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1. Full Text The Hippo signaling pathway in stem cell biology and cancer
by Mo, Jung‐Soon and Park, Hyun Woo and Guan, Kun‐Liang
EMBO reports, ISSN 1469-221X, 06/2014, Volume 15, Issue 6, pp. 642 - 656
The Hippo signaling pathway, consisting of a highly conserved kinase cascade (MST and Lats) and downstream transcription coactivators (YAP and TAZ), plays a... 
YAP | cancer | Hippo pathway | stem cell | regeneration | YES-ASSOCIATED PROTEIN | TISSUE-GROWTH | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIOMYOCYTE PROLIFERATION | SELF-RENEWAL | MAMMALIAN DEVELOPMENT | CELL BIOLOGY | NUCLEAR-LOCALIZATION | ORGAN SIZE | YAP ONCOPROTEIN | TUMOR-SUPPRESSOR PATHWAY | PROMOTES APOPTOSIS | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Humans | Liver - metabolism | Nervous System - metabolism | Embryonic Development - physiology | Intestines - metabolism | Regeneration - physiology | Models, Biological | Homeostasis - physiology | Signal Transduction - physiology | Stem Cells - physiology | Neoplasms - physiopathology | Protein-Serine-Threonine Kinases - metabolism | Homeostasis | Kinases | Stem cells | Cancer | Reviews
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2. Full Text The Hippo-YAP signaling pathway and contact inhibition of growth
by Gumbiner, Barry M and Kim, Nam-Gyun
Journal of Cell Science, ISSN 0021-9533, 02/2014, Volume 127, Issue 4, pp. 709 - 717
The Hippo-YAP pathway mediates the control of cell proliferation by contact inhibition as well as other attributes of the physical state of cells in tissues.... 
Polarity | YAP | Mechanotransduction | Cadherin | Hippo | Mitogenesis | YES-ASSOCIATED PROTEIN | SIZE CONTROL | ADHESION MOLECULE UVOMORULIN | CELL-ADHESION | PROLIFERATION | TRANSCRIPTIONAL COACTIVATOR | CELL BIOLOGY | ALPHA-CATENIN | PREIMPLANTATION EMBRYOS | TUMOR-SUPPRESSOR | Transcription Factors - metabolism | Cell Polarity | Animals | Cell Proliferation | Signal Transduction | Humans | Cell Communication | Nuclear Proteins - metabolism | Cell Adhesion | Protein-Serine-Threonine Kinases - metabolism | Intercellular Signaling Peptides and Proteins - physiology
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3. Full Text The Hippo signaling pathway and stem cell biology
by Ramos, Azucena and Camargo, Fernando D
Trends in Cell Biology, ISSN 0962-8924, 2012, Volume 22, Issue 7, pp. 339 - 346
Stem cell (SC) activity fluctuates throughout an organism's lifetime to maintain homeostatic conditions in all tissues. As animals develop and age, their... 
Pathology | stem cells | Yap | Hippo signaling | tumorigenesis | size regulation | regeneration | Regeneration | Tumorigenesis | Size regulation | Stem cells | CARDIOMYOCYTE PROLIFERATION | SELF-RENEWAL | DROSOPHILA | CELL BIOLOGY | ORGAN SIZE | CYCLE EXIT | ALPHA-CATENIN | YAP ONCOPROTEIN | GROWTH-FACTOR | TUMOR-SUPPRESSOR PATHWAY | PROMOTES APOPTOSIS | Drosophila melanogaster - metabolism | Animals | Cell Proliferation | Signal Transduction | Humans | Drosophila melanogaster - cytology | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Stem Cells - metabolism | Protein-Serine-Threonine Kinases - metabolism | Physiological aspects | Analysis
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4. Full Text Signaling pathway cooperation in TGF-β-induced epithelial–mesenchymal transition
by Derynck, Rik and Muthusamy, Baby Periyanayaki and Saeteurn, Koy Y
Current Opinion in Cell Biology, ISSN 0955-0674, 2014, Volume 31, pp. 56 - 66
Transdifferentiation of epithelial cells into cells with mesenchymal properties and appearance, that is, epithelial–mesenchymal transition (EMT), is essential... 
Internal Medicine | CROSS-TALK | TRANSCRIPTION FACTORS | GROWTH-FACTOR-BETA | GLYCOGEN-SYNTHASE KINASE-3 | PROSTATE-CANCER CELLS | ENDOTHELIAL-CELLS | HIPPO PATHWAY | DIFFERENTIAL REGULATION | UP-REGULATION | MEDIATED PHOSPHORYLATION | CELL BIOLOGY | Animals | Epithelial Cells - metabolism | Signal Transduction | Humans | Epithelial-Mesenchymal Transition | Embryonic Development | Fibrosis - pathology | Epithelial Cells - cytology | Neoplasms - pathology | Transforming Growth Factor beta - metabolism
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5. Full Text The Hippo Signaling Pathway in Pancreatic Cancer
by Ansari, D and Ohlsson, H and Althini, C and Bauden, M and Zhou, QM and Hu, DY and Andersson, R
ANTICANCER RESEARCH, ISSN 0250-7005, 07/2019, Volume 39, Issue 7, pp. 3317 - 3321
Hippo signaling is a key regulator of organ size, tissue hemostasis and regeneration. Dysregulation of the Hippo pathway has been recognized in a variety of... 
immunomodulation | treatment | CELLS | stroma | YAP | PROLIFERATION | Pancreatic Cancer | TAZ | EMT | EPITHELIAL-MESENCHYMAL TRANSITION | chemoresistance | INVASION | Hippo pathway | tumor progression | ONCOLOGY | YAP/TAZ | review | PROMOTES | TUMORIGENESIS | Stellate cells | Transcription | Chemoresistance | Macrophages | Suppressor cells | Yes-associated protein | Regeneration | Signaling | Signal transduction | Molecular modelling | Hemostasis | Pancreatic cancer | Hemostatics | Tumors | Cancer
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6. Full Text The Spectrin cytoskeleton regulates the Hippo signalling pathway
by Fletcher, Georgina C and Elbediwy, Ahmed and Khanal, Ichha and Ribeiro, Paulo S and Tapon, Nic and Thompson, Barry J
The EMBO Journal, ISSN 0261-4189, 04/2015, Volume 34, Issue 7, pp. 940 - 954
The Spectrin cytoskeleton is known to be polarised in epithelial cells, yet its role remains poorly understood. Here, we show that the Spectrin cytoskeleton... 
Spectrin | YAP | cytoskeleton | Hippo signalling | TISSUE-GROWTH | DROSOPHILA HOMOLOG | BIOCHEMISTRY & MOLECULAR BIOLOGY | MEMBRANE SKELETON | CELL-PROLIFERATION | CELL BIOLOGY | BETA-SPECTRIN | ALPHA-CATENIN | YAP ONCOPROTEIN | TUMOR-SUPPRESSOR | CONTACT INHIBITION | PROMOTES APOPTOSIS | Cell Line | Membrane Proteins - genetics | Humans | Cytoskeleton - genetics | Protein-Serine-Threonine Kinases - genetics | Nuclear Proteins - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Mechanotransduction, Cellular - physiology | Animals | Trans-Activators - genetics | Cytoskeleton - metabolism | Female | Spectrin - genetics | Trans-Activators - metabolism | Membrane Proteins - metabolism | Drosophila Proteins - genetics | Spectrin - metabolism | Nuclear Proteins - genetics | Ovarian Follicle - cytology | Drosophila melanogaster | Intracellular Signaling Peptides and Proteins - genetics | Ovarian Follicle - metabolism | Protein-Serine-Threonine Kinases - metabolism | Insects | Molecular biology | Cytoskeleton
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7. Full Text The Hippo signaling pathway restricts the oncogenic potential of an intestinal regeneration program
by Cai, Jing and Zhang, Nailing and Zheng, Yonggang and De Wilde, Roeland F and Maitra, Anirban and Pan, Duojia
Genes and Development, ISSN 0890-9369, 11/2010, Volume 24, Issue 21, pp. 2383 - 2388
Although a developmental role for Hippo signaling in organ size control is well appreciated, how this pathway functions in tissue regeneration is largely... 
Regeneration | Hippo signaling | Mouse | Growth control | Cancer | regeneration | ORGAN SIZE CONTROL | STAT3 | YAP | CELL-PROLIFERATION | DEVELOPMENTAL BIOLOGY | DROSOPHILA | CELL BIOLOGY | mouse | EPITHELIAL-CELLS | COLITIS | LIVER | GENETICS & HEREDITY | growth control | cancer | TUMORIGENESIS | Immunohistochemistry | Dextran Sulfate | Humans | Male | Intestines - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | RNA, Messenger - metabolism | Colonic Polyps - physiopathology | Colonic Polyps - genetics | Regeneration - genetics | Cell Cycle Proteins - genetics | Female | Phosphoproteins - physiology | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Intestines - pathology | Mice, Inbred C57BL | RNA, Messenger - genetics | Cell Cycle Proteins - metabolism | Protein-Serine-Threonine Kinases - genetics | Signal Transduction - genetics | Phosphoproteins - genetics | Regeneration - physiology | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Colonic Polyps - chemically induced | Mice, Knockout | Adaptor Proteins, Signal Transducing - physiology | Animals | Adaptor Proteins, Signal Transducing - deficiency | Phosphoproteins - deficiency | Adaptor Proteins, Signal Transducing - genetics | Signal Transduction - physiology | Mice | Drosophila Proteins - genetics | Intestines - physiopathology | Dextran | Usage | Analysis | Genetic aspects | Chemical properties | Research | Gene expression | Research Communication
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8. Full Text The Hippo Signaling Pathway in Regenerative Medicine
by Hong, Lixin and Li, Yuxi and Liu, Qingxu and Chen, Qinghua and Chen, Lanfen and Zhou, Dawang
Methods in molecular biology (Clifton, N.J.), ISSN 1064-3745, 2019, Volume 1893, pp. 353 - 370
The major role of Hippo signaling is to inhibit their downstream effectors YAP/TAZ for organ size control during development and regeneration (Nat Rev Drug... 
Protocol | Tissue regeneration | Hippo signaling
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9. Full Text The Hippo signaling pathway provides novel anti-cancer drug targets
by Bae, June Sung and Kim, Sun Mi and Lee, Ho
Oncotarget, ISSN 1949-2553, 2017, Volume 8, Issue 9, pp. 16084 - 16098
The Hippo signaling pathway plays a crucial role in cell proliferation, apoptosis, differentiation, and development. Major effectors of the Hippo signaling... 
YAP | Anti-cancer target | TAZ | Tumor suppressive pathway | Hippo | TGF-BETA | ORGAN SIZE CONTROL | PROTEIN-KINASE | SCF-BETA-TRCP | anti-cancer target | CELL BIOLOGY | BREAST-CANCER CELLS | AMPK-MEDIATED REGULATION | EMBRYONIC STEM-CELLS | YAP PATHWAY | tumor suppressive pathway | TUMOR-SUPPRESSOR PATHWAY | PROMOTES APOPTOSIS | Antineoplastic Agents - therapeutic use | Signal Transduction | Humans | Neoplasms - drug therapy
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10. Full Text The Hippo Signaling Pathway in Development and Disease
by Zheng, Yonggang and Pan, Duojia
Developmental Cell, ISSN 1534-5807, 08/2019, Volume 50, Issue 3, pp. 264 - 282
The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases,... 
regeneration | cytoskeleton | mechanotransduction | yorkie | YAP | tumor suppressor | TAZ | oncogene | tissue homeostasis | scalloped | TEAD | merlin | adherens junction | actomyosin | growth control | neurofibromatosis | cancer | spectrin | NF2 | cell polarity | hippo signaling | TISSUE-GROWTH | REGULATE CELL-PROLIFERATION | TGF-BETA | AMPK-MEDIATED REGULATION | ORGAN SIZE CONTROL | STRUCTURAL BASIS | CONTACT INHIBITION | DEVELOPMENTAL BIOLOGY | YAP PATHWAY | TUMOR-SUPPRESSOR PATHWAY | GENOME-WIDE ASSOCIATION | CELL BIOLOGY
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11. Roles of RUNX in Hippo pathway signaling
by Passaniti, Antonino and Brusgard, Jessica L and Qiao, Yiting and Sudol, Marius and Finch-Edmondson, Megan
Advances in Experimental Medicine and Biology, ISSN 0065-2598, 2017, Volume 962, pp. 435 - 448
The Runt-domain (RD) transcription factors (RUNX genes) are an important family of transcriptional mediators that interact with a variety of proteins including... 
Hippo pathway | TEAD | sE-Cad | RUNX proteins | YAP | Breast cancer | TAZ | Gastric cancer | YES-ASSOCIATED PROTEIN | MEDICINE, RESEARCH & EXPERIMENTAL | DEVELOPMENTAL BIOLOGY | TRANSCRIPTIONAL COACTIVATOR | EPITHELIAL-MESENCHYMAL TRANSITION | BREAST-CANCER CELLS | SOLUBLE-E-CADHERIN | ONCOLOGY | GASTRIC-CANCER | PROSTATE-CANCER | TUMOR-SUPPRESSOR | PROMOTES APOPTOSIS | MAMMARY-GLAND | Neoplasms - metabolism | Tumor Suppressor Proteins - metabolism | Animals | Humans | Core Binding Factor alpha Subunits - metabolism | Signal Transduction - physiology | Neoplasms - pathology | Protein-Serine-Threonine Kinases - metabolism
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12. Full Text Dynamic alterations in Hippo signaling pathway and YAP activation during liver regeneration
by Grijalva, James L and Huizenga, Megan and Mueller, Kaly and Rodriguez, Steven and Brazzo, Joseph and Camargo, Fernando and Sadri-Vakili, Ghazaleh and Vakili, Khashayar
American Journal of Physiology - Gastrointestinal and Liver Physiology, ISSN 0193-1857, 07/2014, Volume 307, Issue 2, pp. G196 - G204
The Hippo signaling pathway has been implicated in mammalian organ size regulation and tumor suppression. Specifically, the Hippo pathway plays a critical role... 
Regeneration | YAP | Hippo signaling pathway | Partial hepatectomy | Liver | partial hepatectomy | GROWTH-CONTROL | PHYSIOLOGY | liver | regeneration | SIZE | MST1 | TRANSCRIPTION | COCAINE | CELL-PROLIFERATION | INDUCTION | INACTIVATION | COMPONENT | GASTROENTEROLOGY & HEPATOLOGY | Proto-Oncogene Proteins - metabolism | Liver - pathology | Liver Regeneration | Phosphorylation | Cell Proliferation | Liver - enzymology | Signal Transduction | Gene Expression Regulation | Rats, Inbred Lew | Organ Size | Rats | Male | Apoptosis Regulatory Proteins - metabolism | Hepatectomy | Hepatocyte Growth Factor - metabolism | Animals | Time Factors | Models, Animal | Transcription, Genetic | Enzyme Activation | Liver - surgery | Protein-Serine-Threonine Kinases - metabolism
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13. Full Text Hippo‐YAP signaling pathway: A new paradigm for cancer therapy
by Ma, Yanlei and Yang, Yongzhi and Wang, Feng and Wei, Qing and Qin, Huanlong
International Journal of Cancer, ISSN 0020-7136, 11/2015, Volume 137, Issue 10, pp. 2275 - 2286
In the past decades, the Hippo signaling pathway has been delineated and shown to play multiple roles in the control of organ size in both Drosophila and... 
yap | cancer | hippo | therapy | YES-ASSOCIATED PROTEIN | LATS1 TUMOR-SUPPRESSOR | ORGAN SIZE CONTROL | PDZ-BINDING MOTIF | MEDIATES CONTACT INHIBITION | CELL-PROLIFERATION | ACTIN-BINDING | TRANSCRIPTIONAL COACTIVATOR | ONCOLOGY | POLARITY DETERMINANT CRUMBS | HEPATOCELLULAR-CARCINOMA DEVELOPMENT | Neoplasms - metabolism | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Humans | Organ Size | Adaptor Proteins, Signal Transducing - metabolism | Molecular Targeted Therapy | Neoplasms - pathology | Phosphoproteins - metabolism | Protein-Serine-Threonine Kinases - metabolism | Neoplasms - drug therapy | Antimitotic agents | Care and treatment | Antineoplastic agents | Health aspects | Cancer | Kinases | Cancer therapies | Tumorigenesis
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