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Cellular Signalling, ISSN 0898-6568, 06/2019, Volume 58, pp. 99 - 110
It has been well-established that AKT2 plays an important role in the development and progression of colon cancer; however, its precise function remains... 
Phosphorylation | Tumorigenesis | Colon cancer | Metastasis | AKT2 | HK2
Journal Article
Radiotherapy and Oncology, ISSN 0167-8140, 10/2015, Volume 117, Issue 1, pp. 118 - 124
To investigate the relationship between FDG-PET maximum standard uptake value (SUVmax), p16, EGFR, GLUT1 and HK2 expression in head and neck squamous cell... 
FDG | GLUT1 | p16 | HK2 | EGFR | HPV
Journal Article
by Tong Sun and and Bulin Du and Yao Diao and Xuena Li and Song Chen and Yaming Li
BMB Reports, ISSN 1976-6696, 2019, Volume 52, Issue 7, p. 457
[18F]Fluorodeoxyglucose (FDG) PET/CT imaging has been widely used in the diagnosis of malignant tumors. ATPase family AAA domain-containing protein 2 (ATAD2)... 
GLUT1 | [18F]FDG accumulation | ATAD2 | Lung adenocarcinoma | HK2
Journal Article
Current Signal Transduction Therapy, ISSN 1574-3624, 2014, Volume 9, Issue 2, pp. 101 - 105
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 01/2019, Volume 25, Issue 2, pp. 881 - 891
Purpose: The impact of androgen receptor (AR) activity in breast cancer biology is unclear. We characterized and tested a novel therapy to an AR-governed... 
WOMEN | LEVONORGESTREL | ONCOLOGY | BENIGN | PROSTATE-SPECIFIC ANTIGEN | TAMOXIFEN | DISEASE | ANTIBODY | SERUM | EXPRESSION | HK2
Journal Article
Asian Pacific Journal of Cancer Prevention, ISSN 1513-7368, 2015, Volume 16, Issue 16, pp. 7085 - 7088
Journal Article
Oncotarget, ISSN 1949-2553, 04/2018, Volume 9, Issue 27, pp. 18949 - 18969
Malignant tumors often display an aberrant energy metabolism that relies primarily on glycolysis to produce adenosine triphosphate (ATP) the so-called Warburg... 
Glycolysis | Hexokinase 1 (HK1) | Hexokinase 2 (HK2) | Tumor metastasis | Warburg effect
Journal Article
Cancers, ISSN 2072-6694, 06/2019, Volume 11, Issue 6, p. 813
Metabolic reprogramming is a common phenomenon in cancers. Thus, glycolytic enzymes could be exploited to selectively target cancer cells in cancer therapy.... 
metastasis | FAK/ERK signaling | ovarian cancer | HK2 | stemness
Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2018, Volume 501, Issue 4, pp. 885 - 892
Hexokinase-2 (HK2), the initial as well as the rate-limiting step in glycolysis, is overexpressed in many human cancers, and correlates with poor clinical... 
Uveal melanoma | MiR-216a-5p | HK2 | Warburg effect | MIR-216A | METASTASIS | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | CARCINOMA | Prevention | Lactates | Glucose metabolism | Medical research | Enzymes | Medical colleges | MicroRNA | Growth | Melanoma | Physiological aspects | Medicine, Experimental | Cancer | Index Medicus
Journal Article
Molecular Metabolism, ISSN 2212-8778, 2013, Volume 3, Issue 1, pp. 29 - 41
Abstract Circadian rhythms control metabolism and energy homeostasis, but the role of the skeletal muscle clock has never been explored. We generated... 
Endocrinology & Metabolism | Circadian rhythms | Glucose metabolism | Glucose uptake | Muscle insulin resistance | Bmal1 | Skeletal muscle | ENDOCRINOLOGY & METABOLISM
Journal Article
by Miao, Y and Zhang, LF and Zhang, M and Guo, R and Liu, MF and Li, B
HUMAN GENE THERAPY, ISSN 1043-0342, 07/2019, Volume 30, Issue 7, pp. 882 - 892
Poorly differentiated thyroid carcinoma cells tend to be more aggressive and show enhanced glucose uptake which could be exploited for anti-cancer strategy.... 
MIGRATION | MEDICINE, RESEARCH & EXPERIMENTAL | SUPPRESSOR | CELLS | microPET/CT | HEXOKINASE 2 | PROLIFERATION | MICRORNA-143 | HK2 | IN-VITRO | RETINOIC ACID | INHIBITION | miR-143 | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | poorly differentiated thyroid carcinoma | visual evaluation | HALLMARKS
Journal Article
Experimental Cell Research, ISSN 0014-4827, 01/2019, Volume 374, Issue 1, pp. 249 - 258
Many cell death regulators physically or functionally interact with metabolic enzymes. These interactions provide insights into mechanisms of anticancer... 
VDAC | GSK3β | Akt | Zinc | HK2 | p53 | CANCER-CELLS | PROSTATE | APOPTOSIS | MECHANISM | HEXOKINASE | CISPLATIN RESISTANCE | CELL BIOLOGY | MALIGNANCY | INHIBITION | METABOLISM | ONCOLOGY | GSK3 beta | Enzymes | Synthesis | Glycogen | Cell death | Analysis | Physiological aspects | Permeability | Tumor proteins | Prostate cancer | Protein kinases
Journal Article
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, ISSN 1940-5901, 2019, Volume 12, Issue 7, pp. 8450 - 8460
Hexokinase 2 (HK2) is strongly expressed in multiple human cancers. Dysregulation of HK2 has been associated with malignant progression of tumor cells,... 
miR-143-3p | GLYCOLYSIS | MEDICINE, RESEARCH & EXPERIMENTAL | HEXOKINASE 2 | CELL-PROLIFERATION | Neuroblastoma | MICRORNAS | HK2 | epigenetics | PROGRESSION
Journal Article
by Sun, T and Du, BL and Diao, Y and Li, XN and Chen, S and Li, YM
BMB REPORTS, ISSN 1976-6696, 07/2019, Volume 52, Issue 7, pp. 457 - 462
[18F]Fluorodeoxyglucose (FDG) PET/CT imaging has been widely used in the diagnosis of malignant tumors. ATPase family AAA domain-containing protein 2 (ATAD2)... 
GLUT1 | OVEREXPRESSION | ACTIVATION | [18F]FDG accumulation | METABOLISM | POOR-PROGNOSIS | MYC | BIOCHEMISTRY & MOLECULAR BIOLOGY | ATAD2 | CELL-PROLIFERATION | Lung adenocarcinoma | HK2
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 08/2018, Volume 104, pp. 28 - 35
Clear-cell renal cell carcinoma (ccRCC) has the highest prevalence, approximately 80%, amongst all RCC cases. Therefore, the development of novel therapeutic... 
Glycolysis | ccRCC | HK2 | PG | Apoptosis | CANCER-CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | LOCALIZATION | DEATH | DEHYDROGENASE | RUMEX-JAPONICUS HOUTT | HEPATOCELLULAR-CARCINOMA | INVASION | PHARMACOLOGY & PHARMACY | SUPPRESSES | WARBURG | Index Medicus
Journal Article
by Wu, HY and Pan, LL and Gao, CX and Xu, HT and Li, YP and Zhang, LH and Ma, LW and Meng, L and Sun, XL and Qin, HB
MOLECULES, ISSN 1420-3049, 05/2019, Volume 24, Issue 10, p. 1993
Increased glycolysis in tumor cells is associated with increased risk of tumor progression and mortality. Therefore, disruption of glycolysis, one of the main... 
ANGIOGENESIS | hexokinase-2(HK2) | BIOCHEMISTRY & MOLECULAR BIOLOGY | glycolysis | hepatocellular carcinoma (HCC) | RISK | FLAVONOIDS | SUPPRESSION | CHEMISTRY, MULTIDISCIPLINARY | LUNG-CANCER | HEPATOCELLULAR-CARCINOMA | METABOLISM | AEROBIC GLYCOLYSIS | quercetin | UP-REGULATION | TUMOR-GROWTH
Journal Article
by Wang, LS and Zang, WD and Sang, YX and Xie, DL and Wei, L and Ji, WD and Pan, YS and Li, ZQ and Shen, JW and Shi, YY
PLOS ONE, ISSN 1932-6203, 06/2013, Volume 8, Issue 6, p. e0160298
Objectives: To assess the association of polymorphism rs198977 in the human kallikrein-2 gene (KLK2) and risk of prostate cancer (PCa). Methods: Two... 
METAANALYSIS | MULTIDISCIPLINARY SCIENCES | BIOPSY | TISSUE | MARKERS | RISK | HK2 | ANTIGEN | FAMILY
Journal Article
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