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1,3-dipolar cycloaddition (5) 5
highly functionalized dispiropyrrolidines (5) 5
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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 11/2016, Volume 24, Issue 22, pp. 5873 - 5883
A facile stereoselective synthesis of novel dispiro indeno pyrrolidine/pyrrolothiazole–thiochroman hybrids has been achieved by 1,3-dipolar cycloaddition of... 
1,3-Dipolar cycloaddition | M. tuberculosis H37Rv | AchE inhibition | Azomethine ylides | Dispiro heterocycles | CCRF-CEM | M. tuberculosis H | M. tuberculosis HRv | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | EXPEDIENT SYNTHESIS | EFFICIENT SYNTHESIS | CHEMISTRY, ORGANIC | POTENT INHIBITORS | HIGHLY FUNCTIONALIZED DISPIROPYRROLIDINES | PYRROLIDINE | HUMAN STEROID SULFATASE | REGIOSELECTIVE SYNTHESIS | 3-COMPONENT | DERIVATIVES | Stereoisomerism | Antineoplastic Agents - chemical synthesis | Humans | Cholinesterase Inhibitors - chemistry | Cholinesterase Inhibitors - chemical synthesis | Structure-Activity Relationship | Indenes - chemistry | Mycobacterium tuberculosis - drug effects | Pyrrolidines - pharmacology | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Anti-Bacterial Agents - chemistry | Antineoplastic Agents - pharmacology | Molecular Structure | Chromones - pharmacology | Spiro Compounds - chemistry | Cell Survival - drug effects | Indenes - pharmacology | Models, Molecular | Antineoplastic Agents - chemistry | Pyrrolidines - chemistry | Anti-Bacterial Agents - chemical synthesis | Chromones - chemistry | Cholinesterase Inhibitors - pharmacology | Cell Line, Tumor | Thiazoles - chemistry | Anti-Bacterial Agents - pharmacology | Cell Proliferation - drug effects | Thiazoles - pharmacology | Acetylcholinesterase - metabolism | Spiro Compounds - pharmacology | Drug Screening Assays, Antitumor | Care and treatment | Analysis | Cancer
Journal Article
Synthetic Communications, ISSN 0039-7911, 06/2017, Volume 47, Issue 11, pp. 1090 - 1095
Indanones 3 were prepared from the reaction of indanone (1) with corresponding benzaldehyde derivatives 2, as described in the literature. Then, indenones 3... 
Michael addition | malononitrile | Indenones | phase-transfer catalyst | CHEMISTRY, ORGANIC | ALPHA,BETA-UNSATURATED IMIDES | CATALYST | HIGHLY FUNCTIONALIZED DISPIROPYRROLIDINES | CHALCONE DERIVATIVES | REGIOSELECTIVE SYNTHESIS | CHEMISTRY | CONJUGATE ADDITIONS | FACILE 3-COMPONENT
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