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The Journal of Infectious Diseases, ISSN 0022-1899, 10/2007, Volume 196, Issue 8, pp. 1180 - 1190
Journal Article
by Rhee, Soo-Yon and Blanco, Jose Luis and Jordan, Michael R and Taylor, Jonathan and Lemey, Philippe and Varghese, Vici and Hamers, Raph L and Bertagnolio, Silvia and Rinke de Wit, Tobias F and Aghokeng, Avelin F and Albert, Jan and Avi, Radko and Avila-Rios, Santiago and Bessong, Pascal O and Brooks, James I and Boucher, Charles A. B and Brumme, Zabrina L and Busch, Michael P and Bussmann, Hermann and Chaix, Marie-Laure and Chin, Bum Sik and D'Aquin, Toni T and de Gascun, Cillian F and Derache, Anne and Descamps, Diane and Deshpande, Alaka K and Djoko, Cyrille F and Eshleman, Susan H and Fleury, Herve and Frange, Pierre and Fujisaki, Seiichiro and Harrigan, P. Richard and Hattori, Junko and Holguin, Africa and Hunt, Gillian M and Ichimura, Hiroshi and Kaleebu, Pontiano and Katzenstein, David and Kiertiburanakul, Sasisopin and Kim, Jerome H and Kim, Sung Soon and Li, Yanpeng and Lutsar, Irja and Morris, Lynn and Ndembi, Nicaise and Ng, Kee Peng and Paranjape, Ramesh S and Peeters, Martine and Poljak, Mario and Price, Matt A and Ragonnet-Cronin, Manon L and Reyes-Terán, Gustavo and Rolland, Morgane and Sirivichayakul, Sunee and Smith, Davey M and Soares, Marcelo A and Soriano, Vincent V and Ssemwanga, Deogratius and Stanojevic, Maja and Stefani, Mariane A and Sugiura, Wataru and Sungkanuparph, Somnuek and Tanuri, Amilcar and tee, Kok Keng and Truong, Hong-Ha M and van de Vijver, David A. M. C and Vidal, Nicole and Yang, Chunfu and Yang, Rongge and Yebra, Gonzalo and Ioannidis, John P. A and Vandamme, Anne-Mieke and Shafer, Robert W
PLoS medicine, ISSN 1549-1277, 2015, Volume 12, Issue 4, pp. e1001810 - e1001810
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 3/2010, Volume 201, Issue 5, pp. 672 - 680
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2008, Volume 105, Issue 5, pp. 1466 - 1471
TMC278 is a diarylpyrimidine (DAPY) nonnucleoside reverse transcriptase inhibitor (NNRTI) that is highly effective in treating wild-type and drug-resistant... 
Molecules | Molecular structure | Atomic interactions | Crystals | Atoms | Amino acids | Drug design | HIV 1 | Crystal structure | Tunnels | Nonnucleoside reverse transcriptase inhibitor | Polymerase | X-ray crystallography | Drug resistance | DRUG | NONNUCLEOSIDE INHIBITORS | WILD-TYPE | MUTANT | MACROMOLECULAR STRUCTURES | drug design | polymerase | POSITIONAL ADAPTABILITY | MULTIDISCIPLINARY SCIENCES | nonnucleoside reverse transcriptase inhibitor | CRYSTAL-STRUCTURES | x-ray crystallography | ANGSTROM RESOLUTION | IMMUNODEFICIENCY-VIRUS TYPE-1 | ANTIVIRAL ACTIVITY | drug resistance | Amino Acid Sequence | Rilpivirine | Humans | Molecular Sequence Data | Crystallography, X-Ray | HIV Reverse Transcriptase - genetics | Pyrimidines - chemistry | Reverse Transcriptase Inhibitors - chemistry | Anti-HIV Agents - chemistry | Drug Resistance, Viral - genetics | Enzyme Inhibitors - chemistry | Drug Design | Nitriles - chemistry | Protein Engineering | Protein Conformation | Mutation | Amino Acid Motifs - genetics | HIV Reverse Transcriptase - chemistry | Drugs | Reverse transcriptase | Structure-activity relationship (Pharmacology) | Models | Research | HIV (Viruses) | Structure | Structure-activity relationships | Proteins | Protease inhibitors | Human immunodeficiency virus--HIV | Clinical trials | Binding sites | Index Medicus | MUTAGENESIS | MUTANTS | SHAPE | CLINICAL TRIALS | FLEXIBILITY | RESOLUTION | CRYSTAL STRUCTURE | national synchrotron light source | AROMATICS | MATERIALS SCIENCE | CHAINS | MUTATIONS | Biological Sciences
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