X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
hif1-alpha (126) 126
index medicus (73) 73
humans (59) 59
hypoxia (58) 58
expression (47) 47
oncology (35) 35
hypoxia-inducible factor 1, alpha subunit - metabolism (34) 34
animals (32) 32
cancer (29) 29
male (28) 28
cell biology (26) 26
female (25) 25
hif1-α (24) 24
biochemistry & molecular biology (23) 23
angiogenesis (21) 21
hif-1-alpha (21) 21
cell line, tumor (20) 20
mice (19) 19
apoptosis (18) 18
metabolism (17) 17
middle aged (17) 17
hypoxia-inducible factor 1, alpha subunit - genetics (16) 16
immunohistochemistry (16) 16
tumors (16) 16
activation (15) 15
gene expression (15) 15
adult (14) 14
proteins (14) 14
aged (13) 13
cells (13) 13
growth (12) 12
medicine, research & experimental (12) 12
survival (12) 12
analysis (11) 11
metastasis (11) 11
prognosis (11) 11
article (10) 10
differentiation (10) 10
gene (10) 10
hif (10) 10
hif-2-alpha (10) 10
protein (10) 10
binding (9) 9
biology (9) 9
biophysics (9) 9
gene expression regulation, neoplastic (9) 9
hif-1 alpha (9) 9
hif-1α (9) 9
hypoxia-inducible factors (9) 9
physiology (9) 9
proliferation (9) 9
research (9) 9
rna (9) 9
signal transduction (9) 9
cell hypoxia (8) 8
cell proliferation (8) 8
glycolysis (8) 8
hif-1 (8) 8
kidney neoplasms - metabolism (8) 8
multidisciplinary sciences (8) 8
mutation (8) 8
overexpression (8) 8
pathway (8) 8
pheochromocytoma (8) 8
rats (8) 8
carcinoma, renal cell - metabolism (7) 7
genes (7) 7
inhibition (7) 7
medicine (7) 7
paraganglioma (7) 7
pathology (7) 7
stem-cells (7) 7
therapy (7) 7
transfection (7) 7
biomarkers (6) 6
development and progression (6) 6
endocrinology & metabolism (6) 6
enzymes (6) 6
factor 1-alpha (6) 6
gene-expression (6) 6
genetics & heredity (6) 6
hypoxia-inducible factor 1 (6) 6
hypoxia-inducible factor-1-alpha (6) 6
medical prognosis (6) 6
paraganglioma - genetics (6) 6
pharmacology & pharmacy (6) 6
physiological aspects (6) 6
research paper (6) 6
succinate dehydrogenase - genetics (6) 6
transcription (6) 6
vegf (6) 6
vhl (6) 6
adolescent (5) 5
aged, 80 and over (5) 5
alpha (5) 5
basic helix-loop-helix transcription factors - metabolism (5) 5
cancer-cells (5) 5
carcinoma (5) 5
cell survival (5) 5
chemotherapy (5) 5
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


CANCER RESEARCH, ISSN 0008-5472, 05/2019, Volume 79, Issue 10, pp. 2564 - 2579
We hypothesized that candidate dependencies for which there are small molecules that are either approved or in advanced development for a nononcology... 
HYPOXIA-INDUCIBLE-FACTOR-1-ALPHA | HIF PROLYL HYDROXYLASES | GENE | ONCOLOGY | ANEMIA | HIF-1-ALPHA | HYPOXIA | SUPPRESSION | ROXADUSTAT FG-4592 | EXPRESSION | HIF1-ALPHA
Journal Article
CANCER RESEARCH, ISSN 0008-5472, 10/2003, Volume 63, Issue 19, pp. 6130 - 6134
Tumor hypoxia induces the up-regulation of a gene program associated with angiogenesis, glycolysis, adaptation to pH, and apoptosis via the hypoxia-inducible... 
ACTIVATION | DOMAIN | HIF | FACTOR-1-ALPHA | ANGIOGENESIS | ONCOLOGY | INDUCTION | TUMOR-GROWTH | EXPRESSION | HIF1-ALPHA | CARCINOMA
Journal Article
Cancer Cell, ISSN 1535-6108, 06/2013, Volume 23, Issue 6, pp. 739 - 752
Journal Article
Gene, ISSN 0378-1119, 08/2019, Volume 711, p. 143938
The pathogenesis of endometrial cancer (EC) involves many regulatory pathways including transcriptional regulatory networks supported by transcription factors... 
Estrogen receptor | Obesity | HIF1-α | Endometrial cancer | SLUG | miR-221 | MECHANISM | MESENCHYMAL TRANSITION | MICRORNA-221 | SLUG EXPRESSION | PATHWAY | GENETICS & HEREDITY | MIRNAS | HIF1-alpha
Journal Article
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, ISSN 2212-4403, 01/2019, Volume 127, Issue 1, pp. e8 - e17
Intratumoral hypoxia (IH) occurs during cellular proliferation of malignant tumors. This phenomenon is characterized by a decrease in oxygen levels in the... 
BREAST-CANCER | SURVIVAL | INVADOPODIA | HEAD | HYPOXIA-INDUCIBLE FACTOR-1-ALPHA | SRC | DENTISTRY, ORAL SURGERY & MEDICINE | GROWTH-FACTOR | EXPRESSION | HIF1-ALPHA
Journal Article
by Liu, PF and Gu, Y and Luo, J and Ye, P and Zheng, YG and Yu, WD and Chen, SL
EXPERIMENTAL CELL RESEARCH, ISSN 0014-4827, 07/2019, Volume 380, Issue 1, pp. 36 - 46
Pulmonary arterial hypertension (PAH) is a diffuse pulmonary microvascular remodeling disease accompanied by malignant proliferation of pulmonary artery smooth... 
Pulmonary arterial remodeling | MIGRATION | Berberine | APOPTOSIS | CELLS | ERYTHROPOIETIN | INDUCIBLE FACTOR-I | Src | RECEPTOR | PROLIFERATION | Pulmonary hypertension | CELL BIOLOGY | PP1 | ONCOLOGY | THERAPEUTIC TARGETS | HIF1-alpha | C-SRC | KINASES
Journal Article
BBA - Molecular Basis of Disease, ISSN 0925-4439, 07/2017, Volume 1863, Issue 7, pp. 1805 - 1816
Long noncoding RNAs (lncRNAs) have been shown to play important roles in various cancers. However, the clinical significances and biological roles of lncRNAs... 
Hepatocellular carcinoma | Proliferation | Metastasis | YBX1 | Long noncoding RNA | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | RISK | TRANSLATIONAL ACTIVATION | HIF1-ALPHA | YB-1 PROMOTES | BIOPHYSICS | GROWTH | OSTEOSARCOMA | CANCER STATISTICS | RECURRENCE | Development and progression | Antisense RNA | Hepatoma | Genetic translation | Analysis | Genetic transcription
Journal Article
American Journal of Surgical Pathology, ISSN 0147-5185, 11/2011, Volume 35, Issue 11, pp. 1712 - 1721
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 06/2013, Volume 22, Issue 11, pp. 2169 - 2176
Journal Article
Journal Article
International Journal of Cancer, ISSN 0020-7136, 07/2016, Volume 139, Issue 2, pp. 396 - 403
In our study, we demonstrate that ccRCC cell lines with impaired function of pVHL to degrade HIFα express elevated levels of PD‐L1. In vitro analysis provided... 
ccRCC | HIF | pVHL | PD‐L1 | PD-L1 | CANCER-CELLS | PATHWAYS | ANTIBODY | IDENTIFICATION | HIF1-ALPHA | ESCAPE | TUMOR-SUPPRESSOR PVHL | THERAPY | ONCOLOGY | MUTATIONS | BLOCKADE | Immunohistochemistry | Gene Expression | Kidney Neoplasms - genetics | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Humans | Gene Expression Regulation, Neoplastic | Gene Silencing | Carcinoma, Renal Cell - genetics | Kidney Neoplasms - metabolism | B7-H1 Antigen - genetics | Case-Control Studies | Carcinoma, Renal Cell - metabolism | B7-H1 Antigen - metabolism | B7-H1 Antigen - blood | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Cell Line, Tumor | Von Hippel-Lindau Tumor Suppressor Protein - genetics | Mutation | Analysis | Cancer | Chemotherapy | Rodents | Kidney cancer | Hypoxia | Ligands | T cell receptors | Apoptosis | Drugs | Biotechnology | Hypoxia-inducible factor 1 | Correlation | Target recognition | PD-1 protein | Genes | Lymphocytes T | In vitro testing | Drug delivery | Inactivation | Immunosuppressive agents | Degradation | Inhibition | Hypoxia-inducible factors | Deactivation | Mortality | Immunosurveillance | Tumor cell lines | Patients | Surveillance | Cell death | PD-L1 protein | Reagents | VHL protein | Aberration | Neoplasia | Clear cell-type renal cell carcinoma | Tumors | Kidney transplantation
Journal Article