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Cancer Discovery, ISSN 2159-8274, 11/2017, Volume 7, Issue 11, pp. 1221 - 1223
Clear cell renal cell carcinoma (ccRCC) is characterized by loss of the von Hippel-Lindau tumor suppressor gene (VHL), and the functional tumorigenic... 
ONCOLOGY | HIF-ALPHA | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 2010, Volume 38, Issue 6, pp. 864 - 878
To survive in hypoxic environments, organisms must be able to cope with redox imbalance and oxygen deficiency. The SIRT1 deacetylase and the HIF-1... 
PROTEINS | HUMDISEASE | SIGNALING | CELLS | TRANSCRIPTIONAL ACTIVITY | REGULATES SIRT1 | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | HIF-1-ALPHA | VHL | HIF-ALPHA | CANCER | CALORIE RESTRICTION | CELL BIOLOGY
Journal Article
Nature Reviews Cancer, ISSN 1474-175X, 11/2008, Volume 8, Issue 11, pp. 865 - 873
The von Hippel-Lindau disease is caused by inactivating germline mutations of the VHL tumour suppressor gene and is associated with an increased risk of a... 
RNA-POLYMERASE-II | HYDROXYLASE DOMAIN PROTEIN-2 | ONCOLOGY | HYPOXIA-INDUCIBLE-FACTOR | PROLINE HYDROXYLATION | RENAL-CELL-CARCINOMA | VASCULAR TUMORS | HIF-ALPHA | GENE-PRODUCT | PROLYL HYDROXYLASE | FACTOR-ALPHA
Journal Article
Molecular Cell, ISSN 1097-2765, 2007, Volume 25, Issue 2, pp. 207 - 217
Hypoxia-inducible factor 1 (HIF-1) regulates transcription in response to changes in O concentration. O -dependent degradation of the HIF-1α subunit is... 
PROTEINS | HYPOXIA-INDUCIBLE FACTOR | FACTOR 1-ALPHA | PROTEIN-KINASE-C | TRANSCRIPTIONAL ACTIVITY | COMPLEX | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | VHL | HIF-ALPHA | CANCER | CELL BIOLOGY
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 07/2011, Volume 31, Issue 13, pp. 2696 - 2706
Author's Correction ( vol. 32 , p. 898 ) Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike... 
SIGNAL-TRANSDUCTION | BREAST-CANCER | RECRUITMENT | GENE | PROLYL HYDROXYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | MICRORNA TARGETS | HIF-1-ALPHA | TRANSCRIPTION FACTOR | HIF-ALPHA | CANCER-THERAPY | CELL BIOLOGY
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 06/2005, Volume 280, Issue 23, pp. 22473 - 22481
Non-small cell lung cancer (NSCLC) expresses a particularly aggressive metastatic phenotype, and patients with this disease have a poor prognosis. CXC... 
METASTASIS | ANGIOGENESIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOLOGY | HYDROXYLATION | TUMOR-SUPPRESSOR GENE | PTEN | FACTOR-I | HIF-1-ALPHA | PROMOTER | HIF-ALPHA
Journal Article
European Journal of Immunology, ISSN 0014-2980, 09/2008, Volume 38, Issue 9, pp. 2412 - 2418
Recent data suggest that hypoxia and its principal molecular signature HIF-1 (hypoxia-inducing factor-1) may tune down inflammation by dictating... 
HIF-1 | Hypoxia | Inflammation | Foxp3 | Regulatory T cells | hypoxia | INDUCIBLE FACTOR-1-ALPHA | DNA-BINDING | ACTIVATION | HYDROXYLATION | IMMUNOLOGY | regulatory T cells | inflammation | KV1.3 CHANNELS | HIF-ALPHA | LYMPHOCYTES
Journal Article
Cell, ISSN 0092-8674, 2007, Volume 131, Issue 3, pp. 584 - 595
SUMOylation is a dynamic process, catalyzed by SUMO-specific ligases and reversed by Sentrin/SUMO-specific proteases (SENPs). The physiologic consequences of... 
CELLBIO | PROTEINS | DEVBIO | INDUCIBLE FACTOR 1-ALPHA | DEPENDENT TRANSCRIPTION | PROLYL HYDROXYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR-SUPPRESSOR PROTEIN | DEGRADATION | VHL | HIF-1-ALPHA | DIFFERENTIAL REGULATION | O-2 TENSION | HIF-ALPHA | CELL BIOLOGY
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2005, Volume 201, Issue 1, pp. 105 - 115
Neutrophils are key effector cells of the innate immune response and are required to migrate and function within adverse microenvironmental conditions. These... 
PROGRAMMED CELL-DEATH | MEDICINE, RESEARCH & EXPERIMENTAL | CONSTITUTIVE APOPTOSIS | TUMOR-NECROSIS-FACTOR | INDUCIBLE FACTOR-1-ALPHA | PROTEIN | IMMUNOLOGY | O-2 HOMEOSTASIS | GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE GENE | HIF-ALPHA | EXPRESSION | FACTOR-ALPHA
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2008, Volume 105, Issue 49, pp. 19426 - 19431
Journal Article
by Yeo, EJ and Chun, YS and Cho, YS and Kim, JH and Lee, JC and Kim, MS and Park, JW
JOURNAL OF THE NATIONAL CANCER INSTITUTE, ISSN 0027-8874, 04/2003, Volume 95, Issue 7, pp. 516 - 525
Hypoxia-inducible factor 1 alpha (HIF-1alpha), a component of HIF-1, is expressed in human tumors and renders cells able to survive and grow under hypoxic... 
SOLUBLE GUANYLYL CYCLASE | FACTOR 1-ALPHA | OVEREXPRESSION | ANGIOGENESIS | ONCOLOGY | PROLYL HYDROXYLATION | YC-1 | GENE-EXPRESSION | HIF-ALPHA | CANCER-THERAPY | ENDOTHELIAL GROWTH-FACTOR
Journal Article
Genes and Development, ISSN 0890-9369, 06/2012, Volume 26, Issue 12, pp. 1326 - 1338
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 6/2007, Volume 177, Issue 6, pp. 1029 - 1036
Mammalian cells increase transcription of genes for adaptation to hypoxia through the stabilization of hypoxia-inducible factor 1α (HIF-1α) protein. How cells... 
Oxidases | Oxygen | Reactive oxygen species | Mitochondria | Cell lines | Superoxides | Hypoxia | Cytochromes | Cells | Electrons | RESPIRATORY-CHAIN | SUPEROXIDE ANION | TRANSCRIPTIONAL ACTIVITY | STRUCTURAL BASIS | BOVINE HEART-MITOCHONDRIA | CYTOCHROME C REDUCTASE | HYDROGEN-PEROXIDE | GENERATION | INDUCIBLE FACTOR-1 | HIF-ALPHA | CELL BIOLOGY
Journal Article
Virology, ISSN 0042-6822, 04/2019, Volume 530, pp. 51 - 58
Virus reprogramming of host cellular function is a critical strategy for viral survival and replication. A better understanding of virus-host interaction may... 
Factor inhibiting HIF-1 | H1N1 | Hypoxia-inducible factor-1 | Proteasome | PROTEIN | MECHANISM | INVOLVEMENT | LUNG INJURY | VIROLOGY | METABOLISM | FIH-1 | HIF-1-ALPHA | VHL | HIF-ALPHA
Journal Article
Nature, ISSN 0028-0836, 01/2012, Volume 481, Issue 7381, pp. 380 - 384
Acetyl coenzyme A (AcCoA) is the central biosynthetic precursor for fatty-acid synthesis and protein acetylation. In the conventional view of mammalian cell... 
FLUX ANALYSIS | DISTRIBUTIONS | FATTY-ACID SYNTHESIS | MULTIDISCIPLINARY SCIENCES | GROWTH | HYDROXYLATION | CELL-PROLIFERATION | SUPPRESSION | HIF-ALPHA | CANCER | DEHYDROGENASE | CD8-Positive T-Lymphocytes - cytology | Palmitic Acid - metabolism | Isocitrate Dehydrogenase - deficiency | Humans | Glutamine - metabolism | Kidney Neoplasms - metabolism | Aryl Hydrocarbon Receptor Nuclear Translocator - metabolism | Oxygen - metabolism | Cell Hypoxia | Basic Helix-Loop-Helix Transcription Factors - metabolism | Acetyl Coenzyme A - biosynthesis | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Ketoglutaric Acids - metabolism | Lipogenesis | Von Hippel-Lindau Tumor Suppressor Protein - metabolism | Carbon - metabolism | Basic Helix-Loop-Helix Transcription Factors - genetics | Oxidation-Reduction | Carcinoma, Renal Cell - pathology | Cells, Cultured | Isocitrate Dehydrogenase - genetics | Acetyl Coenzyme A - metabolism | Citric Acid Cycle | Carcinoma, Renal Cell - metabolism | Cell Line, Tumor | Isocitrate Dehydrogenase - metabolism | Kidney Neoplasms - pathology | Physiological aspects | Hypoxia | Research | Lipid metabolism | Electron transport | Proteins | Confidence intervals | Metabolites | Lipids | Biosynthesis | Glucose | Experiments | Index Medicus
Journal Article