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Biochemical journal, ISSN 1470-8728, 2010, Volume 425, Issue 1, pp. 137 - 148
CsA (cyclosporin A) is a hydrophobic undecapeptide that inhibits CyPs (cyclophilins), a family of PPIases (peptidylprolyl cis-trans isomerases). In some... 
Ischaemia | Cyclosporin A (CsA) | Hippocampal neuron | Glutamate toxicity | Cyclophilin (CyP) | Necrosis | glutamate toxicity | PERMEABILITY TRANSITION PORE | OXIDATIVE STRESS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | REPERFUSION INJURY | NEURONAL CELL-DEATH | INORGANIC-PHOSPHATE | HIPPOCAMPAL-NEURONS | cyclosporin A (CsA) | hippocampal neuron | ischaemia | cyclophilin (CyP) | necrosis | ISCHEMIA-REPERFUSION | CASPASE ACTIVATION | GLUTAMATE EXCITOTOXICITY | Oxygen - pharmacology | Cyclosporine - pharmacology | Mitochondria, Liver - metabolism | Neurons - cytology | Cyclophilins - metabolism | Membrane Potential, Mitochondrial - drug effects | Oxygen - metabolism | Mitochondria, Liver - physiology | Cyclophilins - antagonists & inhibitors | Enzyme Inhibitors - pharmacokinetics | Enzyme Inhibitors - chemistry | Cytoprotection - drug effects | Cyclosporine - pharmacokinetics | Cyclophilin A - genetics | Molecular Structure | Neurons - metabolism | Neurons - drug effects | Animals, Newborn | Cyclophilin A - metabolism | Cell Survival - drug effects | Glutamic Acid - pharmacology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Cyclophilins - genetics | Glucose - pharmacology | Hippocampus - cytology | Rats, Sprague-Dawley | Animals | Cyclosporine - chemistry | Cell Line, Tumor | Glucose - metabolism | Protein Binding | Calcineurin - metabolism | ESI–MS, electrospray ionization MS | NBA, Neurobasal A | THF, tetrahydrofuran | PyBOP, benzotriazol-1-yl-tris-pyrrolidinophosphonium hexafluorophosphate | CsA, cyclosporin A | DCM, dichloromethane | L-NAME, NG-nitro-L-arginine-methyl ester | DMEM, Dulbecco's minimal essential medium | R, ischaemia | NBQX, 2,3-dihydro-6-nitro-7-sulfamoylbenzoquinoxaline | HBSS, Hanks balanced salt solution | OGD, oxygen and glucose deprivation | PPIase, peptidylprolyl cis–trans isomerase | DMF, dimethylformamide | TMRE, tetramethylrhodamine ethyl ester | reperfusion | TPP+, triphenylphosphonium | PT, permeability transition | CyP, cyclophilin | FBS, fetal bovine serum | Fmoc, fluoren-9-ylmethoxycarbonyl | SMBz-CsA, [sarcosine-3(4-methylbenzoate)]-CsA | LDA, lithium diisopropylamide | mtCsA, mitochondrially targeted CsA | NMDA, N-methyl-D-aspartate | CyP-D+, cell line overexpressing CyP-D
Journal Article
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2010, Volume 30, Issue 36, pp. 11938 - 11950
Aggregation of amyloid-beta (A beta) and Tau protein are hallmarks of Alzheimer's disease (AD), and according to the A beta-cascade hypothesis, A beta is... 
AMYLOID-INDUCED NEURODEGENERATION | OXIDATIVE STRESS | PROTEIN OLIGOMERS | NEURITE OUTGROWTH | MECHANISM | ALZHEIMERS-DISEASE | AXONAL-TRANSPORT | PRECURSOR PROTEIN | NEUROTOXICITY | NEUROSCIENCES | CULTURED HIPPOCAMPAL-NEURONS
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 09/2003, Volume 23, Issue 25, pp. 8692 - 8700
Interleukin (IL)-1beta is a proinflammatory cytokine implicated in various pathophysiological conditions of the CNS involving NMDA receptor activation.... 
Tyrosine kinase | NR2A/B subunits | Hippocampal neurons | IL-1 receptor type I | Cytokines | Excitotoxicity | ANTAGONIST | TYROSINE PHOSPHORYLATION | NR2B SUBUNIT | tyrosine kinase | DEPENDENT PROTEIN-KINASE | ISCHEMIA | D-ASPARTATE RECEPTOR | NEUROSCIENCES | hippocampal neurons | HIPPOCAMPUS | IN-VITRO | cytokines | RAT-BRAIN | excitotoxicity | B subunits | Cellular | NR2A | Molecular
Journal Article
Current Opinion in Neurobiology, ISSN 0959-4388, 2016, Volume 37, pp. 66 - 74
Highlights • Mixed selectivity: neurons respond to diverse non-linear combinations of task relevant variables. • Mixed selectivity is a signature of high... 
Neurology | Psychiatry | DEPENDENT COMPUTATION | NEURAL-NETWORKS | CONTEXT REPRESENTATIONS | DECISION-MAKING | HIERARCHICAL-MODELS | OBJECT RECOGNITION | PARIETAL CORTEX | HIPPOCAMPAL-NEURONS | NEUROSCIENCES | PREFRONTAL CORTEX | WORKING-MEMORY | Cognition - physiology | Animals | Models, Neurological | Humans | Neurons - physiology | Neurons | Neurosciences | Cognition
Journal Article
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 2008, Volume 59, Issue 2, pp. 214 - 225
Alzheimer's disease is characterized by the deposition of senile plaques and progressive dementia. The molecular mechanisms that couple plaque deposition to... 
HUMDISEASE | MOLNEURO | SIGNALING | AMYLOID DEPOSITION | CORTICAL-NEURONS | CA2 | ALZHEIMERS-DISEASE | MOUSE MODEL | MUTANT PRESENILIN-1 | HIPPOCAMPAL-NEURONS | CHANNEL ACTIVITY | NEUROSCIENCES | TRANSGENIC MICE | SYNAPTIC DEPRESSION
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 02/2011, Volume 31, Issue 6, pp. 2225 - 2237
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the single most common cause of inherited Parkinson's disease. Little is known about its involvement in... 
MOTOR-NERVE TERMINALS | CLATHRIN-MEDIATED ENDOCYTOSIS | READILY RELEASABLE POOL | PAIRED-PULSE DEPRESSION | REPEAT KINASE 2 | NEUROTRANSMITTER RELEASE | SINGLE-PARTICLE TRACKING | NEUROSCIENCES | CULTURED HIPPOCAMPAL-NEURONS | SHORT-TERM | PARKINSONS-DISEASE | N-Ethylmaleimide-Sensitive Proteins - metabolism | Calcium - metabolism | Embryo, Mammalian | Humans | Gene Expression Regulation, Developmental - genetics | Neurons - cytology | Protein Transport - drug effects | Synaptosomes - metabolism | Excitatory Postsynaptic Potentials - drug effects | Patch-Clamp Techniques - methods | Cerebral Cortex - ultrastructure | Excitatory Postsynaptic Potentials - physiology | Transfection - methods | Potassium Chloride - pharmacology | Tetrodotoxin - pharmacology | Electric Stimulation - methods | Synaptic Vesicles - physiology | Tandem Mass Spectrometry - methods | Microscopy, Electron, Transmission | Immunoprecipitation - methods | Synaptic Vesicles - ultrastructure | Protein-Serine-Threonine Kinases - physiology | RNA, Small Interfering - pharmacology | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Sodium Channel Blockers - pharmacology | Synapses - ultrastructure | Mutation - genetics | Protein Transport - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Nerve Tissue Proteins - metabolism | Animals | Analysis of Variance | Synaptic Vesicles - drug effects | Mice
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 06/2014, Volume 5
Postsynaptic long-term potentiation of inhibition (iLTP) can rely on increased GABA(A) receptors (GABA(A)Rs) at synapses by promoted exocytosis. However, the... 
DIRECT BINDING | SIGNALING PATHWAYS | AMPA RECEPTORS | PYRAMIDAL CELLS | MULTIDISCIPLINARY SCIENCES | DEPENDENT PROTEIN-KINASE | GLYCINE RECEPTOR | GAMMA-2 SUBUNIT | LONG-TERM POTENTIATION | HIPPOCAMPAL-NEURONS | INTRACELLULAR DOMAINS
Journal Article
Science (American Association for the Advancement of Science), ISSN 0036-8075, 10/2010, Volume 330, Issue 6001, pp. 198 - 198
Amyloid-beta (A beta) peptides, derived from the amyloid precursor protein, and the microtubule-associated protein tau are key pathogenic factors in... 
Axons | Mitochondria | Plasmids | Freight transport | Behavioral neuroscience | T tests | BREVIA | Freight | OVEREXPRESSION | MECHANISM | ALZHEIMERS-DISEASE | AMYLOID-BETA | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | TRAFFICKING | HIPPOCAMPAL-NEURONS
Journal Article
Nature reviews. Molecular cell biology, ISSN 1471-0080, 2014, Volume 16, Issue 2, pp. 95 - 109
Journal Article