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Journal Article
Nature genetics, ISSN 1546-1718, 02/2016, Volume 48, Issue 3, pp. 318 - 322
Journal Article
Nature genetics, ISSN 1546-1718, 09/2014, Volume 46, Issue 10, pp. 1131 - 1134
Pancreatitis occurs in approximately 4% of patients treated with the thiopurines azathioprine or mercaptopurine. Its development is unpredictable and almost... 
POPULATION | INFLAMMATORY-BOWEL-DISEASE | THERAPY | CROHNS-DISEASE | COMPLICATION | GENOTYPE | AZATHIOPRINE | GENOME-WIDE ASSOCIATION | HYPERSENSITIVITY | Life Sciences & Biomedicine | Genetics & Heredity | Science & Technology | Haplotypes | Humans | HLA-DQ alpha-Chains - chemistry | HLA-DQ alpha-Chains - genetics | Mercaptopurine - chemistry | Pancreatitis - genetics | Mercaptopurine - metabolism | Immunosuppressive Agents - metabolism | Molecular Structure | HLA-DRB1 Chains - metabolism | Inflammatory Bowel Diseases - drug therapy | Protein Structure, Tertiary | Genetic Predisposition to Disease - genetics | Genome-Wide Association Study | Azathioprine - metabolism | HLA-DRB1 Chains - genetics | Gene Frequency | Risk Factors | Mercaptopurine - adverse effects | Models, Molecular | Genotype | Pancreatitis - chemically induced | Azathioprine - chemistry | Protein Binding | Immunosuppressive Agents - adverse effects | Polymorphism, Single Nucleotide | HLA-DRB1 Chains - chemistry | Azathioprine - adverse effects | HLA-DQ alpha-Chains - metabolism | Immunosuppressive Agents - chemistry | Complications and side effects | Pancreatitis | Genetic aspects | Histocompatibility | Health aspects | Risk factors | Immunosuppressive agents | Studies | Inflammatory bowel disease | Medical research | Genomes | Drug therapy | Methods | Crohns disease | Index Medicus
Journal Article
The Journal of infectious diseases, ISSN 1537-6613, 12/2017, Volume 216, Issue 11, pp. 1460 - 1470
.... A genome-wide study identified HLA as the strongest genetic risk factor. Risk and protective HLA_DQA1_DQB1 haplotypes bound with different affinities to core epitopes of pathogenic GAS M proteins... 
Epitope mapping | GWAS | Rheumatic heart disease | HLA | Acute rheumatic fever | Infectious Diseases | Immunology | Life Sciences & Biomedicine | Microbiology | Science & Technology | HLA-DQ alpha-Chains - immunology | Haplotypes | Rheumatic Heart Disease - genetics | Humans | HLA-DQ alpha-Chains - chemistry | HLA Antigens - genetics | HLA-DQ alpha-Chains - genetics | Streptococcus - pathogenicity | HLA-DQ Antigens - immunology | Rheumatic Heart Disease - microbiology | Epitopes - immunology | Streptococcal Infections - genetics | Molecular Mimicry | HLA-DQ Antigens - chemistry | HLA-DQ alpha-Chains - classification | Odds Ratio | Genetic Predisposition to Disease | Genome-Wide Association Study | Bacterial Outer Membrane Proteins - immunology | Myosins - immunology | Risk Factors | HLA Antigens - immunology | Genotype | Cross Reactions - immunology | Rheumatic Heart Disease - immunology | HLA-DQ Antigens - classification | HLA-DQ Antigens - genetics | Polymorphism, Single Nucleotide - genetics | Streptococcal Infections - immunology | Australia | Genome-wide association studies | Histocompatibility antigens | Demographic aspects | Bacterial proteins | HLA histocompatibility antigens | Reports | Australian aborigines | Research | Health aspects | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
by Joshi, Peter K and Pirastu, Nicola and Kentistou, Katherine A and Fischer, Krista and Hofer, Edith and Schraut, Katharina E and Clark, David W and Nutile, Teresa and Barnes, Catriona L. K and Timmers, Paul R. H. J and Shen, Xia and Gandin, Ilaria and McDaid, Aaron F and Hansen, Thomas Folkmann and Gordon, Scott D and Giulianini, Franco and Boutin, Thibaud S and Abdellaoui, Abdel and Zhao, Wei and Medina-Gomez, Carolina and Bartz, Traci M and Trompet, Stella and Lange, Leslie A and Raffield, Laura and van der Spek, Ashley and Galesloot, Tessel E and Proitsi, Petroula and Yanek, Lisa R and Bielak, Lawrence F and Payton, Antony and Murgia, Federico and Concas, Maria Pina and Biino, Ginevra and Tajuddin, Salman M and Seppälä, Ilkka and Amin, Najaf and Boerwinkle, Eric and Børglum, Anders D and Campbell, Archie and Demerath, Ellen W and Demuth, Ilja and Faul, Jessica D and Ford, Ian and Gialluisi, Alessandro and Gögele, Martin and Graff, MariaElisa and Hingorani, Aroon and Hottenga, Jouke-Jan and Hougaard, David M and Hurme, Mikko A and Ikram, M. Arfan and Jylhä, Marja and Kuh, Diana and Ligthart, Lannie and Lill, Christina M and Lindenberger, Ulman and Lumley, Thomas and Mägi, Reedik and Marques-Vidal, Pedro and Medland, Sarah E and Milani, Lili and Nagy, Reka and Ollier, William E. R and Peyser, Patricia A and Pramstaller, Peter P and Ridker, Paul M and Rivadeneira, Fernando and Ruggiero, Daniela and Saba, Yasaman and Schmidt, Reinhold and Schmidt, Helena and Slagboom, P. Eline and Smith, Blair H and Smith, Jennifer A and Sotoodehnia, Nona and Steinhagen-Thiessen, Elisabeth and van Rooij, Frank J. A and Verbeek, André L and Vermeulen, Sita H and Vollenweider, Peter and Wang, Yunpeng and Werge, Thomas and Whitfield, John B and Zonderman, Alan B and Lehtimäki, Terho and Evans, Michele K and Pirastu, Mario and Fuchsberger, Christian and Bertram, Lars and Pendleton, Neil and Kardia, Sharon L. R and Ciullo, Marina and Becker, Diane M and Wong, Andrew and Psaty, Bruce M and van Duijn, Cornelia M and Wilson, James G and Jukema, J. Wouter and Kiemeney, Lambertus and Uitterlinden, André G and ...
Nature communications, ISSN 2041-1723, 10/2017, Volume 8, Issue 1, pp. 910 - 13
Journal Article
Annals of the rheumatic diseases, ISSN 1468-2060, 06/2019, Volume 78, Issue 6, pp. 773 - 780
Journal Article