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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, ISSN 0960-894X, 07/2014, Volume 24, Issue 14, pp. 3164 - 3167
In order to probe the energetics associated with a putative cation-it interaction, thermodynamic parameters are determined for complex formation between the... 
Protein-ligand interactions | CARBONIC-ANHYDRASE | CHEMISTRY, MEDICINAL | HIGH-AFFINITY | CHEMISTRY, ORGANIC | ENTHALPY-ENTROPY COMPENSATION | AROMATIC RINGS | Binding thermodynamics | X-ray crystallography | SH2 DOMAIN | BINDING-AFFINITY | Molecular recognition | BIOLOGICAL RECOGNITION | OPTIMIZATION | Structure | INTERMOLECULAR INTERACTIONS
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2012, Volume 287, Issue 52, pp. 43694 - 43707
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 10/2009, Volume 158, Issue 4, pp. 1153 - 1164
Background and purpose:  ABC multidrug transporters (MDR-ABC proteins) cause multiple drug resistance in cancer and may be involved in the decreased... 
ADME-Tox | CML | TKI | ABCB1 | Bcr-Abl | MDR | ABCG2 | ADME‐Tox | Bcr‐Abl | CHRONIC MYELOGENOUS LEUKEMIA | MULTIDRUG TRANSPORTER | DRUG-RESISTANCE | CHRONIC MYELOID-LEUKEMIA | P-GLYCOPROTEIN | TYROSINE KINASE INHIBITORS | HIGH-AFFINITY INTERACTION | HEMATOPOIETIC STEM-CELLS | PHARMACOLOGY & PHARMACY | IMATINIB MESYLATE | ATP Binding Cassette Transporter, Sub-Family G, Member 2 | Thiazoles - metabolism | Nitriles - pharmacology | Aniline Compounds - metabolism | Protein-Tyrosine Kinases - metabolism | Drug Resistance, Multiple - drug effects | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Substrate Specificity | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Thiazoles - therapeutic use | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Neoplasm Proteins - metabolism | Cyclosporins - pharmacology | Pyrimidines - metabolism | Quinolines - pharmacology | Dose-Response Relationship, Drug | ATP-Binding Cassette Transporters - metabolism | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Dasatinib | Nitriles - metabolism | Aniline Compounds - pharmacology | Pyrimidines - pharmacology | Neoplasms - drug therapy | Quinolines - metabolism | Pyrimidines - therapeutic use | K562 Cells | Cell Line, Tumor | ATP Binding Cassette Transporter, Sub-Family B | Protein Kinase Inhibitors - pharmacology | Quinolines - therapeutic use | Thiazoles - pharmacology | Aniline Compounds - therapeutic use | Fusion Proteins, bcr-abl - metabolism | ATP-Binding Cassette Transporters - antagonists & inhibitors | Nitriles - therapeutic use | Index Medicus | Research Papers
Journal Article
Chemical Science, ISSN 2041-6520, 12/2014, Volume 5, Issue 12, pp. 4851 - 4862
Metal ion homeostasis in conjunction with amyloid-beta (A beta) aggregation in the brain has been implicated in Alzheimer's disease (AD) pathogenesis. To... 
OXIDATIVE STRESS | SMALL MOLECULES | ALZHEIMERS-DISEASE | DIPHENYLPROPYNONE DERIVATIVES | HIGH-AFFINITY | COPPER | FLAVONOIDS | ALPHA-SYNUCLEIN | BINDING | CHEMISTRY, MULTIDISCIPLINARY | AGGREGATION | Binding | Flavonoids | Chelation | In vitro testing | Entropy | Catechol | Agglomeration | Inclusions
Journal Article
The EMBO Journal, ISSN 0261-4189, 04/2005, Volume 24, Issue 8, pp. 1512 - 1522
Journal Article
Nature Communications, ISSN 2041-1723, 12/2016, Volume 7, Issue 1, pp. 13855 - 13855
Bromodomains are critical components of many chromatin modifying/remodelling proteins and are emerging therapeutic targets, yet how they interact with... 
TARGET GENES | DOMAIN | STRUCTURAL BASIS | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | TRANSCRIPTION | CHROMATIN MODIFICATIONS | HISTONE H4 | HIGH-AFFINITY BINDING | CORE PARTICLE | FAMILY | Index Medicus
Journal Article
ChemBioChem, ISSN 1439-4227, 02/2013, Volume 14, Issue 3, pp. 332 - 342
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 01/2016, Volume 136, Issue 2, pp. 262 - 275
The astroglial glutamate transporter GLT‐1 shows selective expression in astrocytes and its expression can be induced by neurons. In this study, we demonstrate... 
Pax6 | astrocytes | transcriptional regulation | GLT | glutamate transport | EAAT | EAAT2 | GLT-1 | DIFFERENTIAL EXPRESSION | SUBTYPES | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIGH-AFFINITY | NEUROLOGICAL DISORDERS | GLUTAMATE TRANSPORTER EXPRESSION | NEUROSCIENCES | HETEROGENEITY | IN-VITRO | RAT-BRAIN | NF-KAPPA-B | CNS DEVELOPMENT | Paired Box Transcription Factors - genetics | RNA, Small Interfering - genetics | Coculture Techniques | Homeodomain Proteins - metabolism | Humans | Repressor Proteins - pharmacology | Glial Fibrillary Acidic Protein - metabolism | Gangliosides - metabolism | Neurons - physiology | Electrophoretic Mobility Shift Assay | Excitatory Amino Acid Transporter 2 - genetics | Eye Proteins - genetics | Homeodomain Proteins - pharmacology | Repressor Proteins - metabolism | Animals, Newborn | Astrocytes - drug effects | Brain - cytology | Transduction, Genetic | Paired Box Transcription Factors - pharmacology | Gene Expression Regulation - genetics | RNA, Small Interfering - pharmacology | Cells, Cultured | Gene Expression Regulation - physiology | Repressor Proteins - genetics | Mice, Transgenic | PAX6 Transcription Factor | Excitatory Amino Acid Transporter 2 - metabolism | Homeodomain Proteins - genetics | Gene Expression Regulation - drug effects | Animals | Eye Proteins - metabolism | Enhancer Elements, Genetic - genetics | Enhancer Elements, Genetic - physiology | Glutamic Acid - metabolism | Mice | Paired Box Transcription Factors - metabolism | Astrocytes - metabolism | Eye Proteins - pharmacology | Glutamate | Analysis | Genetic engineering | Neurochemistry | Protein expression | Transcription factors | Neurotransmitters | Index Medicus
Journal Article