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Nature, ISSN 0028-0836, 04/2011, Volume 472, Issue 7343, pp. 361 - 365
TRIM5 is a RING domain-E3 ubiquitin ligase that restricts infection by human immunodeficiency virus (HIV)-1 and other retroviruses immediately following virus... 
HIV-1 | CYCLOPHILIN-A | UNANCHORED POLYUBIQUITIN CHAINS | TRIM5-ALPHA PROTEIN | RECOGNITION | HUMAN-CELLS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | RESISTANCE | INFECTION | RESTRICTION | Capsid - chemistry | Receptors, Pattern Recognition - immunology | Humans | Ubiquitin - metabolism | NF-kappa B - metabolism | Lipopolysaccharides - immunology | Transcription Factor AP-1 - metabolism | Receptors, Pattern Recognition - metabolism | Signal Transduction - immunology | Ubiquitin-Protein Ligases - immunology | HIV-1 - chemistry | HEK293 Cells | Carrier Proteins - immunology | Cell Line | Retroviridae - chemistry | Ubiquitin-Protein Ligases - metabolism | Retroviridae - immunology | MAP Kinase Kinase Kinases - metabolism | Transcription Factors - metabolism | Capsid - immunology | Carrier Proteins - genetics | Immunity, Innate - immunology | HIV-1 - immunology | Carrier Proteins - metabolism | Signal Transduction - drug effects | Ubiquitin-Conjugating Enzymes - metabolism | Lipopolysaccharides - pharmacology | Protein Binding | Enzyme Activation | Ubiquitin-Protein Ligases - genetics | Signal transduction | Efficiency | RNA polymerase | Pattern recognition | Kinases | Evacuations & rescues | Immune system | Index Medicus | HIV-1/immunology | Capsid/immunology | Life Sciences | MAP Kinase Kinase Kinases/metabolism | Carrier Proteins/immunology | Immunology | Transcription Factors/metabolism | Capsid/chemistry | HIV-1/chemistry | Ubiquitin/metabolism | Receptors, Pattern Recognition/immunology | Retroviridae/chemistry | Ubiquitin-Protein Ligases/immunology | Ubiquitin-Conjugating Enzymes/metabolism | HumansImmunity, Innate/immunology | Lipopolysaccharides/pharmacology | Signal Transduction/drug effects | Retroviridae/immunology | Transcription Factor AP-1/metabolism | Lipopolysaccharides/immunology | Ubiquitin-Protein Ligases/metabolism | Carrier Proteins/genetics | Signal Transduction/immunology | NF-kappa B/metabolism | Ubiquitin-Protein Ligases/genetics | Carrier Proteins/metabolism | Receptors, Pattern Recognition/metabolism
Journal Article
Journal Article
Mucosal Immunology, ISSN 1933-0219, 01/2016, Volume 9, Issue 1, pp. 24 - 37
HIV-1-associated disruption of intestinal homeostasis is a major factor contributing to chronic immune activation and inflammation. Dendritic cells (DCs) are... 
TRANSLOCATION | RESPONSES | LYMPHOID-TISSUE | INFLAMMATION | PREDICT MORTALITY | IMMUNE ACTIVATION | ANTIRETROVIRAL THERAPY | INTESTINAL LAMINA PROPRIA | IMMUNOLOGY | VIRUS TYPE-1 INFECTION | SIV INFECTION | Antigens, CD - immunology | Immunoglobulins - immunology | Dendritic Cells - immunology | Humans | Middle Aged | Colon - immunology | Male | Immunoglobulins - genetics | Antigens, CD - genetics | Case-Control Studies | Viral Load | Ruminococcus - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | HIV Infections - microbiology | Prevotella - immunology | HIV Infections - pathology | Prevotella - growth & development | Adult | Female | CD40 Antigens - genetics | Interferon-gamma - genetics | Membrane Glycoproteins - immunology | Ruminococcus - growth & development | Glycoproteins - genetics | Antigens, CD1 - immunology | CD4-Positive T-Lymphocytes - microbiology | CD8-Positive T-Lymphocytes - microbiology | Signal Transduction | Lymphocyte Activation | Gene Expression Regulation | Membrane Glycoproteins - genetics | Glycoproteins - immunology | HIV-1 - immunology | Mucous Membrane - immunology | Interferon-gamma - immunology | Dendritic Cells - microbiology | Colon - microbiology | Antigens, CD1 - genetics | Gastrointestinal Microbiome - immunology | CD8-Positive T-Lymphocytes - immunology | CD40 Antigens - immunology | Mucous Membrane - microbiology | Cell Lineage - immunology | Index Medicus | mucosal immunology | HIV-1 pathogenesis | microbiome | Human intestinal dendritic cells
Journal Article
AIDS, ISSN 0269-9370, 02/2012, Volume 26, Issue 4, pp. F1 - F12
Background: In an effort to raise protective antiviral immunity, dendritic cell immunotherapy was evaluated in six adults infected with human immunodeficiency... 
HIV-1 | dendritic cells | therapeutic vaccination | mRNA electroporation | immunotherapy | VIRAL LOAD | INFECTIOUS DISEASES | ASSAY | INDUCTION | IMMUNOLOGY | GAG | AUTOLOGOUS HIV-1 | VIROLOGY | IMMUNODEFICIENCY-VIRUS TYPE-1 | CHRONIC HIV-1 INFECTION | PROTEINS | NONPROGRESSORS | VACCINES | Recombinant Fusion Proteins - immunology | rev Gene Products, Human Immunodeficiency Virus - immunology | RNA, Messenger - immunology | Human Immunodeficiency Virus Proteins - immunology | Antiviral Agents - immunology | Dendritic Cells - immunology | Humans | Middle Aged | AIDS Vaccines - immunology | Male | AIDS Vaccines - adverse effects | Feasibility Studies | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Lymphocyte Activation - immunology | Adult | tat Gene Products, Human Immunodeficiency Virus - immunology | Electroporation | Antiviral Agents - administration & dosage | Antiretroviral Therapy, Highly Active | HIV-1 - immunology | nef Gene Products, Human Immunodeficiency Virus - immunology | Antiviral Agents - adverse effects | Interferon-gamma - immunology | RNA, Viral - immunology | T-Lymphocytes - immunology | AIDS Vaccines - administration & dosage | CD8-Positive T-Lymphocytes - immunology | gag Gene Products, Human Immunodeficiency Virus - immunology | Index Medicus | AIDS/HIV | Dendritic cells | CD8 antigen | Vaccination | Effector cells | Lymphocytes T | mRNA | Vaccines | CD4 antigen | Monocytes | Gag protein | Immunogenicity | Immunotherapy | gamma -Interferon | highly active antiretroviral therapy | Superinfection
Journal Article
Nature, ISSN 0028-0836, 12/2011, Volume 480, Issue 7377, pp. 336 - 343
Variable regions 1 and 2 (V1/V2) of human immunodeficiency virus-1 (HIV-1) gp120 envelope glycoprotein are critical for viral evasion of antibody... 
SYSTEM | POTENT NEUTRALIZATION | DEXTRAN SULFATE | EPITOPE | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | ENVELOPE GLYCOPROTEIN | RECEPTOR | BINDING | T-CELLS | SOFTWARE | AIDS Vaccines - immunology | Glycopeptides - chemistry | Molecular Sequence Data | Antibody Affinity - immunology | Crystallography, X-Ray | Epitopes - immunology | HIV Envelope Protein gp120 - immunology | Antibodies, Neutralizing - immunology | Glycopeptides - immunology | Antibody Specificity - immunology | HIV Antibodies - immunology | HIV-1 - chemistry | Protein Structure, Quaternary | Conserved Sequence | Polysaccharides - chemistry | HIV Envelope Protein gp120 - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Binding Sites, Antibody - immunology | Models, Molecular | Glycosylation | Polysaccharides - immunology | HIV Antibodies - chemistry | AIDS Vaccines - chemistry | Amino Acid Motifs | HIV-1 - immunology | Immune Evasion | Hydrogen Bonding | Antigen-Antibody Complex - chemistry | Antibodies, Neutralizing - chemistry | Epitopes - chemistry | Antigen-Antibody Complex - immunology | Viral envelopes | Genetic aspects | Research | HIV (Viruses) | Structure | Binding sites (Biochemistry) | Proteins | Crystals | Vaccines | Index Medicus | ANTIBODIES | AIDS VIRUS | BASIC BIOLOGICAL SCIENCES | AFFINITY | BIOLOGY | GLYCOPROTEINS | VULNERABILITY | ANTIGENS | IMMUNOLOGY | 60 APPLIED LIFE SCIENCES
Journal Article
Nature, ISSN 0028-0836, 08/2014, Volume 514, Issue 7524, pp. 642 - 645
To protect against human immunodeficiency virus (HIV-1) infection, broadly neutralizing antibodies (bnAbs) must be active at the portals of viral entry in the... 
HALF-LIFE | CHALLENGE | IMMUNITY | TRANSPORT | NEUTRALIZING ANTIBODIES | HUMAN IGG1 | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | IN-VIVO | MONOCLONAL-ANTIBODIES | HIV-1 VACCINE | HIV Antibodies - blood | Antibodies, Neutralizing - analysis | HIV Infections - prevention & control | Immunity, Mucosal - immunology | Antibody-Dependent Cell Cytotoxicity - immunology | Half-Life | Administration, Rectal | Antibody Affinity - immunology | Male | HIV - immunology | Macaca mulatta | Antibodies, Viral - blood | Receptors, IgG - metabolism | HIV Infections - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | HIV Envelope Protein gp160 - chemistry | Antibodies, Viral - analysis | HIV - chemistry | Intestinal Mucosa - immunology | Female | Transcytosis | Simian Immunodeficiency Virus - immunology | HIV Antibodies - analysis | Mutagenesis, Site-Directed | Histocompatibility Antigens Class I - immunology | Antibody Affinity - genetics | Antibodies, Neutralizing - genetics | Binding Sites - genetics | Receptors, IgG - immunology | Rectum - immunology | Simian Acquired Immunodeficiency Syndrome - prevention & control | Animals | Receptors, Fc - immunology | Simian Acquired Immunodeficiency Syndrome - immunology | Immunization, Passive | Antibodies, Viral - immunology | HIV Envelope Protein gp160 - immunology | Mice | HIV Antibodies - genetics | Antibodies, Neutralizing - blood | Antibodies, Viral - genetics | CD4 Antigens - metabolism | Viral antibodies | Infection | Prevention | Fc receptors | Protein research | Antibodies | Primates | Research | Simian immunodeficiency virus | Health aspects | T cell receptors | Physiology | Mutation | Human immunodeficiency virus--HIV | Viral infections | Index Medicus
Journal Article
Nature immunology, ISSN 1529-2908, 2009, Volume 10, Issue 10, pp. 1081 - U58
Journal Article
Nature, ISSN 0028-0836, 08/2011, Volume 476, Issue 7358, pp. 96 - 101
Natural killer (NK) cells have an important role in the control of viral infections, recognizing virally infected cells through a variety of activating and... 
MHC CLASS-I | RESPONSES | NATURAL-KILLER-CELLS | RECOGNITION | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | HLA-B | INHIBITORY RECEPTOR | BINDING-SITE | KIR3DL1 | VIRAL PEPTIDES | env Gene Products, Human Immunodeficiency Virus - immunology | Human Immunodeficiency Virus Proteins - immunology | Humans | env Gene Products, Human Immunodeficiency Virus - metabolism | Host-Pathogen Interactions - immunology | CD4-Positive T-Lymphocytes - immunology | HIV Infections - immunology | Antibodies, Neutralizing - immunology | env Gene Products, Human Immunodeficiency Virus - genetics | HIV-1 - physiology | Receptors, KIR2DL2 - genetics | Adaptation, Physiological - genetics | Receptors, KIR - metabolism | Receptors, KIR2DL2 - deficiency | Killer Cells, Natural - immunology | CD4-Positive T-Lymphocytes - virology | Receptors, KIR - deficiency | Receptors, KIR - genetics | Receptors, KIR2DL2 - immunology | Viral Regulatory and Accessory Proteins - immunology | HIV Infections - virology | Receptors, KIR2DL2 - chemistry | Viral Regulatory and Accessory Proteins - genetics | Genotype | HIV-1 - genetics | Viral Regulatory and Accessory Proteins - metabolism | Polymorphism, Genetic | Human Immunodeficiency Virus Proteins - metabolism | Adaptation, Physiological - immunology | HIV-1 - immunology | Virus Replication | Human Immunodeficiency Virus Proteins - genetics | Decision Trees | Immune Evasion - immunology | Receptors, KIR - immunology | Evolution, Molecular | Killer cells | Immune response | Management | Research | Observations | HIV infection | Hepatitis | Viruses | Immunology | Acids | Multivariate analysis | Viral infections | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 09/2010, Volume 467, Issue 7315, pp. 591 - 595
Journal Article