | Pyrroles - pharmacology | Animals | Cell Transformation, Neoplastic | Cell Line, Tumor | Erythropoietin - antagonists & inhibitors | Indoles - therapeutic use | Kidney Neoplasms - pathology | Mice, Inbred NOD | Aryl Hydrocarbon Receptor Nuclear Translocator - genetics | Mice | Mutation | Kidney Neoplasms - drug therapy | Drug Resistance, Neoplasm - drug effects | Indans - pharmacology | Sulfones - administration & dosage | Physiological aspects | Molecular targeted therapy | Transcription factors | Carcinoma, Renal cell | Methods | kidney cancer | HIF-1β (F446L) | RCC | patient-derived xenograft | EPAS1 | HIF-2α (G323E) | renal cancer | ARNT
Journal Article
Chinese Journal of Cancer Prevention and Treatment, ISSN 1673-5269, 09/2018, Volume 25, Issue 17, pp. 1227 - 1235
Journal Article
Chinese Journal of Cancer Prevention and Treatment, ISSN 1673-5269, 08/2018, Volume 25, Issue 15, pp. 1071 - 1074
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 04/2018, Volume 119, Issue 4, pp. 3247 - 3256
The aim of this study was to investigate the role of NEAT1 in hepatocellular carcinoma (HCC), and probe whether NEAT1 participate in the epithelial‐mesenchymal... 
hepatocellular carcinoma (HCC) | HIF‐2α | NEAT1 | metastasis | epithelial‐mesenchymal transition (EMT) | epithelial-mesenchymal transition (EMT) | HIF-2α | Liver cancer | Biotechnology | Deactivation | Mesenchyme | Cell lines | Hepatocellular carcinoma | Metastasis | Inactivation | Tissues | Cell migration | Cancer | Metastases
Journal Article
Hepatology, ISSN 0270-9139, 06/2018, Volume 67, Issue 6, pp. 2196 - 2214
Mechanisms underlying progression of nonalcoholic fatty liver disease (NAFLD) are still incompletely characterized. Hypoxia and hypoxia‐inducible factors... 
Nutrient deficiency | Liver diseases | Disease | Transcription | Liver | Methionine | Amino acids | Macrophages | Nuclei | Cytosol | Fatty liver | Histidine | Clonal deletion | Hepatocytes | Diet | Rodents | Choline | Fibrosis | Hypoxia | Evolution
Journal Article
Medical Journal of Wuhan University, ISSN 1671-8852, 07/2018, Volume 39, Issue 4, pp. 577 - 582
Journal Article
Journal Article
International Journal of Clinical and Experimental Pathology, ISSN 1936-2625, 2016, Volume 9, Issue 9, pp. 9394 - 9400
Objective: To identify the prognostic significance of CD147 and HIF-2 alpha expressions in localized clear cell renal cell carcinoma (ccRCC). Methods: Tissue... 
Prognosis | CD147 | HIF-2α | Localized ccRCC | HIF-2 alpha | PATHOLOGY | ONCOLOGY | localized ccRCC | prognosis
Journal Article
International Journal of Biochemistry and Cell Biology, ISSN 1357-2725, 04/2019, Volume 109, pp. 33 - 39
Erythropoietin (EPO) is a secreted hormone that stimulates the production of red blood cells, and the level of EPO is increased under hypoxia. The expression... 
Hypoxia-inducible factor | Histone demethylase | JMJD1A | Erythropoietin | HIF-2α | INDUCIBLE FACTOR | METHYLATION | HIF-2 alpha | GENE | BIOCHEMISTRY & MOLECULAR BIOLOGY | JHDM2A | CELL BIOLOGY | Epigenetic inheritance | Medical colleges | Methylation
Journal Article
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