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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, ISSN 0002-7863, 07/2019, Volume 141, Issue 28, pp. 10948 - 10952
Chemically induced dimerization (CID) systems, in which two proteins dimerize only in the presence of a small molecule ligand, offer versatile tools for small... 
ANTIBODIES | HIGH-AFFINITY | ACTIVATION | LIGAND-BINDING PROTEINS | CHEMISTRY, MULTIDISCIPLINARY
Journal Article
Chemical Engineering Journal, ISSN 1385-8947, 01/2020, Volume 380
The effective removal of radioactive vapor wastes in fission is of significant importance and numerous porous solids have been developed to control volatile... 
High affinity | Porous organic polymers | Iodine capture | Ferrocene
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2018, Volume 61, Issue 19, pp. 8797 - 8810
While the treatment of gastrointestinal stromal tumors (GISTs) has been revolutionized by the application of targeted tyrosine kinase inhibitors capable of... 
CHEMISTRY, MEDICINAL | IMATINIB | REGORAFENIB | HIGH-AFFINITY | SUNITINIB | MUTATIONS | SHOW | SELECTION
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 04/2010, Volume 333, Issue 1, pp. 328 - 340
Cariprazine {RGH-188; trans-N-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-N',N'-dimethylurea hydrochloride}, a novel candidate antipsychotic,... 
MODELS | SB-277011-A | HALOPERIDOL | DRUGS | HIGH-AFFINITY | UNIQUE | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY | RAT-BRAIN | BINDING | ARIPIPRAZOLE
Journal Article
Biological Psychiatry, ISSN 0006-3223, 04/2018, Volume 83, Issue 8, pp. 635 - 637
Journal Article
NATURE, ISSN 0028-0836, 07/2008, Volume 454, Issue 7203, pp. 486 - 491
G-protein-coupled receptors have a major role in transmembrane signalling in most eukaryotes and many are important drug targets. Here we report the 2.7... 
AGONIST ACTIVATION | BETA-ADRENERGIC-RECEPTORS | 2ND EXTRACELLULAR LOOP | CRYSTAL-STRUCTURE | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | BETA-1-ADRENERGIC RECEPTOR | HIGH-AFFINITY BINDING | MUSCARINIC RECEPTOR | PROVIDE EVIDENCE | BETA-ADRENERGIC RECEPTOR
Journal Article
CHEMICAL REVIEWS, ISSN 0009-2665, 01/2016, Volume 116, Issue 2, pp. 719 - 766
Diverse radiochemistry is an essential component of nuclear medicine; this includes imaging techniques such as positron emission tomography (PET). As such, PET... 
CROSS-COUPLING REACTIONS | COPPER-MEDIATED FLUORINATION | F BOND FORMATION | F-18 ACETYL HYPOFLUORITE | HIGH-AFFINITY RADIOLIGAND | NICOTINIC ACETYLCHOLINE-RECEPTORS | ELECTRON-RICH ARENES | IN-VIVO EVALUATION | CHEMISTRY, MULTIDISCIPLINARY | HIGH-YIELD SYNTHESIS | NUCLEOPHILIC AROMATIC-SUBSTITUTION
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 12/2017, Volume 174, Issue S1, pp. S17 - S129
The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective... 
HIGH-AFFINITY | PHARMACOLOGY & PHARMACY | POTENT | SERIES | ANTAGONISTS | AGONIST | Pharmacology | G proteins | G protein-coupled receptors | Nomenclature | Ion channels (ligand-gated) | Ligands | Ions | Ion channels | Nuclear receptors | Index Medicus | The Concise Guide to Pharmacology 2017
Journal Article
Journal Article
by Lin, AF and Hu, QS and Li, CL and Xing, Z and Ma, GL and Wang, C and Li, J and Ye, Y and Yao, J and Liang, K and Wang, SY and Park, PK and Marks, JR and Zhou, Y and Zhou, JW and Hung, MC and Liang, H and Hu, ZB and Shen, HB and Hawke, DH and Han, L and Zhou, YB and Lin, CR and Yang, LQ
NATURE CELL BIOLOGY, ISSN 1465-7392, 03/2017, Volume 19, Issue 3, pp. 238 - 251
Phosphatidylinositol-3,4,5-trisphosphate (Ptdlns(3,4,5)P-3 or PIP3) mediates signalling pathways as a second messenger in response to extracellular signals.... 
BREAST-CANCER | INOSITOL PHOSPHATES | IN-VITRO | PROTEIN-KINASE-B | LONG NONCODING RNA | SOLID TUMORS | SIGNALING PATHWAY | PLECKSTRIN HOMOLOGY DOMAIN | GLOBAL ANALYSIS | HIGH-AFFINITY BINDING | CELL BIOLOGY
Journal Article
IMMUNITY, ISSN 1074-7613, 06/2017, Volume 46, Issue 6, pp. 1005 - 1005
CCR5 is the primary chemokine receptor utilized by HIV to infect leukocytes, whereas CCR5 ligands inhibit infection by blocking CCR5 engagement with HIV gp120.... 
AMINO-TERMINAL DOMAIN | CORECEPTOR | ENTRY | RANTES | CRYSTAL-STRUCTURE | IMMUNODEFICIENCY-VIRUS TYPE-1 | HIGH-AFFINITY BINDING | N-TERMINUS | GP120 | IMMUNOLOGY | MEMBRANE-PROTEINS
Journal Article
FEBS Letters, ISSN 0014-5793, 05/2015, Volume 589, Issue 13, pp. 1406 - 1411
Biselyngbyasides (BLSs), macrolides from a marine cyanobacterium, are cytotoxic natural products whose target molecule is unknown. Here we report that BLSs are... 
High affinity | Ion pump | Inhibitor | Ca2+-ATPase | Macrolide | Crystal structure
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 6/2019, Volume 39, Issue 6, pp. 1138 - 1147
Translocator protein 18 kDa (TSPO) has been widely imaged as a marker of neuroinflammation using several radioligands, including [11C]PBR28. In order to study... 
mixed-affinity binder | high-affinity binder | [ | Translocator protein | C]PBR28 | distribution volume
Journal Article
17.