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Cell, ISSN 0092-8674, 10/2014, Volume 159, Issue 2, pp. 458 - 458.e1
Histone proteins are decorated by a variety of protein posttranslational modifications called histone marks that modulate chromatin structure and function,... 
CODE | POSTTRANSLATIONAL MODIFICATIONS | CHROMATIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | Amino Acid Sequence | Animals | Histones - chemistry | Humans | Molecular Sequence Data | Rats | Histone Code | Lysine - metabolism | Mice | Protein Processing, Post-Translational | Histones - metabolism | Histones | Epigenetic inheritance | Gene expression | Acylation | Index Medicus
Journal Article
Nature Neuroscience, ISSN 1097-6256, 02/2018, Volume 21, Issue 2, pp. 195 - 206
Internal N-6-methyladenosine (m(6)A) modification is widespread in messenger RNAs (mRNAs) and is catalyzed by heterodimers of methyltransferase-like protein 3... 
FTO | METHYLATION | DEVELOPMENTAL REGULATORS | MESSENGER-RNA | GENE | CHROMATIN | PROLIFERATION | NUCLEAR-RNA | DIFFERENTIATION | TRANSLATION | NEUROSCIENCES | Embryo, Mammalian | Cell Self Renewal - physiology | Methyltransferases - metabolism | Methyltransferases - genetics | Gene Expression Regulation, Developmental - genetics | Male | RNA, Messenger - metabolism | Cerebral Cortex - cytology | PAX6 Transcription Factor - genetics | Cell Self Renewal - genetics | Neurogenesis - genetics | Cell Differentiation - genetics | Deoxyadenosines - genetics | Female | Neurogenesis - drug effects | Protein Synthesis Inhibitors - pharmacology | Gene Expression Regulation, Developmental - physiology | Animals, Newborn | PAX6 Transcription Factor - metabolism | Mice, Inbred C57BL | Gene Expression Regulation, Developmental - drug effects | Neural Stem Cells - physiology | Mice, Transgenic | Deoxyadenosines - metabolism | Fibronectins - metabolism | Animals | Cerebral Cortex - embryology | Cell Differentiation - drug effects | Neurogenesis - physiology | Mice | Histones - metabolism | Dactinomycin - pharmacology | RNA modification | Chromatin | Gene regulation | Embryo cells | Cortex | Methyltransferase | Stem cell transplantation | Genomes | Gene expression | Neurogenesis | Mammalian cells | Embryogenesis | Ribonucleic acids | Stem cells | Neural stem cells
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 11/2017, Volume 118, Issue 11, pp. 3866 - 3874
FA is genotoxic and post‐translationally modified p53 leading to cell growth arrest and apoptosis of HepG2 cells. The results indicate that Ser‐15... 
p‐Ser‐15‐p53 | FUSARIC ACID | DNA DAMAGE | a‐K382‐p53 | POST‐TRANSLATIONAL MODIFICATIONS | p53 | a-K382-p53 | POST-TRANSLATIONAL MODIFICATIONS | p-Ser-15-p53 | DOMAIN | ACTIVATION | MECHANISM | PHOSPHORYLATION | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CELL BIOLOGY | INHIBITION | HYPOTENSIVE AGENT | MYCOTOXIN | STRESS | Fusaric Acid - pharmacology | Protein Processing, Post-Translational - drug effects | Apoptosis - drug effects | Humans | Carcinoma, Hepatocellular - pathology | Liver Neoplasms - metabolism | Tumor Suppressor Protein p53 - metabolism | Liver Neoplasms - pathology | Cell Proliferation - drug effects | DNA Damage | Carcinoma, Hepatocellular - metabolism | Hep G2 Cells | Ubiquitin | Cell death | DNA damage | Analysis | DNA | Genetic research | Histones | Genetic aspects | Hepatoma | Tumor proteins | Cancer | Cell proliferation | Cell culture | Histone deacetylase | Phosphorylation | Toxicity | p53 Protein | Genotoxicity | Hepatocellular carcinoma | Event-related potentials | Maize | Western blotting | Comet assay | Proteins | Fungi | Liver cancer | Ubiquitination | Protein folding | Fusaric acid | Post-translation | Acetylation | Damage | Deoxyribonucleic acid--DNA | Plants (botany) | MDM2 protein | Translation | Bioassay | Bioassays | Corn | Gene expression | Histone acetyltransferase | SIRT1 protein | Damage detection | Acids | Contaminants | Protein expression | Tumor suppressor genes | Apoptosis | Index Medicus
Journal Article
Immunity, ISSN 1074-7613, 10/2013, Volume 39, Issue 4, pp. 661 - 675
The transcription factor Blimp-1 regulates the overall accumulation of virus-specific CD8 T cells during acute viral infections. We found that increased... 
VIRAL-INFECTIONS | EFFECTOR | HOMEOSTASIS | ACTIVATION | CD27 | IL-2 | TRANSCRIPTIONAL REPRESSOR BLIMP-1 | IMMUNOLOGY | EXPRESSION | HISTONE METHYLTRANSFERASE | G9A | Lymphocytic choriomeningitis virus - immunology | Histone Deacetylase 2 - immunology | RNA, Small Interfering - genetics | CD8-Positive T-Lymphocytes - pathology | Interleukin-2 Receptor alpha Subunit - antagonists & inhibitors | Humans | Molecular Sequence Data | Lymphocytic Choriomeningitis - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - antagonists & inhibitors | Interleukin-2 Receptor alpha Subunit - genetics | RNA, Small Interfering - immunology | Transcription Factors - immunology | Interleukin-2 Receptor alpha Subunit - immunology | Lymphocytic Choriomeningitis - genetics | Histone-Lysine N-Methyltransferase - immunology | Tumor Necrosis Factor Receptor Superfamily, Member 7 - immunology | Amino Acid Sequence | Histone Deacetylase 2 - genetics | Histone-Lysine N-Methyltransferase - genetics | Lymphocytic Choriomeningitis - virology | Histones - immunology | Signal Transduction | Lymphocytic Choriomeningitis - pathology | Mice, Transgenic | Transcription Factors - genetics | Tumor Necrosis Factor Receptor Superfamily, Member 7 - genetics | Disease Progression | Animals | Histones - genetics | CD8-Positive T-Lymphocytes - virology | Epigenesis, Genetic - immunology | Immunologic Memory | Mice | CD8-Positive T-Lymphocytes - immunology | Methylation | Positive Regulatory Domain I-Binding Factor 1 | T cell receptors | Infections | Gene expression | Lymphocytes | Rodents | Viral infections | Index Medicus
Journal Article
Journal Article
Journal Article
European Journal of Immunology, ISSN 0014-2980, 09/2015, Volume 45, Issue 9, pp. 2683 - 2693
The innate immune system has been shown to play an important pathologic role in systemic lupus erythematosus (SLE). TLR2, a PRR, recognizes exogenous PAMPs,... 
Histone modification | Systemic lupus erythematosus | IL‐17 | T cells | TLR2 | IL-17 | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | INDUCTION | IMMUNOLOGY | BLOOD MONONUCLEAR-CELLS | DISEASE-ACTIVITY | PATHOGENESIS | EPIGENETICS | AUTOIMMUNITY | TOLL-LIKE RECEPTORS | TNF-ALPHA | Forkhead Transcription Factors - immunology | RNA, Small Interfering - genetics | CD8-Positive T-Lymphocytes - pathology | Toll-Like Receptor 2 - antagonists & inhibitors | Toll-Like Receptor 2 - genetics | Humans | Middle Aged | Interleukin-17 - immunology | Lupus Erythematosus, Systemic - metabolism | Male | CD4-Positive T-Lymphocytes - pathology | CD40 Ligand - immunology | CD4-Positive T-Lymphocytes - immunology | DNA Methylation | RNA, Small Interfering - immunology | Lupus Erythematosus, Systemic - immunology | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | B-Lymphocytes - pathology | B-Lymphocytes - metabolism | CD27 Ligand - immunology | Promoter Regions, Genetic | Histones - immunology | Signal Transduction | CD4-Positive T-Lymphocytes - metabolism | CD27 Ligand - genetics | Interleukin-17 - genetics | Forkhead Transcription Factors - genetics | Immunity, Innate | B-Lymphocytes - immunology | Histones - genetics | CD40 Ligand - genetics | Epigenesis, Genetic - immunology | Lupus Erythematosus, Systemic - genetics | Adolescent | Toll-Like Receptor 2 - immunology | Histones - metabolism | Primary Cell Culture | CD8-Positive T-Lymphocytes - immunology | Lupus Erythematosus, Systemic - pathology | Lupus | B cells | Methylation | Autoimmune diseases | Lymphocytes | Genes | Index Medicus
Journal Article
Journal Article