Journal of Immunology, ISSN 0022-1767, 12/2013, Volume 191, Issue 12, pp. 5831 - 5839
Prediction of HLA binding affinity is widely used to identify candidate T cell epitopes, and an affinity of 500 nM is routinely used as a threshold for peptide...
IMMUNODOMINANCE | T-CELL RESPONSES | DATABASE | MHC BINDING | VACCINIA-VIRUS | SUPERTYPES | ANTIGENIC PEPTIDES | NEURAL-NETWORK | IMMUNOLOGY | PREDICTIVE TOOLS | MOLECULES | HLA-A2 Antigen - genetics | HLA-A1 Antigen - genetics | HLA-B7 Antigen - immunology | Antigen Presentation | Dengue Virus - immunology | Peptide Fragments - immunology | Inhibitory Concentration 50 | Epitopes, T-Lymphocyte - immunology | HLA-A1 Antigen - metabolism | Immunization | Peptide Fragments - metabolism | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Antigens, Viral - chemistry | Mice, Transgenic | HLA-B7 Antigen - metabolism | Antigens, Viral - immunology | Peptide Fragments - chemistry | Algorithms | Animals | Alleles | Protein Binding | Genes, MHC Class I | HLA-A1 Antigen - immunology | Mice | HLA-A2 Antigen - metabolism | Epitopes, T-Lymphocyte - metabolism
IMMUNODOMINANCE | T-CELL RESPONSES | DATABASE | MHC BINDING | VACCINIA-VIRUS | SUPERTYPES | ANTIGENIC PEPTIDES | NEURAL-NETWORK | IMMUNOLOGY | PREDICTIVE TOOLS | MOLECULES | HLA-A2 Antigen - genetics | HLA-A1 Antigen - genetics | HLA-B7 Antigen - immunology | Antigen Presentation | Dengue Virus - immunology | Peptide Fragments - immunology | Inhibitory Concentration 50 | Epitopes, T-Lymphocyte - immunology | HLA-A1 Antigen - metabolism | Immunization | Peptide Fragments - metabolism | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Antigens, Viral - chemistry | Mice, Transgenic | HLA-B7 Antigen - metabolism | Antigens, Viral - immunology | Peptide Fragments - chemistry | Algorithms | Animals | Alleles | Protein Binding | Genes, MHC Class I | HLA-A1 Antigen - immunology | Mice | HLA-A2 Antigen - metabolism | Epitopes, T-Lymphocyte - metabolism
Journal Article
Annals of the Rheumatic Diseases, ISSN 0003-4967, 03/2017, Volume 76, Issue 3, pp. 593 - 601
ObjectiveAssociation of position 97 (P97) residue polymorphisms in human leucocyte antigen (HLA)-B, including HLA-B*27, with ankylosing spondylitis (AS) has...
Ankylosing Spondylitis | Autoimmunity | Gene Polymorphism | SPONDYLARTHRITIS | COMPLEX | RECOGNITION | MECHANISM | HLA-B27 HOMODIMERS | B27 | DISEASE | ERAP1 | TRANSGENIC RATS | RHEUMATOLOGY | ARTHRITIS | Humans | HLA-B27 Antigen - metabolism | Spondylitis, Ankylosing - immunology | ATP-Binding Cassette Transporters - deficiency | Membrane Transport Proteins - deficiency | Flow Cytometry | Transfection | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | Threonine - genetics | Minor Histocompatibility Antigens - genetics | Antigens, Surface - metabolism | beta 2-Microglobulin - metabolism | Asparagine - genetics | Aminopeptidases - genetics | HLA-B7 Antigen - genetics | Spondylitis, Ankylosing - genetics | Antigens, Surface - genetics | HLA-B51 Antigen - genetics | Serine - genetics | Aminopeptidases - deficiency | HLA-B7 Antigen - metabolism | HLA-B51 Antigen - metabolism | Valine - genetics | HeLa Cells | Mutation | HLA-B27 Antigen - chemistry | HLA-B27 Antigen - genetics | beta 2-Microglobulin - genetics | Antigens | Hypotheses | Plasmids | Pathogenesis | Lymphocytes | Amino acids | Arthritis | Stains & staining
Ankylosing Spondylitis | Autoimmunity | Gene Polymorphism | SPONDYLARTHRITIS | COMPLEX | RECOGNITION | MECHANISM | HLA-B27 HOMODIMERS | B27 | DISEASE | ERAP1 | TRANSGENIC RATS | RHEUMATOLOGY | ARTHRITIS | Humans | HLA-B27 Antigen - metabolism | Spondylitis, Ankylosing - immunology | ATP-Binding Cassette Transporters - deficiency | Membrane Transport Proteins - deficiency | Flow Cytometry | Transfection | ATP-Binding Cassette Transporters - genetics | Membrane Transport Proteins - genetics | Threonine - genetics | Minor Histocompatibility Antigens - genetics | Antigens, Surface - metabolism | beta 2-Microglobulin - metabolism | Asparagine - genetics | Aminopeptidases - genetics | HLA-B7 Antigen - genetics | Spondylitis, Ankylosing - genetics | Antigens, Surface - genetics | HLA-B51 Antigen - genetics | Serine - genetics | Aminopeptidases - deficiency | HLA-B7 Antigen - metabolism | HLA-B51 Antigen - metabolism | Valine - genetics | HeLa Cells | Mutation | HLA-B27 Antigen - chemistry | HLA-B27 Antigen - genetics | beta 2-Microglobulin - genetics | Antigens | Hypotheses | Plasmids | Pathogenesis | Lymphocytes | Amino acids | Arthritis | Stains & staining
Journal Article
BMC Genomics, ISSN 1471-2164, 01/2018, Volume 19, Issue Suppl 1, pp. 42 - 29
Background: Ebolavirus (EBOV) is responsible for one of the most fatal diseases encountered by mankind. Cellular T-cell responses have been implicated to be...
Ebolavirus | Antigenic diversity | HLA supertype | T-cell epitope | VIRUS | POLYMORPHISM | IDENTIFICATION | PREDICTION | VACCINE DEVELOPMENT | CTL EPITOPES | DATABASE | HEMORRHAGIC-FEVER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | TARGETS | INFECTION | HLA-A3 Antigen - genetics | T-Lymphocytes, Cytotoxic - immunology | HLA-A2 Antigen - genetics | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Humans | Viral Proteins - immunology | HLA-A3 Antigen - immunology | HLA-B7 Antigen - metabolism | Ebolavirus - immunology | Ebolavirus - isolation & purification | Genetic Variation | HLA-A3 Antigen - metabolism | HLA-B7 Antigen - immunology | Hemorrhagic Fever, Ebola - virology | Proteome - immunology | Epitope Mapping - methods | Hemorrhagic Fever, Ebola - immunology | Epitopes, T-Lymphocyte - immunology | HLA-A2 Antigen - metabolism | Proteome - metabolism | Hemorrhagic Fever, Ebola - metabolism | Ebola virus | Microbial genetics | Microbiological research | Histocompatibility antigens | HLA histocompatibility antigens | Genetic research | Genetic aspects | Research | Identification and classification
Ebolavirus | Antigenic diversity | HLA supertype | T-cell epitope | VIRUS | POLYMORPHISM | IDENTIFICATION | PREDICTION | VACCINE DEVELOPMENT | CTL EPITOPES | DATABASE | HEMORRHAGIC-FEVER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | TARGETS | INFECTION | HLA-A3 Antigen - genetics | T-Lymphocytes, Cytotoxic - immunology | HLA-A2 Antigen - genetics | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Humans | Viral Proteins - immunology | HLA-A3 Antigen - immunology | HLA-B7 Antigen - metabolism | Ebolavirus - immunology | Ebolavirus - isolation & purification | Genetic Variation | HLA-A3 Antigen - metabolism | HLA-B7 Antigen - immunology | Hemorrhagic Fever, Ebola - virology | Proteome - immunology | Epitope Mapping - methods | Hemorrhagic Fever, Ebola - immunology | Epitopes, T-Lymphocyte - immunology | HLA-A2 Antigen - metabolism | Proteome - metabolism | Hemorrhagic Fever, Ebola - metabolism | Ebola virus | Microbial genetics | Microbiological research | Histocompatibility antigens | HLA histocompatibility antigens | Genetic research | Genetic aspects | Research | Identification and classification
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0135385
Constitutive cell surface expression of Human Leukocyte Antigen (HLA) class I antigens vary extremely from tissue to tissue and individual antigens may differ...
SINGLE AMINO-ACID | COMPLEX | TAP | TUMOR ESCAPE | PEPTIDE-BINDING | TAPASIN | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | CLASS-I MOLECULES | IMMUNE RECOGNITION | LYMPHOCYTES | HLA-A3 Antigen - genetics | Recombinant Fusion Proteins - immunology | RNA, Messenger - immunology | HLA-A2 Antigen - genetics | Humans | HLA-A3 Antigen - chemistry | Molecular Sequence Data | HLA-A3 Antigen - immunology | HLA-B7 Antigen - immunology | Transfection | HEK293 Cells | HLA-B7 Antigen - chemistry | HLA-B8 Antigen - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Interferon-gamma | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Histocompatibility Testing | RNA, Messenger - genetics | Gene Expression Regulation | HLA-B8 Antigen - chemistry | Recombinant Fusion Proteins - chemistry | Plasmids - metabolism | HLA-A2 Antigen - chemistry | Alleles | HLA-B8 Antigen - immunology | Plasmids - chemistry | Recombinant Fusion Proteins - genetics | Infection | Allelomorphism | Histocompatibility antigens | Health aspects | HLA histocompatibility antigens | Stem cells | Post-transcription | Flow cytometry | Peptides | Gene regulation | Stem cell transplantation | Amino acids | Viruses | Transplantation | Cell surface | B7 antigen | Immunology | Human immunodeficiency virus--HIV | Post-translation | Antigens | Complications | Cloning | Molecular chains | Polymerase chain reaction | White blood cells | Plasmids | Histocompatibility antigen HLA | Cancer | HIV | Human immunodeficiency virus
SINGLE AMINO-ACID | COMPLEX | TAP | TUMOR ESCAPE | PEPTIDE-BINDING | TAPASIN | MULTIDISCIPLINARY SCIENCES | DOWN-REGULATION | CLASS-I MOLECULES | IMMUNE RECOGNITION | LYMPHOCYTES | HLA-A3 Antigen - genetics | Recombinant Fusion Proteins - immunology | RNA, Messenger - immunology | HLA-A2 Antigen - genetics | Humans | HLA-A3 Antigen - chemistry | Molecular Sequence Data | HLA-A3 Antigen - immunology | HLA-B7 Antigen - immunology | Transfection | HEK293 Cells | HLA-B7 Antigen - chemistry | HLA-B8 Antigen - genetics | Protein Structure, Tertiary | Amino Acid Sequence | Interferon-gamma | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Histocompatibility Testing | RNA, Messenger - genetics | Gene Expression Regulation | HLA-B8 Antigen - chemistry | Recombinant Fusion Proteins - chemistry | Plasmids - metabolism | HLA-A2 Antigen - chemistry | Alleles | HLA-B8 Antigen - immunology | Plasmids - chemistry | Recombinant Fusion Proteins - genetics | Infection | Allelomorphism | Histocompatibility antigens | Health aspects | HLA histocompatibility antigens | Stem cells | Post-transcription | Flow cytometry | Peptides | Gene regulation | Stem cell transplantation | Amino acids | Viruses | Transplantation | Cell surface | B7 antigen | Immunology | Human immunodeficiency virus--HIV | Post-translation | Antigens | Complications | Cloning | Molecular chains | Polymerase chain reaction | White blood cells | Plasmids | Histocompatibility antigen HLA | Cancer | HIV | Human immunodeficiency virus
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1026 - 13
Human leukocyte antigen (HLA)-I molecules generally bind short peptides (8-10 amino acids), although extended HLA-I restricted peptides (> 10 amino acids) can...
MHC CLASS-I | IMMUNE-RESPONSE | MOLECULAR FLEXIBILITY | STRUCTURAL BASIS | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | CROSS-REACTIVITY | MAJOR HISTOCOMPATIBILITY COMPLEX | BULGED VIRAL PEPTIDE | SELECTION | EPITOPES | Neoplasms - metabolism | Receptors, Antigen, T-Cell - chemistry | HLA-B7 Antigen - genetics | Peptides - chemistry | Receptors, Antigen, T-Cell - metabolism | Humans | Peptides - genetics | Models, Molecular | Neoplasm Proteins - chemistry | Neoplasm Proteins - metabolism | HLA-B7 Antigen - metabolism | Peptides - metabolism | Neoplasms - genetics | HLA-B7 Antigen - chemistry | Protein Binding | Receptors, Antigen, T-Cell - genetics | Neoplasm Proteins - genetics | Peptides | Amino acids | T cell receptors | Lymphocytes T | Epitopes | Immunity | T-cell receptor | White blood cells | Receptors | Lymphocytes | Histocompatibility antigen HLA | Recognition | Tumors
MHC CLASS-I | IMMUNE-RESPONSE | MOLECULAR FLEXIBILITY | STRUCTURAL BASIS | AMINO-ACIDS | MULTIDISCIPLINARY SCIENCES | CROSS-REACTIVITY | MAJOR HISTOCOMPATIBILITY COMPLEX | BULGED VIRAL PEPTIDE | SELECTION | EPITOPES | Neoplasms - metabolism | Receptors, Antigen, T-Cell - chemistry | HLA-B7 Antigen - genetics | Peptides - chemistry | Receptors, Antigen, T-Cell - metabolism | Humans | Peptides - genetics | Models, Molecular | Neoplasm Proteins - chemistry | Neoplasm Proteins - metabolism | HLA-B7 Antigen - metabolism | Peptides - metabolism | Neoplasms - genetics | HLA-B7 Antigen - chemistry | Protein Binding | Receptors, Antigen, T-Cell - genetics | Neoplasm Proteins - genetics | Peptides | Amino acids | T cell receptors | Lymphocytes T | Epitopes | Immunity | T-cell receptor | White blood cells | Receptors | Lymphocytes | Histocompatibility antigen HLA | Recognition | Tumors
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2010, Volume 184, Issue 9, pp. 5383 - 5391
HIV-1 specific CTL responses play a key role in limiting viral replication. CTL responses are sensitive to viral escape mutations, which influence recognition...
IMMUNE CONTROL | LYMPHOCYTE RESPONSES | VIRUS | RECOGNITION | CROSS-REACTIVITY | AIDS | CLASS-II MOLECULES | INFECTION | HLA-A | IMMUNOLOGY | ASSOCIATION | Predictive Value of Tests | HLA-A2 Antigen - genetics | Humans | Amino Acid Substitution - immunology | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Male | HLA-A Antigens - metabolism | Histocompatibility Antigens Class I - metabolism | HLA-B44 Antigen | CD8-Positive T-Lymphocytes - metabolism | Female | Receptors, Antigen, T-Cell - immunology | Epitopes, T-Lymphocyte - immunology | HLA-B Antigens - genetics | Cytotoxicity, Immunologic - genetics | HLA-A2 Antigen - immunology | Receptors, Antigen, T-Cell - metabolism | HLA-B Antigens - immunology | Histocompatibility Antigens Class I - immunology | HLA-B7 Antigen | Histocompatibility Antigens Class I - genetics | HLA-B Antigens - metabolism | HIV-1 - immunology | HLA-A Antigens - immunology | CD8-Positive T-Lymphocytes - virology | HLA-A Antigens - genetics | Amino Acid Substitution - genetics | Receptors, Antigen, T-Cell - genetics | HLA-A2 Antigen - metabolism | CD8-Positive T-Lymphocytes - immunology | Epitopes, T-Lymphocyte - metabolism
IMMUNE CONTROL | LYMPHOCYTE RESPONSES | VIRUS | RECOGNITION | CROSS-REACTIVITY | AIDS | CLASS-II MOLECULES | INFECTION | HLA-A | IMMUNOLOGY | ASSOCIATION | Predictive Value of Tests | HLA-A2 Antigen - genetics | Humans | Amino Acid Substitution - immunology | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Male | HLA-A Antigens - metabolism | Histocompatibility Antigens Class I - metabolism | HLA-B44 Antigen | CD8-Positive T-Lymphocytes - metabolism | Female | Receptors, Antigen, T-Cell - immunology | Epitopes, T-Lymphocyte - immunology | HLA-B Antigens - genetics | Cytotoxicity, Immunologic - genetics | HLA-A2 Antigen - immunology | Receptors, Antigen, T-Cell - metabolism | HLA-B Antigens - immunology | Histocompatibility Antigens Class I - immunology | HLA-B7 Antigen | Histocompatibility Antigens Class I - genetics | HLA-B Antigens - metabolism | HIV-1 - immunology | HLA-A Antigens - immunology | CD8-Positive T-Lymphocytes - virology | HLA-A Antigens - genetics | Amino Acid Substitution - genetics | Receptors, Antigen, T-Cell - genetics | HLA-A2 Antigen - metabolism | CD8-Positive T-Lymphocytes - immunology | Epitopes, T-Lymphocyte - metabolism
Journal Article
Human Gene Therapy, ISSN 1043-0342, 12/2017, Volume 28, Issue 12, pp. 1158 - 1168
T-cell receptor (TCR) immunotherapy uses T cells engineered with new TCRs to enable detection and killing of cancer cells. Efficacy of TCR immunotherapy...
Research Articles | T cell receptor (TCR) discovery | MHC cell library | immunodominance | human papillomavirus ES | immunotherapy | TCR gene therapy | HLA-B7 Antigen - genetics | Humans | Peptides - immunology | Peptides - genetics | Neoplasms - therapy | HLA-B15 Antigen - genetics | HLA-B7 Antigen - immunology | Adoptive Transfer - methods | Neoplasms - genetics | Neoplasms - immunology | K562 Cells | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | HLA-B15 Antigen - immunology | Neoplasms - pathology | MEDICINE, RESEARCH & EXPERIMENTAL | TCR | PROTEIN | ANTITUMOR-ACTIVITY | CANCER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | human papillamavirus ES | ANTIGEN-PRESENTING CELLS | GENERATION | EXPRESSION | E5 ONCOPROTEIN | LYMPHOCYTES | EPITOPES | Killing | Antigens | Peptides | T cell receptors | Lymphocytes T | T-cell receptor | Receptors | Major histocompatibility complex | Lymphocytes | Immunotherapy | Histocompatibility antigen HLA | Histocompatibility | Cancer
Research Articles | T cell receptor (TCR) discovery | MHC cell library | immunodominance | human papillomavirus ES | immunotherapy | TCR gene therapy | HLA-B7 Antigen - genetics | Humans | Peptides - immunology | Peptides - genetics | Neoplasms - therapy | HLA-B15 Antigen - genetics | HLA-B7 Antigen - immunology | Adoptive Transfer - methods | Neoplasms - genetics | Neoplasms - immunology | K562 Cells | Receptors, Antigen, T-Cell - immunology | T-Lymphocytes - immunology | Receptors, Antigen, T-Cell - genetics | HLA-B15 Antigen - immunology | Neoplasms - pathology | MEDICINE, RESEARCH & EXPERIMENTAL | TCR | PROTEIN | ANTITUMOR-ACTIVITY | CANCER | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GENETICS & HEREDITY | human papillamavirus ES | ANTIGEN-PRESENTING CELLS | GENERATION | EXPRESSION | E5 ONCOPROTEIN | LYMPHOCYTES | EPITOPES | Killing | Antigens | Peptides | T cell receptors | Lymphocytes T | T-cell receptor | Receptors | Major histocompatibility complex | Lymphocytes | Immunotherapy | Histocompatibility antigen HLA | Histocompatibility | Cancer
Journal Article
Pharmacogenomics, ISSN 1462-2416, 09/2006, Volume 7, Issue 6, pp. 813 - 818
Background: A strong pharmacogenetic association has been reported in Chinese patients between human leukocyte antigen (HLA)-8*1502 and carbamazepine...
HLA-B | Pharmacogenetics | Adverse drug reactions | Epilepsy | Hypersensitivity | Carbamazepine | epilepsy | ABACAVIR | hypersensitivity | MARKER | PATTERNS | ALPHA | carbamazepine | REGION | adverse drug reactions | PHARMACOLOGY & PHARMACY | MICE | GENETIC-VARIATIONS | HUMAN MHC | ASSOCIATION | EXPRESSION | pharmacogenetics | European Continental Ancestry Group - genetics | Gene Frequency | Humans | Asian Continental Ancestry Group - genetics | HLA-B7 Antigen | United Kingdom | Genetic Markers | Case-Control Studies | Carbamazepine - adverse effects | HLA-DR3 Antigen - genetics | HLA-B8 Antigen | Drug Hypersensitivity - immunology | HLA-DQ Antigens - genetics | Toxicogenetics | Alleles | Drug Hypersensitivity - genetics | HLA-B15 Antigen | HLA-B Antigens - genetics
HLA-B | Pharmacogenetics | Adverse drug reactions | Epilepsy | Hypersensitivity | Carbamazepine | epilepsy | ABACAVIR | hypersensitivity | MARKER | PATTERNS | ALPHA | carbamazepine | REGION | adverse drug reactions | PHARMACOLOGY & PHARMACY | MICE | GENETIC-VARIATIONS | HUMAN MHC | ASSOCIATION | EXPRESSION | pharmacogenetics | European Continental Ancestry Group - genetics | Gene Frequency | Humans | Asian Continental Ancestry Group - genetics | HLA-B7 Antigen | United Kingdom | Genetic Markers | Case-Control Studies | Carbamazepine - adverse effects | HLA-DR3 Antigen - genetics | HLA-B8 Antigen | Drug Hypersensitivity - immunology | HLA-DQ Antigens - genetics | Toxicogenetics | Alleles | Drug Hypersensitivity - genetics | HLA-B15 Antigen | HLA-B Antigens - genetics
Journal Article
European Journal of Immunology, ISSN 0014-2980, 12/2013, Volume 43, Issue 12, pp. 3254 - 3267
It is recognized that host response following viral infection is characterized by immunodominance, but deciphering the different factors contributing to...
Influenza A | HLA‐B7 and HLA‐B27 | Immunodominance | Thymic selection | HLA-B7 and HLA-B27 | REPERTOIRE | LYMPHOCYTE | T-CELL IMMUNODOMINANCE | ANTIGEN PRESENTATION | IMMUNOLOGY | CTL EPITOPES | EPITOPE AFFECTS | A VIRUSES | ENDOPLASMIC-RETICULUM | CLASS-I MOLECULES | TRANSGENIC MICE | Immunodominant Epitopes - immunology | Antigens, Viral - metabolism | CD8-Positive T-Lymphocytes - pathology | Humans | Influenza A Virus, H3N2 Subtype - metabolism | Antigens, Viral - genetics | Receptors, Antigen, T-Cell, alpha-beta - immunology | Influenza A Virus, H3N2 Subtype - genetics | Orthomyxoviridae Infections - genetics | HLA-B7 Antigen - immunology | Immunodominant Epitopes - metabolism | HLA-B7 Antigen - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | HLA-B27 Antigen - immunology | Immunodominant Epitopes - genetics | Gene Expression | Immunity, Cellular - genetics | HLA-B7 Antigen - genetics | Orthomyxoviridae Infections - metabolism | Orthomyxoviridae Infections - pathology | Influenza A Virus, H3N2 Subtype - immunology | Receptors, Antigen, T-Cell, alpha-beta - genetics | Mice, Knockout | Antigens, Viral - immunology | Animals | HLA-B27 Antigen - biosynthesis | Mice | Receptors, Antigen, T-Cell, alpha-beta - metabolism | CD8-Positive T-Lymphocytes - immunology | HLA-B27 Antigen - genetics | Orthomyxoviridae Infections - immunology | Allelomorphism | Peptides | Influenza | Genetic engineering | T cells | Health aspects | Antigenic determinants | Medical research | Rodents
Influenza A | HLA‐B7 and HLA‐B27 | Immunodominance | Thymic selection | HLA-B7 and HLA-B27 | REPERTOIRE | LYMPHOCYTE | T-CELL IMMUNODOMINANCE | ANTIGEN PRESENTATION | IMMUNOLOGY | CTL EPITOPES | EPITOPE AFFECTS | A VIRUSES | ENDOPLASMIC-RETICULUM | CLASS-I MOLECULES | TRANSGENIC MICE | Immunodominant Epitopes - immunology | Antigens, Viral - metabolism | CD8-Positive T-Lymphocytes - pathology | Humans | Influenza A Virus, H3N2 Subtype - metabolism | Antigens, Viral - genetics | Receptors, Antigen, T-Cell, alpha-beta - immunology | Influenza A Virus, H3N2 Subtype - genetics | Orthomyxoviridae Infections - genetics | HLA-B7 Antigen - immunology | Immunodominant Epitopes - metabolism | HLA-B7 Antigen - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | HLA-B27 Antigen - immunology | Immunodominant Epitopes - genetics | Gene Expression | Immunity, Cellular - genetics | HLA-B7 Antigen - genetics | Orthomyxoviridae Infections - metabolism | Orthomyxoviridae Infections - pathology | Influenza A Virus, H3N2 Subtype - immunology | Receptors, Antigen, T-Cell, alpha-beta - genetics | Mice, Knockout | Antigens, Viral - immunology | Animals | HLA-B27 Antigen - biosynthesis | Mice | Receptors, Antigen, T-Cell, alpha-beta - metabolism | CD8-Positive T-Lymphocytes - immunology | HLA-B27 Antigen - genetics | Orthomyxoviridae Infections - immunology | Allelomorphism | Peptides | Influenza | Genetic engineering | T cells | Health aspects | Antigenic determinants | Medical research | Rodents
Journal Article
Journal of Hepatology, ISSN 0168-8278, 2007, Volume 46, Issue 5, pp. 899 - 906
Background/Aims Combinations of killer immunoglobulin-like receptors (KIRs) and HLA class I ligands that reduce natural killer (NK) cell inhibition have been...
Gastroenterology and Hepatology | Primary sclerosing cholangitis | Natural killer cells | Genetic susceptibility | Human leukocyte antigen | Killer immunoglobulin-like receptor | human leukocyte antigen | SUSCEPTIBILITY | HAPLOTYPES | DELTA T-CELLS | natural killer cells | COMBINATIONS | NK CELLS | killer immunoglobulin-like receptor | DISEASE | genetic susceptibility | CLASS-I MOLECULES | GASTROENTEROLOGY & HEPATOLOGY | FUNCTIONAL-CHARACTERISTICS | primary sclerosing cholangitis | INNATE IMMUNITY | LYMPHOCYTES | Receptors, KIR2DL1 | Humans | Middle Aged | Cholangitis, Sclerosing - genetics | Haplotypes - genetics | Adult | HLA-B8 Antigen - genetics | Receptors, KIR3DL1 | Child | HLA-B Antigens - genetics | Genetic Predisposition to Disease | HLA-B7 Antigen - genetics | Gene Frequency | Receptors, KIR | Linkage Disequilibrium | Polymorphism, Genetic | Radiography | Cholangitis, Sclerosing - diagnostic imaging | HLA-DR3 Antigen - genetics | Cholangitis, Sclerosing - immunology | Norway | Autoimmune Diseases | HLA-DRB1 Chains | Adolescent | HLA-A Antigens - genetics | HLA-DR6 Antigen - genetics | Ligands | Aged | HLA-C Antigens - genetics | Killer Cells, Natural - metabolism | Receptors, Immunologic - genetics | Genetic research
Gastroenterology and Hepatology | Primary sclerosing cholangitis | Natural killer cells | Genetic susceptibility | Human leukocyte antigen | Killer immunoglobulin-like receptor | human leukocyte antigen | SUSCEPTIBILITY | HAPLOTYPES | DELTA T-CELLS | natural killer cells | COMBINATIONS | NK CELLS | killer immunoglobulin-like receptor | DISEASE | genetic susceptibility | CLASS-I MOLECULES | GASTROENTEROLOGY & HEPATOLOGY | FUNCTIONAL-CHARACTERISTICS | primary sclerosing cholangitis | INNATE IMMUNITY | LYMPHOCYTES | Receptors, KIR2DL1 | Humans | Middle Aged | Cholangitis, Sclerosing - genetics | Haplotypes - genetics | Adult | HLA-B8 Antigen - genetics | Receptors, KIR3DL1 | Child | HLA-B Antigens - genetics | Genetic Predisposition to Disease | HLA-B7 Antigen - genetics | Gene Frequency | Receptors, KIR | Linkage Disequilibrium | Polymorphism, Genetic | Radiography | Cholangitis, Sclerosing - diagnostic imaging | HLA-DR3 Antigen - genetics | Cholangitis, Sclerosing - immunology | Norway | Autoimmune Diseases | HLA-DRB1 Chains | Adolescent | HLA-A Antigens - genetics | HLA-DR6 Antigen - genetics | Ligands | Aged | HLA-C Antigens - genetics | Killer Cells, Natural - metabolism | Receptors, Immunologic - genetics | Genetic research
Journal Article
European Journal of Immunology, ISSN 0014-2980, 12/2014, Volume 44, Issue 12, pp. 3573 - 3584
Human herpesvirus 6B (HHV‐6B) is a ubiquitous pathogen with frequent reactivation observed in immunocompromised patients such as BM transplant (BMT)...
HHV‐6 | Immediate‐early 1 protein | Infectious disease | Immunotherapy | CD8 T cells | Virology | Immediate-early 1 protein | HHV-6 | SPECIFICITY | NUCLEAR ANTIGEN-1 | IMMUNOLOGY | CYTOMEGALOVIRUS | TRANSPLANTATION | PREDICTION | INHIBITION | REACTIVATION | SEQUENCE | EPSTEIN-BARR-VIRUS | LYMPHOCYTES | HLA-A3 Antigen - genetics | HLA-A2 Antigen - genetics | CD8-Positive T-Lymphocytes - pathology | Humans | Middle Aged | Roseolovirus Infections - therapy | Epitopes, T-Lymphocyte - genetics | Male | Adoptive Transfer | HLA-A3 Antigen - immunology | HLA-B7 Antigen - immunology | Herpesvirus 6, Human - immunology | Adult | Female | Epitopes, T-Lymphocyte - immunology | Cell Proliferation - genetics | Immediate-Early Proteins - immunology | Roseolovirus Infections - pathology | Immunity, Cellular - genetics | Roseolovirus Infections - genetics | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Mice, Transgenic | Roseolovirus Infections - immunology | Herpesvirus 6, Human - genetics | Animals | Immediate-Early Proteins - genetics | Adolescent | Mice | CD8-Positive T-Lymphocytes - immunology | Histocompatibility antigens | T cells | HLA histocompatibility antigens | Antigenic determinants | T cell receptors
HHV‐6 | Immediate‐early 1 protein | Infectious disease | Immunotherapy | CD8 T cells | Virology | Immediate-early 1 protein | HHV-6 | SPECIFICITY | NUCLEAR ANTIGEN-1 | IMMUNOLOGY | CYTOMEGALOVIRUS | TRANSPLANTATION | PREDICTION | INHIBITION | REACTIVATION | SEQUENCE | EPSTEIN-BARR-VIRUS | LYMPHOCYTES | HLA-A3 Antigen - genetics | HLA-A2 Antigen - genetics | CD8-Positive T-Lymphocytes - pathology | Humans | Middle Aged | Roseolovirus Infections - therapy | Epitopes, T-Lymphocyte - genetics | Male | Adoptive Transfer | HLA-A3 Antigen - immunology | HLA-B7 Antigen - immunology | Herpesvirus 6, Human - immunology | Adult | Female | Epitopes, T-Lymphocyte - immunology | Cell Proliferation - genetics | Immediate-Early Proteins - immunology | Roseolovirus Infections - pathology | Immunity, Cellular - genetics | Roseolovirus Infections - genetics | HLA-A2 Antigen - immunology | HLA-B7 Antigen - genetics | Mice, Transgenic | Roseolovirus Infections - immunology | Herpesvirus 6, Human - genetics | Animals | Immediate-Early Proteins - genetics | Adolescent | Mice | CD8-Positive T-Lymphocytes - immunology | Histocompatibility antigens | T cells | HLA histocompatibility antigens | Antigenic determinants | T cell receptors
Journal Article
Nature Communications, ISSN 2041-1723, 12/2019, Volume 10, Issue 1, pp. 1150 - 9
Frontal fibrosing alopecia (FFA) is a recently described inflammatory and scarring type of hair loss affecting almost exclusively women. Despite a dramatic...
LICHEN-PLANOPILARIS | SET | GENE | MULTIDISCIPLINARY SCIENCES | IMMUNE PRIVILEGE | Adaptive Immunity | Cytochrome P-450 CYP1B1 - genetics | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | HLA-B7 Antigen - genetics | Humans | Alopecia - physiopathology | Cytochrome P-450 CYP1B1 - immunology | Transcriptome - immunology | Genetic Loci | Immunity, Innate | Case-Control Studies | Alopecia - congenital | HLA-B7 Antigen - immunology | Alopecia - genetics | Female | Polymorphism, Single Nucleotide | Genome, Human | Alopecia - diagnosis | Cohort Studies | Immune response | Baldness | Pathogenesis | Chromosome 6 | Genomes | Mapping | Loci | Chromosome 2 | Scars | Alopecia | Scalp | Histocompatibility antigen HLA | Gene mapping | Females | Immune system
LICHEN-PLANOPILARIS | SET | GENE | MULTIDISCIPLINARY SCIENCES | IMMUNE PRIVILEGE | Adaptive Immunity | Cytochrome P-450 CYP1B1 - genetics | Gene Expression | Genetic Predisposition to Disease | Genome-Wide Association Study | HLA-B7 Antigen - genetics | Humans | Alopecia - physiopathology | Cytochrome P-450 CYP1B1 - immunology | Transcriptome - immunology | Genetic Loci | Immunity, Innate | Case-Control Studies | Alopecia - congenital | HLA-B7 Antigen - immunology | Alopecia - genetics | Female | Polymorphism, Single Nucleotide | Genome, Human | Alopecia - diagnosis | Cohort Studies | Immune response | Baldness | Pathogenesis | Chromosome 6 | Genomes | Mapping | Loci | Chromosome 2 | Scars | Alopecia | Scalp | Histocompatibility antigen HLA | Gene mapping | Females | Immune system
Journal Article
PLoS genetics, ISSN 1553-7404, 01/2019, Volume 15, Issue 1, p. e1007808
Multiple sclerosis (MS) is an autoimmune disease with high prevalence among populations of northern European ancestry. Past studies have shown that exposure to...
POPULATION | IMPUTATION | VARIANTS | GENETICS & HEREDITY | WHOLE-GENOME ASSOCIATION | AFRICAN-AMERICANS | WIDE ASSOCIATION | HLA | INFERENCE | LOCUS | HLA-A3 Antigen - genetics | Haplotypes | Genetic Predisposition to Disease | Genome-Wide Association Study | HLA-B7 Antigen - genetics | HLA-DRB1 Chains - genetics | Humans | Hispanic Americans | African Americans | European Continental Ancestry Group | Male | Multiple Sclerosis - genetics | Transcription Factors - genetics | Alleles | Multiple Sclerosis - pathology | Female | Polymorphism, Single Nucleotide | Asian Americans | Epigenetic inheritance | Multiple sclerosis | Genetic aspects | Health aspects | Risk factors | Pediatrics | Laboratories | U.V. radiation | Genomics | Genomes | Single-nucleotide polymorphism | Epidemiology | Neurology | Hospitals | Chromosome 8 | Drb1 protein | Population | Histocompatibility antigen HLA | Gene mapping | Autoimmune diseases
POPULATION | IMPUTATION | VARIANTS | GENETICS & HEREDITY | WHOLE-GENOME ASSOCIATION | AFRICAN-AMERICANS | WIDE ASSOCIATION | HLA | INFERENCE | LOCUS | HLA-A3 Antigen - genetics | Haplotypes | Genetic Predisposition to Disease | Genome-Wide Association Study | HLA-B7 Antigen - genetics | HLA-DRB1 Chains - genetics | Humans | Hispanic Americans | African Americans | European Continental Ancestry Group | Male | Multiple Sclerosis - genetics | Transcription Factors - genetics | Alleles | Multiple Sclerosis - pathology | Female | Polymorphism, Single Nucleotide | Asian Americans | Epigenetic inheritance | Multiple sclerosis | Genetic aspects | Health aspects | Risk factors | Pediatrics | Laboratories | U.V. radiation | Genomics | Genomes | Single-nucleotide polymorphism | Epidemiology | Neurology | Hospitals | Chromosome 8 | Drb1 protein | Population | Histocompatibility antigen HLA | Gene mapping | Autoimmune diseases
Journal Article