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PLoS pathogens, ISSN 1553-7374, 2015, Volume 11, Issue 9, p. e1005142
Pharmacologically-induced activation of replication competent proviruses from latency in the presence of antiretroviral treatment (ART) has been proposed as a... 
ACTIVATION | RNA | PERSISTENCE | CD4(+) T-CELLS | MICROBIOLOGY | VIROLOGY | HISTONE DEACETYLASES | ACTIVE ANTIRETROVIRAL THERAPY | IMMUNODEFICIENCY-VIRUS TYPE-1 | STEM-CELL | INFECTION | PARASITOLOGY | VIRAL RESERVOIR | Follow-Up Studies | Humans | Middle Aged | Antiretroviral Therapy, Highly Active - adverse effects | Male | RNA, Viral - blood | AIDS Vaccines - therapeutic use | Virus Latency - drug effects | AIDS Vaccines - adverse effects | Anti-HIV Agents - administration & dosage | HIV Infections - immunology | Drug Interactions | HIV-1 - physiology | Lymphocytes - immunology | Protein Processing, Post-Translational - drug effects | HIV-1 - isolation & purification | Adult | Anti-HIV Agents - therapeutic use | Female | Depsipeptides - therapeutic use | RNA, Viral - metabolism | Depsipeptides - adverse effects | Biomarkers - metabolism | Lymphocytes - metabolism | HIV-1 - drug effects | Anti-HIV Agents - adverse effects | HIV Infections - virology | Biomarkers - blood | Histones - blood | Acetylation - drug effects | HIV-1 - immunology | Virus Activation - drug effects | Lymphocytes - drug effects | HIV Infections - drug therapy | Histones - metabolism | Infusions, Intravenous | Viral Load - drug effects | Cohort Studies | Depsipeptides - administration & dosage | HIV Infections - metabolism | Studies | Plasma | HIV | Acquired immune deficiency syndrome | Cytokines | Lymphocytes | Curing | AIDS | Infections | Human immunodeficiency virus | Research | Drug therapy
Journal Article
Nature (London), ISSN 1476-4687, 2012, Volume 487, Issue 7408, pp. 482 - 485
.... Here we isolated the circulating resting CD4(+) T cells of patients in whom viraemia was fully suppressed by antiretroviral therapy, and directly studied the effect of VOR on this latent reservoir... 
CELLS | ACTIVATION | SUBEROYLANILIDE HYDROXAMIC ACID | MULTIDISCIPLINARY SCIENCES | IN-VIVO | VALPROIC ACID | INFECTION | HISTONE DEACETYLASE INHIBITORS | TYPE-1 | EXPRESSION | PCR | Gene Expression Regulation, Viral - drug effects | Humans | Hydroxamic Acids - adverse effects | Histone Deacetylase Inhibitors - administration & dosage | RNA, Viral - blood | Virus Latency - drug effects | Proviruses - drug effects | HIV-1 - growth & development | Proviruses - genetics | Hydroxamic Acids - administration & dosage | Anti-HIV Agents - therapeutic use | CD4-Positive T-Lymphocytes - virology | Hydroxamic Acids - pharmacology | Biomarkers - metabolism | HIV Infections - blood | Risk Assessment | HIV-1 - drug effects | CD4-Positive T-Lymphocytes - cytology | HIV Infections - virology | RNA, Viral - biosynthesis | CD4-Positive T-Lymphocytes - metabolism | Viremia - drug therapy | HIV-1 - genetics | Proviruses - growth & development | Histones - drug effects | Up-Regulation - drug effects | Acetylation - drug effects | Viremia - virology | HIV Infections - drug therapy | Histone Deacetylase Inhibitors - pharmacology | Histones - metabolism | CD4-Positive T-Lymphocytes - drug effects | Histone Deacetylase Inhibitors - adverse effects | Physiological aspects | Antiviral agents | HIV patients | Health aspects | Vorinostat | Antiretroviral drugs | Plasma | Cell culture | Lymphocytes | Human immunodeficiency virus--HIV | Genomes | Drug therapy | Drug dosages
Journal Article
Nature (London), ISSN 1476-4687, 2016, Volume 530, Issue 7588, pp. 51 - 56
.... Although combinations of antiretroviral drugs usually suppress viral replication and reduce viral RNA to undetectable levels in blood, it is unclear whether treatment fully suppresses viral... 
EVOLUTION | SEQUENCE DATA | COMBINATION THERAPY | DNA | MULTIDISCIPLINARY SCIENCES | ACTIVE ANTIRETROVIRAL THERAPY | IN-VIVO | IMMUNODEFICIENCY-VIRUS TYPE-1 | CD4(+) T-CELLS | PERIPHERAL-BLOOD | INFECTION | Anti-HIV Agents - pharmacology | Carrier State - blood | Humans | Molecular Sequence Data | Phylogeny | Selection, Genetic - drug effects | Anti-HIV Agents - administration & dosage | HIV-1 - growth & development | Time Factors | HIV-1 - isolation & purification | Haplotypes - drug effects | Anti-HIV Agents - therapeutic use | Lymph Nodes - drug effects | Spatio-Temporal Analysis | HIV Infections - blood | Virus Replication - drug effects | HIV-1 - drug effects | HIV Infections - virology | Lymph Nodes - virology | HIV-1 - genetics | Sequence Analysis, DNA | Carrier State - virology | Models, Biological | Carrier State - drug therapy | Drug Resistance, Viral - drug effects | HIV Infections - drug therapy | Viral Load - drug effects | Infection | Highly active antiretroviral therapy | Care and treatment | Analysis | Patient outcomes | Physiological aspects | Development and progression | HIV (Viruses) | Health aspects | HIV infection | Haplotypes | Antiretroviral drugs | Tissue | Lymphatic system | Human immunodeficiency virus--HIV | Phylogenetics | Infections | Drug resistance
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e64010
...) and inhibited the transmission of HIV captured by DC-SIGN(+)-cells to uninfected CD4(+) T cells (EC50:4.1 mu M). Time-of-drug... 
TARGET | HERPES-SIMPLEX-VIRUS | IN-VITRO | ENTRY | MULTIDISCIPLINARY SCIENCES | GRIFFITHSIN | INFECTION | SYNERGISTIC ACTIVITY | SEXUAL TRANSMISSION | TENOFOVIR | GEL | Anti-HIV Agents - pharmacology | Leukocytes, Mononuclear - metabolism | Lactobacillus - growth & development | Simplexvirus - physiology | Bacteriocins - chemistry | Epithelial Cells - drug effects | Giant Cells - drug effects | Humans | Virus Internalization - drug effects | HIV Envelope Protein gp120 - metabolism | Leukocytes, Mononuclear - virology | Lectins, C-Type - metabolism | HIV-1 - physiology | HIV Infections - pathology | HIV-1 - isolation & purification | Lactobacillus - drug effects | Protein Binding - drug effects | Female | Vagina - pathology | Simplexvirus - drug effects | Virus Replication - drug effects | Leukocytes, Mononuclear - drug effects | Receptors, CXCR5 - metabolism | HIV-1 - drug effects | HIV Infections - virology | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Nisin - metabolism | Cell Adhesion Molecules - metabolism | Receptors, CXCR4 - metabolism | Leukocytes, Mononuclear - pathology | Nisin - pharmacology | Epithelial Cells - microbiology | Bacteriocins - pharmacology | Drug Resistance, Viral - drug effects | Vagina - microbiology | Kinetics | CD4 Antigens - metabolism | Prevention | Technology application | Disease transmission | Peptides | T cells | HIV (Viruses) | Acyclovir | Antibacterial agents | Drugs | Sexually transmitted diseases--STD | Toxicity | Amino acids | Viruses | Lymphocytes T | Infections | Lantibiotics | Drug resistance | Proteins | Tenofovir | Synergistic effects | Saquinavir | CD69 antigen | Receptors | Microbicides | Enfuvirtide | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Antiviral activity | Lead | CD25 antigen | Bacteria | Inhibition | Pretreatment | Heparan sulfate | Medical research | Enzymes | Cytokines | Lactobacilli | Vagina | Envelope protein | Inflammation | Virology | CD4 antigen | DC-SIGN protein | Studies | Glycoprotein gp120 | Chemokines | STD | Sexually transmitted diseases | Acquired immune deficiency syndrome | AIDS | HIV | Human immunodeficiency virus
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 50, pp. E8051 - E8058
.... The generally large, flat, and relatively featureless binding sites of protein complexes pose many challenges for drug design... 
Druggable surface | Direct coupling analysis | Drug design | Protein-protein interface | Hot spots | drug design | MULTIDISCIPLINARY SCIENCES | DRUG DISCOVERY | DIMERIZATION | protein-protein interface | INHIBITION | CONSERVATION | hot spots | CDK1 | HOT-SPOTS | direct coupling analysis | HIV-1 PROTEASE | BINDING-SITES | WEB SERVER | druggable surface | COMPUTATIONAL PREDICTION | Histone Deacetylase 1 - chemistry | Molecular Probes | HIV Protease - drug effects | Humans | Proto-Oncogene Proteins c-mdm2 - chemistry | CDC2-CDC28 Kinases - antagonists & inhibitors | Repressor Proteins - antagonists & inhibitors | HIV Protease Inhibitors - pharmacology | Proto-Oncogene Proteins c-mdm2 - drug effects | CDC2 Protein Kinase - drug effects | Drug Design | Histone Deacetylase 1 - drug effects | CDC2 Protein Kinase - chemistry | Histone Deacetylase 1 - antagonists & inhibitors | Binding Sites | Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors | Molecular Docking Simulation - methods | Repressor Proteins - chemistry | Protein Interaction Domains and Motifs - drug effects | CDC2 Protein Kinase - antagonists & inhibitors | HIV-1 - drug effects | CDC2-CDC28 Kinases - chemistry | CDC2-CDC28 Kinases - drug effects | Histone Deacetylases - chemistry | HIV Protease Inhibitors - chemistry | Tumor Necrosis Factor-alpha - chemistry | Tumor Necrosis Factor-alpha - drug effects | HIV-1 - enzymology | Histone Deacetylases - drug effects | Repressor Proteins - drug effects | HIV Protease - chemistry | Protein Multimerization - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Evolution, Molecular | Observations | Protein-protein interactions | Biological Sciences | PNAS Plus | protein−protein interface
Journal Article
Lancet, The, ISSN 0140-6736, 2013, Volume 381, Issue 9883, pp. 2109 - 2117
Journal Article
Journal of Leukocyte Biology, ISSN 0741-5400, 12/2012, Volume 92, Issue 6, pp. 1147 - 1154
Journal Article
Clinical infectious diseases, ISSN 1537-6591, 2017, Volume 64, Issue 12, pp. 1686 - 1695
Journal Article