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1. Full Text p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription
by Chiacchiera, F and Matrone, A and Ferrari, E and Ingravallo, G and Lo Sasso, G and Murzilli, S and Petruzzelli, M and Salvatore, L and Moschetta, A and Simone, C
Cell death and differentiation, ISSN 1350-9047, 2009, Volume 16, Issue 9, pp. 1203 - 1214
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Science & Technology | Cell Biology
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2. Full Text Cobalt chloride-mediated protein kinase Cα (PKCα) phosphorylation induces hypoxia-inducible factor 1α (HIF1α) in the nucleus of gastric cancer cell
by Rath, Suvasmita and Anand, Aditya and Ghosh, Nilabh and Das, Lopamudra and Kokate, Shrikant B and Dixit, Pragyesh and Majhi, Swetapadma and Rout, Niranjan and Singh, Shivaram P and Bhattacharyya, Asima
Biochemical and biophysical research communications, ISSN 0006-291X, 02/2016, Volume 471, Issue 1, pp. 205 - 212
p300 | Hypoxia | PKC | Cobalt chloride | HIF1α | Gastric epithelial cell | Biochemistry & Molecular Biology | Biophysics | Life Sciences & Biomedicine | Science & Technology | Phosphorylation - physiology | Cell Line | Cell Hypoxia - drug effects | Cell Hypoxia - physiology | Protein Kinase C-alpha - metabolism | Humans | Cells, Cultured | Cobalt - administration & dosage | Gastric Mucosa - metabolism | Dose-Response Relationship, Drug | Cell Nucleus - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Gastric Mucosa - drug effects | Phosphorylation - drug effects | Cell Nucleus - drug effects | Index Medicus
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3. Full Text Dietary obesity-associated hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system
by Krishnan, Jaya and Danzer, Carsten and Simka, Tatiana and Ukropec, Josef and Walter, Katharina Manuela and Kumpf, Susann and Mirtschink, Peter and Ukropcova, Barbara and Gasperikova, Daniela and Pedrazzini, Thierry and Krek, Wilhelm
Genes & development, ISSN 0890-9369, 02/2012, Volume 26, Issue 3, pp. 259 - 270
Obesity | Sirt2 | Hif1α | Adipocytes | Diabetes | Metabolism | Genetics & Heredity | Life Sciences & Biomedicine | Developmental Biology | Science & Technology | Cell Biology | Humans | Molecular Sequence Data | Adipocytes - cytology | Male | Sirtuin 2 - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Base Sequence | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Cell Differentiation | Acetylation | Fatty Acids - metabolism | NAD - metabolism | Oxidation-Reduction | Cells, Cultured | Gene Expression Regulation | Mitochondria - metabolism | Obesity - pathology | Sirtuin 2 - genetics | Sequence Alignment | Animals | Diet | Energy Metabolism | Adipocytes - metabolism | Trans-Activators - metabolism | Mice | Transcription Factors | Index Medicus | Research Paper | metabolism | adipocytes | diabetes | obesity
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4. Full Text Rhythmic Oxygen Levels Reset Circadian Clocks through HIF1α
by Adamovich, Yaarit and Ladeuix, Benjamin and Golik, Marina and Koeners, Maarten P and Asher, Gad
Cell metabolism, ISSN 1550-4131, 01/2017, Volume 25, Issue 1, pp. 93 - 101
entrainment | Cry2 | metabolism | Rorα | clock | circadian rhythms | oxygen | HIF1 | jetlag | Endocrinology & Metabolism | Life Sciences & Biomedicine | Science & Technology | Cell Biology | NIH 3T3 Cells | Oxygen - pharmacology | Circadian Clocks - drug effects | Cells, Cultured | Circadian Rhythm - genetics | Circadian Clocks - genetics | Jet Lag Syndrome - genetics | Gene Expression Regulation - drug effects | Animals | Adaptation, Physiological - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Mice | Circadian Rhythm - drug effects | Index Medicus
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5. Full Text Hypoxia-driven osteopontin contributes to breast tumor growth through modulation of HIF1α-mediated VEGF-dependent angiogenesis
by Raja, R and Kale, S and Thorat, D and Soundararajan, G and Lohite, K and Mane, A and Karnik, S and Kundu, G.C
Oncogene, ISSN 0950-9232, 04/2014, Volume 33, Issue 16, pp. 2053 - 2064
hypoxia | HIF1α | angiogenesis | osteopontin | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Osteopontin - genetics | Cell Proliferation | Humans | NF-kappa B - metabolism | Osteopontin - metabolism | Vascular Endothelial Growth Factor A - metabolism | Breast Neoplasms - metabolism | Neovascularization, Pathologic - pathology | Cell Hypoxia | MCF-7 Cells | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Female | Proto-Oncogene Proteins c-akt - metabolism | Protein-Serine-Threonine Kinases - metabolism | Fibroblasts - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Mice, SCID | Xenograft Model Antitumor Assays - methods | Blotting, Western | Mice, Knockout | Animals | Breast Neoplasms - genetics | NF-kappa B - genetics | Breast Neoplasms - pathology | Embryo, Mammalian - cytology | Cell Line, Tumor | Mice, Inbred NOD | Neovascularization, Pathologic - genetics | Fibroblasts - cytology | Mice | Neovascularization, Pathologic - metabolism | Index Medicus
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6. Full Text The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer
by Lin, Aifu and Li, Chunlai and Xing, Zhen and Hu, Qingsong and Liang, Ke and Han, Leng and Wang, Cheng and Hawke, David H and Wang, Shouyu and Zhang, Yanyan and Wei, Yongkun and Ma, Guolin and Park, Peter K and Zhou, Jianwei and Zhou, Yan and Hu, Zhibin and Zhou, Yubin and Marks, Jeffery R and Liang, Han and Hung, Mien-Chie and Lin, Chunru and Yang, Liuqing
Nature cell biology, ISSN 1465-7392, 01/2016, Volume 18, Issue 2, pp. 213 - 224
Life Sciences & Biomedicine | Science & Technology | Cell Biology | Heparin-binding EGF-like Growth Factor - pharmacology | Phosphorylation | Prognosis | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Multiprotein Complexes | Serine | Gene Expression Regulation, Neoplastic | Proline | Cytoplasm - metabolism | E1A-Associated p300 Protein - metabolism | Neoplasm Proteins - metabolism | Transfection | RNA Interference | Time Factors | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Triple Negative Breast Neoplasms - pathology | Female | Transcription, Genetic | Protein Stability | Protein-Serine-Threonine Kinases - metabolism | Tyrosine | ErbB Receptors - metabolism | Hydroxylation | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Long Noncoding - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Triple Negative Breast Neoplasms - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Glycolysis | RNA, Long Noncoding - metabolism | Index Medicus | glycoprotein non-metastatic b (GPNMB) | Epidermal Growth Factor Receptor (EGFR) | Triple-negative Breast Cancer (TNBC) | Long Noncoding RNA | Signaling Transduction | Glycolysis Reprogramming | HIF1α
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7. Full Text Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis
by Nagaraju, Ganji Purnachandra and Bramhachari, Pallaval Veera and Raghu, Godi and El-Rayes, Bassel F
Cancer letters, ISSN 0304-3835, 2015, Volume 366, Issue 1, pp. 11 - 18
Hematology, Oncology and Palliative Medicine | Stemness | Metastasis | HIF1α | Tumor resistance | Colorectal cancer | Life Sciences & Biomedicine | Oncology | Science & Technology | Reactive Oxygen Species - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Colorectal Neoplasms - etiology | Neoplasm Metastasis | Receptors, CXCR4 - physiology | Epithelial-Mesenchymal Transition | Hypoxia-Inducible Factor 1, alpha Subunit - chemistry | beta Catenin - physiology | Hypoxia-Inducible Factor 1, alpha Subunit - physiology | MicroRNAs - physiology | Nuclear Receptor Subfamily 4, Group A, Member 1 - physiology | Protein Stability | Colorectal Neoplasms - pathology | Index Medicus
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8. Full Text Gene Expression Profiling of the Hypoxia Signaling Pathway in Hypoxia-Inducible Factor 1α Null Mouse Embryonic Fibroblasts
by Vengellur, Ajith and Woods, Barbara G and Ryan, Heather E and Johnson, Randall S and Lapres, John J
Gene expression, ISSN 1052-2166, 2003, Volume 11, Issue 3-4, pp. 181 - 197
Genomics Fibroblast | HIF1 protein | Hypoxia | CDNA microarray | Genetics & Heredity | Life Sciences & Biomedicine | Biotechnology & Applied Microbiology | Science & Technology | cobalt chloride
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9. Full Text Hypoxia‐inducible factor 1α promotes interleukin 1β and tumour necrosis factor α expression in lipopolysaccharide‐stimulated human dental pulp cells
by Fujii, M and Kawashima, N and Tazawa, K and Hashimoto, K and Nara, K and Noda, S and Nagai, S and Okiji, T
International endodontic journal, ISSN 0143-2885, 05/2020, Volume 53, Issue 5, pp. 636 - 646
human dental pulp cells | lipopolysaccharide | HIF1α | pro‐inflammatory cytokine | NFκB signalling | Life Sciences & Biomedicine | Dentistry, Oral Surgery & Medicine | Science & Technology | NF-kappa B | Humans | Cells, Cultured | Hypoxia | Interleukin-1beta | Dental Pulp | Tumor Necrosis Factor-alpha | Lipopolysaccharides | Oxygen | Cytokines | Immunocytochemistry | Inflammation | Tumor necrosis factor-α | Gene expression | Western blotting | Transfection | Interleukin 1 | Tumor necrosis factor-TNF | Prolyl hydroxylase | Expression vectors | Tumors | Dental pulp | Dentistry
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10. Full Text SIRT1 and HIF1α signaling in metabolism and immune responses
by Yu, Qing and Dong, Lin and Li, Yan and Liu, Gaungwei
Cancer letters, ISSN 0304-3835, 04/2018, Volume 418, pp. 20 - 26
Immune cell differentiation | Glycolytic signal | Innate immunity | Adaptive immunity | Metabolism | Immune cell functions | HIF1α | SIRT1 | Life Sciences & Biomedicine | Oncology | Science & Technology | Index Medicus
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