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biochemistry & molecular biology (9) 9
biophysics (8) 8
cell biology (7) 7
hmbpp (7) 7
index medicus (7) 7
isoprenoid biosynthesis (7) 7
enzymes (6) 6
escherichia coli - metabolism (5) 5
escherichia-coli (5) 5
mep (5) 5
non-mevalonate pathway (5) 5
physiological aspects (5) 5
analysis (4) 4
bacterial proteins - metabolism (4) 4
dmapp, dimethylallyl diphosphate (4) 4
erythritol - analogs & derivatives (4) 4
erythritol - metabolism (4) 4
ipp, isopentenyl diphosphate (4) 4
phosphates (4) 4
biosynthesis (3) 3
cloning, molecular (3) 3
crystallography, x-ray (3) 3
dmapp (3) 3
drug design (3) 3
enzyme (3) 3
enzymes - chemistry (3) 3
gcpe (3) 3
inhibition (3) 3
ipp (3) 3
isph protein (3) 3
kinetics (3) 3
lytb (3) 3
mecpp (3) 3
methylerythritol phosphate-pathway (3) 3
models, chemical (3) 3
models, molecular (3) 3
oxidoreductases - metabolism (3) 3
recombinant proteins - metabolism (3) 3
terpenes - metabolism (3) 3
x-ray structure (3) 3
2-c-methyl-d-erythritol-4-phosphate (2) 2
2-c-methyl-d-erythritol-4-phosphate pathway (2) 2
4fe-4s cluster (2) 2
antimalarial (2) 2
arabidopsis-thaliana (2) 2
bacterial proteins - chemistry (2) 2
bacterial proteins - genetics (2) 2
catalytic domain (2) 2
chromatography, high pressure liquid (2) 2
deoxyxylulose phosphate-pathway (2) 2
dimethylallyl diphosphate (2) 2
diphosphate synthase gcpe (2) 2
discovery (2) 2
dose-response relationship, drug (2) 2
electrophoresis, polyacrylamide gel (2) 2
escherichia coli (2) 2
escherichia coli - enzymology (2) 2
escherichia coli - genetics (2) 2
escherichia coli proteins - genetics (2) 2
hmbpp,-4-hydroxy-3-methyl-but-2-enyl diphosphate (2) 2
isopentenyl diphosphate (2) 2
isopentenyl pyrophosphate (2) 2
malaria (2) 2
mechanism (2) 2
mep, 2-c-methyl-d-erythritol-4-phosphate (2) 2
metabolites (2) 2
mevalonate pathway (2) 2
molecular sequence data (2) 2
nonmevalonate pathway (2) 2
organophosphates - chemistry (2) 2
organophosphates - pharmacology (2) 2
oxidoreductases - chemistry (2) 2
oxidoreductases - genetics (2) 2
phytochemistry (2) 2
plants (2) 2
plasmodium falciparum (2) 2
plasmodium falciparum - enzymology (2) 2
plasmodium falciparum - metabolism (2) 2
protein binding (2) 2
protein conformation (2) 2
protein structure, tertiary (2) 2
proteins (2) 2
protozoan proteins - chemistry (2) 2
recombinant proteins - chemistry (2) 2
spectrometry, mass, electrospray ionization (2) 2
sugar phosphates - metabolism (2) 2
thermus thermophilus - enzymology (2) 2
virulence (2) 2
-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate (1) 1
-1-hydroxy-2-methyl-but-2-enyl-4-diphosphate synthase (1) 1
-4-hydroxy-3- methylbutyl-2-enyl pyrophosphate (1) 1
-4-hydroxy-3-methyl- but-2-enyl diphosphate (1) 1
-4-hydroxy-3-methyl-but-2-enyl diphosphate (1) 1
-4-hydroxy-3-methyl-but-2-enyl-diphosphate (1) 1
-4-hydroxy-3-methyl-but-2-enyl-diphosphate reductase (1) 1
-4-hydroxy-3-methylbutyl-2-enyl pyrophosphate (1) 1
1-deoxy-d-xylulose 5-phosphate (1) 1
1-deoxy-d-xylulose 5-phosphate reductoisomerase (1) 1
1-deoxy-d-xylulose 5-phosphate synthase (1) 1
1-hydroxy-2-methyl-2--butenyl 4-diphosphate (1) 1
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Journal Article
FEBS Letters, ISSN 0014-5793, 09/2002, Volume 527, Issue 1-3, pp. 315 - 318
The plant pathogen Agrobacterium tumefaciens produces cytokinins upon induction of the virulence genes by secondary metabolites from wounded plants, and these... 
Plant hormone | Terpene | Non-mevalonate pathway | Gene transfer | Cytokinin | Isoprenoid biosynthesis | ZR, zeatin riboside | IPP, isopentenyl diphosphate | HMBPP, 4-hydroxy-3-methyl-2-(E)-butenyl diphosphate | iPMP, isopentenyladenosine 5′-monophosphate | ZMP, zeatin riboside 5′-phosphate | DMAPP, dimethylallyl diphosphate | DXP, 1-deoxyxylulose 5-phosphate | isoprenoid biosynthesis | plant hormone | BACTERIA | gene transfer | BIOCHEMISTRY & MOLECULAR BIOLOGY | terpene | T-DNA | IDENTIFICATION | GENOME | CELL BIOLOGY | non-mevalonate pathway | CYTOKININ BIOSYNTHESIS | cytokinin | ENZYME | BIOPHYSICS | PATHWAY | GENES | PLANTS | EXPRESSION | Organophosphates - metabolism | Protein Engineering - methods | Adenosine Monophosphate - metabolism | Adenosine Monophosphate - chemistry | Bacterial Proteins - genetics | Agrobacterium tumefaciens - genetics | Agrobacterium tumefaciens - metabolism | Isopentenyladenosine - analogs & derivatives | Adenosine Monophosphate - analogs & derivatives | Cloning, Molecular | Isopentenyladenosine - chemistry | Bacterial Proteins - metabolism | Isopentenyladenosine - metabolism | Organophosphates - chemistry | Bacterial Proteins - isolation & purification | Phosphates | Physiological aspects | Cytokinins | Virulence (Microbiology) | Analysis | Plant metabolites | Medical research | Medicine, Experimental
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2002, Volume 532, Issue 3, pp. 432 - 436
The gcpE gene product controls one of the terminal steps of isoprenoid biosynthesis via the mevalonate independent 2‐C‐methyl‐D‐erythritol‐4‐phosphate (MEP)... 
GcpE | 2-C-Methyl-D-erythritol-2,4-cyclodiphosphate | Isoprenoid biosynthesis | 2-C-Methyl-D-erythritol-4-phosphate pathway | (E)-4-Hydroxy-3-methyl-but-2-enyl diphosphate | LytB | PBMC, peripheral blood mononuclear cells | IPP, isopentenyl diphosphate | DOXP, 1-deoxy-D-xylulose-5-phosphate | HMBPP, (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate | MEcPP, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate | DMAPP, dimethylallyl diphosphate | MEP, 2-C-methyl-D-erythritol-4-phosphate | (E)-4-Hydroxy-3-methyl- but-2-enyl diphosphate | isoprenoid biosynthesis | 2-C-methyl-D-erythritol-2,4-cyclodiphosphate | (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate | BIOCHEMISTRY & MOLECULAR BIOLOGY | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE PATHWAY | ESCHERICHIA-COLI | CELL BIOLOGY | EVOLUTION | BIOPHYSICS | GENE | 2-C-methyl-D-erythritol-4-phosphate pathway | Recombinant Proteins - metabolism | Enzymes | Models, Chemical | Lymphocyte Activation | Electrophoresis, Polyacrylamide Gel | Bacterial Proteins - chemistry | Molecular Sequence Data | Thermus thermophilus - metabolism | Chromatography, High Pressure Liquid | Pyrimidines - pharmacology | Plasmids - metabolism | Oxygen - metabolism | Dose-Response Relationship, Drug | Organophosphates - pharmacology | Spectrometry, Mass, Electrospray Ionization | Ultraviolet Rays | T-Lymphocytes - metabolism | Light | Escherichia coli - metabolism | Bacterial Proteins - metabolism | Plastids - metabolism | Polyisoprenyl Phosphates - biosynthesis | Kinetics
Journal Article
FEBS Letters, ISSN 0014-5793, 12/2002, Volume 532, Issue 3, pp. 437 - 440
Journal Article
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 09/2013, Volume 587, Issue 17, pp. 2806 - 2817
The methylerythritol phosphate (MEP) pathway of ( ) has become an attractive target for anti-malarial drug discovery. This study describes a kinetic model of... 
Drug target | Kinetic model | Malaria | Metabolic control analysis | Methylerythritol phosphate (MEP) | flux control coefficient | 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol | HMBPP | IPP | SBML | 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol kinase | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase | MECPPS | BLAST | Isopentenyl pyrophosphate | FCC | basic local alignment search tool | MECPP | CDPME | GAP | MEP | DMAPP | DXP | DXS | methylerythritol phosphate | DXR | glyceraldehyde 3-phosphate | 2-C-methyl-d-erythritol 2,4-cyclodiphosphate | 1-deoxy-d-xylulose 5-phosphate | 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate | PDB | concentration control coefficient | 2-phospho-4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol | protein data bank | BLAST-P | dimethylallyl diphosphate | 4-(cytidine 5′-diphospho)-2-C-methyl-d-erythritol synthase | CCC | PYR | 2-C-methyl-d-erythritol 2,4-cyclodiphosphate synthase | PSI-BLAST | 1-deoxy-d-xylulose 5-phosphate reductoisomerase | HMBPPR | pyruvate | 1-deoxy-d-xylulose 5-phosphate synthase | HMBPPS | system biology markup language | CDPMEP | protein BLAST | CDPMES | position-specific iterated BLAST | CDPMEK | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | NON-MEVALONATE PATHWAY | 1-DEOXY-D-XYLULOSE 5-PHOSPHATE SYNTHASE | CELL BIOLOGY | STEADY-STATE TREATMENT | SUBSTRATE-BINDING | BIOPHYSICS | BIOSYNTHESIS | PLANTS | SYSTEMS BIOLOGY | Enzymes - chemistry | Oxidoreductases - antagonists & inhibitors | Plasmodium falciparum - enzymology | Erythritol - analogs & derivatives | Models, Chemical | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Oxidoreductases - chemistry | Terpenes - metabolism | Computer Simulation | Enzyme Inhibitors - chemistry | Plasmodium falciparum - metabolism | Protozoan Proteins - chemistry | Erythritol - metabolism | Phosphorus-Oxygen Lyases - chemistry | Transferases - antagonists & inhibitors | Escherichia coli Proteins - antagonists & inhibitors | Aldose-Ketose Isomerases - chemistry | Escherichia coli - enzymology | Transferases - chemistry | Biosynthetic Pathways | Multienzyme Complexes - antagonists & inhibitors | Multienzyme Complexes - chemistry | Phosphotransferases (Alcohol Group Acceptor) - antagonists & inhibitors | Algorithms | Models, Biological | Kinetics | Aldose-Ketose Isomerases - antagonists & inhibitors | Escherichia coli Proteins - chemistry | Phosphorus-Oxygen Lyases - antagonists & inhibitors | Phosphates | Plasmodium falciparum | Enzymes | Metabolites | Analysis | Phytochemistry | Physiological aspects | Models | Sugars | Monosaccharides
Journal Article
FEBS Letters, ISSN 0014-5793, 2005, Volume 579, Issue 17, pp. 3802 - 3806
Although flavodoxin I is indispensable for growth, the exact pathway(s) where flavodoxin I is essential has not been identified. We performed transposon... 
2- C-Methyl- D-erythritol 4-phosphate | ( E)-4-Hydroxy-3-methylbutyl-2-enyl pyrophosphate | Flavodoxin I | fldA | γδ T cell | PBS | isopentenyl pyrophosphate | dimethylallyl pyrophosphate | HMBPP | IPP | Luria-Bertani | mevalonate | (E)-4-hydroxy-3-methylbutyl-2-enyl pyrophosphate | phosphate buffered saline | MEP | MVA | DMAPP | 2-C-methyl-D-erythritol 4-phosphate | (E)-4-Hydroxy-3- methylbutyl-2-enyl pyrophosphate | 2-C-Methyl-D-erythritol 4-phosphate | ISPH PROTEIN | METHYLERYTHRITOL PHOSPHATE-PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | 4FE-4S PROTEIN | DELTA-T-CELLS | flavodoxin I | gamma delta T cell | CELL BIOLOGY | SP STRAIN CL190 | GCPE | BIOPHYSICS | ISOPENTENYL DIPHOSPHATE | MEVALONATE PATHWAY | NONMEVALONATE PATHWAY | Glycine - genetics | Flavodoxin - metabolism | Erythritol - analogs & derivatives | Flavodoxin - genetics | Escherichia coli Proteins - physiology | Genes, Essential | Genetic Complementation Test | Aspartic Acid - genetics | Sugar Phosphates - metabolism | Terpenes - metabolism | Mutagenesis | Escherichia coli - genetics | Escherichia coli - metabolism | Escherichia coli Proteins - genetics | Erythritol - metabolism | Amino Acid Substitution | Phosphates | Enzymes | Transposons | Gene mutations | Escherichia coli | Genetic research | Physiological aspects | Universities and colleges
Journal Article
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