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2011, 1. Aufl., Wiley series in drug discovery and development, ISBN 9781118015377, xiii, 506 p., [16] p. of plates
This book comprehensively covers the mechanisms of action and inhibitor design for HIV-1 integrase. It serves as a resource for scientists facing challenging... 
Antiviral agents | HIV Integrase | Enzymes | Inhibitors | Drug Design | pharmacology | HIV (Viruses) | HIV Integrase Inhibitors | Science | Chemistry | Industrial & Technical
Book
2011, Wiley series in drug discovery and development, ISBN 9781118015377
Web Resource
2011, Wiley series in drug discovery and development, ISBN 9781118015377
Web Resource
Journal Article
Journal Article
Journal Article
The EMBO Journal, ISSN 0261-4189, 06/2012, Volume 31, Issue 13, pp. 3020 - 3028
Journal Article
Web Resource
Web Resource
Science, ISSN 0036-8075, 7/2004, Volume 305, Issue 5683, pp. 528 - 532
We describe the efficacy of L-870812, an inhibitor of HIV-1 and SIV integrase, in rhesus macaques infected with the simian-human immunodeficiency virus (SHIV)... 
Antiretrovirals | Animals | Viremia | Antivirals | Viruses | Reports | Infections | Cellular immunity | Integrase inhibitors | Viral load | HIV 1 | CELLS | HIV | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | TRANSCRIPTION | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | Anti-HIV Agents - pharmacology | HIV Integrase Inhibitors - pharmacology | Integrase Inhibitors - blood | Drug Resistance, Viral | Integrase Inhibitors - pharmacology | Macaca mulatta | HIV Integrase - metabolism | HIV Integrase Inhibitors - administration & dosage | Leukocytes, Mononuclear - virology | Viral Load | Anti-HIV Agents - administration & dosage | CD4-Positive T-Lymphocytes - immunology | Acquired Immunodeficiency Syndrome - immunology | Simian Acquired Immunodeficiency Syndrome - virology | Simian Immunodeficiency Virus - genetics | HIV-1 - physiology | Anti-HIV Agents - therapeutic use | Integrases - metabolism | Anti-HIV Agents - blood | Integrase Inhibitors - therapeutic use | Acquired Immunodeficiency Syndrome - virology | Naphthyridines - blood | Virus Replication - drug effects | HIV-1 - drug effects | Cells, Cultured | CD4 Lymphocyte Count | Viremia - drug therapy | HIV-1 - genetics | Acquired Immunodeficiency Syndrome - drug therapy | Simian Immunodeficiency Virus - enzymology | Simian Immunodeficiency Virus - physiology | HIV Integrase - genetics | Integrase Inhibitors - administration & dosage | Simian Acquired Immunodeficiency Syndrome - drug therapy | Simian Acquired Immunodeficiency Syndrome - immunology | Naphthyridines - therapeutic use | HIV Integrase Inhibitors - therapeutic use | HIV Integrase Inhibitors - blood | HIV-1 - enzymology | Mutation | CD8-Positive T-Lymphocytes - immunology | Immunity, Cellular | Integrases - genetics | Naphthyridines - administration & dosage | Simian Immunodeficiency Virus - drug effects | Naphthyridines - pharmacology | Physiological aspects | Research | HIV (Viruses) | Drug therapy | Chemotherapy | Immunology | Monkeys & apes | Human immunodeficiency virus--HIV | Immune system | Index Medicus
Journal Article
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 3/2010, Volume 201, Issue 6, pp. 814 - 822
Journal Article
Lancet, The, ISSN 0140-6736, 2007, Volume 369, Issue 9569, pp. 1261 - 1269
Summary Background Raltegravir (MK-0518) is an HIV-1 integrase inhibitor with potent in-vitro activity against HIV-1 strains including those resistant to... 
Internal Medicine | MEDICINE, GENERAL & INTERNAL | ANTIRETROVIRAL DRUGS | THERAPY | HIV-1-INFECTED INDIVIDUALS | INFECTION | DRUG-RESISTANCE | PREVALENCE | ENFUVIRTIDE | HIV-1 | Drug Resistance, Multiple | Humans | Middle Aged | Male | HIV Integrase Inhibitors - administration & dosage | Viral Load | Oligopeptides - therapeutic use | Dose-Response Relationship, Drug | Atazanavir Sulfate | Adult | Female | Raltegravir Potassium | Organic Chemicals - administration & dosage | Pyridines - therapeutic use | Double-Blind Method | Organic Chemicals - adverse effects | Organic Chemicals - therapeutic use | Logistic Models | Treatment Outcome | Pyrrolidinones | HIV Integrase Inhibitors - adverse effects | Adolescent | HIV Integrase Inhibitors - therapeutic use | HIV Infections - drug therapy | Aged | Pyridines - pharmacology | Oligopeptides - pharmacology | Viral drug resistance | Care and treatment | Dosage and administration | Drug therapy | HIV infection | Raltegravir | Design | Studies | Antiretroviral drugs | Plasma | Inhibitor drugs | Protease inhibitors | Conferences | Human immunodeficiency virus--HIV | Mortality | Gene expression | Drug resistance | Patients | RNA-directed DNA polymerase | Laboratories | Toxicity | Viruses | Genomes | Randomization | Motivation | Antiretroviral agents | Nucleoside reverse transcriptase inhibitors | Safety | Drug dosages | Integrase | Phenotypes | Effectiveness | Proteinase inhibitors | Ribonucleic acid--RNA | Antiretroviral therapy | CD4 antigen | Non-nucleoside reverse transcriptase inhibitors | Inhibitors | Nucleosides | Index Medicus | Abridged Index Medicus
Journal Article
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 10/2007, Volume 46, Issue 2, pp. 125 - 133
Journal Article