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1. Full Text p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription
by Chiacchiera, F and Matrone, A and Ferrari, E and Ingravallo, G and Lo Sasso, G and Murzilli, S and Petruzzelli, M and Salvatore, L and Moschetta, A and Simone, C
Cell Death and Differentiation, ISSN 1350-9047, 2009, Volume 16, Issue 9, pp. 1203 - 1214
Colorectal cancer cell (CRC) fate is governed by an intricate network of signaling pathways, some of which are the direct target of DNA mutations, whereas... 
FoxO | autophagy | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR | AUTOPHAGIC CELL-DEATH | P38 PATHWAY | HYPOXIA | CELL BIOLOGY | colorectal cancer cell metabolism | COLON-CANCER | CARCINOGENESIS | HIF1 alpha | DIFFERENTIATION | p38 alpha
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2. Full Text Cobalt chloride-mediated protein kinase Cα (PKCα) phosphorylation induces hypoxia-inducible factor 1α (HIF1α) in the nucleus of gastric cancer cell
by Rath, Suvasmita and Anand, Aditya and Ghosh, Nilabh and Das, Lopamudra and Kokate, Shrikant B and Dixit, Pragyesh and Majhi, Swetapadma and Rout, Niranjan and Singh, Shivaram P and Bhattacharyya, Asima
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 02/2016, Volume 471, Issue 1, pp. 205 - 212
Hypoxia promotes cancer progression, and metastasis. The major protein expressed in hypoxic solid cancer is hypoxia-inducible factor 1 (HIF1). We show that... 
p300 | Hypoxia | PKC | Cobalt chloride | HIF1α | Gastric epithelial cell | TRANSLOCATION | APOPTOSIS | THREONINE 638 | ISOFORMS | METASTASIS | DELTA | BIOCHEMISTRY & MOLECULAR BIOLOGY | INDUCTION | THERAPY | BIOPHYSICS | HIF1 alpha | RAT VENTRICULAR MYOCYTES | STRESS | Phosphorylation - physiology | Cell Line | Cell Hypoxia - drug effects | Cell Hypoxia - physiology | Protein Kinase C-alpha - metabolism | Humans | Cells, Cultured | Cobalt - administration & dosage | Gastric Mucosa - metabolism | Dose-Response Relationship, Drug | Cell Nucleus - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Gastric Mucosa - drug effects | Phosphorylation - drug effects | Cell Nucleus - drug effects
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3. Full Text Inhibition of Hif1α prevents both trauma-induced and genetic heterotopic ossification
by Shailesh Agarwal and Shawn Loder and Cameron Brownley and David Cholok and Laura Mangiavini and John Li and Christopher Breuler and Hsiao H. Sung and Shuli Li and Kavitha Ranganathan and Joshua Peterson and Ronald Tompkins and David Herndon and Wenzhong Xiao and Dolrudee Jumlongras and Bjorn R. Olsen and Thomas A. Davis and Yuji Mishina and Ernestina Schipani and Benjamin Levi
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2016, Volume 113, Issue 3, pp. E338 - E347
Pathologic extraskeletal bone formation, or heterotopic ossification (HO), occurs following mechanical trauma, burns, orthopedic operations, and in patients... 
Cartilage | Heterotopic ossification | Mesenchymal condensation | HIF1α | Prx | HYPOXIA-INDUCIBLE FACTOR | PX-478 | RISK-FACTORS | MULTIDISCIPLINARY SCIENCES | cartilage | heterotopic ossification | RECEPTOR | mesenchymal condensation | CANCER | HUMAN SKELETAL-MUSCLE | BONE-FORMATION | IN-VIVO | HIF1 alpha | GROWTH-FACTOR | HIF-1-ALPHA | Ossification, Heterotopic - drug therapy | Chondrogenesis - drug effects | Mustard Compounds - pharmacology | Chondrogenesis - genetics | Tendons - drug effects | Humans | Tenotomy | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Luminescent Measurements | Gene Regulatory Networks - drug effects | RNA, Messenger - metabolism | X-Ray Microtomography | Adipose Tissue - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Tendons - surgery | Integrases - metabolism | Burns - complications | Wound Healing - drug effects | Disease Models, Animal | SOX9 Transcription Factor - metabolism | Mesenchymal Stromal Cells - drug effects | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Wounds and Injuries - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Messenger - genetics | Wounds and Injuries - complications | Ossification, Heterotopic - diagnostic imaging | Activin Receptors, Type I - metabolism | Sirolimus - pharmacology | Mice, Knockout | Up-Regulation - drug effects | Phenylpropionates - pharmacology | Animals | Signal Transduction - drug effects | Models, Biological | Tendons - pathology | Ossification, Heterotopic - prevention & control | Ossification, Heterotopic - genetics | Adipose Tissue - drug effects | Burns - genetics | Biological Sciences | PNAS Plus
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4. Full Text Liprin-alpha 4 as a New Therapeutic Target for SCLC as an Upstream Mediator of HIF1 alpha
by Onishi, H and Yamasaki, A and Nakamura, K and Ichimiya, S and Yanai, K and Umebayashi, M and Nagai, S and Morisaki, T
ANTICANCER RESEARCH, ISSN 0250-7005, 03/2019, Volume 39, Issue 3, pp. 1179 - 1184
Background/Aim: Small-cell lung cancer (SCLC) remains one of deadliest types of cancers. Cisdiamminedichloroplatinum (CDDP) is a key chemotherapeutic agent for... 
SCLC | invasion | proliferation | ONCOLOGY | HIF1 alpha | Liprin-alpha 4 | EXPRESSION | PROTEIN-TYROSINE-PHOSPHATASE | FAMILY
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5. Full Text Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1α-mediated VEGF-dependent angiogenesis
by Raja, R and Kale, S and Thorat, D and Soundararajan, G and Lohite, K and Mane, A and Karnik, S and Kundu, G.C
Oncogene, ISSN 0950-9232, 04/2014, Volume 33, Issue 16, pp. 2053 - 2064
Hypoxia is a salient feature of most solid tumors, and hypoxic adaptation of cancer cells has crucial implications in propagation of malignant clonal cell... 
hypoxia | HIF1α | angiogenesis | osteopontin | CANCER-CELLS | ACTIVATION | INDUCIBLE FACTOR 1-ALPHA | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | ONCOLOGY | PROSTATE-CANCER | GENETICS & HEREDITY | GENE-EXPRESSION | HIF1 alpha | LINKED KINASE ILK | HIF-1-ALPHA | NF-KAPPA-B | MALIGNANT PROGRESSION | UP-REGULATION | Osteopontin - genetics | Cell Proliferation | Humans | NF-kappa B - metabolism | Osteopontin - metabolism | Vascular Endothelial Growth Factor A - metabolism | Breast Neoplasms - metabolism | Neovascularization, Pathologic - pathology | Cell Hypoxia | MCF-7 Cells | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Female | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mice, SCID | Xenograft Model Antitumor Assays - methods | Blotting, Western | Mice, Knockout | Animals | Breast Neoplasms - genetics | NF-kappa B - genetics | Breast Neoplasms - pathology | Embryo, Mammalian - cytology | Cell Line, Tumor | Mice, Inbred NOD | Neovascularization, Pathologic - genetics | Fibroblasts - cytology | Mice | Neovascularization, Pathologic - metabolism
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6. Full Text Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1α
by Adamovich, Yaarit and Ladeuix, Benjamin and Golik, Marina and Koeners, Maarten P and Asher, Gad
Cell Metabolism, ISSN 1550-4131, 01/2017, Volume 25, Issue 1, pp. 93 - 101
The mammalian circadian system consists of a master clock in the brain that synchronizes subsidiary oscillators in peripheral tissues. The master clock... 
entrainment | Cry2 | metabolism | Rorα | clock | circadian rhythms | oxygen | HIF1 | jetlag | KIDNEY OXYGENATION | ENTRAINMENT | OSCILLATORS | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | ARCHITECTURE | TIME | BODY-TEMPERATURE | TISSUES | HYPOXIA | CONSCIOUS RATS | CELL BIOLOGY | NIH 3T3 Cells | Oxygen - pharmacology | Circadian Clocks - drug effects | Cells, Cultured | Circadian Rhythm - genetics | Circadian Clocks - genetics | Jet Lag Syndrome - genetics | Gene Expression Regulation - drug effects | Animals | Adaptation, Physiological - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice | Circadian Rhythm - drug effects
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7. C1q contributes to post-stroke angiogenesis via LAIR1-HIF1 alpha-VEGF pathway
by Fan, GF and Li, QM and Chan, J
FRONTIERS IN BIOSCIENCE-LANDMARK, ISSN 1093-9946, 03/2019, Volume 24, pp. 1050 - 1059
Vascular remodeling is a critical event following a stroke. It is a well known fact that C1q is the first molecule in the complement classical pathway.... 
Angiogenesis | RECOVERY | C1q | Stroke | ACTIVATION | VEGF | BIOCHEMISTRY & MOLECULAR BIOLOGY | INJURY | HIF1 alpha | RECEPTOR | LAIR1 | CELL BIOLOGY
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8. Full Text Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis
by Nagaraju, Ganji Purnachandra and Bramhachari, Pallaval Veera and Raghu, Godi and El-Rayes, Bassel F
Cancer Letters, ISSN 0304-3835, 2015, Volume 366, Issue 1, pp. 11 - 18
Highlights • Colorectal cancer (CRC) growth is associated with the physiological state of hypoxia. • Hypoxia-stabilized HIF1α is a key factor for CRC... 
Hematology, Oncology and Palliative Medicine | Stemness | Metastasis | HIF1α | Tumor resistance | Colorectal cancer | CANCER CELLS | DOWN-REGULATION | FACTOR 1-ALPHA | ONCOLOGY | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | HEMATOPOIETIC STEM-CELLS | HIF1 alpha | FREE-RADICAL GENERATION | MULTIDRUG-RESISTANCE | UP-REGULATION | HIF-ALPHA | MITOCHONDRIAL COMPLEX-III | Reactive Oxygen Species - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Colorectal Neoplasms - etiology | Neoplasm Metastasis | Receptors, CXCR4 - physiology | Epithelial-Mesenchymal Transition | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | beta Catenin - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | MicroRNAs - physiology | Nuclear Receptor Subfamily 4, Group A, Member 1 - physiology | Protein Stability | Colorectal Neoplasms - pathology | Index Medicus
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9. Full Text The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
by Lin, Aifu and Li, Chunlai and Xing, Zhen and Hu, Qingsong and Liang, Ke and Han, Leng and Wang, Cheng and Hawke, David H and Wang, Shouyu and Zhang, Yanyan and Wei, Yongkun and Ma, Guolin and Park, Peter K and Zhou, Jianwei and Zhou, Yan and Hu, Zhibin and Zhou, Yubin and Marks, Jeffery R and Liang, Han and Hung, Mien-Chie and Lin, Chunru and Yang, Liuqing
Nature Cell Biology, ISSN 1465-7392, 01/2016, Volume 18, Issue 2, pp. 213 - 224
Although long non-coding RNAs (lncRNAs) predominately reside in the nucleus and exert their functions in many biological processes, their potential involvement... 
TARGET | HIF-1 | PROTEIN | LONG NONCODING RNAS | TYROSINE KINASE | EPIGENETIC REGULATION | BINDING SITES | HYPOXIA | TUMOR-GROWTH | PROMOTES | CELL BIOLOGY | Heparin-binding EGF-like Growth Factor - pharmacology | Phosphorylation | Prognosis | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Multiprotein Complexes | Serine | Gene Expression Regulation, Neoplastic | Proline | Cytoplasm - metabolism | E1A-Associated p300 Protein - metabolism | Neoplasm Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Transfection | RNA Interference | Time Factors | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Triple Negative Breast Neoplasms - pathology | Female | Transcription, Genetic | Protein Stability | Protein-Serine-Threonine Kinases - metabolism | Tyrosine | Hydroxylation | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Long Noncoding - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Triple Negative Breast Neoplasms - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Glycolysis | RNA, Long Noncoding - metabolism | Index Medicus | glycoprotein non-metastatic b (GPNMB) | Epidermal Growth Factor Receptor (EGFR) | Triple-negative Breast Cancer (TNBC) | Long Noncoding RNA | Signaling Transduction | Glycolysis Reprogramming | HIF1α
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10. Full Text Drug resistance and cancer stem cells: the shared but distinct roles of hypoxia‐inducible factors HIF1α and HIF2α
by Schöning, Jennifer Petra and Monteiro, Michael and Gu, Wenyi
Clinical and Experimental Pharmacology and Physiology, ISSN 0305-1870, 02/2017, Volume 44, Issue 2, pp. 153 - 161
Summary Chemotherapy resistance is a major contributor to poor treatment responses and tumour relapse, the development of which has been strongly linked to the... 
drug transporters | hypoxia | PI3K/AKT signalling pathway | quiescence | cancer stem cells | drug resistance | HIF2α | HIF1α | hypoxia‐inducible factors | hypoxia-inducible factors | PHYSIOLOGY | EMBRYONIC-DEVELOPMENT | CISPLATIN RESISTANCE | SELF-RENEWAL | REGULATES SURVIVAL | CHRONIC MYELOID-LEUKEMIA | HIF2 alpha | SIDE-POPULATION CELLS | GENE-EXPRESSION | HIF1 alpha | PHARMACOLOGY & PHARMACY | TUMORIGENIC CAPACITY | NF-KAPPA-B | TUMOR-GROWTH | Neoplasms - metabolism | Cell Survival - drug effects | Basic Helix-Loop-Helix Transcription Factors - physiology | Basic Helix-Loop-Helix Transcription Factors - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Neoplastic Stem Cells - drug effects | Cell Self Renewal - physiology | Humans | Tumor Hypoxia - drug effects | Hypoxia-Inducible Factor 1, alpha Subunit - antagonists & inhibitors | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Cell Self Renewal - drug effects | Neoplasms - drug therapy | Tumor Hypoxia - physiology | Neoplastic Stem Cells - metabolism | Neoplastic Stem Cells - pathology | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | Neoplasms - pathology | Drug Resistance, Neoplasm - physiology | Cell Survival - physiology | Drug Resistance, Neoplasm - drug effects
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11. Full Text NRF2 facilitates breast cancer cell growth via HIF1 alpha-mediated metabolic reprogramming
by Zhang, HS and Du, GY and Zhang, ZG and Zhou, Z and Sun, HL and Yu, XY and Shi, YT and Xiong, DN and Li, H and Huang, YH
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, ISSN 1357-2725, 02/2018, Volume 95, pp. 85 - 92
High aerobic glycolysis not only provides energy to breast cancer cells, but also supports their anabolic growth. The redox sensitive transcription factor NRF2... 
NRF2 | SIGNALING PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | Glycolysis | HIF1 alpha | HYPOXIA | CROSSTALK | Breast cancer cells | CELL BIOLOGY
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12. Full Text HIF1α-associated circdennd4c promotes proliferation of breast cancer cells in hypoxic environment
by Liang, Gehao and Liu, Zihao and Tan, Luyuan and Su, An and Jiang, Wen G and Gong, Chang
Anticancer Research, ISSN 0250-7005, 08/2017, Volume 37, Issue 8, pp. 4337 - 4343
Background: Accumulating evidence has shown that hypoxia plays a key role in regulating proliferation of breast cancer cells. However, the mechanism of how... 
Hypoxia | Breast cancer | Proliferation | HIF1α | CircDENND4C | hypoxia | METASTASIS | proliferation | CIRCULAR RNA | BIOMARKER | breast cancer | IDENTIFICATION | circDENND4C | INDUCIBLE FACTORS | ONCOLOGY | HIF1 alpha | EXPRESSION | TUMOR OXYGENATION | Cell Proliferation | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Gene Expression Regulation, Neoplastic | Tumor Burden | Gene Knockdown Techniques | RNA - genetics | Cell Hypoxia | Breast Neoplasms - genetics | MCF-7 Cells | Breast Neoplasms - pathology | Cell Line, Tumor | Female
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13. Full Text Genetic and Functional Studies Implicate HIF1 alpha as a 14q Kidney Cancer Suppressor Gene
by Shen, C and Beroukhim, R and Schumacher, SE and Zhou, J and Chang, M and Signoretti, S and Kaelin, WG
CANCER DISCOVERY, ISSN 2159-8274, 08/2011, Volume 1, Issue 3, pp. 222 - 235
Kidney cancers often delete chromosome 3p, spanning the VHL tumor suppressor gene, and chromosome 14q, which presumably harbors >= 1 tumor suppressor genes.... 
HYPOXIA-INDUCIBLE FACTOR | HIF-2-ALPHA | HIF | ONCOLOGY | COPY-NUMBER ALTERATIONS | IN-VIVO | FACTOR (HIF)-1-ALPHA | EXPRESSION | RENAL-CELL CARCINOMA | HIPPEL-LINDAU PROTEIN | LINES | Kidney Neoplasms - genetics | Animals | Cell Proliferation | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Mice, Nude | Humans | Carcinoma, Renal Cell - genetics | Cell Line, Tumor | Mice | Mutation - genetics | Genes, Tumor Suppressor | Chromosomes, Human, Pair 14 - genetics | kidney cancer | tumor suppression | hypoxia | 14q deletion | von Hippel-Lindau | HIF1α
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14. Full Text Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC‐associated factor X
by Qin, Nan and de Cubas, Aguirre A and Garcia‐Martin, Ruben and Richter, Susan and Peitzsch, Mirko and Menschikowski, Mario and Lenders, Jacques W.M and Timmers, Henri J. L. M and Mannelli, Massimo and Opocher, Giuseppe and Economopoulou, Matina and Siegert, Gabriele and Chavakis, Triantafyllos and Pacak, Karel and Robledo, Mercedes and Eisenhofer, Graeme
International Journal of Cancer, ISSN 0020-7136, 11/2014, Volume 135, Issue 9, pp. 2054 - 2064
Pheochromocytomas and paragangliomas (PPGLs) are catecholamine‐producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in... 
HIF2α | MAX | phenylethanolamine N‐methyltransferase | HIF1α | pheochromocytoma and paraganglioma | phenylethanolamine N-methyltransferase | HYPOXIA-INDUCIBLE FACTOR | TRANSCRIPTIONAL ACTIVITY | TYROSINE-HYDROXYLASE | C-MYC | MAX MUTATIONS | HIF2 alpha | SPORADIC PHEOCHROMOCYTOMA | HIF-2-ALPHA | ONCOLOGY | HIF1 alpha | SDH MUTATIONS | PC12 CELLS | EXPRESSION | Cell Proliferation | Humans | Chromaffin Cells - pathology | Gene Expression Profiling | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Biomarkers, Tumor - metabolism | Pheochromocytoma - pathology | Cell Differentiation | Tumor Cells, Cultured | Real-Time Polymerase Chain Reaction | Adrenal Gland Neoplasms - pathology | Pheochromocytoma - metabolism | Paraganglioma - pathology | Basic Helix-Loop-Helix Transcription Factors - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Paraganglioma - genetics | RNA, Messenger - genetics | Rats | Mutation - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Chromaffin Cells - metabolism | Animals | Cell Cycle | Paraganglioma - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - genetics | Adrenal Gland Neoplasms - metabolism | Basic Helix-Loop-Helix Leucine Zipper Transcription Factors - metabolism | Pheochromocytoma - genetics | Biomarkers, Tumor - genetics | Adrenal Gland Neoplasms - genetics | Apoptosis
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15. Full Text P4HA1/HIF1α feedback loop drives the glycolytic and malignant phenotypes of pancreatic cancer
by Cao, X.P and Cao, Y and Li, W.J and Zhang, H.H and Zhu, Z.M
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 08/2019, Volume 516, Issue 3, pp. 606 - 612
Hypoxia-inducible factor 1α (HIF1α) activation is profoundly implicated in the initiation and progression of multiple malignant tumors. Prolyl 4-hydroxylase... 
Hypoxia | P4HA1 | HIF1α | Pancreatic cancer | Warburg effect | CELLS | BIOPHYSICS | METABOLISM | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIF1 alpha | EXPRESSION
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