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Thrombosis and Haemostasis, ISSN 0340-6245, 05/2008, Volume 99, Issue 5, pp. 819 - 829
This review discusses the pharmacology and clinical applications of hirudin, a bivalent direct thrombin inhibitor (DTI). Besides the current major indication... 
Deep vein thrombosis | HIT | thrombin | hirudin | Theme Issue Article | Thrombin | Hirudin | ECARIN CLOTTING TIME | DEEP-VEIN THROMBOSIS | HEPARIN-INDUCED THROMBOCYTOPENIA | CARDIOPULMONARY BYPASS | SUBCUTANEOUS RECOMBINANT HIRUDIN | QUANTITATIVE-DETERMINATION | deep vein thrombosis | R-HIRUDIN | ANTIHIRUDIN ANTIBODIES | PERIPHERAL VASCULAR DISEASE | HYPERSENSITIVITY REACTIONS | AORTIC-VALVE-REPLACEMENT | HEMATOLOGY | Anticoagulants - administration & dosage | Humans | Thrombin - antagonists & inhibitors | Heparin - adverse effects | Hirudins - administration & dosage | Hirudin Therapy | Angioplasty, Balloon, Coronary - adverse effects | Fibrinolytic Agents - adverse effects | Thrombocytopenia - drug therapy | Fibrinolytic Agents - pharmacokinetics | Fibrinolytic Agents - therapeutic use | Thrombosis - blood | Prothrombin - metabolism | Hirudins - immunology | Hirudins - pharmacokinetics | Anticoagulants - therapeutic use | Thrombocytopenia - chemically induced | Cardiopulmonary Bypass | Anticoagulants - adverse effects | Fibrinolytic Agents - immunology | Thrombocytopenia - blood | Acute Coronary Syndrome - drug therapy | Animals | Anticoagulants - immunology | Blood Coagulation - drug effects | Thrombosis - etiology | Hirudins - adverse effects | Blood Coagulation Tests | Acute Coronary Syndrome - therapy | Vascular Surgical Procedures | Anticoagulants - pharmacokinetics | Fibrinolytic Agents - administration & dosage | Thrombosis - drug therapy | Hemorrhage - chemically induced | Thrombin - metabolism | Drug Monitoring | Hemostasis, Surgical - methods | Renal Dialysis | Index Medicus
Journal Article
Journal Article
PARASITOLOGY RESEARCH, ISSN 0932-0113, 07/2019, Volume 118, Issue 7, pp. 2223 - 2233
Blood coagulation in vertebrates is a complex mechanism that involves the precisely coordinated and regulated action of a cascade of factors in order to... 
Blood coagulation | RECOMBINANT HIRUDIN | Hirudinaria manillensis | CDNA | Hirudin-like factors | Hirudin | STIMULATED PLATELET ACTIVATION | THROMBIN INHIBITORS | ADHESION | AMINO-ACID-SEQUENCE | CLONING | Medicinal leeches | SALIVARY-GLAND SECRETION | HAEMENTERIA-OFFICINALIS LEECH | AGGREGATION | PARASITOLOGY
Journal Article
Journal of Immunological Methods, ISSN 0022-1759, 07/2012, Volume 381, Issue 1-2, pp. 50 - 58
Journal Article
Chemical Engineering Science, ISSN 0009-2509, 05/2019, Volume 199, pp. 240 - 248
Firstly, negatively charged silk fibroin (SF) was cationically modified by covalent linkage with polyethylene glycol diamine (NH -PEG-NH ). The surface charge... 
Cationisation | Silk fibroin | Electrostatic binding | Anticoagulant activity | Hirudin | RECOMBINANT HIRUDIN | HEMOCOMPATIBILITY | COMPLEX | DOMAIN | THROMBIN | VITRO BLOOD COMPATIBILITY | IMMOBILIZATION | ENGINEERING, CHEMICAL | DIAMETER | FILMS | CYTOCOMPATIBILITY | Silk | Polyethylene glycol | Crystals | Thrombin | Anticoagulants (Medicine) | Structure | Polyols
Journal Article
Biotechnology and Genetic Engineering Reviews, ISSN 0264-8725, 07/2018, Volume 34, Issue 2, pp. 261 - 280
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 04/2014, Volume 53, Issue 15, pp. 3947 - 3951
Hirudin P6 is a leech‐derived anti‐thrombotic protein which possesses two post‐translational modifications, O‐glycosylation and tyrosine sulfation. In this... 
glycosylation | glycoprotein | sulfation | sulfoprotein | ligation | Hirudins - chemical synthesis | Animals | Hirudins - chemistry | Glycoproteins | Glycosylation | Molecular Structure | Protein Processing, Post-Translational - physiology | Proteins | Thrombin | Synthesis | Organic compounds | Tyrosine | Attenuation | Libraries | Sulfation | Hirudin | Naturvetenskap | Kemi | Natural Sciences | Organisk kemi | Chemical Sciences | Organic Chemistry
Journal Article
Journal Article