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Insect molecular biology, ISSN 0962-1075, 04/2018, Volume 27, Issue 2, pp. 198 - 211
Journal Article
Biochemical journal, ISSN 1470-8728, 2007, Volume 408, Issue 3, pp. 297 - 315
The specificities of 65 compounds reported to be relatively specific inhibitors of protein kinases have been profiled against a panel of 70-80 protein kinases... 
Drug discovery | Kinase profiling | Protein kinase | Anti-cancer drugs | Inhibitor specificity | RHO-ASSOCIATED KINASE | TUMOR PROGRESSION | FAMILY-MEMBERS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL-PROLIFERATION | protein kinase | P38 MAP KINASE | CYCLIN-DEPENDENT KINASES | RECEPTOR TYROSINE KINASES | drug discovery | kinase profiling | SB 203580 | anti-cancer drugs | ISOFORMS IN-VITRO | P90 RSK | inhibitor specificity | Amino Acid Sequence | Cell Line | Phosphorylation | Recombinant Proteins - antagonists & inhibitors | Animals | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Humans | Drug Design | Protein Kinase Inhibitors - pharmacology | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Spodoptera | Yes1, Yamaguchi sarcoma viral oncogene homologue 1 | CSK, C-terminal Src kinase | Lck, lymphocyte cell-specific protein-tyrosine kinase | EGF, epidermal growth factor | FGF-R, fibroblast-growth-factor receptor | PAK, p21-activated protein kinase | PDK, 3-phosphoinositide-dependent protein kinase | PI3K, phosphatidylinositol (phosphoinositide) 3-kinase | NEK, NIMA (never in mitosis in Aspergillus nidulans)-related kinase | RSK, p90 ribosomal S6 kinase | HEK-293 cells, human embryonic kidney-293 cells | VEGF, vascular endothelial growth factor (vasoendothelial growth factor) | EF2K, elongation-factor-2 kinase | CK, casein kinase | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | ATM, ataxia telangiectasia mutated | SRPK, serine-arginine protein kinase | IL-1, interleukin 1 | MNK, MAPK-integrating protein kinase | ROCK, Rho-dependent protein kinase | CaMKK, CaMK kinase | GST, glutathione transferase | MKK1, MAPK kinase-1 (also called MEK1, MAPK or ERK kinase 1) | GAK, cyclin G-associated kinase | FMK, fluoromethylketone | MST, mammalian homologue Ste20-like kinase | PKA, cAMP-dependent protein kinase | FKBP, FK506-binding protein | PPAR, peroxisome-proliferator-activated receptor | IKK, inhibitory κB kinase | PH, pleckstrin homology | MBP, myelin basic protein | AICAR, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside | MAPKAP-K, MAPK-activated protein kinase | Sf21, Spodoptera frugiperda (fall armyworm) 21 | MARK, microtubule-affinity-regulating kinase | PIM, provirus integration site for Moloney murine leukaemia virus | LPS, lipopolysaccharide | MSK, mitogen- and stress-activated protein kinase | MAPK, mitogen-activated protein kinase | MELK, maternal embryonic leucine-zipper kinase | His6, hexahistidine | CAK, cyclin-dependent kinase-activating kinase | Eph-A2, Ephrin A2 receptor | PLK, polo-like kinase | ATF2, activating transcription factor 2 | PKD, protein kinase D | Src, sarcoma kinase | AMPK, AMP-activated protein kinase | MMS, methyl methanesulfonate | CHK, checkpoint kinase | JNK, c-Jun N-terminal kinase | TORC1, mTOR (mammalian target of rapamycin)–raptor (regulatory associated protein of mTOR) complex | BRSK, brain-specific kinase | RIP2, receptor-interacting protein 2 | IGF-1, insulin-like growth factor-1 | S6K1, S6 kinase 1 | DYRK, dual-specificity tyrosine-phosphorylated and -regulated kinase | HIPK, homeodomain-interacting protein kinase | ZMP, aminoimidazole-4-carboxamide-1-β-D-ribofuranoside monophosphate | PRAK, p38-regulated activated kinase | PKC, protein kinase C | Src-I1, Src inhibitor 1 | TANK, TRAF (tumour-necrosis-factor-receptor-associated factor)-family-member-associated nuclear factor κB activator | NFAT, nuclear factor for activated T-cells | PHK, phosphorylase kinase | GSK3, glycogen synthase kinase 3 | PKB, protein kinase B (also called Akt) | CaMK, calmodulin-dependent kinase | CDK, cyclin-dependent protein kinase | NDRG, N-myc downstream-regulated gene | SmMLCK, smooth-muscle myosin light-chain kinase | TBK1, TANK-binding kinase 1 | PRK, protein kinase C-related kinase | SGK, serum- and glucocorticoid-induced kinase
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, ISSN 0167-4889, 10/2019, Volume 1866, Issue 10, pp. 1676 - 1686
The three canonical members of the family of homeodomain-interacting protein (HIP) kinases fulfill overlapping and distinct roles in cellular stress response pathways... 
Phosphorylation | ACTIVATION | Nucleocytoplasmic shuttling | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | SUBCELLULAR-LOCALIZATION | HIPKs | INDUCED DESUMOYLATION | P53 | CELL BIOLOGY | Signaling | CYTOPLASMIC TRANSLOCATION | HIPK FAMILY | DEGRADATION | CATALYTIC-ACTIVITY | EXPRESSION
Journal Article
Disease models & mechanisms, ISSN 1754-8411, 2018, Volume 11, Issue 1, p. dmm031146
.... Homeodomain-interacting protein kinase (Hipk) family members are reported to have distinct and contradictory effects on cell proliferation and tissue growth... 
Tumor | Metastasis | Hipk | Cancer | ACTIVATION | INCREASED EXPRESSION | IMAGINAL DISCS | DROSOPHILA-MELANOGASTER | PROLIFERATION | PATHOLOGY | BETA-CATENIN | HIPK2 | CELL BIOLOGY | PATHWAY | TUMOR-SUPPRESSOR | Dros
Journal Article
Current topics in developmental biology, ISSN 0070-2153, 2017, Volume 123, pp. 73 - 103
The Homeodomain-interacting protein kinase (Hipk) family of proteins plays diverse, and at times conflicting, biological roles in normal development and disease... 
Signal transduction | Kinase | Oncogene | Wnt | Developmental roles | Tumor suppressor | Hipk | Hipk2 | p53 | Protein Kinases - metabolism | Animals | Disease | Signal Transduction | Models, Biological | Homeodomain Proteins - metabolism | Humans | Embryonic Development
Journal Article
Journal Article
FEBS letters, ISSN 0014-5793, 2007, Volume 581, Issue 29, pp. 5649 - 5657
We describe here the cloning and characterization of a novel mouse homeodomain-interacting protein kinase (HIPK)-like gene, Hipk4... 
Transcription | Kinase | Tumor suppressor | p53 | Apoptosis | national center for biotechnology information | homeodomain-interacting protein kinase | mouse double minute 2 homolog | BCL2-associated X protein | myelin basic protein | green fluorescent protein | GFP | ultraviolet | NCBI | MDM2 | BAX | MBP | glyceraldehyde-3-phosphate dehydrogenase | HIPK | GAPDH | WILD-TYPE P53 | LOCALIZATION | ACTIVATION | transcription | SURVIVIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | tumor suppressor | apoptosis | HISTONE H3 PHOSPHORYLATION | CELL BIOLOGY | kinase | BIOPHYSICS | GENE | Protein-Serine-Threonine Kinases - analysis | Cell Proliferation | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | Humans | Molecular Sequence Data | Neoplasm Proteins - metabolism | Cloning, Molecular | Cell Differentiation | Catalysis | Neoplasm Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | bcl-2-Associated X Protein - genetics | Amino Acid Sequence | Promoter Regions, Genetic | Inhibitor of Apoptosis Proteins | Protein-Serine-Threonine Kinases - genetics | Tumor Suppressor Protein p53 - metabolism | bcl-2-Associated X Protein - metabolism | Serine - genetics | Serine - metabolism | Sequence Alignment | Animals | Mice | DNA, Complementary - metabolism | Threonine | Tumor proteins | Protein kinases | Serine
Journal Article