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Journal of Immunology, ISSN 0022-1767, 05/2010, Volume 184, Issue 9, pp. 4936 - 4946
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 2716 - 13
Foreign antigens are presented by antigen-presenting cells in the presence of abundant endogenous peptides that are nonstimulatory to the T cell. In mouse T... 
ACTIVATION | COMPLEX | RECOGNITION | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | SENSITIVITY | SELF | IMMUNOLOGICAL SYNAPSE | RECEPTORS | BINDING | MOLECULES | Recombinant Fusion Proteins - immunology | Receptors, Antigen, T-Cell - chemistry | HLA-A2 Antigen - genetics | Antigen-Presenting Cells - cytology | Cricetulus | Humans | Peptides - genetics | Epitopes - immunology | Signal Transduction - immunology | Transfection | Antigen Presentation | Receptors, Antigen, T-Cell - immunology | gag Gene Products, Human Immunodeficiency Virus - genetics | CHO Cells | T-Lymphocytes, Cytotoxic - immunology | Amino Acid Sequence | Gene Expression | Immunological Synapses - ultrastructure | HLA-A2 Antigen - immunology | Peptides - chemistry | Lymphocyte Activation | Peptides - immunology | Plasmids - immunology | Epitopes - genetics | Antigen-Presenting Cells - immunology | Antigens - chemistry | Animals | Immunological Synapses - immunology | Plasmids - chemistry | Recombinant Fusion Proteins - genetics | Antigens - immunology | Epitopes - chemistry | Receptors, Antigen, T-Cell - genetics | gag Gene Products, Human Immunodeficiency Virus - immunology | T-Lymphocytes, Cytotoxic - cytology | Antigens - genetics | Antigens | Phosphorylation | Peptides | CD8 antigen | Cytotoxicity | Lymphocytes T | T cell receptors | Epitopes | Molecular chains | CD4 antigen | T-cell receptor | Amplification | Signal transduction | Signaling | Major histocompatibility complex | Lymphocytes | Antigen-presenting cells | Human immunodeficiency virus--HIV | Histocompatibility antigen HLA | Human behavior
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2015, Volume 194, Issue 7, pp. 3487 - 3500
TCR alpha- and beta-chains cooperatively recognize peptide -MHC complexes. It has been shown that a "chain-centric" TCR hemichain can, by itself, dictate... 
METASTATIC MELANOMA | CANCER REGRESSION | SELF-PEPTIDE | ENHANCED ANTITUMOR-ACTIVITY | T-CELL-RECEPTOR | HIGH-AFFINITY | ANTIGEN-PRESENTING CELLS | GENE-TRANSFER | IMMUNOLOGY | DIRECTED EVOLUTION | MOLECULAR-BASIS | Recombinant Fusion Proteins - immunology | T-Lymphocyte Subsets - immunology | Complementarity Determining Regions - genetics | Receptors, Antigen, T-Cell - chemistry | HLA-A2 Antigen - genetics | Humans | Protein Multimerization | Epitopes, T-Lymphocyte - genetics | Recombinant Fusion Proteins - metabolism | Complementarity Determining Regions - chemistry | MART-1 Antigen - metabolism | Peptide Fragments - immunology | Epitopes, T-Lymphocyte - immunology | Complementarity Determining Regions - metabolism | Peptide Fragments - genetics | MART-1 Antigen - chemistry | Amino Acid Sequence | Cell Line | Peptide Fragments - metabolism | Transduction, Genetic | HLA-A2 Antigen - immunology | Receptors, Antigen, T-Cell - metabolism | Immunophenotyping | Receptors, Antigen, T-Cell, alpha-beta - genetics | Epitopes, T-Lymphocyte - chemistry | HLA-A2 Antigen - chemistry | Peptide Fragments - chemistry | T-Lymphocyte Subsets - metabolism | MART-1 Antigen - genetics | Cell Line, Tumor | Protein Binding | Recombinant Fusion Proteins - genetics | Receptors, Antigen, T-Cell - genetics | Receptors, Antigen, T-Cell, alpha-beta - metabolism
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 02/2016, Volume 183, Issue 2, pp. 206 - 220
Journal Article
European Journal of Immunology, ISSN 0014-2980, 02/2015, Volume 45, Issue 2, pp. 584 - 591
MHC anchor residue-modified "heteroclitic" peptides have been used in many cancer vaccine trials and often induce greater immune responses than the wild-type... 
TCR | T-cell | MART-1 | Cross-reactivity | Melanoma | Peptide-major histocompatibility complex | Surface plasmon resonance | Melan-A | Crystal structure | TCR-BINDING | RECOGNITION | RECEPTOR | CANCER-IMMUNOTHERAPY | SELF-ANTIGEN | IMMUNOLOGY | THERMODYNAMICS | COMPLEX CLASS-I | HUMAN-MELANOMA | TUMOR-REACTIVE CTL | VACCINES | HLA-A2 Antigen - genetics | Humans | Receptors, Antigen, T-Cell, alpha-beta - chemistry | Peptides - genetics | Molecular Sequence Data | Alanine - chemistry | Crystallography, X-Ray | Epitopes, T-Lymphocyte - genetics | Receptors, Antigen, T-Cell, alpha-beta - immunology | Alanine - genetics | Escherichia coli - metabolism | Protein Interaction Domains and Motifs | Epitopes, T-Lymphocyte - immunology | Leucine - genetics | MART-1 Antigen - chemistry | MART-1 Antigen - immunology | T-Lymphocytes, Cytotoxic - immunology | Amino Acid Sequence | Gene Expression | HLA-A2 Antigen - immunology | Peptides - chemistry | Peptides - immunology | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Receptors, Antigen, T-Cell, alpha-beta - genetics | Leucine - chemistry | HLA-A2 Antigen - chemistry | Recombinant Proteins - immunology | T-Lymphocytes, Cytotoxic - metabolism | Escherichia coli - genetics | MART-1 Antigen - genetics | Protein Binding | T-Lymphocytes, Cytotoxic - cytology | Epitopes, T-Lymphocyte - metabolism | Amino Acid Substitution | Histocompatibility antigens | Peptides | Analysis | HLA histocompatibility antigens | Crystals | T cells | Structure | Antigenic determinants | Medical research | T cell receptors | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2017, Volume 292, Issue 45, pp. 18618 - 18627
Influenza A virus (IAV) causes an acute infection in humans that is normally eliminated by CD8(+) cytotoxic T lymphocytes. Individuals expressing the MHC class... 
TCR | MEMORY REPERTOIRES | RECOGNITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | DISTINCT | RECEPTOR | ALPHA | MHC | surface plasmon resonance (SPR) | protein complex | FEATURES | T-cell receptor | major histocompatibility complex (MHC) | EXPANSION | crystal structure | influenza virus | epitope | SELECTION | Antibody Diversity | HLA-A2 Antigen - genetics | Viral Matrix Proteins - genetics | Antigens, Viral - metabolism | Humans | Receptors, Antigen, T-Cell, alpha-beta - chemistry | Antigens, Viral - genetics | Epitopes, T-Lymphocyte - genetics | Clonal Deletion | Immunodominant Epitopes - metabolism | Antigen-Antibody Complex - genetics | Influenza A virus - immunology | Viral Matrix Proteins - metabolism | Antigen-Antibody Complex - metabolism | Immunodominant Epitopes - genetics | Recombinant Proteins - metabolism | T-Lymphocytes, Cytotoxic - immunology | Protein Conformation, alpha-Helical | Peptide Fragments - metabolism | Immunodominant Epitopes - chemistry | T-Lymphocytes, Cytotoxic - virology | Models, Molecular | Recombinant Proteins - chemistry | Antibody Affinity | Antigens, Viral - chemistry | Receptors, Antigen, T-Cell, alpha-beta - genetics | Epitopes, T-Lymphocyte - chemistry | HLA-A2 Antigen - chemistry | Peptide Fragments - chemistry | Influenza A virus - metabolism | Hydrogen Bonding | T-Lymphocytes, Cytotoxic - metabolism | Viral Matrix Proteins - chemistry | Antigen-Antibody Complex - chemistry | T-Cell Antigen Receptor Specificity | Protein Conformation | HLA-A2 Antigen - metabolism | Mutation | Receptors, Antigen, T-Cell, alpha-beta - metabolism | T-Lymphocytes, Cytotoxic - cytology | Epitopes, T-Lymphocyte - metabolism | Amino Acid Substitution | 60 APPLIED LIFE SCIENCES | Immunology
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0135385
Constitutive cell surface expression of Human Leukocyte Antigen (HLA) class I antigens vary extremely from tissue to tissue and individual antigens may differ... 
SINGLE AMINO-ACID | COMPLEX | TAP | TUMOR ESCAPE | PEPTIDE-BINDING | TAPASIN | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | CLASS-I MOLECULES | IMMUNE RECOGNITION | LYMPHOCYTES | HLA-A3 Antigen - genetics | Recombinant Fusion Proteins - immunology | RNA, Messenger - immunology | HLA-A2 Antigen - genetics | Humans | HLA-A3 Antigen - chemistry | Molecular Sequence Data | HLA-A3 Antigen - immunology | HLA-B7 Antigen - immunology | Transfection | HEK293 Cells | HLA-B7 Antigen - chemistry | HLA-B8 Antigen - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Interferon-gamma | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Histocompatibility Testing | RNA, Messenger - genetics | Gene Expression Regulation | HLA-B8 Antigen - chemistry | Recombinant Fusion Proteins - chemistry | Plasmids - metabolism | HLA-A2 Antigen - chemistry | Alleles | HLA-B8 Antigen - immunology | Plasmids - chemistry | Recombinant Fusion Proteins - genetics | Infection | Allelomorphism | Histocompatibility antigens | Health aspects | HLA histocompatibility antigens | Stem cells | Post-transcription | Flow cytometry | Peptides | Gene regulation | Stem cell transplantation | Amino acids | Viruses | Transplantation | Cell surface | B7 antigen | Immunology | Human immunodeficiency virus--HIV | Post-translation | Antigens | Complications | Cloning | Molecular chains | Polymerase chain reaction | White blood cells | Plasmids | Histocompatibility antigen HLA | Cancer | HIV | Human immunodeficiency virus
Journal Article
Journal of experimental medicine, ISSN 0022-1007, 2006, Volume 203, Issue 5, pp. 1259 - 1271
Journal Article
PLoS ONE, ISSN 1932-6203, 05/2013, Volume 8, Issue 5, p. e62778
Current influenza vaccines stimulate neutralising antibody to the haemagglutinin antigen but as there is antigenic drift in HA it is difficult to prepare a... 
EFFECTOR | CROSS-REACT | INFECTIONS | PROTECTION | RECOGNITION | MULTIDISCIPLINARY SCIENCES | HUMANS | PHENOTYPE | A-VIRUS | RECIPIENTS | LYMPHOCYTES | HLA-A2 Antigen - genetics | Influenza Vaccines - administration & dosage | Viral Matrix Proteins - genetics | Perforin - genetics | Humans | Middle Aged | Nucleoproteins - genetics | Vaccination | Viral Vaccines - genetics | Antigens, Viral - genetics | Epitopes, T-Lymphocyte - genetics | Granzymes - genetics | Hemagglutinins - immunology | Orthomyxoviridae - immunology | Adult | Granzymes - immunology | Orthomyxoviridae - drug effects | Perforin - immunology | Epitopes, T-Lymphocyte - immunology | Nucleoproteins - immunology | CD57 Antigens - immunology | HLA-A2 Antigen - immunology | Recombinant Proteins - genetics | Viral Vaccines - administration & dosage | Hemagglutinins - genetics | Antigens, Viral - immunology | Influenza Vaccines - immunology | Influenza Vaccines - genetics | Recombinant Proteins - immunology | CD8-Positive T-Lymphocytes - virology | Influenza, Human - genetics | Viral Core Proteins - genetics | Adolescent | CD57 Antigens - genetics | Vaccines, Synthetic | Viral Core Proteins - immunology | Viral Matrix Proteins - immunology | CD8-Positive T-Lymphocytes - immunology | Influenza, Human - prevention & control | Viral Vaccines - immunology | Influenza, Human - immunology | Influenza viruses | Influenza vaccines | Proteins | Medical research | Influenza | Medicine, Experimental | T cells | Antigenic determinants | CD57 antigen | Flow cytometry | CD8 antigen | Cytotoxicity | Viruses | Infections | Lymphocytes T | Vaccines | Avian flu | Genotype & phenotype | Hepatitis | Immunology | Lymphocytes | Perforin | Antigens | Immunization | Antigenic drift | T cell receptors | Epitopes | CD4 antigen | Medicine | Studies | Swine flu | Histocompatibility antigen HLA | Drift
Journal Article