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1. Full Text Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome
by Wei, Chun-Yu, MS and Chung, Wen-Hung, MD, PhD and Huang, Hsiao-Wen, MS and Chen, Yuan-Tsong, MD, PhD and Hung, Shuen-Iu, PhD
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2012, Volume 129, Issue 6, pp. 1562 - 1569.e5
Background Increasing studies have revealed that HLA alleles are the major genetic determinants of drug hypersensitivity; however, the underlying molecular... 
Allergy and Immunology | Stevens-Johnson syndrome | HLA | drug hypersensitivity | Carbamazepine | toxic epidermal necrolysis | MARKER | RISK | IMMUNOLOGY | OXCARBAZEPINE | CUTANEOUS ADVERSE-REACTIONS | PEPTIDES | ALLERGY | HYPERSENSITIVITY REACTIONS | HLA-B-ASTERISK-1502 ALLELE | ASSOCIATION | Stevens-Johnson Syndrome - immunology | HLA-B15 Antigen - chemistry | Humans | Middle Aged | Male | Young Adult | Carbamazepine - chemistry | Stevens-Johnson Syndrome - chemically induced | Lymphocyte Activation - immunology | HLA-B15 Antigen - genetics | Drug Hypersensitivity - genetics | Adult | Female | Child | T-Lymphocytes, Cytotoxic - immunology | Cell Line | Peptides - immunology | Models, Molecular | Carbamazepine - immunology | Antigen Presentation - immunology | Protein Binding - immunology | Stevens-Johnson Syndrome - genetics | Carbamazepine - adverse effects | Drug Hypersensitivity - immunology | Adolescent | HLA-B15 Antigen - metabolism | T-Lymphocytes - immunology | Aged | Medical colleges | Care and treatment | Anticonvulsants | Histocompatibility antigens | Lymphocytes | HLA histocompatibility antigens | Universities and colleges | T cells | Drugs | Hypersensitivity | Antigen processing | Cytotoxicity | Lymphocytes T | Toxic epidermal necrolysis | Molecular modelling | surface plasmon resonance | Site-directed mutagenesis | Drug metabolism | Histocompatibility antigen HLA | Mathematical models | Antigenic determinants
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2. Full Text Carbamazepine-Induced Toxic Effects and HLA-B1502 Screening in Taiwan
by Chen, Pei and Chen, Chien-Hsiun and Chen, Ying-Ju and Chen, Yuan-Tsong and Chen, Luke and Lin, Shu-Yi and Lin, Juei-Jueng and Lin, Yu-Hsuan and Lu, Chung-Ta and Lu, Chin-Song and Lu, Cheng-Hsien and Ong, Cheung-Ter and Hsieh, Peiyuan F and Yang, Chih-Chao and Tai, Chih-Ta and Wu, Jer-Yuarn and Wu, Shey-Lin and Hsu, Yung-Chu and Yu, Hsiang-Yu and Ro, Long-Sun and Chu, Chun-Che and Tsai, Pei-Joung and Tsai, Jing-Jane and Su, Yu-Hsiang and Lan, Sheng-Hsing and Sung, Sheng-Feng and Chuang, Hui-Ping and Huang, Li-Chen and Liao, Hung-Ting and Chung, Wen-Hung and Hung, Shuen-Iu and Chang, Chi-Feng and Shen, Chen-Yang and Taiwan SJS Consortium
The New England Journal of Medicine, ISSN 0028-4793, 03/2011, Volume 364, Issue 12, pp. 1126 - 1133
In this prospective study, Han Chinese subjects who were candidates for carbamazepine therapy were screened for the HLA-B*1502 allele because of its... 
ALLELE | EPIDERMAL NECROLYSIS | POPULATION | MEDICINE, GENERAL & INTERNAL | MARKER | DEATH | ADVERSE DRUG-REACTIONS | STEVENS-JOHNSON-SYNDROME | ASSOCIATION | Drug-Related Side Effects and Adverse Reactions - prevention & control | Genetic Testing | Humans | Middle Aged | Asian Continental Ancestry Group - genetics | Stevens-Johnson Syndrome - prevention & control | Child, Preschool | Infant | Male | Incidence | Young Adult | Stevens-Johnson Syndrome - chemically induced | Anticonvulsants - adverse effects | Stevens-Johnson Syndrome - epidemiology | Drug-Related Side Effects and Adverse Reactions - genetics | Aged, 80 and over | Adult | Female | HLA-B15 Antigen | Child | HLA-B Antigens - genetics | Pharmacogenetics | Anticonvulsants - therapeutic use | Carbamazepine - therapeutic use | Genotype | Stevens-Johnson Syndrome - genetics | Carbamazepine - adverse effects | Adolescent | Taiwan | Aged | Taiwanese | Complications and side effects | Stevens-Johnson syndrome | Toxic epidermal necrolysis | Usage | Histocompatibility antigens | HLA histocompatibility antigens | Causes of | Medical screening | Health aspects | Carbamazepine | Testing | Confidence intervals | Medical research | Clinical medicine | Apoptosis | Index Medicus | Abridged Index Medicus
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3. Full Text Unbiased Identification of T-Cell Receptors Targeting Immunodominant Peptide–MHC Complexes for T-Cell Receptor Immunotherapy
by Lorenz, Felix K.M and Ellinger, Christian and Kieback, Elisa and Wilde, Susanne and Lietz, Maria and Schendel, Dolores J and Uckert, Wolfgang
Human Gene Therapy, ISSN 1043-0342, 12/2017, Volume 28, Issue 12, pp. 1158 - 1168
T-cell receptor (TCR) immunotherapy uses T cells engineered with new TCRs to enable detection and killing of cancer cells. Efficacy of TCR immunotherapy... 
Research Articles | T cell receptor (TCR) discovery | MHC cell library | immunodominance | human papillomavirus ES | immunotherapy | TCR gene therapy | HLA-B7 Antigen - genetics | Humans | Peptides - immunology | Peptides - genetics | Neoplasms - therapy | HLA-B15 Antigen - genetics | HLA-B7 Antigen - immunology | Adoptive Transfer - methods | Neoplasms - genetics | Neoplasms - immunology | K562 Cells | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | HLA-B15 Antigen - immunology | Neoplasms - pathology | GAMMA ELISPOT ASSAYS | MEDICINE, RESEARCH & EXPERIMENTAL | DENDRITIC CELLS | ANTITUMOR-ACTIVITY | RETROVIRAL VECTORS | CANCER | TCR GENE-THERAPY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | human papillamavirus ES | ANTIGEN-PRESENTING CELLS | EXPRESSION | E5 ONCOPROTEIN | LYMPHOCYTES | Killing | Antigens | Peptides | T cell receptors | Lymphocytes T | T-cell receptor | Receptors | Major histocompatibility complex | Lymphocytes | Immunotherapy | Histocompatibility antigen HLA | Histocompatibility | Cancer
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4. Full Text PharmGKB summary: very important pharmacogene information for human leukocyte antigen B
by Barbarino, Julia M and Kroetz, Deanna L and Klein, Teri E and Altman, Russ B
Pharmacogenetics and Genomics, ISSN 1744-6872, 04/2015, Volume 25, Issue 4, pp. 205 - 221
HLA-B | SINGLE-NUCLEOTIDE POLYMORPHISM | TOXIC EPIDERMAL NECROLYSIS | MHC CLASS-I | IMPLEMENTATION CONSORTIUM GUIDELINES | CUTANEOUS ADVERSE-REACTIONS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | PHARMACOLOGY & PHARMACY | HLA-B-ASTERISK-1502 ALLELE | STEVENS-JOHNSON-SYNDROME | INDUCED HYPERSENSITIVITY REACTIONS | GENOME-WIDE ASSOCIATION | Genetic Variation | Pharmacogenetics | Genetic Association Studies | HLA-B Antigens - genetics | Gene Frequency | Humans | HLA-B58:01 | HLA-B57:01 | Abacavir | allopurinol | phenytoin | HLA-B15:02 | pharmacogenetics | carbamazepine | PharmGKB
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5. HLA-B locus in Caucasian patients with carbamazepine hypersensitivity
by Alfirevic, Ana and Jorgensen, Andrea L and Williamson, Paula R and Chadwick, David W and Park, B. Kevin and Pirmohamed, Munir
Pharmacogenomics, ISSN 1462-2416, 09/2006, Volume 7, Issue 6, pp. 813 - 818
Background: A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-8*1502 and carbamazepine... 
HLA-B | Pharmacogenetics | Adverse drug reactions | Epilepsy | Hypersensitivity | Carbamazepine | epilepsy | ABACAVIR | hypersensitivity | MARKER | PATTERNS | ALPHA | carbamazepine | REGION | adverse drug reactions | PHARMACOLOGY & PHARMACY | MICE | GENETIC-VARIATIONS | HUMAN MHC | ASSOCIATION | EXPRESSION | pharmacogenetics | European Continental Ancestry Group - genetics | Gene Frequency | Humans | Asian Continental Ancestry Group - genetics | HLA-B7 Antigen | United Kingdom | Genetic Markers | Case-Control Studies | Carbamazepine - adverse effects | HLA-DR3 Antigen - genetics | HLA-B8 Antigen | Drug Hypersensitivity - immunology | HLA-DQ Antigens - genetics | Toxicogenetics | Alleles | Drug Hypersensitivity - genetics | HLA-B15 Antigen | HLA-B Antigens - genetics
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6. Full Text Integrated whole genome and transcriptome analysis identified a therapeutic minor histocompatibility antigen in a splice variant of ITGB2
by Pont, Margot J and Van Der Lee, Dyantha I and Van Der Meijden, Edith D and Van Bergen, Cornelis A. M and Kester, Michel G. D and Honders, Maria W and Vermaat, Martijn and Eefting, Matthias and Marijt, Erik W. A and Kielbasa, Szymon M and T'Hoen, Peter A. C and Frederik Falkenburg, J.H and Griffioen, Marieke
Clinical Cancer Research, ISSN 1078-0432, 08/2016, Volume 22, Issue 16, pp. 4185 - 4196
Purpose: In HLA-matched allogeneic hematopoietic stem cell transplantation (alloSCT), donor T cells recognizing minor histocompatibility antigens (MiHAs) can... 
DONOR LYMPHOCYTE INFUSION | INTERFERON | REACTIVE T-CELLS | MESSENGER-RNA | GENE | ONCOLOGY | MYELOID-LEUKEMIA | VERSUS-HOST-DISEASE | ASSOCIATION | EXPRESSION | TRANSPLANTATION | Amino Acid Sequence | Alternative Splicing | T-Lymphocytes | Humans | Integrin beta3 - chemistry | Peptides - immunology | Peptides - genetics | Hematopoietic Stem Cell Transplantation | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - genetics | Epitopes, T-Lymphocyte - genetics | Gene Expression Profiling | Transplantation, Homologous | Whole Genome Sequencing | HLA-B15 Antigen - genetics | Base Sequence | Minor Histocompatibility Antigens - genetics | Female | Integrin beta3 - genetics | Epitopes, T-Lymphocyte - immunology | HLA-B15 Antigen - immunology | Leukemia, Myelogenous, Chronic, BCR-ABL Positive - immunology | Minor Histocompatibility Antigens - immunology | Minor Histocompatibility Antigens - chemistry
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7. Full Text HLA-B1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients
by Kaniwa, Nahoko and Saito, Yoshiro and Aihara, Michiko and Matsunaga, Kayoko and Tohkin, Masahiro and Kurose, Kouichi and Furuya, Hirokazu and Takahashi, Yukitoshi and Muramatsu, Masaaki and Kinoshita, Shigeru and Abe, Masamichi and Ikeda, Hiroko and Kashiwagi, Mariko and Song, Yixuan and Ueta, Mayumi and Sotozono, Chie and Ikezawa, Zenro and Hasegawa, Ryuichi and JSAR Res Grp and JSAR research group
Epilepsia, ISSN 0013-9580, 12/2010, Volume 51, Issue 12, pp. 2461 - 2465
P>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but life-threatening severe cutaneous adverse reactions. Recently, strong... 
HLA-B1502 | HLA-B75 | Serotype | ALLELE | HLA CLASS-I | ASSOCIATION | THAI POPULATION | CLINICAL NEUROLOGY | Pharmacogenetics | Humans | Middle Aged | Risk Factors | Asian Continental Ancestry Group - genetics | Carbamazepine - therapeutic use | Genotype | Male | Thailand | India | Stevens-Johnson Syndrome - genetics | Carbamazepine - adverse effects | Adolescent | Adult | Family | Female | Aged | HLA-B15 Antigen | Child | HLA-B Antigens - genetics | Nervous system diseases | Histocompatibility antigens | Epilepsy | HLA histocompatibility antigens | Universities and colleges | Risk factors | Carbamazepine | Indexing in process
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8. Full Text Recommendations for HLA‐B15:02 and HLA‐A31:01 genetic testing to reduce the risk of carbamazepine‐induced hypersensitivity reactions
by Amstutz, Ursula and Shear, Neil H and Rieder, Michael J and Hwang, Soomi and Fung, Vincent and Nakamura, Hidefumi and Connolly, Mary B and Ito, Shinya and Carleton, Bruce C and CPNDS Clinical Recommendation Grp and CPNDS clinical recommendation group and the CPNDS clinical recommendation group
Epilepsia, ISSN 0013-9580, 04/2014, Volume 55, Issue 4, pp. 496 - 506
Objective To systematically review evidence on genetic risk factors for carbamazepine (CBZ)-induced hypersensitivity reactions (HSRs) and provide practice... 
Toxic epidermal necrolysis | Stevens‐Johnson syndrome | Rash | Drug‐induced hypersensitivity syndrome | Pharmacogenetic testing | Maculopapular exanthema | Drug-induced hypersensitivity syndrome | Stevens-Johnson syndrome | HLA-B GENOTYPE | ADVERSE DRUG-REACTIONS | CLINICAL NEUROLOGY | SEVERE CUTANEOUS ADVERSE | IMPLEMENTATION CONSORTIUM GUIDELINES | ANTIEPILEPTIC DRUGS | JAPANESE PATIENTS | STEVENS-JOHNSON-SYNDROME | HAN CHINESE | THAI POPULATION | Anticonvulsants - adverse effects | Carbamazepine - adverse effects | HLA-B15 Antigen - genetics | Genetic Markers - genetics | Humans | Risk Factors | Drug Hypersensitivity - genetics | HLA-A Antigens - genetics | Drug Hypersensitivity - diagnosis | Genetic Testing - methods | Allergy | Genetic markers | Histocompatibility antigens | HLA histocompatibility antigens | Allergic reaction | Risk factors | Genetic screening | Carbamazepine | Medical research | Clinical medicine
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9. Full Text Association of HLA‐B1502 allele with carbamazepine‐induced toxic epidermal necrolysis and Stevens–Johnson syndrome in the multi‐ethnic Malaysian population
by Chang, Choong‐Chor and Too, Chun‐Lai and Murad, Shahnaz and Hussein, Suraiya Hani
International Journal of Dermatology, ISSN 0011-9059, 02/2011, Volume 50, Issue 2, pp. 221 - 224
Background  Carbamazepine (CBZ), a frequently used anticonvulsant drug, is one of the most common causes of life‐threatening cutaneous adverse drug reactions... 
FREQUENCIES | HLA CLASS-I | B-ALLELES | MARKER | HAPLOTYPES | SURVEILLANCE | INDUCED CUTANEOUS REACTIONS | ADVERSE DRUG-REACTIONS | HAN CHINESE | HLA-DRB1 | DERMATOLOGY | Genetic Predisposition to Disease | Humans | Stevens-Johnson Syndrome - etiology | Asian Continental Ancestry Group - genetics | Genetic Markers | Incidence | Stevens-Johnson Syndrome - chemically induced | Stevens-Johnson Syndrome - genetics | Anticonvulsants - adverse effects | Carbamazepine - adverse effects | Stevens-Johnson Syndrome - epidemiology | Malaysia - epidemiology | HLA-B15 Antigen | HLA-B Antigens - genetics | Stevens-Johnson syndrome | Histocompatibility antigens | HLA histocompatibility antigens | Drugs | Polymerase chain reaction | Toxic epidermal necrolysis | Anticonvulsants | Genetic markers | Gene frequency | Data processing | Histocompatibility antigen HLA | Leukocytes | Population genetics | Carbamazepine | Index Medicus
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10. Full Text Genetic screening for human leukocyte antigen alleles prior to carbamazepine treatment
by Tan, Jeremy C.K and Murrell, Dedee F and Hersch, Mark I
Journal of Clinical Neuroscience, ISSN 0967-5868, 2015, Volume 22, Issue 12, pp. 1992 - 1993
Highlights • Carbamazepine (CBZ)-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) is strongly associated with the HLA-B*1502 allele. •... 
Neurology | HLA-B1502 | Toxic epidermal necrolysis | Stevens–Johnson syndrome | Carbamazepine | Genetic screening | HLA-B | 1502 Stevens-Johnson syndrome | Stevens-Johnson syndrome | HLA-B-ASTERISK-1502 ALLELE | STEVENS-JOHNSON-SYNDROME | NEUROSCIENCES | CLINICAL NEUROLOGY | Genetic Predisposition to Disease - genetics | Genetic Testing | Prospective Studies | Humans | Asian Continental Ancestry Group - genetics | Genotype | Male | Incidence | Stevens-Johnson Syndrome - genetics | Anticonvulsants - adverse effects | Carbamazepine - adverse effects | HLA-B15 Antigen - genetics | Alleles | Adult | Histocompatibility antigens | HLA histocompatibility antigens | Index Medicus
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11. Full Text Genotype–phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: Strength and clinical correlations
by Hsiao, Yi-Hsin and Hui, Rosaline Chung-Yee and Wu, Tony and Chang, Wan-Chun and Hsih, Mo-Song and Yang, Chih-Hsun and Ho, Hsin-Chun and Chang, Ya-Ging and Chen, Ming-Jing and Lin, Jing-Yi and Chen, Ding-Ping and Chang, Pi-Yueh and Wu, Tsu-Lan and Hung, Shuen-Iu and Chung, Wen-Hung
Journal of Dermatological Science, ISSN 0923-1811, 2013, Volume 73, Issue 2, pp. 101 - 109
Abstract Background Increasing studies reported genetic susceptibility to drug hypersensitivity reactions, as exemplified by the HLA-A*31:01 and HLA-B*15:02... 
Dermatology | Stevens–Johnson syndrome | Maculopapular exanthema | Carbamazepine | Human leukocyte antigens | Drug rash with eosinophilia and systemic symptoms | Stevens-Johnson syndrome | TAIWAN | HLA-A-ASTERISK-3101 | RISK | DRESS SYNDROME | TOXIC EPIDERMAL NECROLYSIS | ADVERSE DRUG-REACTIONS | DERMATOLOGY | ERUPTION | HLA-B-ASTERISK-1502 ALLELE | STEVENS-JOHNSON-SYNDROME | THAI POPULATION | Exanthema - genetics | Humans | Middle Aged | Male | HLA Antigens - genetics | Young Adult | Anticonvulsants - adverse effects | HLA-B15 Antigen - genetics | China | Drug Hypersensitivity - genetics | Eosinophilia - genetics | Aged, 80 and over | Adult | Female | Odds Ratio | Child | Pharmacogenetics | Genetic Association Studies | Gene Frequency | Gene Dosage | Stevens-Johnson Syndrome - genetics | Carbamazepine - adverse effects | Adolescent | HLA-A Antigens - genetics | Aged | Cohort Studies | Allergy | Medical colleges | Histocompatibility antigens | HLA histocompatibility antigens | Genetic aspects | Allergic reaction | Index Medicus
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12. Full Text Association of human leukocyte A, B, and DR antigens in Colombian patients with diagnosis of spondyloarthritis
by Santos, Ana M and Peña, Paola and Avila, Mabel and Briceño, Ignacio and Jaramillo, Carlos and Vargas-Alarcon, Gilberto and Rueda, Juan C and Saldarriaga, Eugenia-Lucia and Angarita, Jose-Ignacio and Martinez-Rodriguez, Nancy and Londono, John
Clinical Rheumatology, ISSN 0770-3198, 4/2017, Volume 36, Issue 4, pp. 953 - 958
There is substantial evidence that non-B27 major histocompatibility complex (MHC) genes are associated with spondyloarthritis (SpA). Studies in Mexican and... 
Colombia | Allele frequency | Medicine & Public Health | Humans | Rheumatology | Genetics | HLA-B15 | Spondyloarthritis | RHEUMATOID-ARTHRITIS | CRITERIA | HLA-DR GENES | SUSCEPTIBILITY | CLASSIFICATION | MHC | ANKYLOSING-SPONDYLITIS | RHEUMATOLOGY | SEVERITY | HLA-DRB1 Chains - genetics | Spondylitis, Ankylosing - genetics | Gene Frequency | Middle Aged | Male | Case-Control Studies | Young Adult | Arthritis, Reactive - diagnosis | HLA-B15 Antigen - genetics | Spondylitis, Ankylosing - diagnosis | Arthritis, Reactive - genetics | Adult | Female | Mexico | HLA-B27 Antigen - genetics | Medicine, Experimental | Medical research | Histocompatibility antigens | HLA histocompatibility antigens
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13. Full Text Association between HLA‐B1502 and carbamazepine‐induced severe cutaneous adverse drug reactions in a Thai population
by Tassaneeyakul, Wichittra and Tiamkao, Somsak and Jantararoungtong, Thawinee and Chen, Pei and Lin, Shu‐Yi and Chen, Wei‐Hsuan and Konyoung, Parinya and Khunarkornsiri, Usanee and Auvichayapat, Narong and Pavakul, Kasemsin and Kulkantrakorn, Kongkiat and Choonhakarn, Charoen and Phonhiamhan, Siranun and Piyatrakul, Namfon and Aungaree, Thiti and Pongpakdee, Sunsanee and Yodnopaglaw, Praphan
Epilepsia, ISSN 0013-9580, 05/2010, Volume 51, Issue 5, pp. 926 - 930
Carbamazepine (CBZ) has been reported as the most common culprit drug for Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in several Asian... 
Severe cutaneous adverse drug reactions | HLA‐B1502 | Toxic epidermal necrolysis (TEN) | Carbamazepine | Stevens‐Johnson syndrome (SJS) | HLA-B1502 | Stevens-Johnson syndrome (SJS) | Prevalence | Humans | Middle Aged | Thailand - epidemiology | Asian Continental Ancestry Group - genetics | Male | Mass Screening - methods | Stevens-Johnson Syndrome - chemically induced | Anticonvulsants - adverse effects | Stevens-Johnson Syndrome - epidemiology | Adult | Female | HLA-B15 Antigen | Child | HLA-B Antigens - genetics | Genetic Predisposition to Disease - genetics | Pharmacogenetics | Risk Factors | Stevens-Johnson Syndrome - etiology | Anticonvulsants - therapeutic use | Carbamazepine - therapeutic use | Genotype | Stevens-Johnson Syndrome - genetics | Carbamazepine - adverse effects | Thailand - ethnology | Genetic Markers - genetics | Aged | Asian Continental Ancestry Group - statistics & numerical data | Complications and side effects | Psychiatric hospital care | Histocompatibility antigens | Pharmacy | HLA histocompatibility antigens | Universities and colleges | Psychiatric hospitals | Genetic screening
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